Incidental Mutation 'R0070:Olfr1362'
ID16434
Institutional Source Beutler Lab
Gene Symbol Olfr1362
Ensembl Gene ENSMUSG00000051258
Gene Nameolfactory receptor 1362
SynonymsGA_x6K02T2QHY8-11628399-11628868, GA_x6K02T2QHY8-11617756-11618682, MOR256-8, Olfr1363-ps1
MMRRC Submission 038361-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.126) question?
Stock #R0070 (G1)
Quality Score
Status Validated
Chromosome13
Chromosomal Location21610978-21614022 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 21611261 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Arginine at position 236 (K236R)
Ref Sequence ENSEMBL: ENSMUSP00000061660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051874]
Predicted Effect possibly damaging
Transcript: ENSMUST00000051874
AA Change: K236R

PolyPhen 2 Score 0.599 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000061660
Gene: ENSMUSG00000051258
AA Change: K236R

DomainStartEndE-ValueType
Pfam:7tm_4 32 307 3.5e-51 PFAM
Pfam:7tm_1 41 290 9e-24 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 88.0%
  • 3x: 83.9%
  • 10x: 69.3%
  • 20x: 41.9%
Validation Efficiency 88% (67/76)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgre4 T C 17: 55,802,154 I387T probably damaging Het
Ankfn1 A T 11: 89,392,302 L173Q probably damaging Het
Atp2a1 T C 7: 126,447,452 E892G probably benign Het
AU018091 T C 7: 3,158,898 probably null Het
Capn12 T C 7: 28,889,126 probably benign Het
Capn2 C A 1: 182,473,869 probably benign Het
Cd79b A G 11: 106,311,918 probably benign Het
Cdh7 C T 1: 110,098,372 A446V probably benign Het
Ciapin1 T C 8: 94,825,219 N246S possibly damaging Het
Fam126a T C 5: 23,964,999 S451G probably damaging Het
Flt3 A G 5: 147,372,726 probably benign Het
Gm2027 T A 12: 44,222,362 probably benign Het
Hipk2 G A 6: 38,818,984 R117* probably null Het
Hykk T A 9: 54,922,348 probably benign Het
Kansl1l T C 1: 66,801,103 D346G probably damaging Het
Kcnt1 T C 2: 25,892,362 V191A probably benign Het
Lcorl G A 5: 45,733,701 R437C probably damaging Het
Mtch1 T A 17: 29,340,059 probably benign Het
Myo1c A G 11: 75,660,250 N217S probably benign Het
Nav2 A G 7: 49,570,714 E1669G probably damaging Het
Olfr132 A G 17: 38,130,889 L101P probably damaging Het
Olfr470 T G 7: 107,844,917 D272A probably damaging Het
Phf20l1 T G 15: 66,639,991 W940G probably damaging Het
Pi4k2b A C 5: 52,756,918 D309A probably damaging Het
Pkd2 T C 5: 104,466,990 C233R probably damaging Het
Prkd3 A G 17: 78,954,510 Y792H probably damaging Het
Pxdn T C 12: 29,982,727 L146S probably damaging Het
Serpinh1 A T 7: 99,349,314 S36R probably damaging Het
Setx A T 2: 29,161,525 T2030S probably benign Het
Sin3b T A 8: 72,725,582 H105Q probably damaging Het
Slx4 A T 16: 3,988,016 D557E possibly damaging Het
Stag1 C T 9: 100,956,408 P1238S probably null Het
Stra6 C T 9: 58,152,615 probably benign Het
Taok1 T A 11: 77,553,717 M511L probably benign Het
Tmem127 T C 2: 127,257,059 V171A probably damaging Het
Tmem147 T C 7: 30,728,101 Y97C probably damaging Het
Tmem150a A G 6: 72,358,759 probably null Het
Top2a C G 11: 99,015,060 probably null Het
Zc3hav1l A T 6: 38,295,190 S215T probably damaging Het
Zscan20 C T 4: 128,585,882 V939I possibly damaging Het
Other mutations in Olfr1362
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00949:Olfr1362 APN 13 21611351 missense probably damaging 0.99
R0070:Olfr1362 UTSW 13 21611261 missense possibly damaging 0.60
R1458:Olfr1362 UTSW 13 21611822 missense probably benign 0.37
R1587:Olfr1362 UTSW 13 21611913 missense probably benign 0.01
R1588:Olfr1362 UTSW 13 21611913 missense probably benign 0.01
R1607:Olfr1362 UTSW 13 21611764 missense probably benign 0.04
R1708:Olfr1362 UTSW 13 21611070 missense probably damaging 0.98
R4633:Olfr1362 UTSW 13 21611228 missense probably damaging 0.99
R6223:Olfr1362 UTSW 13 21611366 missense probably benign
R6229:Olfr1362 UTSW 13 21611649 missense probably benign
R7140:Olfr1362 UTSW 13 21611127 missense possibly damaging 0.87
Posted On2013-01-20