Incidental Mutation 'R1381:Rusc2'
| ID |
162994 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rusc2
|
| Ensembl Gene |
ENSMUSG00000035969 |
| Gene Name |
RUN and SH3 domain containing 2 |
| Synonyms |
|
| MMRRC Submission |
039443-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.207)
|
| Stock # |
R1381 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
43381979-43427088 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 43416137 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 481
(V481E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133715
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035645]
[ENSMUST00000098106]
[ENSMUST00000125399]
[ENSMUST00000131668]
[ENSMUST00000135216]
[ENSMUST00000173682]
[ENSMUST00000149221]
[ENSMUST00000136360]
[ENSMUST00000139198]
[ENSMUST00000152322]
[ENSMUST00000144911]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000035645
AA Change: V481E
PolyPhen 2
Score 0.674 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000038379
Gene: ENSMUSG00000035969
AA Change: V481E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000098106
AA Change: V481E
PolyPhen 2
Score 0.674 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000095710
Gene: ENSMUSG00000035969
AA Change: V481E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125393
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125399
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131037
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131668
AA Change: V481E
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000118528
Gene: ENSMUSG00000035969
AA Change: V481E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135216
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173682
AA Change: V481E
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000133715
Gene: ENSMUSG00000035969
AA Change: V481E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
703 |
N/A |
INTRINSIC |
|
low complexity region
|
733 |
740 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150066
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146710
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149556
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149221
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136360
|
| SMART Domains |
Protein: ENSMUSP00000123431
Gene: ENSMUSG00000035969
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139198
|
| SMART Domains |
Protein: ENSMUSP00000121528
Gene: ENSMUSG00000035969
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152322
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144911
|
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.8%
- 10x: 94.4%
- 20x: 86.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932414N04Rik |
C |
A |
2: 68,561,430 (GRCm39) |
F252L |
probably benign |
Het |
| Aadac |
A |
T |
3: 59,947,351 (GRCm39) |
M350L |
probably damaging |
Het |
| Agtrap |
G |
A |
4: 148,168,422 (GRCm39) |
T19I |
probably damaging |
Het |
| Apba3 |
C |
T |
10: 81,107,590 (GRCm39) |
T142M |
possibly damaging |
Het |
| Cd55b |
T |
A |
1: 130,347,412 (GRCm39) |
K133I |
probably damaging |
Het |
| Cep295 |
A |
C |
9: 15,233,861 (GRCm39) |
C2312G |
probably benign |
Het |
| Ces1a |
A |
G |
8: 93,760,659 (GRCm39) |
V231A |
probably damaging |
Het |
| Chdh |
C |
A |
14: 29,758,791 (GRCm39) |
L579I |
probably damaging |
Het |
| Cyb5r4 |
T |
A |
9: 86,904,286 (GRCm39) |
S19T |
probably benign |
Het |
| Cyp2d22 |
C |
A |
15: 82,256,709 (GRCm39) |
R355L |
probably benign |
Het |
| Dach2 |
T |
C |
X: 112,208,472 (GRCm39) |
Y117H |
probably damaging |
Het |
| Dennd4c |
G |
A |
4: 86,692,769 (GRCm39) |
R93K |
probably benign |
Het |
| Dph2 |
G |
T |
4: 117,746,865 (GRCm39) |
L452I |
probably damaging |
Het |
| Exoc6b |
T |
C |
6: 84,812,099 (GRCm39) |
D634G |
probably benign |
Het |
| Fam217b |
G |
A |
2: 178,062,218 (GRCm39) |
