Incidental Mutation 'R1475:Olfr1051'
ID 163979
Institutional Source Beutler Lab
Gene Symbol Olfr1051
Ensembl Gene ENSMUSG00000075193
Gene Name olfactory receptor 1051
Synonyms GA_x6K02T2Q125-47756192-47755266, MOR187-5
MMRRC Submission 039528-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R1475 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86273814-86279088 bp(-) (GRCm38)
Type of Mutation makesense
DNA Base Change (assembly) A to T at 86275561 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Stop codon to Arginine at position 309 (*309R)
Ref Sequence ENSEMBL: ENSMUSP00000150061 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099898] [ENSMUST00000216432] [ENSMUST00000217245] [ENSMUST00000217294]
AlphaFold Q7TR76
Predicted Effect probably null
Transcript: ENSMUST00000099898
AA Change: *309R
SMART Domains Protein: ENSMUSP00000097482
Gene: ENSMUSG00000075193
AA Change: *309R

Pfam:7tm_4 31 308 1.8e-53 PFAM
Pfam:7tm_1 41 290 2.7e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216432
AA Change: *309R
Predicted Effect probably null
Transcript: ENSMUST00000217245
AA Change: *309R
Predicted Effect probably null
Transcript: ENSMUST00000217294
AA Change: *309R
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency 96% (46/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018B08Rik A T 8: 121,540,588 probably benign Het
9230112D13Rik T A 14: 34,512,055 D93V unknown Het
Aatk G A 11: 120,010,888 T894M probably damaging Het
Acacb T C 5: 114,195,252 I479T possibly damaging Het
Acap3 T C 4: 155,902,821 I431T probably damaging Het
Adgrl1 A G 8: 83,938,350 K1267R possibly damaging Het
Bphl A C 13: 34,060,524 D208A probably benign Het
C2cd5 T C 6: 143,072,572 D308G possibly damaging Het
Camsap3 C T 8: 3,604,708 R782C probably damaging Het
Cdk11b G A 4: 155,634,217 R208H probably damaging Het
Cfap44 T C 16: 44,433,812 probably benign Het
Chrna4 T C 2: 181,029,379 S195G probably benign Het
Cpsf2 T C 12: 101,985,236 L144S probably damaging Het
Creld2 G A 15: 88,820,631 W103* probably null Het
Dffa T A 4: 149,117,478 L171Q probably damaging Het
Emcn C T 3: 137,379,907 H89Y possibly damaging Het
Espn G A 4: 152,134,271 P452S probably damaging Het
Fam78b T A 1: 167,001,777 I71N probably damaging Het
Fam89b A G 19: 5,729,419 S37P probably damaging Het
Fat4 G A 3: 38,888,323 R455H probably damaging Het
Fbxo6 A G 4: 148,146,110 F232L probably benign Het
Fcamr T A 1: 130,814,484 probably null Het
Fermt3 T C 19: 7,018,874 probably null Het
Fsip2 A T 2: 82,987,195 D4424V probably damaging Het
Gaa G A 11: 119,274,316 probably null Het
Glce T C 9: 62,060,928 T314A possibly damaging Het
Hdac5 T C 11: 102,202,186 Q575R possibly damaging Het
Il23r C A 6: 67,452,296 probably null Het
Kcnj4 T A 15: 79,484,630 E383V probably damaging Het
Lrsam1 G T 2: 32,954,265 Q115K possibly damaging Het
Lyst T A 13: 13,708,212 probably null Het
Myf5 A G 10: 107,484,654 V190A probably benign Het
Nmnat2 G A 1: 153,074,695 R42H probably damaging Het
Olfr901 T A 9: 38,430,864 V194D probably benign Het
Osbpl1a T A 18: 12,757,680 K380M probably damaging Het
Pgd T C 4: 149,156,775 T226A probably benign Het
Pitpnm3 T C 11: 72,074,627 T127A probably damaging Het
Plekhm2 T C 4: 141,627,854 D954G possibly damaging Het
Pramef17 T C 4: 143,994,312 K20E probably benign Het
Rasal1 T A 5: 120,662,982 F236I possibly damaging Het
Stab1 T C 14: 31,163,828 N63S probably benign Het
Syf2 T A 4: 134,935,434 M145K possibly damaging Het
Usp34 C A 11: 23,473,253 L3152I probably damaging Het
Usp50 T C 2: 126,769,867 probably null Het
Wdfy4 A T 14: 33,108,688 I929N probably benign Het
Zfp874b A T 13: 67,474,092 probably null Het
Other mutations in Olfr1051
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01578:Olfr1051 APN 2 86275741 missense probably damaging 0.99
IGL02263:Olfr1051 APN 2 86276202 missense probably benign 0.01
IGL03143:Olfr1051 APN 2 86276236 missense probably benign 0.03
R1182:Olfr1051 UTSW 2 86276268 missense probably damaging 0.98
R1712:Olfr1051 UTSW 2 86275993 missense probably damaging 0.97
R1903:Olfr1051 UTSW 2 86275846 missense probably benign 0.00
R2097:Olfr1051 UTSW 2 86276039 nonsense probably null
R4680:Olfr1051 UTSW 2 86276173 missense possibly damaging 0.88
R4879:Olfr1051 UTSW 2 86275763 nonsense probably null
R5094:Olfr1051 UTSW 2 86276040 missense probably damaging 1.00
R6448:Olfr1051 UTSW 2 86276347 missense probably benign 0.07
R8250:Olfr1051 UTSW 2 86276154 missense probably damaging 1.00
R9525:Olfr1051 UTSW 2 86276140 missense probably benign 0.22
R9761:Olfr1051 UTSW 2 86275806 missense probably benign 0.06
X0064:Olfr1051 UTSW 2 86276118 missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-03-28