Mutagenetix > Incidental Mutation

Incidental Mutation 'R1489:Ptprc'

163575

Institutional Source

Beutler Lab

Gene Symbol

Ptprc

Ensembl Gene

ENSMUSG00000026395

Gene Name

protein tyrosine phosphatase, receptor type, C

Synonyms

B220, Ly-5, Lyt-4, CD45, T200

MMRRC Submission

039541-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1489 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

138062861-138175708 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 138120086 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 60 (T60A)

Ref Sequence

ENSEMBL: ENSMUSP00000142052 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000182283] [ENSMUST00000182755] [ENSMUST00000183301] [ENSMUST00000193650] [ENSMUST00000195533]

AlphaFold

P06800

Predicted Effect

probably benign
Transcript: ENSMUST00000027645
AA Change: T101A

PolyPhen 2 Score 0.407 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000027645
Gene: ENSMUSG00000026395
AA Change: T101A

Domain	Start	End	E-Value	Type
Pfam:PTP_N	5	30	5e-16	PFAM
low complexity region	109	126	N/A	INTRINSIC
low complexity region	168	203	N/A	INTRINSIC
Pfam:CD45	210	267	3.1e-20	PFAM
FN3	372	456	2.28e0	SMART
FN3	472	550	3.48e-1	SMART
transmembrane domain	565	586	N/A	INTRINSIC
PTPc	639	901	7.57e-127	SMART
PTPc	930	1216	1.39e-102	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000112036

SMART Domains

Protein: ENSMUSP00000107667
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	5	30	5.8e-13	PFAM
low complexity region	31	64	N/A	INTRINSIC
Pfam:CD45	70	129	1.8e-24	PFAM
FN3	233	317	2.28e0	SMART
FN3	333	411	3.48e-1	SMART
transmembrane domain	426	447	N/A	INTRINSIC
PTPc	500	762	7.57e-127	SMART
PTPc	791	1077	1.39e-102	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182138

Predicted Effect

probably benign
Transcript: ENSMUST00000182283

SMART Domains

Protein: ENSMUSP00000138800
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	32	4.2e-13	PFAM
low complexity region	33	66	N/A	INTRINSIC
Pfam:CD45	72	131	2.3e-24	PFAM
FN3	235	319	2.28e0	SMART
FN3	335	413	3.48e-1	SMART
transmembrane domain	428	449	N/A	INTRINSIC
PTPc	502	764	7.57e-127	SMART
PTPc	793	1079	1.39e-102	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182755

SMART Domains

Protein: ENSMUSP00000138275
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	34	5.5e-13	PFAM
Pfam:CD45	48	107	2.3e-24	PFAM
FN3	211	295	2.28e0	SMART
FN3	311	389	3.48e-1	SMART
transmembrane domain	404	425	N/A	INTRINSIC
PTPc	478	740	7.57e-127	SMART
PTPc	769	1055	1.39e-102	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183262

Predicted Effect

probably benign
Transcript: ENSMUST00000183301
AA Change: T103A

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000138350
Gene: ENSMUSG00000026395
AA Change: T103A

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	2.7e-13	PFAM
low complexity region	111	128	N/A	INTRINSIC
low complexity region	170	205	N/A	INTRINSIC
Pfam:CD45	211	270	2.1e-24	PFAM
FN3	374	458	2.28e0	SMART
FN3	474	552	3.48e-1	SMART
transmembrane domain	567	588	N/A	INTRINSIC
PTPc	641	903	7.57e-127	SMART
PTPc	932	1218	1.39e-102	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000187586

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188596

Predicted Effect

probably benign
Transcript: ENSMUST00000193650

SMART Domains

Protein: ENSMUSP00000141524
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	8.4e-12	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000195533
AA Change: T60A

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000142052
Gene: ENSMUSG00000026395
AA Change: T60A

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	7.4e-11	PFAM
low complexity region	68	115	N/A	INTRINSIC
Pfam:CD45	121	180	2.1e-22	PFAM

