Mutagenetix > Incidental Mutation

Incidental Mutation 'R1474:Pkd1l2'

163921

Institutional Source

Beutler Lab

Gene Symbol

Pkd1l2

Ensembl Gene

ENSMUSG00000034416

Gene Name

polycystic kidney disease 1 like 2

Synonyms

MMRRC Submission

039527-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1474 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

116995679-117082449 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 117065497 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104721 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098375] [ENSMUST00000109093]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000098375

SMART Domains

Protein: ENSMUSP00000095977
Gene: ENSMUSG00000034416

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CLECT	26	152	1.56e-21	SMART
Pfam:Gal_Lectin	168	250	1.8e-18	PFAM
PKD	260	341	3.84e-1	SMART
low complexity region	496	507	N/A	INTRINSIC
Pfam:REJ	510	886	1.8e-13	PFAM
low complexity region	1050	1060	N/A	INTRINSIC
GPS	1278	1327	1.61e-11	SMART
transmembrane domain	1346	1365	N/A	INTRINSIC
LH2	1390	1509	6.05e-13	SMART
transmembrane domain	1552	1574	N/A	INTRINSIC
transmembrane domain	1589	1611	N/A	INTRINSIC
transmembrane domain	1815	1837	N/A	INTRINSIC
transmembrane domain	1852	1874	N/A	INTRINSIC
transmembrane domain	1940	1962	N/A	INTRINSIC
Pfam:PKD_channel	1980	2403	6.4e-107	PFAM
Pfam:Ion_trans	2187	2396	2.5e-12	PFAM
low complexity region	2441	2458	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000109093

SMART Domains

Protein: ENSMUSP00000104721
Gene: ENSMUSG00000034416

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
CLECT	26	152	1.56e-21	SMART
Pfam:Gal_Lectin	168	250	6.9e-19	PFAM
PKD	260	341	3.84e-1	SMART
low complexity region	496	507	N/A	INTRINSIC
Pfam:REJ	519	883	7e-11	PFAM
low complexity region	1051	1061	N/A	INTRINSIC
GPS	1279	1328	1.61e-11	SMART
transmembrane domain	1347	1366	N/A	INTRINSIC
LH2	1391	1510	6.05e-13	SMART
transmembrane domain	1553	1575	N/A	INTRINSIC
transmembrane domain	1590	1612	N/A	INTRINSIC
transmembrane domain	1816	1838	N/A	INTRINSIC
transmembrane domain	1853	1875	N/A	INTRINSIC
transmembrane domain	1941	1963	N/A	INTRINSIC
Pfam:PKD_channel	1981	2403	5.9e-106	PFAM
Pfam:Ion_trans	2138	2409	3.4e-12	PFAM
low complexity region	2442	2459	N/A	INTRINSIC

