Mutagenetix > Incidental Mutation

Incidental Mutation 'R0121:Lama1'

163269

Institutional Source

Beutler Lab

Gene Symbol

Lama1

Ensembl Gene

ENSMUSG00000032796

Gene Name

laminin, alpha 1

Synonyms

Lama

MMRRC Submission

038406-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0121 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

67697265-67822645 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 67798513 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000043957 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035471]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000035471

SMART Domains

Protein: ENSMUSP00000043957
Gene: ENSMUSG00000032796

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
LamNT	23	275	1.2e-131	SMART
EGF_Lam	277	331	1e-5	SMART
EGF_Lam	334	401	6.6e-6	SMART
EGF_Lam	404	458	9.11e-9	SMART
EGF_Lam	461	507	8.12e-6	SMART
LamB	570	702	2.09e-57	SMART
EGF_like	715	746	3.36e0	SMART
EGF_Lam	749	795	7.01e-10	SMART
EGF_Lam	798	853	3.59e-7	SMART
EGF_Lam	856	906	1.53e-10	SMART
EGF_Lam	909	955	1.13e-13	SMART
EGF_Lam	958	1002	1.36e-7	SMART
EGF_Lam	1005	1048	7.29e-8	SMART
EGF_like	1034	1082	4.83e1	SMART
EGF_Lam	1051	1094	1.67e-7	SMART
EGF_Lam	1097	1154	1.32e-5	SMART
LamB	1220	1352	8.7e-46	SMART
Pfam:Laminin_EGF	1367	1397	1.7e-6	PFAM
EGF_Lam	1410	1456	7.12e-11	SMART
EGF_Lam	1459	1513	3.25e-5	SMART
EGF_like	1497	1547	6.41e1	SMART
EGF_Lam	1516	1560	1.71e-13	SMART
Pfam:Laminin_I	1574	1838	1.7e-91	PFAM
low complexity region	2012	2031	N/A	INTRINSIC
low complexity region	2087	2098	N/A	INTRINSIC
LamG	2145	2287	3.66e-30	SMART
LamG	2332	2473	5.98e-35	SMART
LamG	2513	2661	1.11e-29	SMART
low complexity region	2695	2708	N/A	INTRINSIC
LamG	2743	2877	9.72e-35	SMART
LamG	2920	3056	4.63e-41	SMART

