|Institutional Source||Beutler Lab|
|Gene Name||matrix metallopeptidase 10|
|Is this an essential gene?||Probably non essential (E-score: 0.094)|
|Stock #||R1487 (G1)|
|Chromosomal Location||7502352-7510240 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to G at 7509977 bp|
|Amino Acid Change||Tryptophan to Glycine at position 473 (W473G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000034488 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034488]|
|Predicted Effect||probably damaging
AA Change: W473G
PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
AA Change: W473G
|Coding Region Coverage||
FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. The lack of encoded protein in mice promotes experimental lung cancer formation, exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mmp10||
(F):5'- TGCCTCCCACACTGTGATCTAAGAG -3'
(R):5'- ATGAAAGACATCTGCTGCGCTCATC -3'
(F):5'- aaaagcagagaaatgaagttaaatcc -3'
(R):5'- AGGTGGGAAGTCATGAGACTCA -3'