Incidental Mutation 'R1490:Or1o3'
ID 163685
Institutional Source Beutler Lab
Gene Symbol Or1o3
Ensembl Gene ENSMUSG00000063660
Gene Name olfactory receptor family 1 subfamily O member 3
Synonyms Olfr98, GA_x6K02T2PSCP-1703582-1702653, MOR156-4
MMRRC Submission 039542-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R1490 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 37573624-37574553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37573733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 274 (M274T)
Ref Sequence ENSEMBL: ENSMUSP00000094936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080759]
AlphaFold Q8VFD9
Predicted Effect probably benign
Transcript: ENSMUST00000080759
AA Change: M274T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000094936
Gene: ENSMUSG00000063660
AA Change: M274T

Pfam:7tm_4 28 305 9.2e-53 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.9e-5 PFAM
Pfam:7tm_1 38 287 2.4e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122476
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174168
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 G A 10: 83,356,234 (GRCm39) T52I probably damaging Het
Arhgef28 G A 13: 98,114,952 (GRCm39) R633W probably damaging Het
Atg9a T C 1: 75,162,389 (GRCm39) N507S possibly damaging Het
Bsn A G 9: 107,991,193 (GRCm39) S1520P probably benign Het
Cacul1 G T 19: 60,568,837 (GRCm39) A107E probably damaging Het
Cd74 A G 18: 60,944,438 (GRCm39) D216G probably damaging Het
Cdh16 A T 8: 105,348,702 (GRCm39) W109R probably damaging Het
Cdip1 C T 16: 4,586,775 (GRCm39) V100I probably damaging Het
Ceacam3 A G 7: 16,897,071 (GRCm39) D679G probably damaging Het
Comp A G 8: 70,826,563 (GRCm39) D46G possibly damaging Het
Dlx3 T C 11: 95,011,430 (GRCm39) Y95H probably benign Het
Dmrta2 T C 4: 109,837,072 (GRCm39) S5P unknown Het
E130308A19Rik A G 4: 59,719,746 (GRCm39) Y426C probably damaging Het
Entpd3 A G 9: 120,383,225 (GRCm39) S87G probably benign Het
Eps8l1 A G 7: 4,473,888 (GRCm39) R232G probably damaging Het
Gart A T 16: 91,421,232 (GRCm39) V812D probably damaging Het
Gm10153 C T 7: 141,743,879 (GRCm39) C83Y unknown Het
Gpd2 T C 2: 57,245,487 (GRCm39) V394A probably damaging Het
Hpcal1 A T 12: 17,836,225 (GRCm39) E18D probably benign Het
Mdga2 T C 12: 66,844,530 (GRCm39) D156G probably benign Het
Mks1 A G 11: 87,753,595 (GRCm39) K510E probably benign Het
Ms4a19 A G 19: 11,118,902 (GRCm39) I69T probably benign Het
Mtmr4 G A 11: 87,503,051 (GRCm39) R1035Q probably damaging Het
Myh6 T A 14: 55,200,175 (GRCm39) K235* probably null Het
Nedd1 A G 10: 92,536,660 (GRCm39) F214S probably damaging Het
Or1e32 A G 11: 73,705,197 (GRCm39) V237A possibly damaging Het
Or2l13 T C 16: 19,305,672 (GRCm39) M28T probably benign Het
Or52e15 A G 7: 104,645,700 (GRCm39) I137T possibly damaging Het
Pfkfb2 A C 1: 130,625,626 (GRCm39) probably null Het
Pfkfb4 T C 9: 108,856,688 (GRCm39) L398P probably damaging Het
Pfn3 T G 13: 55,562,732 (GRCm39) D83A probably damaging Het
Pi4ka C A 16: 17,204,132 (GRCm39) W54L probably damaging Het
Ppp3r1 A G 11: 17,148,275 (GRCm39) D161G probably benign Het
Prrc2a A G 17: 35,372,230 (GRCm39) S1757P probably benign Het
Samd7 A G 3: 30,812,502 (GRCm39) E314G probably benign Het
Slc17a4 A G 13: 24,088,736 (GRCm39) I217T probably benign Het
Slc22a1 A T 17: 12,881,780 (GRCm39) probably null Het
Slc7a7 C T 14: 54,646,103 (GRCm39) R120H probably damaging Het
Sos1 A T 17: 80,721,104 (GRCm39) H905Q probably benign Het
Thada G A 17: 84,754,029 (GRCm39) T314I possibly damaging Het
Tirap ACTGCTGCTGCTGCTGCTG ACTGCTGCTGCTGCTG 9: 35,100,362 (GRCm39) probably benign Het
Tlr11 A C 14: 50,600,633 (GRCm39) H873P probably benign Het
Tlr4 A T 4: 66,757,611 (GRCm39) T135S possibly damaging Het
Tmem116 T C 5: 121,633,174 (GRCm39) S183P probably damaging Het
Tubgcp3 A T 8: 12,689,550 (GRCm39) I572K probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Ush2a C T 1: 188,092,038 (GRCm39) T523I probably benign Het
Usp40 G A 1: 87,916,687 (GRCm39) Q364* probably null Het
Vmn1r61 T C 7: 5,614,242 (GRCm39) Q24R probably benign Het
Wdfy4 C A 14: 32,874,495 (GRCm39) probably null Het
Zfp458 G A 13: 67,405,573 (GRCm39) P286S probably damaging Het
Zfp68 A T 5: 138,605,091 (GRCm39) C373S probably benign Het
Zfp768 T A 7: 126,942,803 (GRCm39) I442F probably damaging Het
Zfp990 A G 4: 145,263,853 (GRCm39) R284G probably benign Het
Other mutations in Or1o3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02402:Or1o3 APN 17 37,574,111 (GRCm39) missense possibly damaging 0.46
PIT4495001:Or1o3 UTSW 17 37,573,721 (GRCm39) missense possibly damaging 0.88
R0574:Or1o3 UTSW 17 37,573,772 (GRCm39) missense probably damaging 1.00
R1633:Or1o3 UTSW 17 37,574,553 (GRCm39) start codon destroyed probably benign 0.02
R2105:Or1o3 UTSW 17 37,573,964 (GRCm39) missense probably benign 0.26
R4996:Or1o3 UTSW 17 37,573,758 (GRCm39) missense probably benign 0.02
R5114:Or1o3 UTSW 17 37,573,730 (GRCm39) missense probably damaging 1.00
R5225:Or1o3 UTSW 17 37,573,919 (GRCm39) missense probably benign 0.30
R5338:Or1o3 UTSW 17 37,574,532 (GRCm39) missense probably benign 0.00
R5995:Or1o3 UTSW 17 37,574,539 (GRCm39) missense probably benign 0.01
R6190:Or1o3 UTSW 17 37,573,635 (GRCm39) missense probably benign 0.00
R7006:Or1o3 UTSW 17 37,573,625 (GRCm39) makesense probably null
R7246:Or1o3 UTSW 17 37,573,905 (GRCm39) missense probably benign 0.00
R7261:Or1o3 UTSW 17 37,574,076 (GRCm39) missense probably benign
R7611:Or1o3 UTSW 17 37,573,745 (GRCm39) missense probably benign 0.02
R7642:Or1o3 UTSW 17 37,573,964 (GRCm39) missense probably benign 0.26
R8837:Or1o3 UTSW 17 37,573,807 (GRCm39) nonsense probably null
R9528:Or1o3 UTSW 17 37,574,087 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-03-28