Mutagenetix > Incidental Mutation

Incidental Mutation 'R1481:Olfr713'

164371

Institutional Source

Beutler Lab

Gene Symbol

Olfr713

Ensembl Gene

ENSMUSG00000073898

Gene Name

olfactory receptor 713

Synonyms

GA_x6K02T2PBJ9-9415724-9416677, MOR263-1, P3

MMRRC Submission

039534-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R1481 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

107031174-107040994 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 107036149 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Arginine at position 5 (L5R)

Ref Sequence

ENSEMBL: ENSMUSP00000095743 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098139] [ENSMUST00000213623]

AlphaFold

Q920G5

Predicted Effect

probably benign
Transcript: ENSMUST00000098139
AA Change: L5R

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000095743
Gene: ENSMUSG00000073898
AA Change: L5R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	39	316	4.4e-57	PFAM
Pfam:7tm_1	49	298	2e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213623

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.3%
20x: 92.6%

Validation Efficiency

100% (71/71)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter allele exhibit abnormal olfactory sensory neuron projections. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 37,008,434 (GRCm38)	V3365A	probably damaging	Het
Arhgef5	A	G	6: 43,274,634 (GRCm38)	H773R	probably damaging	Het
Bmp3	G	A	5: 98,872,470 (GRCm38)	V251M	probably damaging	Het
Ccdc175	C	A	12: 72,101,948 (GRCm38)		probably benign	Het
Ccdc178	C	T	18: 22,105,621 (GRCm38)	G313D	probably benign	Het
Cd300ld2	T	A	11: 115,012,633 (GRCm38)	I129F	probably benign	Het
Cep170	T	C	1: 176,782,385 (GRCm38)	Q120R	possibly damaging	Het
Ckb	T	C	12: 111,671,262 (GRCm38)	H145R	probably benign	Het
Cntnap5a	T	A	1: 116,117,663 (GRCm38)	N336K	probably damaging	Het
Coil	T	A	11: 88,974,060 (GRCm38)	C38S	possibly damaging	Het
Cps1	T	C	1: 67,143,882 (GRCm38)	V133A	probably damaging	Het
Cspg4	A	G	9: 56,887,810 (GRCm38)	E943G	probably damaging	Het
Cyp2c54	C	T	19: 40,047,588 (GRCm38)	D293N	probably benign	Het
Cyp2f2	T	C	7: 27,121,877 (GRCm38)	S72P	probably benign	Het
Dip2c	G	A	13: 9,551,866 (GRCm38)		probably null	Het
Dock6	T	C	9: 21,820,622 (GRCm38)	T1158A	probably benign	Het
Dscaml1	G	A	9: 45,672,643 (GRCm38)	V469I	probably benign	Het
Efcab14	A	G	4: 115,756,517 (GRCm38)	T221A	probably benign	Het
Ehbp1	T	C	11: 22,006,782 (GRCm38)	*1207W	probably null	Het
Eln	T	C	5: 134,706,572 (GRCm38)	K786E	probably damaging	Het
Fyb	C	T	15: 6,619,647 (GRCm38)	P385S	probably benign	Het
Galr1	A	G	18: 82,405,741 (GRCm38)	I137T	possibly damaging	Het
Gcm1	A	T	9: 78,059,717 (GRCm38)	K73*	probably null	Het
Gemin5	T	C	11: 58,141,654 (GRCm38)	N775D	probably damaging	Het
Gli3	C	T	13: 15,613,850 (GRCm38)	H147Y	probably damaging	Het
Gm10754	G	T	10: 97,682,227 (GRCm38)		probably benign	Het
Gpr37	T	C	6: 25,669,138 (GRCm38)	D569G	probably damaging	Het
Grina	T	A	15: 76,249,089 (GRCm38)	Y286N	probably damaging	Het
Gtf3c1	C	A	7: 125,693,138 (GRCm38)		probably null	Het
Kcnc4	C	T	3: 107,448,218 (GRCm38)	V305M	probably benign	Het
Kntc1	T	C	5: 123,778,275 (GRCm38)	F724L	probably benign	Het
Kpnb1	T	C	11: 97,178,310 (GRCm38)	Y249C	probably damaging	Het
Krt6b	T	C	15: 101,678,374 (GRCm38)	T269A	probably benign	Het
Lamc1	T	C	1: 153,221,634 (GRCm38)	K1555E	probably damaging	Het
Maneal	T	C	4: 124,861,857 (GRCm38)	Y104C	probably damaging	Het
Map1b	T	C	13: 99,431,171 (GRCm38)	T1681A	unknown	Het
Mettl17	T	C	14: 51,890,703 (GRCm38)	L272P	probably benign	Het
Mib2	T	A	4: 155,656,999 (GRCm38)	S357C	probably benign	Het
Mmp19	C	A	10: 128,798,178 (GRCm38)	T316K	possibly damaging	Het
Mroh9	C	T	1: 163,026,509 (GRCm38)	G774E	probably damaging	Het
Myh1	T	C	11: 67,205,499 (GRCm38)		probably benign	Het
Ncor2	C	A	5: 125,027,138 (GRCm38)	E963*	probably null	Het
Nol6	T	A	4: 41,123,596 (GRCm38)	T51S	probably benign	Het
Nsun3	A	T	16: 62,735,369 (GRCm38)	C265S	probably damaging	Het
Nup214	C	T	2: 32,034,466 (GRCm38)	S1669F	probably damaging	Het
Nutm2	T	A	13: 50,469,481 (GRCm38)	N71K	probably damaging	Het
Olfr498	C	T	7: 108,465,960 (GRCm38)	T212I	probably benign	Het
Orc3	T	A	4: 34,607,228 (GRCm38)	E34V	possibly damaging	Het
Pcdhb13	T	A	18: 37,442,836 (GRCm38)	L89Q	probably damaging	Het
Polr3a	A	T	14: 24,452,548 (GRCm38)	V1241E	probably null	Het
Prpf39	C	T	12: 65,053,314 (GRCm38)	P135S	probably damaging	Het
Psrc1	T	C	3: 108,384,993 (GRCm38)	V34A	probably benign	Het
Rab27a	G	A	9: 73,082,402 (GRCm38)	V52M	probably benign	Het
Rassf9	A	G	10: 102,546,034 (GRCm38)	T424A	probably benign	Het
Ripor3	G	T	2: 168,000,377 (GRCm38)	R61S	possibly damaging	Het
Ryr3	C	T	2: 112,636,522 (GRCm38)		probably benign	Het
Samd4b	C	T	7: 28,414,010 (GRCm38)	G177R	probably damaging	Het
Setbp1	C	T	18: 78,783,301 (GRCm38)	V1366M	probably benign	Het
Smad1	G	A	8: 79,343,730 (GRCm38)	A393V	probably benign	Het
Tctn2	T	C	5: 124,607,763 (GRCm38)		noncoding transcript	Het
Tmem45a	A	T	16: 56,811,602 (GRCm38)	F218I	possibly damaging	Het
Tpte	A	T	8: 22,355,471 (GRCm38)	R512S	probably damaging	Het
Trim37	T	A	11: 87,129,759 (GRCm38)	L22*	probably null	Het
Ttc6	A	G	12: 57,737,130 (GRCm38)	N1792D	probably damaging	Het
Ttn	A	G	2: 76,945,616 (GRCm38)	M1694T	probably damaging	Het
Vmn1r181	T	A	7: 23,984,712 (GRCm38)	W201R	probably damaging	Het
Wdr74	C	T	19: 8,738,228 (GRCm38)	L198F	possibly damaging	Het
Zfp560	T	C	9: 20,348,790 (GRCm38)	T259A	probably benign	Het

