Incidental Mutation 'R1493:Zfp692'
ID 165570
Institutional Source Beutler Lab
Gene Symbol Zfp692
Ensembl Gene ENSMUSG00000037243
Gene Name zinc finger protein 692
Synonyms Zfp692-ps
MMRRC Submission 039544-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1493 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 58197895-58205453 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58204866 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 409 (I409F)
Ref Sequence ENSEMBL: ENSMUSP00000131896 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049353] [ENSMUST00000057836] [ENSMUST00000064786] [ENSMUST00000108829] [ENSMUST00000153510] [ENSMUST00000155662] [ENSMUST00000186859]
AlphaFold Q3U381
Predicted Effect probably damaging
Transcript: ENSMUST00000049353
AA Change: I409F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000131896
Gene: ENSMUSG00000037243
AA Change: I409F

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000057836
SMART Domains Protein: ENSMUSP00000060088
Gene: ENSMUSG00000049755

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000064786
SMART Domains Protein: ENSMUSP00000070567
Gene: ENSMUSG00000049755

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108829
SMART Domains Protein: ENSMUSP00000104457
Gene: ENSMUSG00000049755

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
ZnF_C2H2 43 65 8.75e0 SMART
ZnF_C2H2 71 93 1.18e-2 SMART
ZnF_C2H2 100 123 1.76e-1 SMART
ZnF_C2H2 129 151 1.59e1 SMART
ZnF_C2H2 167 189 4.47e-3 SMART
ZnF_C2H2 202 224 9.58e-3 SMART
ZnF_C2H2 230 252 7.37e-4 SMART
ZnF_C2H2 258 280 3.16e-3 SMART
ZnF_C2H2 286 308 1.45e-2 SMART
ZnF_C2H2 314 336 4.01e-5 SMART
ZnF_C2H2 342 364 5.5e-3 SMART
ZnF_C2H2 370 392 1.12e-3 SMART
ZnF_C2H2 398 420 6.67e-2 SMART
low complexity region 421 441 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000153510
AA Change: I409F

PolyPhen 2 Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000126674
Gene: ENSMUSG00000037243
AA Change: I409F

DomainStartEndE-ValueType
low complexity region 10 23 N/A INTRINSIC
low complexity region 94 110 N/A INTRINSIC
low complexity region 159 175 N/A INTRINSIC
low complexity region 193 204 N/A INTRINSIC
low complexity region 215 232 N/A INTRINSIC
ZnF_C2H2 327 352 4.11e-2 SMART
ZnF_C2H2 358 382 2.05e-2 SMART
ZnF_C2H2 388 410 1.69e-3 SMART
ZnF_C2H2 416 438 1.69e-3 SMART
ZnF_C2H2 447 470 6.23e-2 SMART
low complexity region 502 520 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000155662
SMART Domains Protein: ENSMUSP00000114561
Gene: ENSMUSG00000049755

DomainStartEndE-ValueType
ZnF_C2H2 15 37 4.17e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186859
SMART Domains Protein: ENSMUSP00000140236
Gene: ENSMUSG00000049755

