Mutagenetix > Incidental Mutations

Incidental Mutation 'R1483:Olfr1431'

165741

Institutional Source

Beutler Lab

Gene Symbol

Olfr1431

Ensembl Gene

ENSMUSG00000094133

Gene Name

olfactory receptor 1431

Synonyms

GA_x6K02T2RE5P-2573738-2574676, MOR214-5

MMRRC Submission

039536-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

R1483 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

12200634-12212191 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 12209750 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 61 (Y61*)

Ref Sequence

ENSEMBL: ENSMUSP00000150967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072316] [ENSMUST00000213759]

Predicted Effect

probably null
Transcript: ENSMUST00000072316
AA Change: Y61*

SMART Domains

Protein: ENSMUSP00000072158
Gene: ENSMUSG00000094133
AA Change: Y61*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	8.4e-56	PFAM
Pfam:7tm_1	42	309	2.4e-18	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000213759
AA Change: Y61*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214138

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.8%
20x: 91.0%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700014D04Rik	A	T	13: 59,742,903	S368T	probably damaging	Het
9930021J03Rik	G	A	19: 29,719,345	P916L	possibly damaging	Het
Adam12	T	A	7: 133,930,025	T494S	probably benign	Het
Akap6	C	T	12: 52,796,087	P73S	probably damaging	Het
Amotl2	A	T	9: 102,730,897	T763S	probably benign	Het
C87499	T	A	4: 88,628,834	Q116L	probably damaging	Het
Cdc5l	A	T	17: 45,408,364	V541D	possibly damaging	Het
Chl1	A	G	6: 103,647,287	Y52C	probably damaging	Het
D6Wsu163e	A	G	6: 126,954,770	E255G	probably benign	Het
Ddhd2	A	G	8: 25,753,128	S126P	probably benign	Het
Dner	CGCTGCTGCTGCTGCTGCTGCTGCTGC	CGCTGCTGCTGCTGCTGCTGCTGC	1: 84,585,549		probably benign	Het
Drc3	A	G	11: 60,388,889	I427V	probably benign	Het
Drg2	T	C	11: 60,459,527	I104T	probably damaging	Het
Dst	C	T	1: 34,252,998	A932V	probably damaging	Het
Ecm1	G	A	3: 95,735,963	R342C	probably damaging	Het
Eif3a	A	T	19: 60,768,726	D880E	unknown	Het
Elf1	T	A	14: 79,580,638	D569E	probably benign	Het
Esp6	T	A	17: 40,562,925	M1K	probably null	Het
Fer1l6	T	C	15: 58,637,970	V1427A	possibly damaging	Het
Gm17689	G	A	9: 36,581,324	S95L	probably benign	Het
Gsta1	A	T	9: 78,242,493	K196M	probably damaging	Het
Gzme	T	A	14: 56,118,712	I110F	probably damaging	Het
H2-DMa	T	A	17: 34,135,750	V27E	possibly damaging	Het
H2-T10	A	T	17: 36,121,146	S2T	probably benign	Het
Hadhb	A	G	5: 30,169,494		probably null	Het
Hoxa11	G	T	6: 52,243,456	D282E	probably damaging	Het
Ifit1bl1	A	G	19: 34,594,641	Y139H	possibly damaging	Het
Ift27	A	G	15: 78,165,236	V88A	possibly damaging	Het
Knop1	C	T	7: 118,853,050	A149T	probably damaging	Het
Macf1	T	A	4: 123,510,977	K597I	probably damaging	Het
Med16	A	T	10: 79,903,100	I284N	possibly damaging	Het
Melk	T	A	4: 44,308,937	I98K	probably damaging	Het
Mst1	G	T	9: 108,081,650	G127V	probably benign	Het
Nacad	A	G	11: 6,602,217	S325P	probably damaging	Het
Nbea	G	A	3: 56,002,790	P1328L	probably benign	Het
Nek5	C	T	8: 22,096,790	S335N	probably benign	Het
Nif3l1	C	A	1: 58,447,726	R24S	probably benign	Het
Nlrp14	T	G	7: 107,190,122	N39K	possibly damaging	Het
Nup50	T	A	15: 84,939,727	V427D	probably damaging	Het
Nwd1	C	T	8: 72,657,086	P78L	probably damaging	Het
Pnkd	A	G	1: 74,349,391	Y242C	probably benign	Het
Ppm1g	T	C	5: 31,203,121	D423G	probably benign	Het
Prkci	A	T	3: 31,043,792	N464Y	probably damaging	Het
Ptprf	C	T	4: 118,235,964	V494M	possibly damaging	Het
Rapgef4	T	G	2: 72,055,026		probably null	Het
Rbak	T	C	5: 143,174,344	E318G	probably damaging	Het
Rora	A	G	9: 69,364,385	D215G	probably benign	Het
Rp1l1	C	T	14: 64,029,047	T694I	possibly damaging	Het
Scrib	A	G	15: 76,057,922	L1032P	probably damaging	Het
Sectm1b	G	A	11: 121,055,826	T81M	probably benign	Het
Sgk3	T	C	1: 9,872,293	F97L	possibly damaging	Het
Socs3	A	T	11: 117,967,568	Y221*	probably null	Het
Tdrd6	T	A	17: 43,627,607	H850L	probably benign	Het
Tex44	G	T	1: 86,427,186	Q272H	probably damaging	Het
Tgfbr2	A	C	9: 116,109,557	S426A	probably benign	Het
Tmem39b	T	C	4: 129,676,663	Y461C	probably damaging	Het
Ttn	T	A	2: 76,724,993	D30556V	probably damaging	Het
Tubgcp5	T	A	7: 55,825,707		probably null	Het
Vmn2r70	T	C	7: 85,559,167	I701V	probably benign	Het
Vps39	A	T	2: 120,323,648	L622Q	probably damaging	Het
Wdfy4	T	A	14: 33,100,966	H1347L	probably benign	Het
Xpo1	A	G	11: 23,284,863	I540V	probably benign	Het
Xylt2	A	C	11: 94,669,567	M294R	probably benign	Het
Zfp788	T	G	7: 41,649,075	Y326*	probably null	Het
Zim1	A	G	7: 6,682,125	F109L	probably benign	Het