Other mutations in Olfr713

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01324:Olfr713	APN	7	107,036,847 (GRCm38)	missense	probably damaging	0.99
IGL01630:Olfr713	APN	7	107,037,111 (GRCm38)	utr 3 prime	probably benign
IGL02539:Olfr713	APN	7	107,036,434 (GRCm38)	missense	probably damaging	1.00
IGL02727:Olfr713	APN	7	107,036,695 (GRCm38)	missense	probably damaging	1.00
IGL03336:Olfr713	APN	7	107,036,335 (GRCm38)	missense	probably damaging	1.00
R0501:Olfr713	UTSW	7	107,036,232 (GRCm38)	missense	probably benign
R0684:Olfr713	UTSW	7	107,036,682 (GRCm38)	missense	probably damaging	1.00
R0909:Olfr713	UTSW	7	107,036,194 (GRCm38)	missense	probably benign	0.19
R1958:Olfr713	UTSW	7	107,036,271 (GRCm38)	missense	possibly damaging	0.77
R1965:Olfr713	UTSW	7	107,036,358 (GRCm38)	missense	probably damaging	1.00
R2119:Olfr713	UTSW	7	107,036,731 (GRCm38)	missense	probably damaging	1.00
R2149:Olfr713	UTSW	7	107,036,338 (GRCm38)	missense	possibly damaging	0.68
R3012:Olfr713	UTSW	7	107,036,362 (GRCm38)	missense	possibly damaging	0.79
R3428:Olfr713	UTSW	7	107,036,716 (GRCm38)	missense	probably benign
R4425:Olfr713	UTSW	7	107,036,491 (GRCm38)	missense	probably damaging	1.00
R4795:Olfr713	UTSW	7	107,036,914 (GRCm38)	missense	probably benign	0.00
R4796:Olfr713	UTSW	7	107,036,914 (GRCm38)	missense	probably benign	0.00
R4908:Olfr713	UTSW	7	107,036,157 (GRCm38)	start codon destroyed	probably benign	0.02
R4945:Olfr713	UTSW	7	107,036,319 (GRCm38)	missense	probably benign	0.00
R5122:Olfr713	UTSW	7	107,036,848 (GRCm38)	nonsense	probably null
R5721:Olfr713	UTSW	7	107,036,358 (GRCm38)	missense	probably damaging	1.00
R5979:Olfr713	UTSW	7	107,036,336 (GRCm38)	missense	probably damaging	1.00
R6739:Olfr713	UTSW	7	107,036,811 (GRCm38)	missense	probably damaging	1.00
R6981:Olfr713	UTSW	7	107,036,749 (GRCm38)	missense	possibly damaging	0.77
R7197:Olfr713	UTSW	7	107,036,157 (GRCm38)	missense	probably benign	0.03
R7228:Olfr713	UTSW	7	107,037,100 (GRCm38)	missense	probably benign
R7444:Olfr713	UTSW	7	107,036,347 (GRCm38)	missense	probably damaging	1.00
R8830:Olfr713	UTSW	7	107,036,682 (GRCm38)	missense	probably benign	0.28
R9109:Olfr713	UTSW	7	107,036,433 (GRCm38)	missense	probably damaging	1.00
R9298:Olfr713	UTSW	7	107,036,433 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTACGCTGGCTTTATGACTTCGC -3'
(R):5'- CCCCAACATTTTGGGCACAATGAC -3'

Sequencing Primer
(F):5'- CCATTAGATATGACCGTGCCG -3'
(R):5'- AATACATGGGGCTTTGCAGC -3'

Posted On

2014-03-28