Incidental Mutation 'R1466:Corin'
| ID |
166033 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin |
| Synonyms |
Lrp4 |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.253)
|
| Stock # |
R1466 (G1)
|
| Quality Score |
173 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
72300025-72504473 bp(-) (GRCm38) |
| Type of Mutation |
critical splice donor site (1 bp from exon) |
| DNA Base Change (assembly) |
C to T
at 72302790 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000094710]
[ENSMUST00000126664]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000005352
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094710
|
| SMART Domains |
Protein: ENSMUSP00000142749
Gene: ENSMUSG00000046808
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1eula_
|
5 |
180 |
9e-15 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126664
|
| SMART Domains |
Protein: ENSMUSP00000143594
Gene: ENSMUSG00000046808
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:PhoLip_ATPase_N
|
111 |
176 |
1.2e-21 |
PFAM |
|
Pfam:E1-E2_ATPase
|
181 |
450 |
3e-10 |
PFAM |
|
low complexity region
|
523 |
534 |
N/A |
INTRINSIC |
|
low complexity region
|
684 |
696 |
N/A |
INTRINSIC |
|
Pfam:Cation_ATPase
|
739 |
859 |
3.4e-7 |
PFAM |
|
Pfam:HAD
|
754 |
1114 |
1.3e-12 |
PFAM |
|
Pfam:PhoLip_ATPase_C
|
1131 |
1376 |
4.3e-77 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136350
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146393
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158570
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000167460
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175766
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176974
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177290
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Meta Mutation Damage Score |
0.9470 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 97.9%
- 10x: 90.8%
- 20x: 71.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd15 |
C |
T |
11: 77,515,410 (GRCm38) |
A71V |
probably damaging |
Het |
| Adamts12 |
T |
C |
15: 11,311,359 (GRCm38) |
F1234S |
probably benign |
Het |
| Ahnak |
A |
G |
19: 9,015,875 (GRCm38) |
D4841G |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,729,049 (GRCm38) |
S2095P |
possibly damaging |
Het |
| Ampd2 |
T |
C |
3: 108,080,337 (GRCm38) |
|
probably null |
Het |
| Arhgef17 |
G |
T |
7: 100,929,659 (GRCm38) |
P694Q |
possibly damaging |
Het |
| Arrdc1 |
T |
C |
2: 24,925,795 (GRCm38) |
I398V |
probably benign |
Het |
| Ash1l |
T |
C |
3: 89,052,065 (GRCm38) |
Y2250H |
probably damaging |
Het |
| Aspg |
A |
G |
12: 112,121,852 (GRCm38) |
N385D |
probably benign |
Het |
| Atxn3 |
G |
A |
12: 101,926,499 (GRCm38) |
R319C |
possibly damaging |
Het |
| BC005561 |
T |
A |
5: 104,518,257 (GRCm38) |
I215N |
probably damaging |
Het |
| Brca2 |
G |
A |
5: 150,552,258 (GRCm38) |