V61I |
probably benign |
Het |
| Fbln7 |
A |
C |
2: 128,719,299 (GRCm39) |
Q32P |
probably damaging |
Het |
| Fgfr1op2 |
A |
G |
6: 146,490,239 (GRCm39) |
Y46C |
probably damaging |
Het |
| Fhod3 |
T |
A |
18: 25,223,528 (GRCm39) |
I958N |
probably damaging |
Het |
| Foxp2 |
T |
A |
6: 15,409,765 (GRCm39) |
M455K |
possibly damaging |
Het |
| Gabrr2 |
G |
A |
4: 33,081,420 (GRCm39) |
G152D |
probably damaging |
Het |
| Galntl6 |
G |
T |
8: 58,925,989 (GRCm39) |
P92Q |
probably damaging |
Het |
| Gm5592 |
A |
T |
7: 40,935,596 (GRCm39) |
T33S |
probably benign |
Het |
| Grid2ip |
A |
T |
5: 143,348,406 (GRCm39) |
T166S |
probably benign |
Het |
| Grsf1 |
G |
A |
5: 88,813,723 (GRCm39) |
S225L |
probably benign |
Het |
| Hadha |
G |
T |
5: 30,333,834 (GRCm39) |
T395K |
probably benign |
Het |
| Hars2 |
C |
T |
18: 36,922,270 (GRCm39) |
A295V |
possibly damaging |
Het |
| Hsf5 |
T |
A |
11: 87,528,995 (GRCm39) |
S577T |
probably benign |
Het |
| Ice2 |
A |
G |
9: 69,307,809 (GRCm39) |
Y31C |
probably damaging |
Het |
| Ift80 |
A |
T |
3: 68,822,116 (GRCm39) |
I643N |
possibly damaging |
Het |
| Iglon5 |
A |
T |
7: 43,126,064 (GRCm39) |
D222E |
probably benign |
Het |
| Ilvbl |
C |
A |
10: 78,412,430 (GRCm39) |
S50R |
probably damaging |
Het |
| Invs |
C |
A |
4: 48,421,942 (GRCm39) |
S858* |
probably null |
Het |
| Ipo13 |
T |
G |
4: 117,761,592 (GRCm39) |
T508P |
probably damaging |
Het |
| Itgb4 |
T |
C |
11: 115,885,163 (GRCm39) |
I1015T |
probably benign |
Het |
| Kank4 |
A |
T |
4: 98,668,175 (GRCm39) |
W91R |
probably damaging |
Het |
| Kansl1l |
C |
T |
1: 66,760,063 (GRCm39) |
A906T |
probably benign |
Het |
| Klk4 |
G |
A |
7: 43,534,706 (GRCm39) |
V222M |
probably damaging |
Het |
| Lipo4 |
T |
A |
19: 33,476,741 (GRCm39) |
M336L |
probably benign |
Het |
| Lrig1 |
T |
C |
6: 94,583,111 (GRCm39) |
N1002D |
probably benign |
Het |
| Lzts3 |
A |
G |
2: 130,477,219 (GRCm39) |
S524P |
probably damaging |
Het |
| Maz |
A |
T |
7: 126,622,324 (GRCm39) |
C409* |
probably null |
Het |
| Mmp24 |
A |
T |
2: 155,656,047 (GRCm39) |
Q495L |
possibly damaging |
Het |
| Mrgpra9 |
C |
T |
7: 46,885,050 (GRCm39) |
V206I |
possibly damaging |
Het |
| Myof |
A |
G |
19: 37,983,933 (GRCm39) |
Y124H |
probably damaging |
Het |
| Nalcn |
A |
T |
14: 123,551,517 (GRCm39) |
V1030D |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,150,544 (GRCm39) |
I2495F |
probably damaging |
Het |
| Nfix |
G |
A |
8: 85,453,155 (GRCm39) |
R300C |
probably damaging |
Het |
| Nrbf2 |
G |
A |
10: 67,103,605 (GRCm39) |
T166M |
probably damaging |
Het |
| Nup153 |
T |
C |
13: 46,842,657 (GRCm39) |
D837G |
probably damaging |
Het |
| Nup210 |
C |
A |
6: 91,052,942 (GRCm39) |
G331V |
probably damaging |
Het |
| Or5b97 |
T |
C |
19: 12,878,320 (GRCm39) |
T275A |
probably benign |
Het |
| Or5w18 |
T |
C |
2: 87,633,480 (GRCm39) |
L245P |
probably damaging |
Het |
| Or6z7 |
A |
G |
7: 6,484,008 (GRCm39) |
|
probably null |
Het |
| Or8b56 |
T |
A |
9: 38,739,634 (GRCm39) |
S210T |
probably benign |
Het |
| Pabpc4 |
T |
A |
4: 123,182,852 (GRCm39) |
L163H |
probably damaging |
Het |
| Pcdh7 |
T |
A |
5: 57,878,882 (GRCm39) |
Y126* |
probably null |
Het |
| Pdzd2 |
A |
G |
15: 12,385,525 (GRCm39) |
S1082P |
probably benign |
Het |
| Pkd2l1 |
T |
C |
19: 44,138,902 (GRCm39) |
I649M |
probably benign |
Het |
| Plcl2 |
G |
A |
17: 50,914,757 (GRCm39) |
E589K |
probably damaging |
Het |
| Plppr1 |
C |
A |
4: 49,337,674 (GRCm39) |
T325N |
possibly damaging |
Het |
| Prss8 |
GCTGCCCAAGTCCC |
GC |
7: 127,529,021 (GRCm39) |
|
probably benign |
Het |
| Ptcd2 |
A |
G |
13: 99,481,105 (GRCm39) |
S25P |
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Sephs2 |
G |
T |
7: 126,872,139 (GRCm39) |
T318K |
probably damaging |
Het |
| Sf3b1 |
T |
A |
1: 55,042,313 (GRCm39) |
I497L |
probably damaging |
Het |
| Slc30a7 |
C |
T |
3: 115,750,519 (GRCm39) |