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.5%
20x: 89.8%

Validation Efficiency

100% (63/63)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,259,786 (GRCm38)		probably null	Het
Adgra3	T	C	5: 50,025,786 (GRCm38)		probably benign	Het
Anxa7	A	T	14: 20,460,159 (GRCm38)	L386M	probably damaging	Het
Ap2b1	A	G	11: 83,321,967 (GRCm38)	M58V	possibly damaging	Het
Arfip2	A	G	7: 105,636,371 (GRCm38)	L224P	probably damaging	Het
Arhgap20	A	G	9: 51,838,951 (GRCm38)	N373S	possibly damaging	Het
Asph	T	C	4: 9,635,918 (GRCm38)	D73G	probably damaging	Het
Atp1a2	T	A	1: 172,289,342 (GRCm38)	E236V	probably damaging	Het
Atp2a1	A	G	7: 126,457,944 (GRCm38)	S170P	probably damaging	Het
Atp4a	C	G	7: 30,720,101 (GRCm38)	R659G	probably benign	Het
B4galnt3	C	T	6: 120,215,038 (GRCm38)	R578H	probably benign	Het
Ccdc178	C	A	18: 21,845,024 (GRCm38)		probably null	Het
Ccnh	T	A	13: 85,206,193 (GRCm38)	M252K	probably damaging	Het
Clec4b2	A	G	6: 123,204,172 (GRCm38)	D172G	probably benign	Het
Col1a1	A	G	11: 94,938,069 (GRCm38)	E79G	unknown	Het
Csf3r	A	G	4: 126,029,849 (GRCm38)	N51D	probably benign	Het
Cul7	C	T	17: 46,663,373 (GRCm38)	L1489F	probably damaging	Het
Cyp2b13	G	A	7: 26,086,585 (GRCm38)	C309Y	probably benign	Het
Dync2h1	A	T	9: 7,001,327 (GRCm38)		probably benign	Het
Edn1	A	G	13: 42,305,265 (GRCm38)	T135A	probably benign	Het
Ephb2	A	G	4: 136,771,057 (GRCm38)	I237T	probably damaging	Het
Fam111a	T	A	19: 12,584,080 (GRCm38)	F12L	probably benign	Het
Foxi2	C	A	7: 135,411,911 (GRCm38)	A290E	probably benign	Het
Gabra6	A	G	11: 42,314,971 (GRCm38)	S353P	probably benign	Het
Gm4847	T	C	1: 166,642,288 (GRCm38)	D72G	probably damaging	Het
Grhl3	A	G	4: 135,552,549 (GRCm38)	I398T	probably damaging	Het
Gtdc1	T	C	2: 44,565,538 (GRCm38)		probably benign	Het
Kel	A	C	6: 41,702,064 (GRCm38)		probably benign	Het
L3mbtl3	C	T	10: 26,313,870 (GRCm38)	D499N	unknown	Het
Mamdc2	T	A	19: 23,310,859 (GRCm38)	E605V	probably benign	Het
Nolc1	G	A	19: 46,081,378 (GRCm38)		probably benign	Het
Nudt12	A	T	17: 59,007,639 (GRCm38)	S317T	possibly damaging	Het
Olfr1085	A	G	2: 86,657,819 (GRCm38)	V213A	probably benign	Het
Olfr1153	A	G	2: 87,897,090 (GRCm38)	K297R	possibly damaging	Het
Olfr1277	A	T	2: 111,270,314 (GRCm38)	C18S	probably benign	Het
Olfr937	T	A	9: 39,059,760 (GRCm38)	K302M	probably damaging	Het
Optn	C	T	2: 5,024,115 (GRCm38)	G526R	probably damaging	Het
Pbld1	C	T	10: 63,071,503 (GRCm38)		probably benign	Het
Prl8a9	T	G	13: 27,560,606 (GRCm38)	N84T	probably benign	Het
Psph	T	A	5: 129,791,570 (GRCm38)		probably benign	Het
Sbf2	A	G	7: 110,489,219 (GRCm38)		probably null	Het
Senp6	A	G	9: 80,116,670 (GRCm38)	D405G	probably benign	Het
Serpinb1a	T	A	13: 32,848,771 (GRCm38)		probably benign	Het
Slc2a9	T	C	5: 38,398,743 (GRCm38)	I287V	probably benign	Het
Sptbn2	T	C	19: 4,745,293 (GRCm38)	F1593S	probably damaging	Het
Tcf21	T	C	10: 22,819,807 (GRCm38)	T33A	probably benign	Het
Tdrd3	A	T	14: 87,539,479 (GRCm38)	Q727L	probably damaging	Het
Tecpr1	C	T	5: 144,210,199 (GRCm38)	E450K	probably benign	Het
Tenm3	G	A	8: 48,342,659 (GRCm38)	T532I	probably damaging	Het
Tg	A	T	15: 66,740,781 (GRCm38)	Q396L	probably benign	Het
Tmtc3	A	G	10: 100,458,908 (GRCm38)		probably benign	Het
Twnk	T	C	19: 45,009,265 (GRCm38)		probably benign	Het
Ubac1	A	G	2: 26,008,859 (GRCm38)		probably null	Het
Ubn2	T	C	6: 38,452,858 (GRCm38)		probably benign	Het
Zfp944	T	A	17: 22,339,268 (GRCm38)	T333S	possibly damaging	Het

