Incidental Mutation 'R0102:Pitpnm3'
ID |
16540 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Pitpnm3
|
Ensembl Gene |
ENSMUSG00000040543 |
Gene Name |
PITPNM family member 3 |
Synonyms |
A330068P14Rik, Ackr6 |
MMRRC Submission |
038388-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.058)
|
Stock # |
R0102 (G1)
|
Quality Score |
|
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
71938354-72026604 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 71947072 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Methionine
at position 776
(V776M)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000104148
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075258]
[ENSMUST00000108508]
|
AlphaFold |
Q3UHE1 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000075258
AA Change: V792M
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000074737 Gene: ENSMUSG00000040543 AA Change: V792M
Domain | Start | End | E-Value | Type |
low complexity region
|
4 |
17 |
N/A |
INTRINSIC |
low complexity region
|
25 |
37 |
N/A |
INTRINSIC |
low complexity region
|
128 |
140 |
N/A |
INTRINSIC |
Blast:DDHD
|
141 |
361 |
1e-105 |
BLAST |
DDHD
|
390 |
594 |
1.49e-91 |
SMART |
LNS2
|
739 |
870 |
2.12e-55 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000108508
AA Change: V776M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000104148 Gene: ENSMUSG00000040543 AA Change: V776M
Domain | Start | End | E-Value | Type |
low complexity region
|
4 |
17 |
N/A |
INTRINSIC |
low complexity region
|
25 |
37 |
N/A |
INTRINSIC |
low complexity region
|
112 |
124 |
N/A |
INTRINSIC |
Blast:DDHD
|
125 |
345 |
1e-106 |
BLAST |
DDHD
|
374 |
578 |
1.49e-91 |
SMART |
LNS2
|
723 |
854 |
2.12e-55 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132781
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134210
|
Meta Mutation Damage Score |
0.5881 |
Coding Region Coverage |
- 1x: 88.8%
- 3x: 85.2%
- 10x: 73.9%
- 20x: 53.9%
|
Validation Efficiency |
97% (84/87) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 58 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1110002E22Rik |
A |
G |
3: 137,773,874 (GRCm39) |
K1021R |
probably damaging |
Het |
2610528J11Rik |
G |
A |
4: 118,386,762 (GRCm39) |
V36M |
probably damaging |
Het |
4930402F06Rik |
T |
A |
2: 35,265,795 (GRCm39) |
R292* |
probably null |
Het |
Abcb4 |
T |
C |
5: 8,959,194 (GRCm39) |
F207S |
probably damaging |
Het |
Adcy4 |
A |
C |
14: 56,008,990 (GRCm39) |
N812K |
probably benign |
Het |
Afap1l2 |
G |
T |
19: 56,916,872 (GRCm39) |
|
probably benign |
Het |
Arfgef2 |
A |
T |
2: 166,687,385 (GRCm39) |
H203L |
probably benign |
Het |
Avl9 |
G |
T |
6: 56,713,468 (GRCm39) |
R242L |
probably benign |
Het |
Bod1l |
G |
A |
5: 41,974,612 (GRCm39) |
P2234L |
probably benign |
Het |
Cfi |
A |
C |
3: 129,642,416 (GRCm39) |
H90P |
probably damaging |
Het |
Cyp2d10 |
C |
T |
15: 82,288,794 (GRCm39) |
M229I |