|
probably null |
Het |
| Slc66a2 |
T |
G |
18: 80,326,529 (GRCm39) |
S126A |
probably benign |
Het |
| Smarca2 |
T |
C |
19: 26,608,228 (GRCm39) |
S96P |
probably damaging |
Het |
| Spata31d1c |
A |
C |
13: 65,184,368 (GRCm39) |
I637L |
probably benign |
Het |
| Ston2 |
A |
T |
12: 91,707,266 (GRCm39) |
S115T |
probably damaging |
Het |
| Tal2 |
A |
C |
4: 53,785,999 (GRCm39) |
E60A |
probably benign |
Het |
| Tdpoz3 |
A |
T |
3: 93,733,447 (GRCm39) |
T41S |
probably benign |
Het |
| Tent4b |
T |
A |
8: 88,969,937 (GRCm39) |
M203K |
possibly damaging |
Het |
| Tespa1 |
T |
C |
10: 130,196,560 (GRCm39) |
I166T |
probably benign |
Het |
| Thsd7a |
A |
T |
6: 12,555,438 (GRCm39) |
C149S |
probably damaging |
Het |
| Trav6-1 |
T |
A |
14: 52,875,967 (GRCm39) |
|
probably benign |
Het |
| Txnl4a |
T |
C |
18: 80,250,479 (GRCm39) |
V25A |
probably benign |
Het |
| Utp4 |
C |
A |
8: 107,632,908 (GRCm39) |
P297Q |
probably benign |
Het |
| Vmn1r34 |
T |
C |
6: 66,613,922 (GRCm39) |
Y272C |
probably damaging |
Het |
| Vmn2r112 |
A |
T |
17: 22,837,467 (GRCm39) |
I643F |
probably damaging |
Het |
| Vmn2r121 |
C |
A |
X: 123,037,837 (GRCm39) |
G728W |
probably damaging |
Het |
| Vmn2r24 |
T |
A |
6: 123,763,692 (GRCm39) |
S190T |
probably damaging |
Het |
| Zfp507 |
A |
G |
7: 35,475,435 (GRCm39) |
V926A |
possibly damaging |
Het |
|
| Other mutations in Rusc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01358:Rusc2
|
APN |
4 |
43,426,116 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01474:Rusc2
|
APN |
4 |
43,416,434 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01541:Rusc2
|
APN |
4 |
43,415,840 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01628:Rusc2
|
APN |
4 |
43,425,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01969:Rusc2
|
APN |
4 |
43,415,738 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02030:Rusc2
|
APN |
4 |
43,416,095 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02079:Rusc2
|
APN |
4 |
43,425,668 (GRCm39) |
missense |
probably benign |
|
|
IGL02115:Rusc2
|
APN |
4 |
43,426,136 (GRCm39) |
splice site |
probably benign |
|
|
IGL02122:Rusc2
|
APN |
4 |
43,421,685 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02350:Rusc2
|
APN |
4 |
43,425,351 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02357:Rusc2
|
APN |
4 |
43,425,351 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02437:Rusc2
|
APN |
4 |
43,415,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02930:Rusc2
|
APN |
4 |
43,416,376 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03154:Rusc2
|
APN |
4 |
43,425,806 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0026:Rusc2
|
UTSW |
4 |
43,415,840 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0036:Rusc2
|
UTSW |
4 |
43,424,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm39) |
splice site |
probably benign |
|
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm39) |
splice site |
probably benign |
|
|
R0114:Rusc2
|
UTSW |
4 |
43,422,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0255:Rusc2
|
UTSW |
4 |
43,423,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0471:Rusc2
|
UTSW |
4 |
43,425,486 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1413:Rusc2
|
UTSW |
4 |
43,416,568 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1416:Rusc2
|
UTSW |
4 |
43,421,617 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1731:Rusc2
|
UTSW |
4 |
43,426,046 (GRCm39) |
missense |
probably benign |
|
|
R1864:Rusc2
|
UTSW |
4 |
43,421,719 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1897:Rusc2
|
UTSW |
4 |
43,421,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2010:Rusc2
|
UTSW |
4 |
43,415,212 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2212:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Rusc2
|
UTSW |
4 |
