Incidental Mutation 'R1493:Zfp735'
ID 165573
Institutional Source Beutler Lab
Gene Symbol Zfp735
Ensembl Gene ENSMUSG00000060630
Gene Name zinc finger protein 735
Synonyms 1700012C15Rik
MMRRC Submission 039544-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1493 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73579604-73604624 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 73601305 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 83 (C83Y)
Ref Sequence ENSEMBL: ENSMUSP00000079269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080407]
AlphaFold B1ARH2
Predicted Effect possibly damaging
Transcript: ENSMUST00000080407
AA Change: C83Y

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: C83Y

DomainStartEndE-ValueType
KRAB 8 68 2.2e-34 SMART
ZnF_C2H2 483 505 4.38e1 SMART
ZnF_C2H2 511 533 2.67e-1 SMART
ZnF_C2H2 539 561 1.81e1 SMART
ZnF_C2H2 567 589 1.5e-4 SMART
ZnF_C2H2 595 617 4.87e-4 SMART
ZnF_C2H2 623 645 4.24e-4 SMART
ZnF_C2H2 651 673 2.27e-4 SMART
ZnF_C2H2 679 701 7.49e-5 SMART
ZnF_C2H2 707 729 4.87e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145996
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149560
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.2%
  • 20x: 92.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810021J22Rik T C 11: 58,767,544 (GRCm39) S14P probably damaging Het
Abca15 A T 7: 119,981,513 (GRCm39) D989V probably benign Het
Abcg8 T C 17: 85,004,107 (GRCm39) S472P probably damaging Het
Ablim2 T C 5: 35,966,605 (GRCm39) F178S probably damaging Het
Adprm A G 11: 66,932,702 (GRCm39) V69A possibly damaging Het
Ankrd27 C T 7: 35,307,790 (GRCm39) S343L probably benign Het
Arfgef3 A G 10: 18,506,627 (GRCm39) S833P probably damaging Het
Arhgap42 T G 9: 9,030,798 (GRCm39) E339D probably benign Het
Axdnd1 T A 1: 156,174,271 (GRCm39) M799L probably benign Het
Cars2 A T 8: 11,567,817 (GRCm39) probably null Het
Cd7 T C 11: 120,928,967 (GRCm39) T95A probably damaging Het
Cep290 A T 10: 100,398,043 (GRCm39) T2200S probably benign Het
Cep44 A G 8: 56,985,870 (GRCm39) S299P probably damaging Het
Cfap58 C T 19: 47,976,943 (GRCm39) H731Y probably damaging Het
Ehbp1 T A 11: 21,956,866 (GRCm39) E1204V probably damaging Het
Fgd5 A G 6: 91,964,612 (GRCm39) K124E probably benign Het
Folh1 T C 7: 86,410,938 (GRCm39) D268G probably damaging Het
Gm4559 A T 7: 141,828,050 (GRCm39) C17* probably null Het
Helz A G 11: 107,504,751 (GRCm39) I413V probably benign Het
Hexd A G 11: 121,112,093 (GRCm39) I438V probably benign Het
Hrh1 G A 6: 114,457,838 (GRCm39) G373D probably damaging Het
Hs3st5 G A 10: 36,708,870 (GRCm39) G135D probably damaging Het
Iqcf6 T C 9: 106,504,641 (GRCm39) Y102H probably benign Het
Kmt2a A T 9: 44,758,202 (GRCm39) S1124R probably damaging Het
Map3k5 A G 10: 19,904,859 (GRCm39) D387G probably damaging Het
Morc2a A G 11: 3,628,557 (GRCm39) N337D probably benign Het
Musk C T 4: 58,354,003 (GRCm39) A352V probably benign Het
Myef2l A G 3: 10,153,944 (GRCm39) K238E probably damaging Het
Nans G A 4: 46,500,761 (GRCm39) E218K probably damaging Het
Niban1 T A 1: 151,581,841 (GRCm39) V479D probably damaging Het
Ninl T G 2: 150,822,015 (GRCm39) D29A probably damaging Het
Nod1 A G 6: 54,921,041 (GRCm39) F426L probably damaging Het
Notch4 T A 17: 34,786,656 (GRCm39) C265* probably null Het
Nsd3 A G 8: 26,203,407 (GRCm39) D1307G probably benign Het
Or51h1 T C 7: 102,308,220 (GRCm39) L64P probably damaging Het
