Incidental Mutation 'R1490:Nedd1'
ID 163661
Institutional Source Beutler Lab
Gene Symbol Nedd1
Ensembl Gene ENSMUSG00000019988
Gene Name neural precursor cell expressed, developmentally down-regulated gene 1
Synonyms
MMRRC Submission 039542-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R1490 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 92684746-92722420 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 92700798 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 214 (F214S)
Ref Sequence ENSEMBL: ENSMUSP00000020163 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020163]
AlphaFold P33215
Predicted Effect probably damaging
Transcript: ENSMUST00000020163
AA Change: F214S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000020163
Gene: ENSMUSG00000019988
AA Change: F214S

DomainStartEndE-ValueType
WD40 21 63 5.97e-1 SMART
WD40 67 105 9.75e-3 SMART
WD40 108 147 6.19e-5 SMART
WD40 149 191 6.42e-1 SMART
WD40 194 235 9.1e-3 SMART
WD40 238 276 2.24e-2 SMART
low complexity region 555 568 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214417
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215970
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700025F22Rik A G 19: 11,141,538 (GRCm38) I69T probably benign Het
Aldh1l2 G A 10: 83,520,370 (GRCm38) T52I probably damaging Het
Arhgef28 G A 13: 97,978,444 (GRCm38) R633W probably damaging Het
Atg9a T C 1: 75,185,745 (GRCm38) N507S possibly damaging Het
Bsn A G 9: 108,113,994 (GRCm38) S1520P probably benign Het
Cacul1 G T 19: 60,580,399 (GRCm38) A107E probably damaging Het
Cd74 A G 18: 60,811,366 (GRCm38) D216G probably damaging Het
Cdh16 A T 8: 104,622,070 (GRCm38) W109R probably damaging Het
Cdip1 C T 16: 4,768,911 (GRCm38) V100I probably damaging Het
Ceacam3 A G 7: 17,163,146 (GRCm38) D679G probably damaging Het
Comp A G 8: 70,373,913 (GRCm38) D46G possibly damaging Het
Dlx3 T C 11: 95,120,604 (GRCm38) Y95H probably benign Het
Dmrta2 T C 4: 109,979,875 (GRCm38) S5P unknown Het
E130308A19Rik A G 4: 59,719,746 (GRCm38) Y426C probably damaging Het
Entpd3 A G 9: 120,554,159 (GRCm38) S87G probably benign Het
Eps8l1 A G 7: 4,470,889 (GRCm38) R232G probably damaging Het
Gart A T 16: 91,624,344 (GRCm38) V812D probably damaging Het
Gm10153 C T 7: 142,190,142 (GRCm38) C83Y unknown Het
Gpd2 T C 2: 57,355,475 (GRCm38) V394A probably damaging Het
Hpcal1 A T 12: 17,786,224 (GRCm38) E18D probably benign Het
Mdga2 T C 12: 66,797,756 (GRCm38) D156G probably benign Het
Mks1 A G 11: 87,862,769 (GRCm38) K510E probably benign Het
Mtmr4 G A 11: 87,612,225 (GRCm38) R1035Q probably damaging Het
Myh6 T A 14: 54,962,718 (GRCm38) K235* probably null Het
Olfr166 T C 16: 19,486,922 (GRCm38) M28T probably benign Het
Olfr392 A G 11: 73,814,371 (GRCm38) V237A possibly damaging Het
Olfr672 A G 7: 104,996,493 (GRCm38) I137T possibly damaging Het
Olfr98 A G 17: 37,262,842 (GRCm38) M274T probably benign Het
Pfkfb2 A C 1: 130,697,889 (GRCm38) probably null Het
Pfkfb4 T C 9: 109,027,620 (GRCm38) L398P probably damaging Het
Pfn3 T G 13: 55,414,919 (GRCm38) D83A probably damaging Het
Pi4ka C A 16: 17,386,268 (GRCm38) W54L probably damaging Het
Ppp3r1 A G 11: 17,198,275 (GRCm38) D161G probably benign Het
Prrc2a A G 17: 35,153,254 (GRCm38) S1757P probably benign Het
Samd7 A G 3: 30,758,353 (GRCm38) E314G probably benign Het
Slc17a4 A G 13: 23,904,753 (GRCm38) I217T probably benign Het
Slc22a1 A T 17: 12,662,893 (GRCm38) probably null Het
Slc7a7 C T 14: 54,408,646 (GRCm38) R120H probably damaging Het
Sos1 A T 17: 80,413,675 (GRCm38) H905Q probably benign Het
Thada G A 17: 84,446,601 (GRCm38) T314I possibly damaging Het
Tirap ACTGCTGCTGCTGCTGCTG ACTGCTGCTGCTGCTG 9: 35,189,066 (GRCm38) probably benign Het
Tlr11 A C 14: 50,363,176 (GRCm38) H873P probably benign Het
Tlr4 A T 4: 66,839,374 (GRCm38) T135S possibly damaging Het
Tmem116 T C 5: 121,495,111 (GRCm38) S183P probably damaging Het