Other mutations in Lama1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Lama1	APN	17	67,815,928 (GRCm38)	missense	probably benign
IGL00336:Lama1	APN	17	67,813,948 (GRCm38)	missense	probably benign	0.07
IGL01066:Lama1	APN	17	67,743,326 (GRCm38)	missense	probably damaging	1.00
IGL01140:Lama1	APN	17	67,802,933 (GRCm38)	missense	probably benign	0.14
IGL01291:Lama1	APN	17	67,738,870 (GRCm38)	missense	probably damaging	1.00
IGL01296:Lama1	APN	17	67,745,051 (GRCm38)	missense	probably benign	0.27
IGL01317:Lama1	APN	17	67,818,701 (GRCm38)	missense	probably damaging	1.00
IGL01490:Lama1	APN	17	67,750,584 (GRCm38)	missense	possibly damaging	0.54
IGL01506:Lama1	APN	17	67,785,070 (GRCm38)	missense	probably benign	0.01
IGL01508:Lama1	APN	17	67,809,361 (GRCm38)	splice site	probably benign
IGL01522:Lama1	APN	17	67,752,774 (GRCm38)	splice site	probably benign
IGL01530:Lama1	APN	17	67,796,790 (GRCm38)	missense	probably benign	0.02
IGL01541:Lama1	APN	17	67,785,070 (GRCm38)	missense	probably benign	0.01
IGL01677:Lama1	APN	17	67,779,148 (GRCm38)	missense	probably benign	0.15
IGL01886:Lama1	APN	17	67,807,797 (GRCm38)	missense	probably benign	0.36
IGL01994:Lama1	APN	17	67,752,439 (GRCm38)	missense	probably benign	0.05
IGL02017:Lama1	APN	17	67,764,725 (GRCm38)	missense	probably benign	0.00
IGL02021:Lama1	APN	17	67,821,626 (GRCm38)	missense	probably damaging	1.00
IGL02026:Lama1	APN	17	67,809,292 (GRCm38)	missense	possibly damaging	0.82
IGL02044:Lama1	APN	17	67,811,490 (GRCm38)	missense	probably benign	0.01
IGL02120:Lama1	APN	17	67,716,789 (GRCm38)	missense	probably damaging	1.00
IGL02425:Lama1	APN	17	67,811,485 (GRCm38)	missense	probably benign	0.45
IGL02549:Lama1	APN	17	67,790,835 (GRCm38)	missense	possibly damaging	0.93
IGL02642:Lama1	APN	17	67,812,366 (GRCm38)	missense	probably benign	0.00
IGL02795:Lama1	APN	17	67,738,894 (GRCm38)	splice site	probably null
IGL02798:Lama1	APN	17	67,795,191 (GRCm38)	splice site	probably benign
IGL02863:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02870:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02876:Lama1	APN	17	67,750,692 (GRCm38)	critical splice donor site	probably null
IGL02885:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02891:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02978:Lama1	APN	17	67,786,081 (GRCm38)	nonsense	probably null
IGL03064:Lama1	APN	17	67,779,104 (GRCm38)	missense	probably benign	0.01
IGL03076:Lama1	APN	17	67,716,799 (GRCm38)	missense	possibly damaging	0.95
IGL03110:Lama1	APN	17	67,798,986 (GRCm38)	missense	probably benign	0.04
IGL03143:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL03159:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL03268:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
ANU05:Lama1	UTSW	17	67,738,870 (GRCm38)	missense	probably damaging	1.00
PIT4472001:Lama1	UTSW	17	67,764,704 (GRCm38)	missense
R0047:Lama1	UTSW	17	67,795,186 (GRCm38)	splice site	probably benign
R0047:Lama1	UTSW	17	67,795,186 (GRCm38)	splice site	probably benign
R0050:Lama1	UTSW	17	67,782,056 (GRCm38)	missense	possibly damaging	0.66
R0096:Lama1	UTSW	17	67,805,413 (GRCm38)	missense	probably benign	0.12