A2478T |
probably damaging |
Het |
| C1s1 |
C |
T |
6: 124,531,131 (GRCm38) |
C633Y |
probably damaging |
Het |
| C8g |
C |
T |
2: 25,500,216 (GRCm38) |
A6T |
probably benign |
Het |
| Cbl |
A |
T |
9: 44,154,244 (GRCm38) |
V706E |
probably benign |
Het |
| Cfhr1 |
C |
T |
1: 139,557,574 (GRCm38) |
E45K |
probably benign |
Het |
| Chd7 |
G |
A |
4: 8,840,561 (GRCm38) |
|
probably null |
Het |
| Chek1 |
G |
T |
9: 36,725,857 (GRCm38) |
A2E |
probably damaging |
Het |
| Cntnap1 |
C |
A |
11: 101,180,360 (GRCm38) |
F366L |
probably damaging |
Het |
| Crb2 |
T |
C |
2: 37,783,388 (GRCm38) |
Y99H |
probably damaging |
Het |
| Ctdspl2 |
G |
A |
2: 122,003,929 (GRCm38) |
R332K |
probably benign |
Het |
| Cym |
G |
A |
3: 107,213,458 (GRCm38) |
T277I |
probably damaging |
Het |
| Cyp2d11 |
C |
T |
15: 82,391,735 (GRCm38) |
C215Y |
probably benign |
Het |
| Dido1 |
G |
A |
2: 180,662,328 (GRCm38) |
P1261L |
probably damaging |
Het |
| Dnah10 |
T |
A |
5: 124,763,096 (GRCm38) |
Y1265N |
probably benign |
Het |
| Dtx3l |
G |
A |
16: 35,932,728 (GRCm38) |
L503F |
probably damaging |
Het |
| Efhb |
A |
G |
17: 53,437,178 (GRCm38) |
F462L |
probably damaging |
Het |
| Enpep |
T |
A |
3: 129,319,448 (GRCm38) |
T203S |
probably damaging |
Het |
| Fat3 |
A |
C |
9: 16,375,482 (GRCm38) |
V915G |
probably damaging |
Het |
| Fbln7 |
A |
G |
2: 128,877,429 (GRCm38) |
T49A |
probably benign |
Het |
| Fcho1 |
C |
T |
8: 71,712,560 (GRCm38) |
A418T |
probably benign |
Het |
| Fgf14 |
T |
A |
14: 124,676,539 (GRCm38) |
K60M |
probably benign |
Het |
| Galnt4 |
A |
G |
10: 99,108,709 (GRCm38) |
R99G |
probably benign |
Het |
| Gimap4 |
C |
A |
6: 48,691,282 (GRCm38) |
Q196K |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,537,964 (GRCm38) |
T6I |
probably damaging |
Het |
| Gm10110 |
A |
T |
14: 89,898,075 (GRCm38) |
|
noncoding transcript |
Het |
| Gm4884 |
A |
G |
7: 41,043,128 (GRCm38) |
K174E |
probably damaging |
Het |
| Gm6583 |
C |
T |
5: 112,354,764 (GRCm38) |
G358D |
probably benign |
Het |
| Grip2 |
A |
T |
6: 91,788,443 (GRCm38) |
D19E |
probably damaging |
Het |
| Grk4 |
T |
C |
5: 34,694,750 (GRCm38) |
S113P |
probably benign |
Het |
| Hectd3 |
G |
A |
4: 116,996,566 (GRCm38) |
E220K |
probably damaging |
Het |
| Helz2 |
G |
A |
2: 181,236,297 (GRCm38) |
P903S |
probably damaging |
Het |
| Hydin |
T |
A |
8: 110,532,953 (GRCm38) |
V2519E |
possibly damaging |
Het |
| Ints11 |
G |
A |
4: 155,888,110 (GRCm38) |
|
probably null |
Het |
| Kif1a |
A |
G |
1: 93,054,929 (GRCm38) |
W718R |
possibly damaging |
Het |
| Kif1b |
A |
T |
4: 149,223,252 (GRCm38) |
Y839N |
probably damaging |
Het |
| Kif20b |
T |
A |
19: 34,950,599 (GRCm38) |
V1047D |
probably benign |
Het |
| Klhl23 |
T |
C |
2: 69,833,888 (GRCm38) |
I527T |
probably damaging |
Het |
| Klra10 |
T |
A |
6: 130,279,315 (GRCm38) |
R125S |
probably damaging |