Coding Region Coverage

1x: 99.3%
3x: 98.4%
10x: 96.6%
20x: 93.6%

Validation Efficiency

95% (104/110)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, where some individuals contain a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 106 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430531B16Rik	C	A	7: 139,976,642 (GRCm38)	R144L	probably benign	Het
9030624J02Rik	T	C	7: 118,760,213 (GRCm38)	F230S	probably damaging	Het
Abca8a	C	A	11: 110,069,809 (GRCm38)	A628S	probably damaging	Het
Abca9	T	C	11: 110,145,579 (GRCm38)	N568S	probably damaging	Het
Ada	C	T	2: 163,732,894 (GRCm38)	A108T	possibly damaging	Het
Adam6a	T	A	12: 113,544,449 (GRCm38)	D147E	possibly damaging	Het
Ampd1	A	T	3: 103,098,838 (GRCm38)	T655S	probably damaging	Het
Ankk1	A	G	9: 49,415,839 (GRCm38)	F680S	probably damaging	Het
Asap1	G	A	15: 64,120,020 (GRCm38)	T783I	probably benign	Het
Astn1	T	A	1: 158,502,353 (GRCm38)	N259K	probably damaging	Het
Birc6	T	C	17: 74,579,678 (GRCm38)	V667A	probably damaging	Het
Brat1	G	A	5: 140,712,627 (GRCm38)	V185I	probably benign	Het
Btnl6	T	C	17: 34,513,646 (GRCm38)	Y318C	probably damaging	Het
Caskin2	G	A	11: 115,803,696 (GRCm38)	P360S	probably benign	Het
Cd68	T	A	11: 69,664,928 (GRCm38)		probably benign	Het
Cdca2	T	C	14: 67,714,906 (GRCm38)		probably benign	Het
Cdk6	G	A	5: 3,473,217 (GRCm38)	M212I	probably benign	Het
Ceacam5	T	A	7: 17,747,234 (GRCm38)	F302Y	probably damaging	Het
Celsr2	T	C	3: 108,393,739 (GRCm38)	E2746G	possibly damaging	Het
Clec4a4	G	A	6: 123,012,744 (GRCm38)	V115I	probably benign	Het
Clip3	C	A	7: 30,298,882 (GRCm38)	A251E	possibly damaging	Het
Cmah	T	C	13: 24,439,197 (GRCm38)	L350P	probably damaging	Het
Cntnap5a	C	T	1: 116,442,373 (GRCm38)	R907*	probably null	Het
Cntnap5b	T	C	1: 100,072,089 (GRCm38)	Y191H	probably benign	Het
Col4a4	A	T	1: 82,480,486 (GRCm38)	C1122*	probably null	Het
Coq5	A	G	5: 115,295,783 (GRCm38)		probably benign	Het
Cpxcr1	A	G	X: 116,477,439 (GRCm38)	K16E	possibly damaging	Het
Dclk3	T	C	9: 111,469,236 (GRCm38)	I616T	probably benign	Het
Ddx58	A	G	4: 40,208,868 (GRCm38)	V703A	possibly damaging	Het
Dhrs3	A	T	4: 144,919,487 (GRCm38)	T122S	probably damaging	Het
Dnm1	T	C	2: 32,320,584 (GRCm38)	I502V	probably benign	Het
Dscaml1	G	T	9: 45,685,221 (GRCm38)	G788W	probably damaging	Het
Dusp10	C	T	1: 184,037,448 (GRCm38)		probably null	Het
Ehbp1l1	C	A	19: 5,719,084 (GRCm38)	L730F	possibly damaging	Het
Eif2ak1	C	T	5: 143,871,967 (GRCm38)	H75Y	probably damaging	Het
Evi2a	T	C	11: 79,527,572 (GRCm38)	T71A	probably benign	Het
Fam184a	A	T	10: 53,635,365 (GRCm38)	S1073T	probably damaging	Het
Fam227a	T	C	15: 79,615,381 (GRCm38)	Y591C	probably damaging	Het
Fam83a	C	T	15: 58,009,876 (GRCm38)	T367M	probably benign	Het
Fam83g	A	G	11: 61,702,993 (GRCm38)	D451G	probably damaging	Het
Fbn1	A	G	2: 125,361,265 (GRCm38)	F1213L	possibly damaging	Het
Fcgbp	G	A	7: 28,091,848 (GRCm38)	V845I	probably benign	Het
Fermt1	C	T	2: 132,925,022 (GRCm38)	E342K	probably benign	Het
Foxn1	T	A	11: 78,361,107 (GRCm38)	M433L	probably benign	Het
Gm6583	T	C	5: 112,355,776 (GRCm38)	T21A	probably benign	Het
Gm6632	T	G	5: 59,054,336 (GRCm38)		noncoding transcript	Het
Gnl3	A	T	14: 31,016,461 (GRCm38)		probably benign	Het
Hhipl1	C	T	12: 108,311,737 (GRCm38)	T108I	probably damaging	Het
Hs2st1	A	T	3: 144,435,495 (GRCm38)	F271I	possibly damaging	Het
Ido1	T	C	8: 24,584,446 (GRCm38)	S303G	probably damaging	Het
