Incidental Mutation 'R1378:Or10d4'
ID 162955
Institutional Source Beutler Lab
Gene Symbol Or10d4
Ensembl Gene ENSMUSG00000064110
Gene Name olfactory receptor family 10 subfamily D member 4
Synonyms MOR224-13, GA_x6K02T2PVTD-33365879-33366814, Olfr963, MOR224-7P
MMRRC Submission 039442-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R1378 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39580355-39581290 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39580962 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 203 (L203P)
Ref Sequence ENSEMBL: ENSMUSP00000148985 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073433] [ENSMUST00000215649]
AlphaFold Q7TRA9
Predicted Effect probably damaging
Transcript: ENSMUST00000073433
AA Change: L203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073139
Gene: ENSMUSG00000064110
AA Change: L203P

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.7e-49 PFAM
Pfam:7tm_1 39 286 2.4e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215649
AA Change: L203P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.3%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1 A G 5: 36,126,030 (GRCm39) T342A probably damaging Het
Alg1 A G 16: 5,061,580 (GRCm39) N406D probably damaging Het
Atp13a4 A T 16: 29,239,246 (GRCm39) M825K probably damaging Het
Birc6 T A 17: 74,967,450 (GRCm39) I4117K probably damaging Het
Brinp2 A T 1: 158,074,624 (GRCm39) L499Q possibly damaging Het
Brwd1 A T 16: 95,842,570 (GRCm39) V789D probably benign Het
Ccdc153 C G 9: 44,154,958 (GRCm39) L94V probably null Het
Ccna1 A G 3: 54,957,150 (GRCm39) V237A probably damaging Het
Cct7 T A 6: 85,444,545 (GRCm39) probably null Het
Cenpb C T 2: 131,020,230 (GRCm39) probably benign Het
Chrne T A 11: 70,505,956 (GRCm39) probably null Het
Clstn3 T A 6: 124,415,378 (GRCm39) D662V probably damaging Het
Clu G T 14: 66,212,350 (GRCm39) C189F probably damaging Het
Cstdc5 A G 16: 36,179,929 (GRCm39) C63R probably benign Het
Cul7 C T 17: 46,973,052 (GRCm39) R1388C probably damaging Het
Dgka T C 10: 128,571,696 (GRCm39) probably null Het
Dop1b A G 16: 93,567,280 (GRCm39) T1236A probably benign Het
Edn2 A G 4: 120,019,095 (GRCm39) E28G probably benign Het
Elp3 T C 14: 65,830,380 (GRCm39) I24V probably benign Het
Faap24 T C 7: 35,092,326 (GRCm39) E197G probably benign Het
Fam13a T A 6: 58,933,736 (GRCm39) M285L probably benign Het
Gm9944 T A 4: 144,179,773 (GRCm39) probably benign Het
Gsdmc3 T C 15: 63,731,435 (GRCm39) probably benign Het
Gvin3 T A 7: 106,201,373 (GRCm39) I624F probably damaging Het
Ift22 A C 5: 136,941,757 (GRCm39) K133T probably benign Het
Il23r T A 6: 67,429,394 (GRCm39) K316I possibly damaging Het
Klra17 T A 6: 129,842,647 (GRCm39) E217V probably damaging Het
Nell2 A T 15: 95,130,402 (GRCm39) V657E probably damaging Het
Nlrp4d C A 7: 10,098,111 (GRCm39) K850N probably benign Het
Nsmce4a C T 7: 130,139,900 (GRCm39) R276Q probably benign Het
Or4p8 T A 2: 88,727,370 (GRCm39) R190S probably benign Het
Or52s1b T C 7: 102,822,475 (GRCm39) D123G probably damaging Het
Or52z14 A T 7: 103,253,145 (GRCm39) R95* probably null Het
Pclo T C 5: 14,732,327 (GRCm39) S3610P probably benign Het
Pon3 T G 6: 5,230,813 (GRCm39) D238A probably benign Het
Ppp4r4 T C 12: 103,547,751 (GRCm39) probably benign Het
Rad18 T C 6: 112,658,297 (GRCm39) probably benign Het
Ralgapa1 T C 12: 55,723,711 (GRCm39) Y1652C probably damaging Het
Rem1 G A 2: 152,476,455 (GRCm39) V238M probably damaging Het
Sel1l T C 12: 91,799,871 (GRCm39) probably null Het
Soat1 A G 1: 156,294,352 (GRCm39) probably benign Het
Tex15 A T 8: 34,065,244 (GRCm39) N1558I probably damaging Het
Tmem132d A T 5: 128,346,011 (GRCm39) F170L probably benign Het
Tro G T X: 149,438,567 (GRCm39) P30Q probably damaging Het
Tubg2 G T 11: 101,047,699 (GRCm39) E95* probably null Het
Unc45b G A 11: 82,827,678 (GRCm39) S725N probably benign Het
Vmn2r7 A G 3: 64,599,025 (GRCm39) S511P possibly damaging Het
Vps35l G T 7: 118,393,795 (GRCm39) E515* probably null Het
Vps35l A T 7: 118,393,796 (GRCm39) E515V probably damaging Het
Zfp174 G A 16: 3,667,353 (GRCm39) E181K probably benign Het
Other mutations in Or10d4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02043:Or10d4 APN 9 39,580,374 (GRCm39) missense probably damaging 1.00
IGL03007:Or10d4 APN 9 39,580,767 (GRCm39) missense possibly damaging 0.95
R1177:Or10d4 UTSW 9 39,580,937 (GRCm39) missense probably benign 0.04
R1517:Or10d4 UTSW 9 39,581,016 (GRCm39) missense probably damaging 0.99
R2016:Or10d4 UTSW 9 39,580,851 (GRCm39) missense probably damaging 1.00
R2212:Or10d4 UTSW 9 39,580,524 (GRCm39) missense probably damaging 1.00
R2393:Or10d4 UTSW 9 39,580,569 (GRCm39) missense possibly damaging 0.53
R5464:Or10d4 UTSW 9 39,581,066 (GRCm39) missense probably damaging 1.00
R5886:Or10d4 UTSW 9 39,581,252 (GRCm39) missense probably benign 0.01
R5935:Or10d4 UTSW 9 39,580,386 (GRCm39) missense probably benign
R7756:Or10d4 UTSW 9 39,580,371 (GRCm39) missense probably benign
R7758:Or10d4 UTSW 9 39,580,371 (GRCm39) missense probably benign
R7775:Or10d4 UTSW 9 39,580,534 (GRCm39) missense possibly damaging 0.65
R7778:Or10d4 UTSW 9 39,580,534 (GRCm39) missense possibly damaging 0.65
R8695:Or10d4 UTSW 9 39,580,376 (GRCm39) missense probably benign 0.26
R8921:Or10d4 UTSW 9 39,580,737 (GRCm39) nonsense probably null
R9133:Or10d4 UTSW 9 39,580,974 (GRCm39) missense possibly damaging 0.88
R9487:Or10d4 UTSW 9 39,580,611 (GRCm39) missense possibly damaging 0.47
Predicted Primers PCR Primer
(F):5'- TGTTCCACCACAGCTCCAAAGATG -3'
(R):5'- TGGTCCATAAGCACAGATGATGGC -3'

Sequencing Primer
(F):5'- CCTATACACAGTGATGGCCTATG -3'
(R):5'- CACAGATGATGGCTGTGAGG -3'
Posted On 2014-03-17