Incidental Mutation 'R1488:Olfr645'
ID165503
Institutional Source Beutler Lab
Gene Symbol Olfr645
Ensembl Gene ENSMUSG00000051340
Gene Nameolfactory receptor 645
SynonymsGA_x6K02T2PBJ9-6819097-6818150, MOR13-5
MMRRC Submission 039540-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.067) question?
Stock #R1488 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location104081789-104085465 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 104084652 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 143 (I143V)
Ref Sequence ENSEMBL: ENSMUSP00000062821 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057104] [ENSMUST00000138055]
Predicted Effect probably benign
Transcript: ENSMUST00000057104
AA Change: I143V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000062821
Gene: ENSMUSG00000051340
AA Change: I143V

DomainStartEndE-ValueType
Pfam:7tm_4 33 313 5.4e-113 PFAM
Pfam:7TM_GPCR_Srsx 37 256 8e-8 PFAM
Pfam:7tm_1 43 295 5.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Meta Mutation Damage Score 0.1925 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.3%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600015I10Rik A G 6: 48,933,447 N691S possibly damaging Het
Arhgap23 A G 11: 97,500,859 S1401G possibly damaging Het
Art2b A C 7: 101,580,207 F162V probably damaging Het
Atg4c T A 4: 99,221,242 W149R probably damaging Het
Atxn1l A G 8: 109,733,417 I71T probably benign Het
Axdnd1 T A 1: 156,348,960 L748F probably damaging Het
Bdh2 A G 3: 135,296,841 Y157C probably damaging Het
C2cd4a G T 9: 67,831,708 R18S probably benign Het
Catsperb A G 12: 101,594,267 H839R probably damaging Het
Ccdc24 C A 4: 117,870,568 S134I possibly damaging Het
Cd55 G T 1: 130,448,378 T70K probably damaging Het
Cdh10 A T 15: 19,013,263 I650F probably damaging Het
Clca2 T A 3: 145,084,164 K470N possibly damaging Het
Csn2 G A 5: 87,694,896 Q91* probably null Het
Ctsh G A 9: 90,071,891 D218N possibly damaging Het
Cyb5r4 C G 9: 87,029,538 Y88* probably null Het
Dgkq A G 5: 108,650,877 F601S probably damaging Het
Eci2 A G 13: 34,977,933 V352A probably benign Het
Krt28 T C 11: 99,365,171 T421A probably benign Het
Lamp5 T C 2: 136,069,091 V248A probably benign Het
Lin9 T A 1: 180,688,285 L483Q possibly damaging Het
Lrp1b C A 2: 41,502,024 M509I probably benign Het
Lrrfip1 T C 1: 91,114,632 V253A probably damaging Het
Mpdz C A 4: 81,348,708 E981* probably null Het
Mpo A C 11: 87,797,430 N305T probably damaging Het
Olfr1385 A G 11: 49,495,118 E195G probably benign Het
Olfr507 A T 7: 108,622,489 I226F probably damaging Het
Papss2 T C 19: 32,637,090 S69P probably benign Het
Pcdhb22 A G 18: 37,519,888 T470A possibly damaging Het
Plce1 A G 19: 38,716,803 D884G possibly damaging Het
Prex2 T A 1: 11,193,528 I1239K probably benign Het
Prkd2 T A 7: 16,858,439 F625I probably damaging Het
Rab20 A T 8: 11,454,268 V144E probably benign Het
Rnf213 A G 11: 119,480,889 N4840S probably benign Het
Scaf8 T G 17: 3,197,597 M1065R probably damaging Het
Slco3a1 A G 7: 74,346,701 L319P possibly damaging Het
Slit1 A G 19: 41,608,385 C1092R probably damaging Het
Tlr4 A G 4: 66,839,549 D193G probably damaging Het
Tmem145 T A 7: 25,307,435 probably null Het
Tmem184a T A 5: 139,807,640 K235N probably benign Het
Tnpo1 A T 13: 98,856,907 D590E probably damaging Het
Trio C A 15: 27,740,967 G2724V probably damaging Het
Ttc6 A T 12: 57,649,515 Y34F possibly damaging Het
Tuba4a T C 1: 75,216,401 T190A probably benign Het
Tubgcp4 T G 2: 121,176,550 V136G possibly damaging Het
Ugcg C T 4: 59,207,798 P46S probably benign Het
Vmn1r74 T C 7: 11,847,583 I270T probably benign Het
Vmn2r103 A T 17: 19,793,660 E238V probably damaging Het
Vmn2r60 T A 7: 42,136,713 F313L probably benign Het
Zfp710 T C 7: 80,082,004 Y310H probably damaging Het
Other mutations in Olfr645
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1303:Olfr645 UTSW 7 104084741 missense probably damaging 1.00
R1556:Olfr645 UTSW 7 104084261 missense probably benign
R2158:Olfr645 UTSW 7 104084826 missense probably benign
R2987:Olfr645 UTSW 7 104084870 missense probably benign 0.01
R4437:Olfr645 UTSW 7 104084921 missense possibly damaging 0.88
R4773:Olfr645 UTSW 7 104084295 missense probably damaging 1.00
R5285:Olfr645 UTSW 7 104084133 makesense probably null
R5396:Olfr645 UTSW 7 104084891 missense probably benign 0.08
R5516:Olfr645 UTSW 7 104084237 missense possibly damaging 0.53
R5761:Olfr645 UTSW 7 104084169 missense probably benign 0.01
R5793:Olfr645 UTSW 7 104085030 missense probably benign 0.10
R5960:Olfr645 UTSW 7 104084353 missense probably damaging 1.00
R6242:Olfr645 UTSW 7 104084564 missense possibly damaging 0.82
R6676:Olfr645 UTSW 7 104084454 missense probably benign 0.02
R6975:Olfr645 UTSW 7 104084795 missense probably benign
Predicted Primers PCR Primer
(F):5'- GCAACACGATGGACAACCCATAGTG -3'
(R):5'- GATCAATGCCTCTCAGGTTCCCAG -3'

Sequencing Primer
(F):5'- TGGCTATTGAGGGAAACATCAG -3'
(R):5'- TCTTACAGGCTTTCCAGGAATG -3'
Posted On2014-03-28