Ints2	C	T	11: 86,226,781 (GRCm38)	R705H	probably damaging	Het
Kcnc2	A	G	10: 112,456,400 (GRCm38)	K49E	probably damaging	Het
Kif3b	T	A	2: 153,320,315 (GRCm38)	V482E	probably damaging	Het
Ldlrad2	G	A	4: 137,572,214 (GRCm38)	P100S	probably benign	Het
Lrba	G	T	3: 86,780,266 (GRCm38)		probably benign	Het
Lsm11	A	T	11: 45,933,903 (GRCm38)	W266R	probably benign	Het
Mob3a	A	T	10: 80,687,154 (GRCm38)	M215K	probably benign	Het
Mterf1b	T	G	5: 4,197,163 (GRCm38)	L268R	probably damaging	Het
Mvk	T	C	5: 114,460,096 (GRCm38)	F365L	probably damaging	Het
Myo16	T	A	8: 10,502,796 (GRCm38)	F945I	probably damaging	Het
Myo1f	G	T	17: 33,594,027 (GRCm38)	K602N	possibly damaging	Het
Nr2c2ap	A	T	8: 70,133,115 (GRCm38)	M108L	probably benign	Het
Ofcc1	C	T	13: 40,208,829 (GRCm38)	G206R	probably benign	Het
Ogfrl1	A	G	1: 23,375,809 (GRCm38)	F206L	probably damaging	Het
Ola1	A	T	2: 73,156,844 (GRCm38)	I148N	probably damaging	Het
Olfr1158	A	G	2: 87,990,990 (GRCm38)	N293S	probably damaging	Het
Olfr1424	T	A	19: 12,059,480 (GRCm38)	T91S	probably benign	Het
Olfr310	G	T	7: 86,269,062 (GRCm38)	H242Q	probably damaging	Het
Olfr583	A	G	7: 103,052,081 (GRCm38)	Y261C	probably damaging	Het
Olfr791	A	T	10: 129,526,955 (GRCm38)	M243L	probably benign	Het
Otof	A	G	5: 30,379,532 (GRCm38)		probably null	Het
Pah	G	T	10: 87,578,313 (GRCm38)	K341N	probably damaging	Het
Pfdn5	T	A	15: 102,328,511 (GRCm38)		probably null	Het
Piezo2	A	G	18: 63,083,131 (GRCm38)	C960R	probably damaging	Het
Pitx2	T	C	3: 129,218,839 (GRCm38)	V306A	probably damaging	Het
Plekho1	T	C	3: 95,989,566 (GRCm38)	E197G	probably damaging	Het
Polr2i	A	G	7: 30,232,802 (GRCm38)	N34S	probably damaging	Het
Psph	A	T	5: 129,771,550 (GRCm38)	D22E	probably damaging	Het
Ptprs	C	A	17: 56,424,128 (GRCm38)	A687S	probably damaging	Het
Ralgapa1	T	C	12: 55,741,480 (GRCm38)	K606R	probably benign	Het
Rims1	A	G	1: 22,538,281 (GRCm38)		probably benign	Het
Rnf213	C	T	11: 119,437,750 (GRCm38)	P2002L	probably damaging	Het
Ryr3	A	T	2: 112,909,962 (GRCm38)	C555S	probably damaging	Het
Sftpd	C	A	14: 41,172,427 (GRCm38)	G345V	probably damaging	Het
Slc41a1	T	A	1: 131,846,581 (GRCm38)	M462K	probably damaging	Het
Slc44a2	A	G	9: 21,353,694 (GRCm38)	E676G	probably damaging	Het
Sox6	T	A	7: 115,701,691 (GRCm38)		probably benign	Het
Spdye4b	G	A	5: 143,195,717 (GRCm38)	R109Q	probably damaging	Het
Spink8	A	T	9: 109,820,638 (GRCm38)	I63L	probably damaging	Het
St3gal3	A	G	4: 118,014,786 (GRCm38)	L73P	probably damaging	Het
Stab1	A	G	14: 31,149,861 (GRCm38)	L1247P	probably benign	Het
Tat	A	G	8: 109,991,563 (GRCm38)	R27G	probably benign	Het
Tcerg1l	C	T	7: 138,280,075 (GRCm38)	R295H	probably damaging	Het
Tfrc	T	C	16: 32,626,649 (GRCm38)	V596A	probably damaging	Het
Tgfb3	C	T	12: 86,069,346 (GRCm38)		probably null	Het
Tmed5	A	T	5: 108,132,382 (GRCm38)	S15T	probably benign	Het
Tph1	A	T	7: 46,653,862 (GRCm38)	S231T	probably benign	Het
Trim30d	G	A	7: 104,472,494 (GRCm38)	S198L	probably damaging	Het
Trpm6	T	C	19: 18,796,495 (GRCm38)	M412T	probably benign	Het
Ttn	G	T	2: 76,782,245 (GRCm38)	D15417E	probably benign	Het
U2surp	A	G	9: 95,493,198 (GRCm38)	I157T	possibly damaging	Het
Ubr4	A	G	4: 139,429,579 (GRCm38)	D2305G	probably damaging	Het
Uvssa	A	G	5: 33,388,821 (GRCm38)	K179E	probably benign	Het
Xirp2	A	G	2: 67,525,067 (GRCm38)	K3391E	probably benign	Het
Xpo7	T	A	14: 70,699,033 (GRCm38)	H170L	probably benign	Het
Zrsr1	T	C	11: 22,974,404 (GRCm38)	W393R	probably benign	Het