R0096:Lama1	UTSW	17	67,805,413 (GRCm38)	missense	probably benign	0.12
R0111:Lama1	UTSW	17	67,737,498 (GRCm38)	missense	probably damaging	0.98
R0116:Lama1	UTSW	17	67,776,923 (GRCm38)	missense	probably benign	0.10
R0278:Lama1	UTSW	17	67,810,183 (GRCm38)	missense	probably null	0.98
R0281:Lama1	UTSW	17	67,817,569 (GRCm38)	missense	probably damaging	1.00
R0312:Lama1	UTSW	17	67,775,851 (GRCm38)	missense	possibly damaging	0.45
R0419:Lama1	UTSW	17	67,791,610 (GRCm38)	critical splice donor site	probably null
R0512:Lama1	UTSW	17	67,779,134 (GRCm38)	missense	possibly damaging	0.67
R0514:Lama1	UTSW	17	67,764,698 (GRCm38)	missense	probably benign	0.40
R0562:Lama1	UTSW	17	67,815,959 (GRCm38)	missense	probably damaging	1.00
R0632:Lama1	UTSW	17	67,752,368 (GRCm38)	splice site	probably benign
R0645:Lama1	UTSW	17	67,773,712 (GRCm38)	missense	probably benign	0.01
R0712:Lama1	UTSW	17	67,779,042 (GRCm38)	splice site	probably null
R0763:Lama1	UTSW	17	67,772,818 (GRCm38)	missense	probably damaging	0.97
R0941:Lama1	UTSW	17	67,775,865 (GRCm38)	missense	probably benign	0.10
R1025:Lama1	UTSW	17	67,752,898 (GRCm38)	missense	probably benign	0.00
R1084:Lama1	UTSW	17	67,804,469 (GRCm38)	missense	probably benign	0.12
R1103:Lama1	UTSW	17	67,790,947 (GRCm38)	missense	probably damaging	0.98
R1420:Lama1	UTSW	17	67,790,947 (GRCm38)	missense	probably damaging	0.98
R1430:Lama1	UTSW	17	67,782,155 (GRCm38)	missense	possibly damaging	0.95
R1569:Lama1	UTSW	17	67,780,618 (GRCm38)	splice site	probably null
R1575:Lama1	UTSW	17	67,810,409 (GRCm38)	missense	possibly damaging	0.96
R1613:Lama1	UTSW	17	67,807,923 (GRCm38)	missense	probably benign	0.42
R1620:Lama1	UTSW	17	67,767,033 (GRCm38)	missense	probably benign	0.01
R1629:Lama1	UTSW	17	67,805,428 (GRCm38)	missense	probably benign	0.00
R1645:Lama1	UTSW	17	67,737,682 (GRCm38)	missense	probably benign	0.14
R1652:Lama1	UTSW	17	67,807,846 (GRCm38)	missense	probably damaging	0.97
R1674:Lama1	UTSW	17	67,791,244 (GRCm38)	missense	probably benign
R1678:Lama1	UTSW	17	67,810,155 (GRCm38)	missense	possibly damaging	0.56
R1710:Lama1	UTSW	17	67,753,791 (GRCm38)	missense	probably benign	0.00
R1712:Lama1	UTSW	17	67,717,186 (GRCm38)	missense	possibly damaging	0.95
R1737:Lama1	UTSW	17	67,802,921 (GRCm38)	missense	probably benign	0.36
R1757:Lama1	UTSW	17	67,697,383 (GRCm38)	missense	unknown
R1757:Lama1	UTSW	17	67,763,836 (GRCm38)	missense	probably benign	0.40
R1813:Lama1	UTSW	17	67,791,223 (GRCm38)	missense	probably benign
R1896:Lama1	UTSW	17	67,791,223 (GRCm38)	missense	probably benign
R1945:Lama1	UTSW	17	67,745,853 (GRCm38)	missense	probably benign	0.14
R2086:Lama1	UTSW	17	67,817,623 (GRCm38)	missense	probably damaging	1.00
R2149:Lama1	UTSW	17	67,773,865 (GRCm38)	missense	possibly damaging	0.95
R2178:Lama1	UTSW	17	67,769,515 (GRCm38)	missense	probably benign	0.07
R2183:Lama1	UTSW	17	67,791,009 (GRCm38)	missense	probably damaging	0.98
R2197:Lama1	UTSW	17	67,752,941 (GRCm38)	missense	probably benign	0.02
R2213:Lama1	UTSW	17	67,777,034 (GRCm38)	nonsense	probably null
R2260:Lama1	UTSW	17	67,737,507 (GRCm38)	missense	probably damaging	0.96