DomainStartEndE-ValueType
ZnF_C2H2 15 37 1.8e-5 SMART
ZnF_C2H2 43 65 3.6e-2 SMART
ZnF_C2H2 71 90 6.1e-1 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.2%
  • 20x: 92.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik T C 11: 58,767,544 (GRCm39) S14P probably damaging Het
Abca15 A T 7: 119,981,513 (GRCm39) D989V probably benign Het
Abcg8 T C 17: 85,004,107 (GRCm39) S472P probably damaging Het
Ablim2 T C 5: 35,966,605 (GRCm39) F178S probably damaging Het
Adprm A G 11: 66,932,702 (GRCm39) V69A possibly damaging Het
Ankrd27 C T 7: 35,307,790 (GRCm39) S343L probably benign Het
Arfgef3 A G 10: 18,506,627 (GRCm39) S833P probably damaging Het
Arhgap42 T G 9: 9,030,798 (GRCm39) E339D probably benign Het
Axdnd1 T A 1: 156,174,271 (GRCm39) M799L probably benign Het
Cars2 A T 8: 11,567,817 (GRCm39) probably null Het
Cd7 T C 11: 120,928,967 (GRCm39) T95A probably damaging Het
Cep290 A T 10: 100,398,043 (GRCm39) T2200S probably benign Het
Cep44 A G 8: 56,985,870 (GRCm39) S299P probably damaging Het
Cfap58 C T 19: 47,976,943 (GRCm39) H731Y probably damaging Het
Ehbp1 T A 11: 21,956,866 (GRCm39) E1204V probably damaging Het
Fgd5 A G 6: 91,964,612 (GRCm39) K124E probably benign Het
Folh1 T C 7: 86,410,938 (GRCm39) D268G probably damaging Het
Gm4559 A T 7: 141,828,050 (GRCm39) C17* probably null Het
Helz A G 11: 107,504,751 (GRCm39) I413V probably benign Het
Hexd A G 11: 121,112,093 (GRCm39) I438V probably benign Het
Hrh1 G A 6: 114,457,838 (GRCm39) G373D probably damaging Het
Hs3st5 G A 10: 36,708,870 (GRCm39) G135D probably damaging Het
Iqcf6 T C 9: 106,504,641 (GRCm39) Y102H probably benign Het
Kmt2a A T 9: 44,758,202 (GRCm39) S1124R probably damaging Het
Map3k5 A G 10: 19,904,859 (GRCm39) D387G probably damaging Het
Morc2a A G 11: 3,628,557 (GRCm39) N337D probably benign Het
Musk C T 4: 58,354,003 (GRCm39) A352V probably benign Het
Myef2l A G 3: 10,153,944 (GRCm39) K238E probably damaging Het
Nans G A 4: 46,500,761 (GRCm39) E218K probably damaging Het
Niban1 T A 1: 151,581,841 (GRCm39) V479D probably damaging Het
Ninl T G 2: 150,822,015 (GRCm39) D29A probably damaging Het
Nod1 A G 6: 54,921,041 (GRCm39) F426L probably damaging Het
Notch4 T A 17: 34,786,656 (GRCm39) C265* probably null Het
Nsd3 A G 8: 26,203,407 (GRCm39) D1307G probably benign Het
Or51h1 T C 7: 102,308,220 (GRCm39) L64P probably damaging Het
Or52e18 T A 7: 104,609,709 (GRCm39) T77S probably damaging Het
Orai3 G A 7: 127,373,077 (GRCm39) V193M possibly damaging Het
Prkag1 T C 15: 98,711,551 (GRCm39) Y271C probably benign Het
Rfc4 T C 16: 22,936,758 (GRCm39) I116V probably damaging Het
Ric1 T C 19: 29,557,249 (GRCm39) Y445H probably benign Het
Rnmt G A 18: 68,446,778 (GRCm39) D268N probably damaging Het
Rsph1 C T 17: 31,484,873 (GRCm39) G139D probably damaging Het
Sez6l2 C A 7: 126,560,984 (GRCm39) P483Q probably damaging Het
Sgo2b A G 8: 64,379,889 (GRCm39) L981P probably damaging Het
Shmt2 A G 10: 127,354,812 (GRCm39) probably null Het
Sorbs3 T C 14: 70,430,076 (GRCm39) T353A possibly damaging Het
Stk25 T C 1: 93,553,322 (GRCm39) T260A probably benign Het
Tasor A G 14: 27,171,926 (GRCm39) S425G probably damaging Het
Thap12 A G 7: 98,364,645 (GRCm39) H271R probably benign Het
Tmprss13 A G 9: 45,247,405 (GRCm39) T256A probably benign Het
Tpo A T 12: 30,181,808 (GRCm39) I29N possibly damaging Het
Trpc2 A T 7: 101,739,783 (GRCm39) N569I probably damaging Het