Other mutations in Pkd1l2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01338:Pkd1l2	APN	8	117,059,520 (GRCm38)	nonsense	probably null
IGL01353:Pkd1l2	APN	8	117,057,443 (GRCm38)	missense	probably benign	0.24
IGL01362:Pkd1l2	APN	8	117,021,856 (GRCm38)	missense	probably damaging	1.00
IGL01486:Pkd1l2	APN	8	117,059,592 (GRCm38)	missense	probably benign
IGL01672:Pkd1l2	APN	8	117,080,732 (GRCm38)	missense	possibly damaging	0.94
IGL01696:Pkd1l2	APN	8	117,056,387 (GRCm38)	missense	probably benign	0.12
IGL01819:Pkd1l2	APN	8	116,998,174 (GRCm38)	missense	probably damaging	1.00
IGL01833:Pkd1l2	APN	8	117,060,525 (GRCm38)	missense	probably benign	0.00
IGL01981:Pkd1l2	APN	8	117,016,916 (GRCm38)	missense	probably benign	0.04
IGL02066:Pkd1l2	APN	8	117,009,564 (GRCm38)	splice site	probably benign
IGL02381:Pkd1l2	APN	8	117,035,800 (GRCm38)	splice site	probably benign
IGL02416:Pkd1l2	APN	8	117,040,835 (GRCm38)	missense	possibly damaging	0.82
IGL02736:Pkd1l2	APN	8	117,040,666 (GRCm38)	missense	probably benign	0.00
IGL02828:Pkd1l2	APN	8	117,029,559 (GRCm38)	missense	probably benign
IGL02861:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02862:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02883:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02884:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02894:Pkd1l2	APN	8	117,013,891 (GRCm38)	missense	probably damaging	0.97
IGL02900:Pkd1l2	APN	8	117,024,091 (GRCm38)	missense	probably benign	0.03
IGL02901:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02929:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02941:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02957:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL02969:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03028:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03059:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03065:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03066:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03083:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03084:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03124:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03162:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03165:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03335:Pkd1l2	APN	8	117,065,745 (GRCm38)	missense	probably benign	0.07
IGL03357:Pkd1l2	APN	8	116,995,809 (GRCm38)	missense	probably damaging	1.00
IGL02835:Pkd1l2	UTSW	8	117,065,745 (GRCm38)	missense	probably benign	0.07
PIT4453001:Pkd1l2	UTSW	8	117,022,022 (GRCm38)	missense	probably benign	0.00
