Incidental Mutation 'R0069:Zswim6'
Institutional Source Beutler Lab
Gene Symbol Zswim6
Ensembl Gene ENSMUSG00000032846
Gene Namezinc finger SWIM-type containing 6
MMRRC Submission 038360-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.392) question?
Stock #R0069 (G1)
Quality Score
Status Validated
Chromosomal Location107724618-107890064 bp(-) (GRCm38)
Type of Mutationexon
DNA Base Change (assembly) T to C at 107738563 bp
Amino Acid Change
Gene Model predicted gene model for transcript(s):
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105097
SMART Domains Protein: ENSMUSP00000100724
Gene: ENSMUSG00000032846

low complexity region 19 39 N/A INTRINSIC
low complexity region 43 71 N/A INTRINSIC
low complexity region 132 193 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224719
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225197
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225822
Meta Mutation Damage Score 0.1804 question?
Coding Region Coverage
  • 1x: 86.4%
  • 3x: 80.4%
  • 10x: 57.4%
  • 20x: 26.1%
Validation Efficiency 94% (60/64)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased striatal volume, abnormal medium spiny neuron morphology, and altered motor control including hyperactivity, impaired rotarod performance, repetitive movements, and behavioral hyperresponsiveness to amphetamine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A T 6: 128,561,562 C632S probably damaging Het
Ccnb1ip1 G A 14: 81,519,382 Q322* probably null Het
Cd101 A G 3: 101,008,217 V678A probably benign Het
Creb1 A G 1: 64,576,208 I240V possibly damaging Het
Dctn2 A T 10: 127,277,485 probably null Het
Diablo A T 5: 123,518,024 S117R probably damaging Het
Ebf2 A T 14: 67,410,050 R349S probably damaging Het
Gne A C 4: 44,060,099 V98G probably damaging Het
Ints3 A G 3: 90,400,647 probably benign Het
Itgal A G 7: 127,310,331 T56A probably benign Het
Lzts3 T A 2: 130,636,540 T213S probably benign Het
Myo1d A G 11: 80,637,953 I681T probably damaging Het
Pde8a T C 7: 81,319,123 probably benign Het
Pole2 A T 12: 69,209,887 V288E probably damaging Het
Poteg T C 8: 27,447,821 S2P probably benign Het
Ppp2r5c A T 12: 110,567,770 M356L probably benign Het
Rad54l2 C A 9: 106,710,365 V734L possibly damaging Het
Ryr1 A C 7: 29,110,505 probably benign Het
Slfn10-ps A G 11: 83,035,542 noncoding transcript Het
Sult1e1 A T 5: 87,579,897 H175Q probably damaging Het
Tcrg-V7 A G 13: 19,178,422 R94G probably benign Het
Ube2e3 C A 2: 78,919,949 probably benign Het
Vps13d A G 4: 145,062,563 I746T probably benign Het
Xpnpep3 T C 15: 81,430,798 V233A probably benign Het
Zfp329 A T 7: 12,810,932 S222T probably damaging Het
Other mutations in Zswim6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01670:Zswim6 APN 13 107728566 splice site noncoding transcript
IGL02367:Zswim6 APN 13 107744102 exon noncoding transcript
IGL02622:Zswim6 APN 13 107748251 exon noncoding transcript
IGL03000:Zswim6 APN 13 107727114 exon noncoding transcript
IGL03000:Zswim6 APN 13 107727115 exon noncoding transcript
R0069:Zswim6 UTSW 13 107738563 exon noncoding transcript
R0834:Zswim6 UTSW 13 107726454 exon noncoding transcript
R1080:Zswim6 UTSW 13 107787651 critical splice donor site noncoding transcript
R1542:Zswim6 UTSW 13 107727234 exon noncoding transcript
R2081:Zswim6 UTSW 13 107773395 exon noncoding transcript
R2133:Zswim6 UTSW 13 107743987 exon noncoding transcript
R3692:Zswim6 UTSW 13 107726541 exon noncoding transcript
R4323:Zswim6 UTSW 13 107889403 exon noncoding transcript
R4345:Zswim6 UTSW 13 107726931 exon noncoding transcript
R4369:Zswim6 UTSW 13 107726694 exon noncoding transcript
R5049:Zswim6 UTSW 13 107726575 exon noncoding transcript
R5111:Zswim6 UTSW 13 107728635 exon noncoding transcript
R5174:Zswim6 UTSW 13 107726681 exon noncoding transcript
R5531:Zswim6 UTSW 13 107769593 exon noncoding transcript
R5933:Zswim6 UTSW 13 107744107 exon noncoding transcript
R5934:Zswim6 UTSW 13 107744107 exon noncoding transcript
R6063:Zswim6 UTSW 13 107728577 exon noncoding transcript
R6168:Zswim6 UTSW 13 107787764 exon noncoding transcript
X0022:Zswim6 UTSW 13 107730324 exon noncoding transcript
Posted On2013-01-20