Unc13c T C 9: 73,546,350 (GRCm39) T1607A probably benign Het
Vldlr A G 19: 27,218,691 (GRCm39) N514S probably benign Het
Vps18 A G 2: 119,127,613 (GRCm39) Y812C probably damaging Het
Zfp735 G A 11: 73,601,305 (GRCm39) C83Y possibly damaging Het
Zic1 A G 9: 91,246,809 (GRCm39) S88P probably damaging Het
Other mutations in Zfp692
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00978:Zfp692 APN 11 58,200,824 (GRCm39) missense possibly damaging 0.92
IGL00978:Zfp692 APN 11 58,204,855 (GRCm39) missense possibly damaging 0.94
IGL01667:Zfp692 APN 11 58,202,379 (GRCm39) missense probably damaging 1.00
IGL02209:Zfp692 APN 11 58,204,824 (GRCm39) nonsense probably null
IGL02873:Zfp692 APN 11 58,199,765 (GRCm39) missense probably damaging 1.00
R0255:Zfp692 UTSW 11 58,201,229 (GRCm39) splice site probably benign
R0267:Zfp692 UTSW 11 58,205,140 (GRCm39) missense possibly damaging 0.64
R0506:Zfp692 UTSW 11 58,199,881 (GRCm39) nonsense probably null
R0554:Zfp692 UTSW 11 58,205,053 (GRCm39) missense probably damaging 1.00
R0628:Zfp692 UTSW 11 58,200,449 (GRCm39) missense probably damaging 1.00
R0712:Zfp692 UTSW 11 58,205,140 (GRCm39) missense probably benign 0.00
R1112:Zfp692 UTSW 11 58,202,388 (GRCm39) missense probably damaging 1.00
R1768:Zfp692 UTSW 11 58,201,002 (GRCm39) splice site probably benign
R1853:Zfp692 UTSW 11 58,200,805 (GRCm39) missense possibly damaging 0.69
R3551:Zfp692 UTSW 11 58,200,254 (GRCm39) missense possibly damaging 0.52
R3552:Zfp692 UTSW 11 58,200,254 (GRCm39) missense possibly damaging 0.52
R4281:Zfp692 UTSW 11 58,205,091 (GRCm39) missense probably damaging 1.00
R4784:Zfp692 UTSW 11 58,200,997 (GRCm39) missense probably null 0.12
R5150:Zfp692 UTSW 11 58,198,413 (GRCm39) start codon destroyed probably null 0.77
R7035:Zfp692 UTSW 11 58,200,268 (GRCm39) critical splice donor site probably null
R7343:Zfp692 UTSW 11 58,202,331 (GRCm39) missense probably damaging 1.00
R7896:Zfp692 UTSW 11 58,205,062 (GRCm39) missense probably damaging 1.00
R8071:Zfp692 UTSW 11 58,198,560 (GRCm39) missense probably damaging 0.96
R8163:Zfp692 UTSW 11 58,201,199 (GRCm39) splice site probably null
R9043:Zfp692 UTSW 11 58,198,550 (GRCm39) missense probably damaging 0.98
R9487:Zfp692 UTSW 11 58,199,765 (GRCm39) missense probably damaging 1.00
R9777:Zfp692 UTSW 11 58,199,638 (GRCm39) missense probably benign 0.14
Z1186:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1186:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1187:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1187:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1188:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1188:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1189:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1189:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1190:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1190:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1191:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1191:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Z1192:Zfp692 UTSW 11 58,200,844 (GRCm39) missense probably benign
Z1192:Zfp692 UTSW 11 58,199,859 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGTACTGACACCACCTGTTGGGAG -3'
(R):5'- GCAGAAATGCTGGGACTAGACACC -3'

Sequencing Primer
(F):5'- AGTGGTGGGCTAAAACCTG -3'
(R):5'- AGTGAGCTACCACACTGTCTG -3'
Posted On 2014-03-28