R0127:Pkd1l2	UTSW	8	117,050,048 (GRCm38)	splice site	probably benign
R0309:Pkd1l2	UTSW	8	116,997,576 (GRCm38)	missense	probably damaging	0.99
R0365:Pkd1l2	UTSW	8	117,021,850 (GRCm38)	missense	probably benign	0.02
R0526:Pkd1l2	UTSW	8	117,082,260 (GRCm38)	missense	probably damaging	1.00
R0571:Pkd1l2	UTSW	8	117,082,218 (GRCm38)	missense	probably benign	0.01
R0716:Pkd1l2	UTSW	8	117,051,100 (GRCm38)	missense	probably damaging	1.00
R0787:Pkd1l2	UTSW	8	117,076,177 (GRCm38)	missense	possibly damaging	0.90
R0893:Pkd1l2	UTSW	8	117,044,492 (GRCm38)	missense	probably damaging	0.99
R1256:Pkd1l2	UTSW	8	117,019,543 (GRCm38)	critical splice acceptor site	probably null
R1391:Pkd1l2	UTSW	8	117,054,934 (GRCm38)	missense	possibly damaging	0.87
R1491:Pkd1l2	UTSW	8	117,028,408 (GRCm38)	missense	probably damaging	1.00
R1520:Pkd1l2	UTSW	8	117,046,159 (GRCm38)	missense	probably benign	0.00
R1521:Pkd1l2	UTSW	8	117,065,500 (GRCm38)	splice site	probably null
R1544:Pkd1l2	UTSW	8	117,038,235 (GRCm38)	frame shift	probably null
R1558:Pkd1l2	UTSW	8	117,082,252 (GRCm38)	missense	possibly damaging	0.94
R1673:Pkd1l2	UTSW	8	117,040,775 (GRCm38)	missense	probably benign	0.00
R1691:Pkd1l2	UTSW	8	117,056,419 (GRCm38)	missense	possibly damaging	0.60
R1754:Pkd1l2	UTSW	8	117,030,719 (GRCm38)	missense	possibly damaging	0.81
R1857:Pkd1l2	UTSW	8	117,040,669 (GRCm38)	missense	possibly damaging	0.70
R1939:Pkd1l2	UTSW	8	117,046,182 (GRCm38)	nonsense	probably null
R1955:Pkd1l2	UTSW	8	117,043,361 (GRCm38)	missense	probably benign
R1957:Pkd1l2	UTSW	8	117,030,682 (GRCm38)	missense	probably damaging	1.00
R1959:Pkd1l2	UTSW	8	117,043,231 (GRCm38)	critical splice donor site	probably null
R2024:Pkd1l2	UTSW	8	117,019,533 (GRCm38)	missense	probably benign
R2046:Pkd1l2	UTSW	8	116,999,955 (GRCm38)	missense	probably damaging	1.00
R2102:Pkd1l2	UTSW	8	117,081,469 (GRCm38)	missense	probably damaging	0.98
R2116:Pkd1l2	UTSW	8	117,030,722 (GRCm38)	missense	possibly damaging	0.93
R2148:Pkd1l2	UTSW	8	117,056,325 (GRCm38)	missense	probably damaging	0.98
R2251:Pkd1l2	UTSW	8	117,057,438 (GRCm38)	missense	probably damaging	1.00
R2252:Pkd1l2	UTSW	8	117,057,438 (GRCm38)	missense	probably damaging	1.00
R2366:Pkd1l2	UTSW	8	117,043,317 (GRCm38)	missense	probably benign	0.01
R2566:Pkd1l2	UTSW	8	117,019,494 (GRCm38)	missense	probably damaging	1.00
R2872:Pkd1l2	UTSW	8	117,038,164 (GRCm38)	missense	probably benign	0.10
R2872:Pkd1l2	UTSW	8	117,038,164 (GRCm38)	missense	probably benign	0.10
R2985:Pkd1l2	UTSW	8	117,065,551 (GRCm38)	missense	probably benign	0.00
R3055:Pkd1l2	UTSW	8	117,068,315 (GRCm38)	critical splice acceptor site	probably null