Or52e18 T A 7: 104,609,709 (GRCm39) T77S probably damaging Het
Orai3 G A 7: 127,373,077 (GRCm39) V193M possibly damaging Het
Prkag1 T C 15: 98,711,551 (GRCm39) Y271C probably benign Het
Rfc4 T C 16: 22,936,758 (GRCm39) I116V probably damaging Het
Ric1 T C 19: 29,557,249 (GRCm39) Y445H probably benign Het
Rnmt G A 18: 68,446,778 (GRCm39) D268N probably damaging Het
Rsph1 C T 17: 31,484,873 (GRCm39) G139D probably damaging Het
Sez6l2 C A 7: 126,560,984 (GRCm39) P483Q probably damaging Het
Sgo2b A G 8: 64,379,889 (GRCm39) L981P probably damaging Het
Shmt2 A G 10: 127,354,812 (GRCm39) probably null Het
Sorbs3 T C 14: 70,430,076 (GRCm39) T353A possibly damaging Het
Stk25 T C 1: 93,553,322 (GRCm39) T260A probably benign Het
Tasor A G 14: 27,171,926 (GRCm39) S425G probably damaging Het
Thap12 A G 7: 98,364,645 (GRCm39) H271R probably benign Het
Tmprss13 A G 9: 45,247,405 (GRCm39) T256A probably benign Het
Tpo A T 12: 30,181,808 (GRCm39) I29N possibly damaging Het
Trpc2 A T 7: 101,739,783 (GRCm39) N569I probably damaging Het
Unc13c T C 9: 73,546,350 (GRCm39) T1607A probably benign Het
Vldlr A G 19: 27,218,691 (GRCm39) N514S probably benign Het
Vps18 A G 2: 119,127,613 (GRCm39) Y812C probably damaging Het
Zfp692 A T 11: 58,204,866 (GRCm39) I409F probably damaging Het
Zic1 A G 9: 91,246,809 (GRCm39) S88P probably damaging Het
Other mutations in Zfp735
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Zfp735 APN 11 73,602,192 (GRCm39) missense possibly damaging 0.86
IGL00798:Zfp735 APN 11 73,602,386 (GRCm39) missense possibly damaging 0.72
IGL01642:Zfp735 APN 11 73,601,305 (GRCm39) missense possibly damaging 0.73
IGL01684:Zfp735 APN 11 73,581,191 (GRCm39) missense possibly damaging 0.86
IGL02096:Zfp735 APN 11 73,602,254 (GRCm39) missense probably benign 0.01
IGL02238:Zfp735 APN 11 73,601,319 (GRCm39) missense probably benign 0.00
IGL02505:Zfp735 APN 11 73,580,626 (GRCm39) missense probably benign 0.03
IGL02740:Zfp735 APN 11 73,601,412 (GRCm39) missense possibly damaging 0.53
IGL02957:Zfp735 APN 11 73,601,755 (GRCm39) missense probably benign 0.00
bananaquit UTSW 11 73,601,412 (GRCm39) nonsense probably null
bescher UTSW 11 73,602,979 (GRCm39) missense possibly damaging 0.93
Galvanic UTSW 11 73,602,504 (GRCm39) nonsense probably null
grassquit UTSW 11 73,603,029 (GRCm39) missense possibly damaging 0.66
R0114:Zfp735 UTSW 11 73,601,488 (GRCm39) missense probably benign 0.33
R0217:Zfp735 UTSW 11 73,602,112 (GRCm39) missense possibly damaging 0.73
R0943:Zfp735 UTSW 11 73,602,909 (GRCm39) missense probably benign 0.04
R1421:Zfp735 UTSW 11 73,601,523 (GRCm39) missense probably benign
R1460:Zfp735 UTSW 11 73,603,159 (GRCm39) missense possibly damaging 0.73
R1517:Zfp735 UTSW 11 73,601,470 (GRCm39) missense probably benign
R1676:Zfp735 UTSW 11 73,602,301 (GRCm39) missense possibly damaging 0.53
R1709:Zfp735 UTSW 11 73,602,589 (GRCm39) missense probably benign 0.01
R1871:Zfp735 UTSW 11 73,601,412 (GRCm39) nonsense probably null
R1931:Zfp735 UTSW 11 73,602,677 (GRCm39) missense possibly damaging 0.69
R2219:Zfp735 UTSW 11 73,601,851 (GRCm39) missense possibly damaging 0.53
R2227:Zfp735 UTSW 11 73,602,223 (GRCm39) nonsense probably null
R2227:Zfp735 UTSW 11 73,602,222 (GRCm39) missense possibly damaging 0.53
R3552:Zfp735 UTSW 11 73,602,067 (GRCm39) nonsense probably null
R3856:Zfp735 UTSW 11 73,602,282 (GRCm39) missense probably benign 0.01
R3925:Zfp735 UTSW 11 73,601,950 (GRCm39) missense probably benign 0.33