Meta Mutation Damage Score

0.0762

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.7%
20x: 93.9%

Validation Efficiency

96% (52/54)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700097O09Rik	A	G	12: 55,059,510 (GRCm38)	S143P	possibly damaging	Het
4930522H14Rik	T	C	4: 109,505,457 (GRCm38)	K218E	possibly damaging	Het
Abcb1a	T	A	5: 8,686,300 (GRCm38)		probably null	Het
Adam39	A	G	8: 40,824,994 (GRCm38)	T141A	possibly damaging	Het
Adam6b	T	A	12: 113,491,451 (GRCm38)	S629R	probably benign	Het
Ap3b2	C	A	7: 81,463,690 (GRCm38)	E924*	probably null	Het
Armc3	A	T	2: 19,310,047 (GRCm38)	Y856F	probably benign	Het
Asap1	A	G	15: 64,172,730 (GRCm38)	L142P	probably damaging	Het
Atg9a	T	A	1: 75,186,090 (GRCm38)	D427V	probably damaging	Het
Atl2	G	A	17: 79,852,706 (GRCm38)	A17V	probably benign	Het
Atxn2l	A	T	7: 126,496,467 (GRCm38)	S379T	probably damaging	Het
C1ql3	G	T	2: 13,010,642 (GRCm38)	P69Q	possibly damaging	Het
Cap2	A	T	13: 46,609,635 (GRCm38)	I114F	probably damaging	Het
Cox16	T	C	12: 81,474,615 (GRCm38)	N135S	probably null	Het
Dnajc13	A	T	9: 104,231,035 (GRCm38)	H180Q	possibly damaging	Het
Dpy19l3	A	T	7: 35,725,410 (GRCm38)	Y73*	probably null	Het
Duox2	T	A	2: 122,293,396 (GRCm38)	M436L	probably benign	Het
Exoc6	T	A	19: 37,597,120 (GRCm38)	M481K	possibly damaging	Het
Fbxw2	GCCCCC	GCCCCCCCC	2: 34,812,817 (GRCm38)		probably benign	Het
Fmn1	T	A	2: 113,365,212 (GRCm38)	V419E	unknown	Het
Fndc4	T	C	5: 31,293,451 (GRCm38)	*232W	probably null	Het
Foxc1	C	T	13: 31,808,612 (GRCm38)	R469*	probably null	Het
Fsip2	A	G	2: 82,979,811 (GRCm38)	H2158R	probably benign	Het
Ghdc	C	T	11: 100,768,257 (GRCm38)	G373D	probably benign	Het
Gm10330	A	T	12: 23,780,031 (GRCm38)	S50T	probably benign	Het
Gm8251	T	C	1: 44,061,507 (GRCm38)	I144V	probably benign	Het
Gm8251	A	G	1: 44,057,790 (GRCm38)	F1383L	probably benign	Het
Hlx	G	T	1: 184,731,987 (GRCm38)	A52D	probably damaging	Het
Lonrf1	A	G	8: 36,222,954 (GRCm38)	V650A	probably damaging	Het
Map1a	T	C	2: 121,300,437 (GRCm38)	V578A	possibly damaging	Het
Mbd3	C	G	10: 80,393,906 (GRCm38)	D190H	probably damaging	Het
Mcpt9	T	C	14: 56,027,519 (GRCm38)	K175R	probably benign	Het
Mia3	A	G	1: 183,338,674 (GRCm38)	S85P	probably benign	Het
Myrip	T	C	9: 120,432,529 (GRCm38)	F403L	probably damaging	Het
Nox4	A	G	7: 87,304,889 (GRCm38)	Y134C	probably damaging	Het
Numb	A	G	12: 83,795,443 (GRCm38)	L642P	probably damaging	Het
Pappa	A	T	4: 65,180,948 (GRCm38)	Y568F	possibly damaging	Het
Pdzrn4	T	C	15: 92,677,712 (GRCm38)	L333P	probably benign	Het
Prl	A	T	13: 27,057,636 (GRCm38)	S3C	probably damaging	Het
Rbm10	C	T	X: 20,637,664 (GRCm38)		probably benign	Het
Slc7a7	C	T	14: 54,408,646 (GRCm38)	R120H	probably damaging	Het
Smpd1	T	C	7: 105,556,554 (GRCm38)		probably null	Het
Spta1	A	G	1: 174,231,325 (GRCm38)	E1942G	probably damaging	Het
Tmem38a	A	G	8: 72,579,635 (GRCm38)	Y66C	probably damaging	Het
Tnnt1	A	T	7: 4,507,525 (GRCm38)	Y232*	probably null	Het
Tpte	T	C	8: 22,349,389 (GRCm38)		probably null	Het
Virma	T	C	4: 11,521,164 (GRCm38)	V907A	probably damaging	Het
Vmn1r174	C	T	7: 23,754,556 (GRCm38)	Q216*	probably null	Het
Zswim3	T	C	2: 164,819,981 (GRCm38)	V127A	probably benign	Het