R3436:Pkd1l2	UTSW	8	117,040,739 (GRCm38)	missense	probably benign	0.01
R4732:Pkd1l2	UTSW	8	116,995,842 (GRCm38)	critical splice acceptor site	probably null
R4733:Pkd1l2	UTSW	8	116,995,842 (GRCm38)	critical splice acceptor site	probably null
R4763:Pkd1l2	UTSW	8	117,019,429 (GRCm38)	missense	probably damaging	0.96
R4789:Pkd1l2	UTSW	8	117,011,575 (GRCm38)	missense	probably damaging	0.99
R4921:Pkd1l2	UTSW	8	117,054,885 (GRCm38)	missense	probably benign	0.03
R4921:Pkd1l2	UTSW	8	117,072,549 (GRCm38)	missense	probably damaging	0.97
R4999:Pkd1l2	UTSW	8	117,047,374 (GRCm38)	splice site	probably null
R5057:Pkd1l2	UTSW	8	117,055,008 (GRCm38)	missense	probably benign	0.21
R5209:Pkd1l2	UTSW	8	117,056,442 (GRCm38)	missense	probably benign	0.23
R5241:Pkd1l2	UTSW	8	117,035,118 (GRCm38)	missense	probably damaging	1.00
R5480:Pkd1l2	UTSW	8	117,030,649 (GRCm38)	missense	probably damaging	0.99
R5501:Pkd1l2	UTSW	8	117,065,830 (GRCm38)	missense	probably damaging	0.98
R5533:Pkd1l2	UTSW	8	117,068,116 (GRCm38)	missense	probably benign	0.03
R5582:Pkd1l2	UTSW	8	117,040,783 (GRCm38)	nonsense	probably null
R5610:Pkd1l2	UTSW	8	117,042,320 (GRCm38)	missense	probably benign	0.04
R5770:Pkd1l2	UTSW	8	117,055,018 (GRCm38)	missense	probably damaging	1.00
R5854:Pkd1l2	UTSW	8	117,065,746 (GRCm38)	missense	possibly damaging	0.48
R5867:Pkd1l2	UTSW	8	117,055,011 (GRCm38)	missense	probably damaging	0.96
R5881:Pkd1l2	UTSW	8	116,997,582 (GRCm38)	missense	probably damaging	0.99
R5906:Pkd1l2	UTSW	8	117,029,648 (GRCm38)	missense	probably damaging	1.00
R5909:Pkd1l2	UTSW	8	117,024,056 (GRCm38)	missense	probably benign	0.00
R6030:Pkd1l2	UTSW	8	117,043,237 (GRCm38)	missense	probably damaging	1.00
R6030:Pkd1l2	UTSW	8	117,043,237 (GRCm38)	missense	probably damaging	1.00
R6084:Pkd1l2	UTSW	8	117,013,987 (GRCm38)	missense	probably damaging	1.00
R6122:Pkd1l2	UTSW	8	117,082,368 (GRCm38)	missense	probably benign	0.02
R6216:Pkd1l2	UTSW	8	117,081,470 (GRCm38)	missense	probably damaging	1.00
R6406:Pkd1l2	UTSW	8	117,035,847 (GRCm38)	missense	probably damaging	0.99
R6417:Pkd1l2	UTSW	8	117,013,899 (GRCm38)	missense	probably damaging	1.00
R6420:Pkd1l2	UTSW	8	117,013,899 (GRCm38)	missense	probably damaging	1.00
R6601:Pkd1l2	UTSW	8	117,040,666 (GRCm38)	missense	probably benign	0.00
R6743:Pkd1l2	UTSW	8	117,030,631 (GRCm38)	missense	probably damaging	1.00
R7053:Pkd1l2	UTSW	8	117,013,942 (GRCm38)	missense	probably damaging	1.00
R7144:Pkd1l2	UTSW	8	117,076,131 (GRCm38)	nonsense	probably null
R7148:Pkd1l2	UTSW	8	117,080,786 (GRCm38)	missense	probably benign	0.00
R7169:Pkd1l2	UTSW	8	117,040,835 (GRCm38)	missense	possibly damaging	0.82