43,416,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2885:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2886:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm39) |
missense |
probably benign |
0.28 |
|
R3412:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3413:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3414:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Rusc2
|
UTSW |
4 |
43,416,424 (GRCm39) |
missense |
probably benign |
0.45 |
|
R4135:Rusc2
|
UTSW |
4 |
43,425,563 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4272:Rusc2
|
UTSW |
4 |
43,415,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4574:Rusc2
|
UTSW |
4 |
43,416,080 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4888:Rusc2
|
UTSW |
4 |
43,423,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5010:Rusc2
|
UTSW |
4 |
43,415,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5071:Rusc2
|
UTSW |
4 |
43,415,240 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5131:Rusc2
|
UTSW |
4 |
43,414,948 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5177:Rusc2
|
UTSW |
4 |
43,421,805 (GRCm39) |
splice site |
probably null |
|
|
R5540:Rusc2
|
UTSW |
4 |
43,423,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5561:Rusc2
|
UTSW |
4 |
43,415,932 (GRCm39) |
nonsense |
probably null |
|
|
R5628:Rusc2
|
UTSW |
4 |
43,425,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5645:Rusc2
|
UTSW |
4 |
43,425,758 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6129:Rusc2
|
UTSW |
4 |
43,424,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6362:Rusc2
|
UTSW |
4 |
43,416,416 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6633:Rusc2
|
UTSW |
4 |
43,414,852 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6980:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm39) |
missense |
probably benign |
0.35 |
|
R7491:Rusc2
|
UTSW |
4 |
43,426,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7641:Rusc2
|
UTSW |
4 |
43,425,335 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7698:Rusc2
|
UTSW |
4 |
43,414,900 (GRCm39) |
nonsense |
probably null |
|
|
R7710:Rusc2
|
UTSW |
4 |
43,416,119 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8052:Rusc2
|
UTSW |
4 |
43,421,851 (GRCm39) |
missense |
probably benign |
|
|
R8061:Rusc2
|
UTSW |
4 |
43,422,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8127:Rusc2
|
UTSW |
4 |
43,423,747 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R8319:Rusc2
|
UTSW |
4 |
43,425,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8355:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8397:Rusc2
|
UTSW |
4 |
43,424,206 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8455:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8553:Rusc2
|
UTSW |
4 |
43,416,508 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8725:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm39) |
intron |
probably benign |
|
|
R8725:Rusc2
|
UTSW |
4 |
43,415,396 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8727:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm39) |
intron |
probably benign |
|
|
R8834:Rusc2
|
UTSW |
4 |
43,416,431 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9295:Rusc2
|
UTSW |
4 |
43,416,382 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9483:Rusc2
|
UTSW |
4 |
43,415,897 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9666:Rusc2
|
UTSW |
4 |
43,416,262 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9705:Rusc2
|
UTSW |
4 |
43,424,936 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0025:Rusc2
|
UTSW |
4 |
43,422,226 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0066:Rusc2
|
UTSW |
4 |
43,422,204 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACGAGTTGCTCTGAAGAACACACC -3'
(R):5'- TTGGGAAGAATCTCCAACGCTCGC -3'
Sequencing Primer
(F):5'- CAAGATAAGTCCTCCACCAGG -3'
(R):5'- CGAAGGAGGTAACCCTTCTG -3'
|
| Posted On |
2014-03-17 |
Incidental Mutation