Mutagenetix > Incidental Mutations

Incidental Mutation 'R1465:Olfr156'

165402

Institutional Source

Beutler Lab

Gene Symbol

Olfr156

Ensembl Gene

ENSMUSG00000110970

Gene Name

olfactory receptor 156

Synonyms

GA_x6K02T2N78B-16125144-16126100, OR37B, Olfr37b, mOR37b, MOR262-6

MMRRC Submission

039519-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.197) question?

Stock #

R1465 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

43820132-43823895 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 43820723 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 213 (F213L)

Ref Sequence

ENSEMBL: ENSMUSP00000148995 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079234] [ENSMUST00000079465] [ENSMUST00000214843] [ENSMUST00000215406]

Predicted Effect

probably benign
Transcript: ENSMUST00000079234
AA Change: F213L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000078226
Gene: ENSMUSG00000110970
AA Change: F213L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	314	4.8e-58	PFAM
Pfam:7tm_1	41	296	2.9e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000079465
AA Change: F213L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000078431
Gene: ENSMUSG00000110970
AA Change: F213L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	314	1.2e-58	PFAM
Pfam:7tm_1	41	296	6.5e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214843
AA Change: F213L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000215406
AA Change: F213L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.2%
3x: 97.3%
10x: 87.6%
20x: 63.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 96 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310030G06Rik	A	G	9: 50,740,566	Y121H	probably damaging	Het
Abca13	G	T	11: 9,399,303	G3626W	probably damaging	Het
Acvr1c	A	G	2: 58,284,961	Y192H	probably damaging	Het
Afm	A	T	5: 90,550,341	D534V	probably damaging	Het
Agl	T	C	3: 116,771,372	E1076G	probably benign	Het
Angptl3	A	T	4: 99,037,520	H361L	probably benign	Het
Apob	T	C	12: 8,011,421	F3301S	possibly damaging	Het
Arhgef33	T	A	17: 80,367,301	C376S	possibly damaging	Het
Ass1	A	G	2: 31,520,416	*413W	probably null	Het
Atp6v1h	T	A	1: 5,095,688	L127Q	probably damaging	Het
Bcl2l1	G	A	2: 152,829,950	S14F	probably damaging	Het
Birc6	G	A	17: 74,623,858	A2477T	probably benign	Het
Bpifb9a	G	A	2: 154,271,021	A589T	possibly damaging	Het
Casp9	C	A	4: 141,805,840	T252K	probably benign	Het
Cct4	G	A	11: 23,002,922	D533N	probably damaging	Het
Clcn6	A	C	4: 148,013,901	I555S	probably damaging	Het
Col4a4	A	T	1: 82,497,822		probably null	Het
Cyp2d10	A	T	15: 82,403,928		probably null	Het
D930048N14Rik	A	G	11: 51,654,913		probably benign	Het
Dlg5	T	C	14: 24,154,696		probably null	Het
Dnah11	T	C	12: 118,038,695	E2240G	probably damaging	Het
Dnmt3a	A	G	12: 3,866,088	E17G	probably damaging	Het
Dock1	A	G	7: 134,782,409	T670A	probably benign	Het
Dpy19l2	A	G	9: 24,669,322	M241T	probably benign	Het
Dpy19l4	A	G	4: 11,296,034	S212P	probably damaging	Het
Ephb6	T	C	6: 41,616,106	F426S	probably damaging	Het
F5	A	T	1: 164,198,833	D1658V	probably benign	Het
Faah	A	T	4: 115,999,558	V469E	probably damaging	Het
Fas	T	C	19: 34,316,613	C123R	probably damaging	Het
Fhod1	T	C	8: 105,338,914		probably benign	Het
Filip1	A	G	9: 79,898,307	V55A	probably benign	Het
Frmpd1	G	A	4: 45,273,197	R372Q	probably damaging	Het
Glyctk	C	T	9: 106,157,607	G87S	probably damaging	Het
Gm4737	T	C	16: 46,153,848	K389E	probably benign	Het
Gm5096	T	G	18: 87,757,258	F302V	probably damaging	Het
Golga3	T	C	5: 110,209,878	L1080P	probably damaging	Het
Gpr137	T	C	19: 6,938,444	T281A	probably benign	Het
Grap2	T	A	15: 80,648,411		probably null	Het
Hlcs	T	C	16: 94,268,292	D170G	probably damaging	Het
Hook1	A	G	4: 96,013,256	T484A	probably benign	Het
Hoxa5	T	A	6: 52,203,791	H187L	probably benign	Het
Inpp1	G	T	1: 52,790,094	S255R	probably benign	Het
Inpp4b	T	A	8: 81,768,157	V67E	probably damaging	Het
Iqgap3	A	G	3: 88,087,309	N105S	probably damaging	Het
Kcnq5	A	G	1: 21,469,468		probably null	Het
Klhl1	T	C	14: 96,240,213	N473S	probably benign	Het
Klk1b24	C	A	7: 44,191,361	T71N	probably benign	Het
Loxhd1	A	G	18: 77,380,573		probably null	Het
Lrp1b	C	T	2: 41,111,059	R2165Q	probably benign	Het
Lrp2bp	A	T	8: 46,025,235	Q328L	possibly damaging	Het
Lrrc63	T	A	14: 75,107,389	K419N	possibly damaging	Het
Lrrc9	A	G	12: 72,500,759	N150S	probably benign	Het
Lrrn4	C	A	2: 132,872,075	C317F	probably damaging	Het
Ltbp2	T	C	12: 84,813,300	S627G	probably damaging	Het
Macf1	A	T	4: 123,493,154	S1224T	probably damaging	Het
Meis2	A	C	2: 116,058,670	H200Q	probably benign	Het
Mesd	C	A	7: 83,895,582	A80E	probably benign	Het
Mroh2a	G	C	1: 88,257,802	E1510D	probably damaging	Het
Myo3a	T	C	2: 22,577,927	F398L	probably benign	Het
Nanp	A	G	2: 151,030,829	C60R	probably benign	Het
Nectin2	T	G	7: 19,730,116	M313L	probably benign	Het
Nek4	C	T	14: 30,956,887	H123Y	probably damaging	Het
Nploc4	A	G	11: 120,408,781	V371A	probably damaging	Het
Olfr1463	T	A	19: 13,234,901	V217E	possibly damaging	Het
Olfr658	T	C	7: 104,644,946	N140S	probably benign	Het
Olfr740	A	G	14: 50,453,177	T42A	possibly damaging	Het
Pcdh20	T	A	14: 88,469,237	Q209L	probably benign	Het
Pcdhb20	G	A	18: 37,504,697	R92H	probably damaging	Het
Pgap1	T	C	1: 54,528,555	H377R	probably benign	Het
Phyhipl	G	T	10: 70,570,968	P52Q	probably damaging	Het
Pwwp2a	T	A	11: 43,705,556	V516E	possibly damaging	Het
Rack1	T	C	11: 48,801,759	V69A	probably damaging	Het
Rexo5	T	A	7: 119,801,358		probably null	Het
Rock1	G	T	18: 10,072,863	Q1161K	possibly damaging	Het
Rps6ka2	T	C	17: 7,292,867	L568P	probably damaging	Het
Seh1l	T	C	18: 67,783,984	S78P	probably damaging	Het
Serpinb3b	A	T	1: 107,155,843		probably null	Het
Setd1a	T	C	7: 127,788,340		probably benign	Het
Setx	G	T	2: 29,140,389		probably null	Het
Sfi1	TCGC	TC	11: 3,146,254		probably null	Het
Shc2	G	T	10: 79,631,302	R146S	probably damaging	Het
Skap2	T	C	6: 51,909,368	T5A	probably benign	Het
Slc35a3	T	C	3: 116,687,334	I93M	probably benign	Het
Sohlh1	C	T	2: 25,843,347	G295D	probably damaging	Het
Sult2a8	A	C	7: 14,416,283	C168G	probably benign	Het
Tbc1d4	T	C	14: 101,447,688	I1176V	possibly damaging	Het
Thada	A	T	17: 84,436,676	F735I	possibly damaging	Het
Tle1	A	C	4: 72,139,831	H52Q	probably damaging	Het
Tmem101	A	T	11: 102,153,329	V244E	probably damaging	Het
Tnfrsf26	C	A	7: 143,617,931	C95F	probably damaging	Het
Uspl1	T	C	5: 149,214,032	S482P	probably benign	Het
Vmn2r118	G	T	17: 55,610,935	N192K	probably benign	Het
Vmn2r14	C	T	5: 109,220,329	V266I	possibly damaging	Het
Vmn2r51	A	G	7: 10,100,322	I263T	probably damaging	Het
Zfp937	T	A	2: 150,239,047	C332*	probably null	Het
Zscan21	T	A	5: 138,125,208	S50T	probably benign	Het