probably benign |
Het |
Dnah5 |
A |
G |
15: 28,245,897 (GRCm39) |
|
probably benign |
Het |
Dnttip2 |
G |
T |
3: 122,069,452 (GRCm39) |
M222I |
probably benign |
Het |
Dync1li2 |
A |
T |
8: 105,154,757 (GRCm39) |
Y284N |
probably benign |
Het |
Ebf1 |
T |
C |
11: 44,882,282 (GRCm39) |
Y413H |
probably benign |
Het |
Exog |
A |
G |
9: 119,281,319 (GRCm39) |
T186A |
possibly damaging |
Het |
Fam171a2 |
T |
C |
11: 102,334,939 (GRCm39) |
N66S |
possibly damaging |
Het |
Gprc5a |
A |
T |
6: 135,056,033 (GRCm39) |
N160I |
probably damaging |
Het |
Haus3 |
A |
G |
5: 34,323,258 (GRCm39) |
|
probably null |
Het |
Klhl20 |
A |
T |
1: 160,918,015 (GRCm39) |
C90* |
probably null |
Het |
Krt84 |
T |
A |
15: 101,437,138 (GRCm39) |
I342L |
probably damaging |
Het |
Lifr |
G |
A |
15: 7,208,373 (GRCm39) |
D584N |
probably damaging |
Het |
Lmbrd2 |
G |
A |
15: 9,184,039 (GRCm39) |
R551K |
probably damaging |
Het |
Lrtm1 |
T |
A |
14: 28,744,184 (GRCm39) |
|
probably benign |
Het |
Mat1a |
T |
A |
14: 40,842,187 (GRCm39) |
|
probably benign |
Het |
Mest |
A |
G |
6: 30,746,269 (GRCm39) |
I279V |
probably damaging |
Het |
Mroh5 |
A |
T |
15: 73,691,199 (GRCm39) |
D155E |
probably benign |
Het |
Naa25 |
A |
G |
5: 121,573,632 (GRCm39) |
D787G |
possibly damaging |
Het |
Naaladl1 |
C |
T |
19: 6,162,534 (GRCm39) |
P465S |
probably damaging |
Het |
Necab3 |
G |
A |
2: 154,387,232 (GRCm39) |
R302C |
probably damaging |
Het |
Nsg1 |
A |
T |
5: 38,316,254 (GRCm39) |
D32E |
probably damaging |
Het |
Ntrk2 |
T |
C |
13: 58,956,607 (GRCm39) |
V22A |
probably benign |
Het |
Nuggc |
A |
G |
14: 65,851,000 (GRCm39) |
D290G |
probably null |
Het |
Nup205 |
A |
T |
6: 35,202,715 (GRCm39) |
|
probably benign |
Het |
Or2t35 |
C |
T |
14: 14,407,876 (GRCm38) |
S218F |
probably damaging |
Het |
Or4f57 |
G |
C |
2: 111,790,942 (GRCm39) |
Q159E |
probably damaging |
Het |
Pde4b |
T |
A |
4: 102,447,375 (GRCm39) |
S9T |
probably benign |
Het |
Phip |
A |
T |
9: 82,787,845 (GRCm39) |
|
probably null |
Het |
Pon2 |
A |
G |
6: 5,289,091 (GRCm39) |
|
probably benign |
Het |
Ppp1r12b |
T |
A |
1: 134,763,637 (GRCm39) |
|
probably null |
Het |
Ppp1r15b |
A |
G |
1: 133,060,908 (GRCm39) |
N475S |
probably damaging |
Het |
Prorp |
A |
G |
12: 55,429,082 (GRCm39) |
D535G |
probably benign |
Het |
Prrt3 |
A |
T |
6: 113,474,790 (GRCm39) |
L144H |
probably damaging |
Het |
Psmb7 |
A |
G |
2: 38,533,377 (GRCm39) |
V50A |
possibly damaging |
Het |
Sacs |
T |
A |
14: 61,442,017 (GRCm39) |
S1354R |
probably damaging |
Het |
Sdcbp2 |
A |
G |
2: 151,425,884 (GRCm39) |
T29A |
probably benign |
Het |
Shbg |
T |
A |
11: 69,508,415 (GRCm39) |
|
probably benign |
Het |
Shcbp1 |
A |
G |
8: 4,794,452 (GRCm39) |
I447T |
probably damaging |
Het |
Spata31h1 |
T |
A |
10: 82,119,390 (GRCm39) |
K4540M |
probably damaging |
Het |
Spata31h2 |
T |
A |
5: 23,542,489 (GRCm39) |
|
noncoding transcript |
Het |
Thbd |
A |