Other mutations in Ptprc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
lochy	APN	1	138,083,790 (GRCm38)	splice site	probably benign
IGL00486:Ptprc	APN	1	138,115,621 (GRCm38)	missense	probably damaging	0.97
IGL00771:Ptprc	APN	1	138,113,677 (GRCm38)	missense	probably benign	0.00
IGL00833:Ptprc	APN	1	138,078,492 (GRCm38)	missense	possibly damaging	0.55
IGL00919:Ptprc	APN	1	138,113,642 (GRCm38)	missense	probably damaging	1.00
IGL01020:Ptprc	APN	1	138,120,173 (GRCm38)	critical splice acceptor site	probably null	0.00
IGL01024:Ptprc	APN	1	138,080,912 (GRCm38)	missense	probably damaging	1.00
IGL01302:Ptprc	APN	1	138,099,631 (GRCm38)	missense	possibly damaging	0.82
IGL01548:Ptprc	APN	1	138,099,481 (GRCm38)	critical splice donor site	probably null	0.00
IGL01620:Ptprc	APN	1	138,068,410 (GRCm38)	missense	possibly damaging	0.88
IGL01775:Ptprc	APN	1	138,064,759 (GRCm38)	missense	probably damaging	1.00
IGL01820:Ptprc	APN	1	138,066,198 (GRCm38)	missense	probably damaging	1.00
IGL02340:Ptprc	APN	1	138,071,219 (GRCm38)	missense	probably damaging	1.00
IGL02943:Ptprc	APN	1	138,099,513 (GRCm38)	missense	probably damaging	0.99
IGL03169:Ptprc	APN	1	138,113,619 (GRCm38)	missense	probably benign	0.15
IGL03308:Ptprc	APN	1	138,126,320 (GRCm38)	missense	possibly damaging	0.70
IGL03404:Ptprc	APN	1	138,093,001 (GRCm38)	missense	probably damaging	1.00
belittle	UTSW	1	138,137,493 (GRCm38)	intron	probably benign
Benighted	UTSW	1	138,126,301 (GRCm38)	critical splice donor site	probably null
bletchley	UTSW	1	138,117,862 (GRCm38)	missense	probably benign
Blush	UTSW	1	138,117,720 (GRCm38)	intron	probably benign
bruise	UTSW	1	138,064,771 (GRCm38)	missense	probably damaging	1.00
chor_muang	UTSW	1	138,113,562 (GRCm38)	critical splice donor site	probably null
crystal	UTSW	1	138,072,255 (GRCm38)	critical splice donor site	probably null
Dumpling	UTSW	1	138,067,890 (GRCm38)	missense	probably damaging	1.00
fluorescent	UTSW	1	138,101,192 (GRCm38)	missense	probably damaging	0.97
fuchsia	UTSW	1	138,101,041 (GRCm38)	critical splice donor site	probably null
Gentian	UTSW	1	138,067,885 (GRCm38)	critical splice donor site	probably null
guotie	UTSW	1	138,068,401 (GRCm38)	nonsense	probably null
guotie2	UTSW	1	138,094,299 (GRCm38)	missense	probably damaging	0.97
Guotie3	UTSW	1	138,078,451 (GRCm38)	missense	possibly damaging	0.92
Gyoza	UTSW	1	138,083,567 (GRCm38)	missense	probably damaging	1.00
Half_measure	UTSW	1	138,071,249 (GRCm38)	missense	probably damaging	0.98
jirisan	UTSW	1	138,113,678 (GRCm38)	nonsense	probably null
mauve	UTSW	1	138,099,685 (GRCm38)	missense	probably benign
Perverse	UTSW	1	138,101,044 (GRCm38)	missense	probably benign	0.02
petechiae	UTSW	1	138,113,708 (GRCm38)	nonsense	probably null
ultra	UTSW	1	138,078,445 (GRCm38)	critical splice donor site	probably null
violaceous	UTSW	1	138,083,639 (GRCm38)	missense	possibly damaging	0.77
R0013:Ptprc	UTSW	1	138,113,559 (GRCm38)	splice site	probably null
R0189:Ptprc	UTSW	1	138,082,715 (GRCm38)	missense	probably benign	0.10
R0390:Ptprc	UTSW	1	138,122,575 (GRCm38)	missense	possibly damaging	0.71
R0504:Ptprc	UTSW	1	138,088,697 (GRCm38)	missense	probably damaging	1.00
R0602:Ptprc	UTSW	1	138,089,485 (GRCm38)	splice site	probably benign
R0627:Ptprc	UTSW	1	138,068,320 (GRCm38)	missense	probably damaging	0.99
R0632:Ptprc	UTSW	1	138,073,610 (GRCm38)	missense	probably benign	0.01
R0751:Ptprc	UTSW	1	138,092,930 (GRCm38)	missense	probably damaging	1.00
R0839:Ptprc	UTSW	1	138,101,132 (GRCm38)	missense	possibly damaging	0.47
R0942:Ptprc	UTSW	1	138,068,401 (GRCm38)	nonsense	probably null
R0943:Ptprc	UTSW	1	138,111,164 (GRCm38)	missense	probably damaging	0.96