Tubgcp3 A T 8: 12,639,550 (GRCm38) I572K probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm38) P46S probably benign Het
Ush2a C T 1: 188,359,841 (GRCm38) T523I probably benign Het
Usp40 G A 1: 87,988,965 (GRCm38) Q364* probably null Het
Vmn1r61 T C 7: 5,611,243 (GRCm38) Q24R probably benign Het
Wdfy4 C A 14: 33,152,538 (GRCm38) probably null Het
Zfp458 G A 13: 67,257,509 (GRCm38) P286S probably damaging Het
Zfp68 A T 5: 138,606,829 (GRCm38) C373S probably benign Het
Zfp768 T A 7: 127,343,631 (GRCm38) I442F probably damaging Het
Zfp990 A G 4: 145,537,283 (GRCm38) R284G probably benign Het
Other mutations in Nedd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00764:Nedd1 APN 10 92,694,974 (GRCm38) splice site probably benign
IGL00988:Nedd1 APN 10 92,689,686 (GRCm38) missense possibly damaging 0.71
IGL01563:Nedd1 APN 10 92,698,169 (GRCm38) critical splice donor site probably null
IGL01588:Nedd1 APN 10 92,686,262 (GRCm38) missense probably benign 0.12
IGL01988:Nedd1 APN 10 92,714,159 (GRCm38) missense probably benign 0.39
IGL02706:Nedd1 APN 10 92,686,285 (GRCm38) missense possibly damaging 0.88
IGL02938:Nedd1 APN 10 92,689,657 (GRCm38) nonsense probably null
IGL03011:Nedd1 APN 10 92,689,641 (GRCm38) missense possibly damaging 0.92
Brainless UTSW 10 92,690,773 (GRCm38) missense probably benign 0.01
R0125:Nedd1 UTSW 10 92,691,929 (GRCm38) missense possibly damaging 0.93
R0173:Nedd1 UTSW 10 92,698,883 (GRCm38) missense probably benign 0.30
R0244:Nedd1 UTSW 10 92,716,265 (GRCm38) intron probably benign
R0645:Nedd1 UTSW 10 92,691,831 (GRCm38) splice site probably null
R0791:Nedd1 UTSW 10 92,719,614 (GRCm38) missense probably damaging 1.00
R1522:Nedd1 UTSW 10 92,719,614 (GRCm38) missense probably damaging 1.00
R1797:Nedd1 UTSW 10 92,698,739 (GRCm38) missense possibly damaging 0.46
R1984:Nedd1 UTSW 10 92,714,160 (GRCm38) missense possibly damaging 0.63
R2474:Nedd1 UTSW 10 92,719,603 (GRCm38) missense probably damaging 0.99
R2877:Nedd1 UTSW 10 92,714,126 (GRCm38) missense possibly damaging 0.89
R2883:Nedd1 UTSW 10 92,694,998 (GRCm38) missense probably damaging 0.98
R4694:Nedd1 UTSW 10 92,719,582 (GRCm38) missense probably benign 0.00
R4798:Nedd1 UTSW 10 92,698,910 (GRCm38) missense probably benign 0.00
R4830:Nedd1 UTSW 10 92,686,258 (GRCm38) missense probably damaging 1.00
R4963:Nedd1 UTSW 10 92,695,031 (GRCm38) missense probably damaging 1.00
R5174:Nedd1 UTSW 10 92,711,212 (GRCm38) missense possibly damaging 0.77
R5329:Nedd1 UTSW 10 92,686,240 (GRCm38) missense probably damaging 1.00
R5404:Nedd1 UTSW 10 92,716,192 (GRCm38) missense probably benign 0.04
R5534:Nedd1 UTSW 10 92,695,032 (GRCm38) missense probably benign 0.01
R6045:Nedd1 UTSW 10 92,695,100 (GRCm38) nonsense probably null
R6154:Nedd1 UTSW 10 92,698,242 (GRCm38) missense possibly damaging 0.65
R6512:Nedd1 UTSW 10 92,691,875 (GRCm38) missense probably benign
R6692:Nedd1 UTSW 10 92,698,337 (GRCm38) missense possibly damaging 0.88
R6693:Nedd1 UTSW 10 92,698,337 (GRCm38) missense possibly damaging 0.88
R6943:Nedd1 UTSW 10 92,711,306 (GRCm38) missense probably damaging 1.00
R7011:Nedd1 UTSW 10 92,690,773 (GRCm38) missense probably benign 0.01
R7406:Nedd1 UTSW 10 92,711,323 (GRCm38) splice site probably null
R7455:Nedd1 UTSW 10 92,700,925 (GRCm38) missense probably benign 0.01
R7587:Nedd1 UTSW 10 92,698,730 (GRCm38) missense probably benign 0.01
R7745:Nedd1 UTSW 10 92,714,172 (GRCm38) missense probably benign
R8104:Nedd1 UTSW 10 92,691,916 (GRCm38) missense probably damaging 1.00
R8209:Nedd1 UTSW 10 92,691,935 (GRCm38) missense probably benign
R8226:Nedd1 UTSW 10 92,691,935 (GRCm38) missense probably benign
R8925:Nedd1 UTSW 10 92,722,396 (GRCm38) start gained probably benign
R8927:Nedd1 UTSW 10 92,722,396 (GRCm38) start gained probably benign
Predicted Primers PCR Primer
(F):5'- AAAGATGTATGATGAAGCCTGCCCC -3'
(R):5'- ATACCTAGCCCGGCATAGACAGAG -3'

Sequencing Primer
(F):5'- cacataaaaccctaagcagcac -3'
(R):5'- CCGGCATAGACAGAGTTGGTG -3'
Posted On 2014-03-28