Incidental Mutation 'R0076:Pla2g10'
ID 16344
Institutional Source Beutler Lab
Gene Symbol Pla2g10
Ensembl Gene ENSMUSG00000022683
Gene Name phospholipase A2, group X
Synonyms mGXsPLA2, PLA2GX, GX sPLA2
MMRRC Submission 038363-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0076 (G1)
Quality Score
Status Validated
Chromosome 16
Chromosomal Location 13532921-13548847 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 13533382 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 131 (Y131F)
Ref Sequence ENSEMBL: ENSMUSP00000023364 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023364] [ENSMUST00000115807]
AlphaFold Q9QXX3
Predicted Effect possibly damaging
Transcript: ENSMUST00000023364
AA Change: Y131F

PolyPhen 2 Score 0.659 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000023364
Gene: ENSMUSG00000022683
AA Change: Y131F

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
PA2c 29 144 1.68e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115807
SMART Domains Protein: ENSMUSP00000111474
Gene: ENSMUSG00000022683

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
PA2c 29 143 2.48e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127780
Meta Mutation Damage Score 0.5477 question?
Coding Region Coverage
  • 1x: 89.9%
  • 3x: 87.5%
  • 10x: 81.6%
  • 20x: 72.8%
Validation Efficiency 92% (83/90)
MGI Phenotype FUNCTION: This gene encodes a member of the phospholipase A2 family of lipolytic enzymes that hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. The encoded protein undergoes proteolytic processing to generate a calcium-dependent enzyme that plays pivotal roles in the liberation of arachidonic acid from membrane phospholipids leading to the production of various inflammatory lipid mediators, such as prostaglandins. In response to myocardial ischemia/reperfusion, mice lacking the encoded protein display a reduction in myocardial infarct size partly through the suppression of neutorphil cytotoxic activities. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased lung inflammatory response and TH2 cytokine production in response to chronic ovalbumin exposure and acute asthma models. Mice homozygous for a knock-out allele exhibit decreased injury following myocardial ischemia and reperfusion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T G 7: 119,972,908 (GRCm39) probably benign Het
Acp3 A G 9: 104,201,417 (GRCm39) probably benign Het
Ada T A 2: 163,569,523 (GRCm39) probably benign Het
Ankrd17 T A 5: 90,392,265 (GRCm39) K1693* probably null Het
Arhgef38 T A 3: 132,866,507 (GRCm39) H210L possibly damaging Het
Car10 G A 11: 93,381,423 (GRCm39) E129K possibly damaging Het
Cask A G X: 13,544,513 (GRCm39) probably benign Het
Cd19 T C 7: 126,010,034 (GRCm39) D406G probably damaging Het
Cd93 T C 2: 148,284,056 (GRCm39) D430G probably benign Het
Cds1 T C 5: 101,965,706 (GRCm39) probably benign Het
Cerkl A T 2: 79,173,633 (GRCm39) S259T possibly damaging Het
Cfap91 G A 16: 38,123,046 (GRCm39) Q661* probably null Het
Cog8 T C 8: 107,780,765 (GRCm39) I164M possibly damaging Het
Col4a1 G A 8: 11,268,713 (GRCm39) P1009L probably damaging Het
Col9a1 G A 1: 24,276,578 (GRCm39) probably null Het
Dcc G A 18: 71,454,117 (GRCm39) Q1241* probably null Het
Dock3 A C 9: 106,788,685 (GRCm39) probably benign Het
Dus1l A T 11: 120,683,634 (GRCm39) probably benign Het
Dvl2 G A 11: 69,898,926 (GRCm39) E438K probably damaging Het
Eif3g A G 9: 20,809,049 (GRCm39) F85S probably damaging Het
Fam234b A G 6: 135,204,224 (GRCm39) M456V probably benign Het
Fbxo47 G A 11: 97,748,481 (GRCm39) probably benign Het
Fyb2 A G 4: 104,802,661 (GRCm39) T188A possibly damaging Het
Gm11437 T C 11: 84,039,462 (GRCm39) T288A possibly damaging Het
Gm5546 T A 3: 104,260,448 (GRCm39) noncoding transcript Het
Gmfb C A 14: 47,054,912 (GRCm39) A11S probably benign Het
Gpat4 G A 8: 23,680,721 (GRCm39) probably benign Het
Ifitm6 T A 7: 140,595,920 (GRCm39) R124S possibly damaging Het
Il17rd T A 14: 26,816,811 (GRCm39) L172Q probably damaging Het
Il4 A T 11: 53,504,741 (GRCm39) L13Q probably damaging Het
Kif2b A G 11: 91,466,735 (GRCm39) M516T probably damaging Het
Kmt2a A G 9: 44,741,356 (GRCm39) probably benign Het
Mark1-ps1 T A 17: 54,254,905 (GRCm39) noncoding transcript Het
Mndal G T 1: 173,702,013 (GRCm39) C96* probably null Het
Mroh1 T C 15: 76,335,340 (GRCm39) S1365P probably benign Het
Mrpl12 A G 11: 120,376,268 (GRCm39) probably benign Het
Mthfsd C A 8: 121,825,478 (GRCm39) V270F probably benign Het
Nbas T A 12: 13,374,337 (GRCm39) V555D probably damaging Het
Pcdhb16 T C 18: 37,611,412 (GRCm39) V124A probably damaging Het
Plec T C 15: 76,075,614 (GRCm39) probably benign Het
Polr2b T A 5: 77,474,408 (GRCm39) V415E possibly damaging Het
Pou6f1 G A 15: 100,485,717 (GRCm39) Q106* probably null Het
Ptprd T C 4: 75,865,276 (GRCm39) probably benign Het
Rad54b G A 4: 11,609,480 (GRCm39) probably benign Het
Rspo1 G A 4: 124,885,190 (GRCm39) R22Q probably benign Het
Scn7a A G 2: 66,544,381 (GRCm39) V370A probably benign Het
Sec1 A G 7: 45,328,315 (GRCm39) V244A probably damaging Het
Serac1 A G 17: 6,115,212 (GRCm39) probably benign Het
Slco2b1 A T 7: 99,334,708 (GRCm39) Y254* probably null Het
Steap3 G A 1: 120,155,460 (GRCm39) R500C probably damaging Het
Stk10 A G 11: 32,553,722 (GRCm39) T580A probably benign Het
Tpo C T 12: 30,154,022 (GRCm39) G228R probably damaging Het
Tpx2 T C 2: 152,735,603 (GRCm39) F744L probably damaging Het
Ube3b G T 5: 114,546,278 (GRCm39) probably null Het
Vmn2r84 A G 10: 130,230,062 (GRCm39) S17P probably damaging Het
Vps13d A T 4: 144,891,264 (GRCm39) probably benign Het
Zfp532 T A 18: 65,818,698 (GRCm39) S851R probably benign Het
Zfp623 G A 15: 75,819,058 (GRCm39) E5K probably benign Het
Other mutations in Pla2g10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01660:Pla2g10 APN 16 13,545,950 (GRCm39) missense probably damaging 1.00
IGL03355:Pla2g10 APN 16 13,548,284 (GRCm39) splice site probably null
R8002:Pla2g10 UTSW 16 13,542,912 (GRCm39) missense unknown
R8155:Pla2g10 UTSW 16 13,543,048 (GRCm39) missense probably damaging 0.99
R8722:Pla2g10 UTSW 16 13,548,254 (GRCm39) missense unknown
R8850:Pla2g10 UTSW 16 13,545,914 (GRCm39) missense probably damaging 1.00
Posted On 2013-01-20