R7217:Pkd1l2	UTSW	8	116,995,797 (GRCm38)	missense	probably benign	0.24
R7310:Pkd1l2	UTSW	8	117,024,034 (GRCm38)	missense	probably benign
R7382:Pkd1l2	UTSW	8	117,054,871 (GRCm38)	missense	possibly damaging	0.95
R7397:Pkd1l2	UTSW	8	117,035,902 (GRCm38)	missense	possibly damaging	0.94
R7408:Pkd1l2	UTSW	8	117,028,479 (GRCm38)	missense	possibly damaging	0.77
R7437:Pkd1l2	UTSW	8	117,030,682 (GRCm38)	missense	probably damaging	0.96
R7492:Pkd1l2	UTSW	8	117,068,110 (GRCm38)	missense	probably damaging	1.00
R7496:Pkd1l2	UTSW	8	117,060,594 (GRCm38)	missense	possibly damaging	0.89
R7519:Pkd1l2	UTSW	8	117,065,529 (GRCm38)	missense	probably benign
R7590:Pkd1l2	UTSW	8	117,080,786 (GRCm38)	missense	probably benign	0.00
R7623:Pkd1l2	UTSW	8	117,029,645 (GRCm38)	missense	probably damaging	1.00
R7768:Pkd1l2	UTSW	8	117,054,860 (GRCm38)	critical splice donor site	probably null
R7897:Pkd1l2	UTSW	8	116,998,088 (GRCm38)	missense	possibly damaging	0.69
R7982:Pkd1l2	UTSW	8	117,051,187 (GRCm38)	missense	possibly damaging	0.70
R8024:Pkd1l2	UTSW	8	117,076,182 (GRCm38)	missense	possibly damaging	0.85
R8140:Pkd1l2	UTSW	8	117,047,497 (GRCm38)	missense	probably benign
R8145:Pkd1l2	UTSW	8	117,055,003 (GRCm38)	missense	probably benign
R8228:Pkd1l2	UTSW	8	117,065,775 (GRCm38)	missense	probably damaging	0.97
R8252:Pkd1l2	UTSW	8	117,040,733 (GRCm38)	missense	probably benign	0.29
R8500:Pkd1l2	UTSW	8	117,047,563 (GRCm38)	critical splice acceptor site	probably null
R8732:Pkd1l2	UTSW	8	117,065,572 (GRCm38)	missense	probably benign	0.28
R8809:Pkd1l2	UTSW	8	116,999,921 (GRCm38)	missense	probably damaging	1.00
R8896:Pkd1l2	UTSW	8	117,013,876 (GRCm38)	missense	possibly damaging	0.91
R8961:Pkd1l2	UTSW	8	116,999,978 (GRCm38)	missense	possibly damaging	0.52
R8985:Pkd1l2	UTSW	8	117,038,110 (GRCm38)	missense	probably benign	0.01
R9008:Pkd1l2	UTSW	8	117,042,298 (GRCm38)	missense	probably benign	0.32
R9091:Pkd1l2	UTSW	8	117,032,694 (GRCm38)	missense	probably damaging	1.00
R9138:Pkd1l2	UTSW	8	117,055,009 (GRCm38)	missense	probably benign	0.43
R9160:Pkd1l2	UTSW	8	117,040,669 (GRCm38)	missense	possibly damaging	0.70
R9249:Pkd1l2	UTSW	8	117,019,420 (GRCm38)	missense	probably damaging	0.99
R9270:Pkd1l2	UTSW	8	117,032,694 (GRCm38)	missense	probably damaging	1.00
R9735:Pkd1l2	UTSW	8	117,046,081 (GRCm38)	missense	possibly damaging	0.94
Z1176:Pkd1l2	UTSW	8	117,054,914 (GRCm38)	missense	probably damaging	1.00
Z1177:Pkd1l2	UTSW	8	117,030,691 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GAATCATTAGGACCACGCTGGAGG -3'
(R):5'- CAAGCTGTCAGCAATGAAGGCAC -3'

Sequencing Primer
(F):5'- CTTAGCAAAGCCCCAGTGG -3'
(R):5'- CTGGAAACTTCACTGTGTACTTTG -3'

Posted On

2014-03-28