Mutagenetix > Incidental Mutation

Incidental Mutation 'R1382:Pate7'

163095

Institutional Source

Beutler Lab

Gene Symbol

Pate7

Ensembl Gene

ENSMUSG00000090738

Gene Name

prostate and testis expressed 7

Synonyms

Gm17727

MMRRC Submission

039444-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R1382 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

35687820-35689405 bp(-) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

T to A at 35689390 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000129553 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171898] [ENSMUST00000184431]

AlphaFold

E9Q4V7

Predicted Effect

probably benign
Transcript: ENSMUST00000171898

SMART Domains

Protein: ENSMUSP00000129553
Gene: ENSMUSG00000090738

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000184431
AA Change: K64M

SMART Domains

Protein: ENSMUSP00000139380
Gene: ENSMUSG00000098847
AA Change: K64M

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
low complexity region	32	43	N/A	INTRINSIC
low complexity region	64	81	N/A	INTRINSIC

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 95.0%
20x: 88.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ago2	C	T	15: 72,998,889 (GRCm39)	C236Y	probably benign	Het
Arhgef6	T	C	X: 56,383,922 (GRCm39)	M5V	probably benign	Het
Asap2	A	G	12: 21,315,955 (GRCm39)	T916A	probably damaging	Het
Ceacam5	T	C	7: 17,486,090 (GRCm39)	V529A	probably benign	Het
Cep192	G	A	18: 67,989,370 (GRCm39)	R1839Q	possibly damaging	Het
Cope	A	G	8: 70,765,513 (GRCm39)	N295S	probably benign	Het
Crocc2	G	A	1: 93,144,815 (GRCm39)		probably null	Het
Cuedc1	C	T	11: 88,068,189 (GRCm39)	P146S	probably benign	Het
Ddc	T	C	11: 11,774,856 (GRCm39)	D345G	possibly damaging	Het
Dsg4	T	A	18: 20,598,181 (GRCm39)	C700S	probably benign	Het
Dst	A	T	1: 34,307,914 (GRCm39)	E6224D	probably damaging	Het
Exo1	A	G	1: 175,721,362 (GRCm39)	T334A	probably damaging	Het
Gjb3	G	A	4: 127,220,224 (GRCm39)	R103W	probably damaging	Het
Glyr1	GCTGCC	G	16: 4,839,209 (GRCm39)		probably null	Het
Gtf3c3	C	T	1: 54,456,937 (GRCm39)	A488T	probably damaging	Het
Lemd3	A	T	10: 120,767,641 (GRCm39)	I711K	probably damaging	Het
Lrrc8b	A	G	5: 105,628,749 (GRCm39)	D365G	probably damaging	Het
Mdga2	A	T	12: 66,517,690 (GRCm39)	I48K	possibly damaging	Het
Or51q1c	G	T	7: 103,652,927 (GRCm39)	L148F	probably benign	Het
Pdzph1	A	G	17: 59,281,742 (GRCm39)	V180A	probably benign	Het
Phactr1	T	C	13: 43,286,451 (GRCm39)	F584S	probably damaging	Het
Ppan	A	G	9: 20,803,214 (GRCm39)	K429E	probably benign	Het
Prkd3	A	G	17: 79,264,674 (GRCm39)	V647A	probably damaging	Het
Prl2c2	G	C	13: 13,176,786 (GRCm39)	T47R	probably damaging	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Ptpru	A	G	4: 131,535,540 (GRCm39)	F407S	probably damaging	Het
Rab3gap1	A	T	1: 127,870,333 (GRCm39)	T985S	probably damaging	Het
Slc5a2	G	C	7: 127,869,803 (GRCm39)	R412P	probably damaging	Het
Sned1	G	A	1: 93,209,376 (GRCm39)	V830M	possibly damaging	Het
Tet2	C	T	3: 133,182,376 (GRCm39)	G1196D	probably damaging	Het
Tub	G	A	7: 108,629,360 (GRCm39)	V426I	probably damaging	Het
Wdr75	A	G	1: 45,856,471 (GRCm39)	Y498C	probably damaging	Het

Other mutations in Pate7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01285:Pate7	APN	9	35,688,044 (GRCm39)	missense	possibly damaging	0.73
IGL02044:Pate7	APN	9	35,687,959 (GRCm39)	missense	probably benign	0.19
IGL02352:Pate7	APN	9	35,689,180 (GRCm39)	start codon destroyed	probably null	0.04
IGL02359:Pate7	APN	9	35,689,180 (GRCm39)	start codon destroyed	probably null	0.04
R0827:Pate7	UTSW	9	35,689,147 (GRCm39)	missense	probably damaging	0.97
R1591:Pate7	UTSW	9	35,687,952 (GRCm39)	missense	probably damaging	0.99
R1794:Pate7	UTSW	9	35,688,418 (GRCm39)	missense	probably benign	0.01
R5419:Pate7	UTSW	9	35,689,407 (GRCm39)	splice site	probably null
R6110:Pate7	UTSW	9	35,688,442 (GRCm39)	missense	possibly damaging	0.90
R6379:Pate7	UTSW	9	35,689,381 (GRCm39)	start gained	probably benign
R6614:Pate7	UTSW	9	35,688,421 (GRCm39)	missense	probably damaging	0.99
R7698:Pate7	UTSW	9	35,688,472 (GRCm39)	missense	probably benign	0.27
R7833:Pate7	UTSW	9	35,688,406 (GRCm39)	missense	probably damaging	1.00
R8110:Pate7	UTSW	9	35,689,329 (GRCm39)	makesense	probably null
R8881:Pate7	UTSW	9	35,689,384 (GRCm39)	utr 5 prime	probably benign
R8978:Pate7	UTSW	9	35,688,069 (GRCm39)	splice site	probably benign

Predicted Primers

PCR Primer
(F):5'- AGTAGCAGAACGATGCTCAGCTCC -3'
(R):5'- CAGTTCACCTCATGGTGACTGTCC -3'

Sequencing Primer
(F):5'- CCATTGAGGATTTGCTAACTCTTG -3'
(R):5'- TCATGGTGACTGTCCACTTTC -3'

Posted On

2014-03-17