R2356:Lama1	UTSW	17	67,810,114 (GRCm38)	missense	probably damaging	1.00
R2420:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2421:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2422:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2424:Lama1	UTSW	17	67,798,665 (GRCm38)	missense	probably benign	0.09
R2442:Lama1	UTSW	17	67,768,317 (GRCm38)	missense	probably benign	0.04
R3147:Lama1	UTSW	17	67,737,658 (GRCm38)	missense	probably damaging	0.98
R3414:Lama1	UTSW	17	67,737,603 (GRCm38)	missense	probably damaging	1.00
R3683:Lama1	UTSW	17	67,768,333 (GRCm38)	missense	probably benign	0.40
R3820:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R3821:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R3822:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R4012:Lama1	UTSW	17	67,812,373 (GRCm38)	nonsense	probably null
R4113:Lama1	UTSW	17	67,764,703 (GRCm38)	missense	probably benign	0.01
R4133:Lama1	UTSW	17	67,812,486 (GRCm38)	missense	probably damaging	1.00
R4133:Lama1	UTSW	17	67,750,655 (GRCm38)	missense	probably damaging	0.98
R4259:Lama1	UTSW	17	67,752,418 (GRCm38)	missense	possibly damaging	0.95
R4278:Lama1	UTSW	17	67,791,517 (GRCm38)	missense	probably null	0.00
R4321:Lama1	UTSW	17	67,771,083 (GRCm38)	missense	probably benign	0.03
R4374:Lama1	UTSW	17	67,804,518 (GRCm38)	missense	probably benign	0.00
R4386:Lama1	UTSW	17	67,773,712 (GRCm38)	missense	probably benign	0.01
R4463:Lama1	UTSW	17	67,761,700 (GRCm38)	missense	probably damaging	1.00
R4629:Lama1	UTSW	17	67,805,360 (GRCm38)	critical splice acceptor site	probably null
R4630:Lama1	UTSW	17	67,794,300 (GRCm38)	missense	probably benign	0.00
R4633:Lama1	UTSW	17	67,798,584 (GRCm38)	missense	probably damaging	0.96
R4668:Lama1	UTSW	17	67,752,434 (GRCm38)	missense	probably benign	0.27
R4684:Lama1	UTSW	17	67,773,778 (GRCm38)	missense	possibly damaging	0.88
R4745:Lama1	UTSW	17	67,738,780 (GRCm38)	missense	probably damaging	1.00
R4786:Lama1	UTSW	17	67,773,859 (GRCm38)	missense	possibly damaging	0.77
R4797:Lama1	UTSW	17	67,716,775 (GRCm38)	missense	probably benign	0.04
R4803:Lama1	UTSW	17	67,809,271 (GRCm38)	missense	probably damaging	1.00
R4925:Lama1	UTSW	17	67,794,314 (GRCm38)	missense	probably benign	0.02
R4939:Lama1	UTSW	17	67,737,475 (GRCm38)	missense	possibly damaging	0.91
R4952:Lama1	UTSW	17	67,767,566 (GRCm38)	critical splice donor site	probably null
R4975:Lama1	UTSW	17	67,738,834 (GRCm38)	missense	possibly damaging	0.95
R4977:Lama1	UTSW	17	67,737,682 (GRCm38)	missense	probably damaging	1.00
R5039:Lama1	UTSW	17	67,745,893 (GRCm38)	missense	possibly damaging	0.66
R5047:Lama1	UTSW	17	67,743,281 (GRCm38)	nonsense	probably null
R5195:Lama1	UTSW	17	67,764,800 (GRCm38)	missense	probably benign	0.13
R5230:Lama1	UTSW	17	67,745,083 (GRCm38)	nonsense	probably null
R5236:Lama1	UTSW	17	67,804,492 (GRCm38)	missense	probably benign	0.24
R5254:Lama1	UTSW	17	67,756,716 (GRCm38)	missense	probably benign	0.01
R5345:Lama1	UTSW	17	67,817,563 (GRCm38)	missense	probably benign
R5438:Lama1	UTSW	17	67,800,774 (GRCm38)	missense	possibly damaging	0.92
R5521:Lama1	UTSW	17	67,780,894 (GRCm38)	nonsense	probably null