R4572:Zfp735 UTSW 11 73,580,611 (GRCm39) missense probably benign 0.02
R4585:Zfp735 UTSW 11 73,580,550 (GRCm39) missense possibly damaging 0.51
R4586:Zfp735 UTSW 11 73,580,550 (GRCm39) missense possibly damaging 0.51
R4619:Zfp735 UTSW 11 73,602,031 (GRCm39) missense probably damaging 0.98
R4687:Zfp735 UTSW 11 73,602,682 (GRCm39) missense probably damaging 0.98
R4687:Zfp735 UTSW 11 73,602,681 (GRCm39) missense probably damaging 0.98
R5435:Zfp735 UTSW 11 73,602,939 (GRCm39) missense possibly damaging 0.72
R5489:Zfp735 UTSW 11 73,601,419 (GRCm39) nonsense probably null
R5516:Zfp735 UTSW 11 73,601,640 (GRCm39) missense probably benign
R5654:Zfp735 UTSW 11 73,602,964 (GRCm39) missense possibly damaging 0.71
R5990:Zfp735 UTSW 11 73,581,174 (GRCm39) missense possibly damaging 0.70
R6332:Zfp735 UTSW 11 73,602,504 (GRCm39) nonsense probably null
R6427:Zfp735 UTSW 11 73,581,140 (GRCm39) missense possibly damaging 0.73
R6460:Zfp735 UTSW 11 73,602,478 (GRCm39) missense probably benign 0.33
R6820:Zfp735 UTSW 11 73,579,783 (GRCm39) start codon destroyed probably null 0.01
R6831:Zfp735 UTSW 11 73,601,434 (GRCm39) missense probably damaging 1.00
R6833:Zfp735 UTSW 11 73,601,434 (GRCm39) missense probably damaging 1.00
R6834:Zfp735 UTSW 11 73,601,434 (GRCm39) missense probably damaging 1.00
R6897:Zfp735 UTSW 11 73,601,880 (GRCm39) missense probably benign 0.08
R6941:Zfp735 UTSW 11 73,581,159 (GRCm39) missense probably benign 0.33
R7335:Zfp735 UTSW 11 73,602,379 (GRCm39) missense possibly damaging 0.47
R7366:Zfp735 UTSW 11 73,602,979 (GRCm39) missense possibly damaging 0.93
R7474:Zfp735 UTSW 11 73,602,002 (GRCm39) missense possibly damaging 0.72
R7487:Zfp735 UTSW 11 73,581,154 (GRCm39) missense possibly damaging 0.53
R7583:Zfp735 UTSW 11 73,601,933 (GRCm39) missense possibly damaging 0.86
R7866:Zfp735 UTSW 11 73,601,629 (GRCm39) missense probably benign 0.00
R8005:Zfp735 UTSW 11 73,603,140 (GRCm39) nonsense probably null
R8500:Zfp735 UTSW 11 73,601,811 (GRCm39) missense possibly damaging 0.53
R8551:Zfp735 UTSW 11 73,603,122 (GRCm39) missense probably benign 0.06
R8754:Zfp735 UTSW 11 73,603,000 (GRCm39) missense possibly damaging 0.85
R8769:Zfp735 UTSW 11 73,581,127 (GRCm39) missense possibly damaging 0.53
R8794:Zfp735 UTSW 11 73,603,029 (GRCm39) missense possibly damaging 0.66
R8835:Zfp735 UTSW 11 73,601,692 (GRCm39) missense possibly damaging 0.53
R8869:Zfp735 UTSW 11 73,602,510 (GRCm39) missense possibly damaging 0.53
R8969:Zfp735 UTSW 11 73,602,699 (GRCm39) missense possibly damaging 0.83
R9072:Zfp735 UTSW 11 73,603,060 (GRCm39) missense probably benign 0.21
R9073:Zfp735 UTSW 11 73,603,060 (GRCm39) missense probably benign 0.21
R9193:Zfp735 UTSW 11 73,580,600 (GRCm39) missense possibly damaging 0.71
R9355:Zfp735 UTSW 11 73,602,362 (GRCm39) missense probably benign 0.01
R9414:Zfp735 UTSW 11 73,602,023 (GRCm39) nonsense probably null
R9456:Zfp735 UTSW 11 73,602,403 (GRCm39) missense possibly damaging 0.53
R9573:Zfp735 UTSW 11 73,602,936 (GRCm39) missense possibly damaging 0.67
R9647:Zfp735 UTSW 11 73,580,600 (GRCm39) missense probably damaging 0.98
R9710:Zfp735 UTSW 11 73,601,806 (GRCm39) missense possibly damaging 0.86
Z1176:Zfp735 UTSW 11 73,601,641 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TCTTGGAACAAAGTGATGCACTTCTGT -3'
(R):5'- CCCACAACTGCTTCCCATGTGA -3'

Sequencing Primer
(F):5'- TCCTTGGATTAGTGCTAGTTGAT -3'
(R):5'- CAGAGAAGTGTGTTTATTCACCC -3'
Posted On 2014-03-28