R1159:Ptprc	UTSW	1	138,072,319 (GRCm38)	missense	probably damaging	1.00
R1442:Ptprc	UTSW	1	138,072,312 (GRCm38)	missense	probably damaging	1.00
R1728:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1728:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1728:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1728:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1728:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1729:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1729:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1729:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1730:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1730:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1730:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1730:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1730:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1739:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1739:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1739:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1739:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1739:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1762:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1762:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1762:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1762:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1762:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1783:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1783:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1783:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1784:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1784:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1784:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1785:Ptprc	UTSW	1	138,099,676 (GRCm38)	missense	probably benign	0.05
R1785:Ptprc	UTSW	1	138,107,823 (GRCm38)	missense	probably benign	0.22
R1785:Ptprc	UTSW	1	138,112,254 (GRCm38)	missense	possibly damaging	0.53
R1785:Ptprc	UTSW	1	138,107,837 (GRCm38)	missense	probably benign	0.09
R1785:Ptprc	UTSW	1	138,107,824 (GRCm38)	missense	probably benign	0.04
R1862:Ptprc	UTSW	1	138,112,227 (GRCm38)	missense	probably benign	0.13
R2145:Ptprc	UTSW	1	138,073,681 (GRCm38)	missense	probably damaging	1.00
R2290:Ptprc	UTSW	1	138,111,188 (GRCm38)	missense	probably benign	0.00
R2403:Ptprc	UTSW	1	138,088,532 (GRCm38)	missense	probably damaging	1.00
R2439:Ptprc	UTSW	1	138,066,152 (GRCm38)	missense	possibly damaging	0.67
R2887:Ptprc	UTSW	1	138,080,178 (GRCm38)	missense	probably damaging	1.00
R2906:Ptprc	UTSW	1	138,064,534 (GRCm38)	missense	possibly damaging	0.93
R3774:Ptprc	UTSW	1	138,064,773 (GRCm38)	missense	probably damaging	0.97
R3775:Ptprc	UTSW	1	138,064,773 (GRCm38)	missense	probably damaging	0.97
R3776:Ptprc	UTSW	1	138,064,773 (GRCm38)	missense	probably damaging	0.97
R3834:Ptprc	UTSW	1	138,083,567 (GRCm38)	missense	probably damaging	1.00
R4019:Ptprc	UTSW	1	138,078,516 (GRCm38)	missense	probably damaging	1.00
R4377:Ptprc	UTSW	1	138,067,925 (GRCm38)	missense	probably benign	0.04
R4580:Ptprc	UTSW	1	138,071,251 (GRCm38)	missense	probably benign	0.09
R4923:Ptprc	UTSW	1	138,078,498 (GRCm38)	missense	possibly damaging	0.93
R4925:Ptprc	UTSW	1	138,099,497 (GRCm38)	missense	probably benign	0.04
R4937:Ptprc	UTSW	1	138,089,500 (GRCm38)	missense	probably damaging	1.00
R4970:Ptprc	UTSW	1	138,094,299 (GRCm38)	missense	probably damaging	0.97
R5112:Ptprc	UTSW	1	138,094,299 (GRCm38)	missense	probably damaging	0.97
R5145:Ptprc	UTSW	1	138,089,566 (GRCm38)	missense	probably benign	0.07