R5568:Lama1	UTSW	17	67,768,298 (GRCm38)	critical splice acceptor site	probably null
R5645:Lama1	UTSW	17	67,802,948 (GRCm38)	missense	probably damaging	1.00
R5665:Lama1	UTSW	17	67,770,987 (GRCm38)	missense	probably damaging	1.00
R5727:Lama1	UTSW	17	67,815,224 (GRCm38)	missense	possibly damaging	0.81
R5757:Lama1	UTSW	17	67,738,787 (GRCm38)	missense	possibly damaging	0.59
R5795:Lama1	UTSW	17	67,796,727 (GRCm38)	missense	probably benign	0.02
R5857:Lama1	UTSW	17	67,807,843 (GRCm38)	missense	probably damaging	0.99
R5894:Lama1	UTSW	17	67,779,047 (GRCm38)	critical splice acceptor site	probably null
R5974:Lama1	UTSW	17	67,773,727 (GRCm38)	missense	probably benign	0.31
R6032:Lama1	UTSW	17	67,750,643 (GRCm38)	missense	probably benign	0.01
R6032:Lama1	UTSW	17	67,750,643 (GRCm38)	missense	probably benign	0.01
R6120:Lama1	UTSW	17	67,780,617 (GRCm38)	critical splice donor site	probably null
R6219:Lama1	UTSW	17	67,790,856 (GRCm38)	missense	probably benign	0.08
R6224:Lama1	UTSW	17	67,802,987 (GRCm38)	missense	possibly damaging	0.56
R6249:Lama1	UTSW	17	67,798,604 (GRCm38)	missense	probably benign
R6265:Lama1	UTSW	17	67,750,655 (GRCm38)	missense	probably damaging	0.98
R6276:Lama1	UTSW	17	67,784,088 (GRCm38)	splice site	probably null
R6284:Lama1	UTSW	17	67,810,096 (GRCm38)	missense	probably damaging	0.99
R6337:Lama1	UTSW	17	67,786,019 (GRCm38)	missense	probably benign	0.27
R6414:Lama1	UTSW	17	67,746,910 (GRCm38)	critical splice donor site	probably null
R6631:Lama1	UTSW	17	67,774,482 (GRCm38)	missense	probably benign	0.21
R6659:Lama1	UTSW	17	67,818,635 (GRCm38)	missense	probably damaging	1.00
R6660:Lama1	UTSW	17	67,804,500 (GRCm38)	missense	probably benign	0.05
R6677:Lama1	UTSW	17	67,795,233 (GRCm38)	missense	probably benign	0.14
R6763:Lama1	UTSW	17	67,746,873 (GRCm38)	missense	unknown
R6787:Lama1	UTSW	17	67,784,025 (GRCm38)	missense	unknown
R6831:Lama1	UTSW	17	67,756,754 (GRCm38)	missense	possibly damaging	0.89
R6855:Lama1	UTSW	17	67,782,155 (GRCm38)	missense	possibly damaging	0.95
R6910:Lama1	UTSW	17	67,791,464 (GRCm38)	missense	possibly damaging	0.60
R6934:Lama1	UTSW	17	67,774,543 (GRCm38)	missense	probably benign	0.04
R6945:Lama1	UTSW	17	67,813,866 (GRCm38)	missense
R6984:Lama1	UTSW	17	67,779,112 (GRCm38)	missense
R6989:Lama1	UTSW	17	67,753,758 (GRCm38)	missense
R6994:Lama1	UTSW	17	67,753,825 (GRCm38)	missense
R6995:Lama1	UTSW	17	67,753,825 (GRCm38)	missense
R7035:Lama1	UTSW	17	67,781,049 (GRCm38)	missense
R7133:Lama1	UTSW	17	67,782,146 (GRCm38)	missense
R7172:Lama1	UTSW	17	67,804,545 (GRCm38)	missense
R7197:Lama1	UTSW	17	67,737,705 (GRCm38)	nonsense	probably null
R7217:Lama1	UTSW	17	67,764,673 (GRCm38)	missense
R7229:Lama1	UTSW	17	67,752,446 (GRCm38)	missense
R7264:Lama1	UTSW	17	67,743,297 (GRCm38)	missense
R7311:Lama1	UTSW	17	67,767,385 (GRCm38)	missense
R7394:Lama1	UTSW	17	67,717,261 (GRCm38)	missense
R7419:Lama1	UTSW	17	67,717,174 (GRCm38)	missense
R7460:Lama1	UTSW	17	67,767,018 (GRCm38)	missense
R7492:Lama1	UTSW	17	67,817,651 (GRCm38)	missense
R7494:Lama1	UTSW	17	67,811,446 (GRCm38)	missense
R7552:Lama1	UTSW	17	67,737,667 (GRCm38)	missense
R7576:Lama1	UTSW	17	67,782,041 (GRCm38)	missense