T |
2: 148,248,903 (GRCm39) |
C322S |
probably damaging |
Het |
Tnfrsf21 |
C |
T |
17: 43,349,104 (GRCm39) |
H239Y |
probably benign |
Het |
Trappc12 |
A |
T |
12: 28,796,751 (GRCm39) |
F260L |
probably damaging |
Het |
Trgv4 |
T |
G |
13: 19,369,370 (GRCm39) |
F38C |
possibly damaging |
Het |
Trim10 |
C |
A |
17: 37,181,074 (GRCm39) |
H102N |
probably damaging |
Het |
Ube2u |
A |
G |
4: 100,407,122 (GRCm39) |
T215A |
possibly damaging |
Het |
Vcan |
T |
G |
13: 89,851,787 (GRCm39) |
T1058P |
probably benign |
Het |
Vwa3b |
A |
C |
1: 37,174,595 (GRCm39) |
E670A |
probably damaging |
Het |
|
Other mutations in Pitpnm3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01818:Pitpnm3
|
APN |
11 |
72,003,077 (GRCm39) |
splice site |
probably benign |
|
IGL01871:Pitpnm3
|
APN |
11 |
71,946,964 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02058:Pitpnm3
|
APN |
11 |
72,010,965 (GRCm39) |
missense |
probably benign |
0.31 |
IGL02267:Pitpnm3
|
APN |
11 |
71,962,274 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02370:Pitpnm3
|
APN |
11 |
71,942,684 (GRCm39) |
missense |
probably benign |
0.04 |
IGL02613:Pitpnm3
|
APN |
11 |
71,948,898 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02835:Pitpnm3
|
APN |
11 |
71,952,292 (GRCm39) |
splice site |
probably benign |
|
IGL02946:Pitpnm3
|
APN |
11 |
71,983,378 (GRCm39) |
missense |
probably benign |
0.08 |
IGL02989:Pitpnm3
|
APN |
11 |
72,011,012 (GRCm39) |
splice site |
probably benign |
|
IGL03173:Pitpnm3
|
APN |
11 |
71,983,389 (GRCm39) |
missense |
probably benign |
0.02 |
IGL03357:Pitpnm3
|
APN |
11 |
71,961,716 (GRCm39) |
nonsense |
probably null |
|
Frank
|
UTSW |
11 |
71,961,222 (GRCm39) |
missense |
probably benign |
|
Mickey
|
UTSW |
11 |
71,961,790 (GRCm39) |
missense |
probably damaging |
1.00 |
Stuart
|
UTSW |
11 |
71,942,755 (GRCm39) |
missense |
probably null |
0.99 |
R0193:Pitpnm3
|
UTSW |
11 |
71,961,318 (GRCm39) |
splice site |
probably benign |
|
R0964:Pitpnm3
|
UTSW |
11 |
71,949,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R1475:Pitpnm3
|
UTSW |
11 |
71,965,453 (GRCm39) |
missense |
probably damaging |
1.00 |
R1566:Pitpnm3
|
UTSW |
11 |
71,949,785 (GRCm39) |
splice site |
probably null |
|
R1951:Pitpnm3
|
UTSW |
11 |
71,965,450 (GRCm39) |
missense |
possibly damaging |
0.88 |
R3915:Pitpnm3
|
UTSW |
11 |
72,003,110 (GRCm39) |
missense |
probably damaging |
1.00 |
R4192:Pitpnm3
|
UTSW |
11 |
71,942,785 (GRCm39) |
missense |
possibly damaging |
0.96 |
R4278:Pitpnm3
|
UTSW |
11 |
71,965,342 (GRCm39) |
missense |
probably damaging |
1.00 |
R4928:Pitpnm3
|
UTSW |
11 |
71,953,998 (GRCm39) |
missense |
probably damaging |
1.00 |
R5543:Pitpnm3
|
UTSW |
11 |
71,947,023 (GRCm39) |
missense |
probably damaging |
0.99 |
R5626:Pitpnm3
|
UTSW |
11 |
72,003,158 (GRCm39) |
missense |
probably benign |
0.04 |
R5635:Pitpnm3
|
UTSW |
11 |
71,957,986 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5958:Pitpnm3