R5158:Ptprc	UTSW	1	138,175,084 (GRCm38)	missense	possibly damaging	0.75
R5223:Ptprc	UTSW	1	138,117,862 (GRCm38)	missense	probably benign
R5593:Ptprc	UTSW	1	138,117,720 (GRCm38)	intron	probably benign
R5689:Ptprc	UTSW	1	138,117,777 (GRCm38)	missense	probably benign	0.01
R5885:Ptprc	UTSW	1	138,088,508 (GRCm38)	missense	probably damaging	1.00
R6010:Ptprc	UTSW	1	138,101,056 (GRCm38)	missense	probably benign	0.09
R6026:Ptprc	UTSW	1	138,071,249 (GRCm38)	missense	probably damaging	0.98
R6047:Ptprc	UTSW	1	138,101,041 (GRCm38)	critical splice donor site	probably null
R6173:Ptprc	UTSW	1	138,067,890 (GRCm38)	missense	probably damaging	1.00
R6328:Ptprc	UTSW	1	138,113,678 (GRCm38)	nonsense	probably null
R6383:Ptprc	UTSW	1	138,078,451 (GRCm38)	missense	possibly damaging	0.92
R6436:Ptprc	UTSW	1	138,083,639 (GRCm38)	missense	possibly damaging	0.77
R6492:Ptprc	UTSW	1	138,113,562 (GRCm38)	critical splice donor site	probably null
R6520:Ptprc	UTSW	1	138,080,143 (GRCm38)	nonsense	probably null
R6805:Ptprc	UTSW	1	138,067,885 (GRCm38)	critical splice donor site	probably null
R6830:Ptprc	UTSW	1	138,072,255 (GRCm38)	critical splice donor site	probably null
R6847:Ptprc	UTSW	1	138,088,545 (GRCm38)	missense	probably damaging	0.99
R6960:Ptprc	UTSW	1	138,078,445 (GRCm38)	critical splice donor site	probably null
R6995:Ptprc	UTSW	1	138,088,744 (GRCm38)	missense	probably damaging	1.00
R7009:Ptprc	UTSW	1	138,064,553 (GRCm38)	missense	probably damaging	0.97
R7041:Ptprc	UTSW	1	138,126,309 (GRCm38)	missense	probably benign	0.04
R7055:Ptprc	UTSW	1	138,089,571 (GRCm38)	missense	probably damaging	1.00
R7098:Ptprc	UTSW	1	138,099,685 (GRCm38)	missense	probably benign
R7164:Ptprc	UTSW	1	138,117,862 (GRCm38)	missense	probably benign
R7188:Ptprc	UTSW	1	138,071,180 (GRCm38)	missense	probably damaging	1.00
R7191:Ptprc	UTSW	1	138,101,044 (GRCm38)	missense	probably benign	0.02
R7204:Ptprc	UTSW	1	138,117,862 (GRCm38)	missense	probably benign
R7316:Ptprc	UTSW	1	138,064,771 (GRCm38)	missense	probably damaging	1.00
R7644:Ptprc	UTSW	1	138,067,907 (GRCm38)	missense	probably benign	0.01
R7948:Ptprc	UTSW	1	138,064,576 (GRCm38)	missense	probably benign	0.45
R8029:Ptprc	UTSW	1	138,078,459 (GRCm38)	missense	probably damaging	1.00
R8677:Ptprc	UTSW	1	138,083,597 (GRCm38)	missense	probably damaging	1.00
R8704:Ptprc	UTSW	1	138,115,624 (GRCm38)	missense	probably benign	0.34
R8824:Ptprc	UTSW	1	138,113,708 (GRCm38)	nonsense	probably null
R8921:Ptprc	UTSW	1	138,126,301 (GRCm38)	critical splice donor site	probably null
R8998:Ptprc	UTSW	1	138,101,192 (GRCm38)	missense	probably damaging	0.97
R8999:Ptprc	UTSW	1	138,101,192 (GRCm38)	missense	probably damaging	0.97
R9154:Ptprc	UTSW	1	138,088,564 (GRCm38)	missense	probably damaging	1.00
R9388:Ptprc	UTSW	1	138,083,642 (GRCm38)	missense	possibly damaging	0.87
R9428:Ptprc	UTSW	1	138,113,747 (GRCm38)	missense	probably benign	0.01
R9467:Ptprc	UTSW	1	138,066,222 (GRCm38)	missense	probably damaging	1.00
R9468:Ptprc	UTSW	1	138,117,016 (GRCm38)	missense	probably benign	0.01
R9479:Ptprc	UTSW	1	138,073,650 (GRCm38)	missense	probably benign	0.38
R9526:Ptprc	UTSW	1	138,068,373 (GRCm38)	missense	probably benign	0.02
R9632:Ptprc	UTSW	1	138,080,889 (GRCm38)	missense	probably damaging	1.00
R9710:Ptprc	UTSW	1	138,080,889 (GRCm38)	missense	probably damaging	1.00
R9714:Ptprc	UTSW	1	138,080,949 (GRCm38)	missense	probably damaging	1.00
R9777:Ptprc	UTSW	1	138,120,163 (GRCm38)	missense
Z1177:Ptprc	UTSW	1	138,067,907 (GRCm38)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AATCAGCAAATGCGCCACATGG -3'
(R):5'- TCCACAAGTTCCCAATGCTGGATG -3'

Sequencing Primer
(F):5'- TGCGCCACATGGAACAAG -3'
(R):5'- CTTAATAAATGGGGTCACGCC -3'

Posted On

2014-03-28