Other mutations in Olfr156

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02508:Olfr156	APN	4	43821289	missense	possibly damaging	0.83
IGL02690:Olfr156	APN	4	43821190	missense	possibly damaging	0.50
R1454:Olfr156	UTSW	4	43820639	missense	probably damaging	1.00
R1465:Olfr156	UTSW	4	43820723	missense	probably benign	0.00
R1859:Olfr156	UTSW	4	43820779	missense	possibly damaging	0.91
R2146:Olfr156	UTSW	4	43821178	missense	probably damaging	1.00
R3160:Olfr156	UTSW	4	43820544	missense	probably benign	0.04
R3162:Olfr156	UTSW	4	43820544	missense	probably benign	0.04
R3162:Olfr156	UTSW	4	43820544	missense	probably benign	0.04
R3414:Olfr156	UTSW	4	43821258	missense	probably benign	0.00
R3936:Olfr156	UTSW	4	43821359	start codon destroyed	probably benign	0.01
R4497:Olfr156	UTSW	4	43821175	missense	probably damaging	1.00
R4631:Olfr156	UTSW	4	43820563	missense	probably benign	0.08
R5125:Olfr156	UTSW	4	43820480	missense	probably benign	0.15
R5371:Olfr156	UTSW	4	43821058	missense	probably damaging	1.00
R5698:Olfr156	UTSW	4	43821183	missense	probably damaging	1.00
R5807:Olfr156	UTSW	4	43820912	missense	probably benign	0.00
R5889:Olfr156	UTSW	4	43820492	missense	possibly damaging	0.89
R6461:Olfr156	UTSW	4	43821355	missense	probably benign
R6865:Olfr156	UTSW	4	43821346	missense	probably benign	0.00
R7566:Olfr156	UTSW	4	43820711	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCATTTCTGACCTACCAGGTTCC -3'
(R):5'- TGAACAAGTCTGCCTATGTGCCC -3'

Sequencing Primer
(F):5'- GAGCTTGTCTGAAACATCCTG -3'
(R):5'- GGCGGTGCTAACTCCTTG -3'

Posted On

2014-03-28