Incidental Mutation 'R0104:Ighv2-7'
ID16446
Institutional Source Beutler Lab
Gene Symbol Ighv2-7
Ensembl Gene ENSMUSG00000096824
Gene Nameimmunoglobulin heavy variable 2-7
SynonymsGm16597
MMRRC Submission 038390-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.339) question?
Stock #R0104 (G1)
Quality Score
Status Validated
Chromosome12
Chromosomal Location113807314-113807752 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 113807468 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 66 (W66R)
Ref Sequence ENSEMBL: ENSMUSP00000100237 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103456]
Predicted Effect probably damaging
Transcript: ENSMUST00000103456
AA Change: W66R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100237
Gene: ENSMUSG00000096824
AA Change: W66R

DomainStartEndE-ValueType
IGv 36 116 8.88e-28 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195089
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 75.5%
  • 3x: 52.6%
  • 10x: 7.5%
  • 20x: 3.0%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3100002H09Rik C A 4: 124,610,676 A28S probably damaging Het
Arhgap5 A T 12: 52,516,717 D157V probably damaging Het
Cfap54 G T 10: 93,028,652 H142N probably damaging Het
Dpp10 A T 1: 123,367,843 M525K probably benign Het
Fsip2 A T 2: 82,978,973 T1879S possibly damaging Het
Gm14129 T C 2: 148,931,573 noncoding transcript Het
Kif11 T A 19: 37,413,215 V880D probably benign Het
Mcpt1 T A 14: 56,019,431 M142K possibly damaging Het
Mlst8 T C 17: 24,476,117 N264S possibly damaging Het
Nmrk1 T A 19: 18,641,218 S88R probably benign Het
Olfr113 T A 17: 37,574,926 I166F probably damaging Het
Olfr930 A G 9: 38,930,965 S265G possibly damaging Het
Rtn1 A T 12: 72,308,845 I109N probably damaging Het
Slc15a2 T A 16: 36,774,635 L156F possibly damaging Het
Slc22a21 A C 11: 53,951,809 M498R probably null Het
Ssc5d T C 7: 4,936,286 S574P probably benign Het
Taf2 T C 15: 55,038,338 D820G probably benign Het
Tas2r135 A T 6: 42,406,324 I266F possibly damaging Het
Tcrg-V4 C T 13: 19,185,310 H75Y probably damaging Het
Vil1 A G 1: 74,418,366 K53E probably benign Het
Zfc3h1 T A 10: 115,415,287 M1261K possibly damaging Het
Zfp655 T C 5: 145,244,015 S228P probably damaging Het
Zfyve9 C A 4: 108,718,163 D574Y probably damaging Het
Other mutations in Ighv2-7
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4805:Ighv2-7 UTSW 12 113807534 missense probably damaging 1.00
R6177:Ighv2-7 UTSW 12 113807435 missense possibly damaging 0.68
Posted On2013-01-20