|
UTSW |
11 |
72,003,193 (GRCm39) |
splice site |
probably null |
|
R6531:Pitpnm3
|
UTSW |
11 |
71,962,313 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6634:Pitpnm3
|
UTSW |
11 |
71,942,755 (GRCm39) |
missense |
probably null |
0.99 |
R6764:Pitpnm3
|
UTSW |
11 |
71,942,059 (GRCm39) |
missense |
probably damaging |
1.00 |
R6912:Pitpnm3
|
UTSW |
11 |
71,961,222 (GRCm39) |
missense |
probably benign |
|
R7132:Pitpnm3
|
UTSW |
11 |
71,942,102 (GRCm39) |
missense |
possibly damaging |
0.86 |
R7307:Pitpnm3
|
UTSW |
11 |
71,961,790 (GRCm39) |
missense |
probably damaging |
1.00 |
R7561:Pitpnm3
|
UTSW |
11 |
71,942,008 (GRCm39) |
missense |
probably benign |
0.02 |
R7771:Pitpnm3
|
UTSW |
11 |
71,952,314 (GRCm39) |
nonsense |
probably null |
|
R8099:Pitpnm3
|
UTSW |
11 |
71,961,144 (GRCm39) |
missense |
possibly damaging |
0.85 |
R8753:Pitpnm3
|
UTSW |
11 |
71,942,704 (GRCm39) |
missense |
probably benign |
0.01 |
R8817:Pitpnm3
|
UTSW |
11 |
71,941,894 (GRCm39) |
missense |
possibly damaging |
0.74 |
R8987:Pitpnm3
|
UTSW |
11 |
72,003,132 (GRCm39) |
missense |
probably damaging |
1.00 |
R9054:Pitpnm3
|
UTSW |
11 |
71,947,017 (GRCm39) |
missense |
probably damaging |
0.97 |
R9450:Pitpnm3
|
UTSW |
11 |
71,952,412 (GRCm39) |
missense |
possibly damaging |
0.50 |
R9508:Pitpnm3
|
UTSW |
11 |
72,003,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R9606:Pitpnm3
|
UTSW |
11 |
71,955,069 (GRCm39) |
missense |
probably benign |
0.02 |
R9740:Pitpnm3
|
UTSW |
11 |
71,947,102 (GRCm39) |
missense |
probably benign |
0.34 |
X0018:Pitpnm3
|
UTSW |
11 |
71,962,266 (GRCm39) |
missense |
probably benign |
0.42 |
X0062:Pitpnm3
|
UTSW |
11 |
71,957,934 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1186:Pitpnm3
|
UTSW |
11 |
72,010,969 (GRCm39) |
missense |
probably benign |
|
Z1186:Pitpnm3
|
UTSW |
11 |
71,954,955 (GRCm39) |
missense |
probably benign |
|
Z1187:Pitpnm3
|
UTSW |
11 |
72,010,969 (GRCm39) |
missense |
probably benign |
|
Z1187:Pitpnm3
|
UTSW |
11 |
71,954,955 (GRCm39) |
missense |
probably benign |
|
Z1188:Pitpnm3
|
UTSW |
11 |
72,010,969 (GRCm39) |
missense |
probably benign |
|
Z1188:Pitpnm3
|
UTSW |
11 |
71,954,955 (GRCm39) |
missense |
probably benign |
|
Z1189:Pitpnm3
|
UTSW |
11 |
72,010,969 (GRCm39) |
missense |
probably benign |
|
Z1189:Pitpnm3
|
UTSW |
11 |
71,954,955 (GRCm39) |
missense |
probably benign |
|
Z1190:Pitpnm3
|
UTSW |
11 |
72,010,969 (GRCm39) |
missense |
probably benign |
|
Z1190:Pitpnm3
|
UTSW |
11 |
71,954,955 (GRCm39) |
missense |
probably benign |
|
Z1191:Pitpnm3
|
UTSW |
11 |
72,010,969 (GRCm39) |
missense |
probably benign |
|
Z1191:Pitpnm3
|
UTSW |
11 |
71,954,955 (GRCm39) |
missense |
probably benign |
|
Z1192:Pitpnm3
|
UTSW |
11 |
72,010,969 (GRCm39) |
missense |
probably benign |
|
Z1192:Pitpnm3
|
UTSW |
11 |
71,954,955 (GRCm39) |
missense |
probably benign |
|
|
Posted On |
2013-01-20 |