Other mutations in Olfr1431

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01330:Olfr1431	APN	19	12210040	missense	possibly damaging	0.65
IGL02206:Olfr1431	APN	19	12210460	missense	probably damaging	1.00
IGL02938:Olfr1431	APN	19	12209682	missense	probably benign	0.00
PIT4812001:Olfr1431	UTSW	19	12210253	missense	probably damaging	1.00
R0402:Olfr1431	UTSW	19	12209589	missense	probably damaging	1.00
R0661:Olfr1431	UTSW	19	12209704	missense	probably damaging	1.00
R1193:Olfr1431	UTSW	19	12210439	missense	probably damaging	1.00
R4091:Olfr1431	UTSW	19	12209779	missense	probably damaging	1.00
R4280:Olfr1431	UTSW	19	12209938	missense	probably damaging	1.00
R5028:Olfr1431	UTSW	19	12210154	missense	possibly damaging	0.94
R5540:Olfr1431	UTSW	19	12210460	missense	probably damaging	1.00
R6042:Olfr1431	UTSW	19	12209922	missense	probably damaging	0.99
R6045:Olfr1431	UTSW	19	12210295	missense	probably damaging	1.00
R7104:Olfr1431	UTSW	19	12209878	missense	possibly damaging	0.82
Z1088:Olfr1431	UTSW	19	12210490	missense	possibly damaging	0.55

Predicted Primers

PCR Primer
(F):5'- TTGGCATCAAGGAACTACCTGCTTC -3'
(R):5'- GGCAACATTCAGTCAGCCCCATAG -3'

Sequencing Primer
(F):5'- TGTCACTAGAGTCAGCAATGC -3'
(R):5'- CAGTCAGCCCCATAGTGGAAAG -3'

Posted On

2014-03-28