R7583:Lama1	UTSW	17	67,761,621 (GRCm38)	missense
R7649:Lama1	UTSW	17	67,737,554 (GRCm38)	missense
R7663:Lama1	UTSW	17	67,780,880 (GRCm38)	missense
R7667:Lama1	UTSW	17	67,780,597 (GRCm38)	missense
R7688:Lama1	UTSW	17	67,761,628 (GRCm38)	missense
R7693:Lama1	UTSW	17	67,817,031 (GRCm38)	missense
R7748:Lama1	UTSW	17	67,750,590 (GRCm38)	missense
R7778:Lama1	UTSW	17	67,804,473 (GRCm38)	missense
R7824:Lama1	UTSW	17	67,804,473 (GRCm38)	missense
R7861:Lama1	UTSW	17	67,809,221 (GRCm38)	missense
R7884:Lama1	UTSW	17	67,769,435 (GRCm38)	missense
R8029:Lama1	UTSW	17	67,817,594 (GRCm38)	missense
R8078:Lama1	UTSW	17	67,791,294 (GRCm38)	missense
R8101:Lama1	UTSW	17	67,745,922 (GRCm38)	missense
R8313:Lama1	UTSW	17	67,750,520 (GRCm38)	missense
R8356:Lama1	UTSW	17	67,737,496 (GRCm38)	missense
R8366:Lama1	UTSW	17	67,818,704 (GRCm38)	missense
R8403:Lama1	UTSW	17	67,745,923 (GRCm38)	missense
R8456:Lama1	UTSW	17	67,737,496 (GRCm38)	missense
R8466:Lama1	UTSW	17	67,813,953 (GRCm38)	missense
R8678:Lama1	UTSW	17	67,817,103 (GRCm38)	missense
R8728:Lama1	UTSW	17	67,818,668 (GRCm38)	missense
R8796:Lama1	UTSW	17	67,810,151 (GRCm38)	missense
R8885:Lama1	UTSW	17	67,773,784 (GRCm38)	missense
R8893:Lama1	UTSW	17	67,805,372 (GRCm38)	missense
R8898:Lama1	UTSW	17	67,821,615 (GRCm38)	missense
R8909:Lama1	UTSW	17	67,772,741 (GRCm38)	missense
R9025:Lama1	UTSW	17	67,812,496 (GRCm38)	missense
R9045:Lama1	UTSW	17	67,753,843 (GRCm38)	missense
R9098:Lama1	UTSW	17	67,804,513 (GRCm38)	missense
R9114:Lama1	UTSW	17	67,821,674 (GRCm38)	missense
R9173:Lama1	UTSW	17	67,769,602 (GRCm38)	missense
R9190:Lama1	UTSW	17	67,804,519 (GRCm38)	missense
R9381:Lama1	UTSW	17	67,737,484 (GRCm38)	missense
R9429:Lama1	UTSW	17	67,811,454 (GRCm38)	missense
R9504:Lama1	UTSW	17	67,821,666 (GRCm38)	missense
R9558:Lama1	UTSW	17	67,817,009 (GRCm38)	missense
R9647:Lama1	UTSW	17	67,717,175 (GRCm38)	missense
R9651:Lama1	UTSW	17	67,794,220 (GRCm38)	missense
R9654:Lama1	UTSW	17	67,794,271 (GRCm38)	missense
R9710:Lama1	UTSW	17	67,822,409 (GRCm38)	missense
R9733:Lama1	UTSW	17	67,809,945 (GRCm38)	missense
RF001:Lama1	UTSW	17	67,752,902 (GRCm38)	missense
RF013:Lama1	UTSW	17	67,781,062 (GRCm38)	missense
V8831:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
X0024:Lama1	UTSW	17	67,738,888 (GRCm38)	missense	probably damaging	1.00
X0028:Lama1	UTSW	17	67,794,310 (GRCm38)	missense	probably benign	0.06
X0028:Lama1	UTSW	17	67,767,422 (GRCm38)	missense	probably benign	0.00
X0066:Lama1	UTSW	17	67,811,566 (GRCm38)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	67,810,171 (GRCm38)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	67,771,082 (GRCm38)	missense	probably benign	0.25
Z1088:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1176:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1177:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1191:Lama1	UTSW	17	67,798,644 (GRCm38)	missense

Predicted Primers

PCR Primer
(F):5'- CCCAGAACATACTAAGGGCATGGC -3'
(R):5'- TGGACTGTGGCATTCACTCTGGAC -3'

Sequencing Primer
(F):5'- GCCTTTGTAGTCACATTGTATAGC -3'
(R):5'- GACAGGTCCTCTGATGTATTGAAGAC -3'

Posted On

2014-03-26