Het |
| Klra10 |
T |
C |
6: 130,279,431 (GRCm38) |
N87D |
probably damaging |
Het |
| Lars |
G |
A |
18: 42,210,050 (GRCm38) |
R1101C |
probably damaging |
Het |
| Lcn4 |
G |
A |
2: 26,668,576 (GRCm38) |
P166L |
probably damaging |
Het |
| Letmd1 |
T |
A |
15: 100,472,542 (GRCm38) |
|
probably null |
Het |
| Map4k2 |
G |
T |
19: 6,341,917 (GRCm38) |
W87L |
probably damaging |
Het |
| Mccc1 |
A |
G |
3: 35,974,286 (GRCm38) |
V457A |
probably benign |
Het |
| Mdn1 |
T |
A |
4: 32,730,788 (GRCm38) |
S2886T |
probably benign |
Het |
| Mroh2b |
G |
T |
15: 4,925,684 (GRCm38) |
D720Y |
probably damaging |
Het |
| Mrpl24 |
T |
A |
3: 87,921,928 (GRCm38) |
Y21* |
probably null |
Het |
| Mrps35 |
C |
T |
6: 147,055,984 (GRCm38) |
T169M |
probably damaging |
Het |
| Mtcl1 |
T |
A |
17: 66,380,435 (GRCm38) |
D492V |
probably damaging |
Het |
| Muc2 |
A |
G |
7: 141,748,974 (GRCm38) |
Y457C |
probably damaging |
Het |
| Muc4 |
G |
A |
16: 32,753,595 (GRCm38) |
G1157D |
probably benign |
Het |
| Myg1 |
T |
A |
15: 102,337,390 (GRCm38) |
L275Q |
probably damaging |
Het |
| Naga |
T |
A |
15: 82,334,788 (GRCm38) |
M237L |
probably null |
Het |
| Oc90 |
T |
A |
15: 65,897,720 (GRCm38) |
Y96F |
probably damaging |
Het |
| Olfr1029 |
T |
A |
2: 85,975,995 (GRCm38) |
F251I |
probably damaging |
Het |
| Olfr103 |
A |
T |
17: 37,336,956 (GRCm38) |
L92H |
probably benign |
Het |
| Olfr1253 |
C |
T |
2: 89,752,267 (GRCm38) |
C187Y |
probably damaging |
Het |
| Olfr46 |
A |
G |
7: 140,610,969 (GRCm38) |
I268V |
probably benign |
Het |
| Olfr522 |
A |
G |
7: 140,162,203 (GRCm38) |
V249A |
probably damaging |
Het |
| Orc4 |
A |
T |
2: 48,909,494 (GRCm38) |
C324S |
possibly damaging |
Het |
| Pcdh10 |
T |
G |
3: 45,379,974 (GRCm38) |
L241R |
probably damaging |
Het |
| Pdzrn4 |
T |
C |
15: 92,770,537 (GRCm38) |
S857P |
probably benign |
Het |
| Plec |
C |
T |
15: 76,185,908 (GRCm38) |
E1000K |
possibly damaging |
Het |
| Plvap |
A |
T |
8: 71,508,481 (GRCm38) |
V149D |
probably benign |
Het |
| Ppef1 |
C |
A |
X: 160,625,674 (GRCm38) |
|
probably null |
Het |
| Prkaa1 |
C |
A |
15: 5,178,798 (GRCm38) |
P507T |
probably benign |
Het |
| Ptch1 |
A |
G |
13: 63,524,969 (GRCm38) |
Y804H |
probably benign |
Het |
| R3hdm2 |
A |
G |
10: 127,476,690 (GRCm38) |
I434V |
probably benign |
Het |
| Rfx5 |
T |
A |
3: 94,956,303 (GRCm38) |
Y88N |
probably damaging |
Het |
| Rnase2b |
A |
T |
14: 51,162,839 (GRCm38) |
K126* |
probably null |
Het |
| Rpl3l |
A |
G |
17: 24,730,871 (GRCm38) |
I15V |
probably benign |
Het |
| Saal1 |
G |
T |
7: 46,702,545 (GRCm38) |
|
probably null |
Het |
| Sbpl |
A |
C |
17: 23,953,254 (GRCm38) |
D230E |
unknown |
Het |
| Scn10a |
T |
C |
9: 119,666,490 (GRCm38) |
Y322C |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,431,157 (GRCm38) |
Y1308N |
probably damaging |
Het |
| Sis |
A |
T |
3: 72,932,060 (GRCm38) |
D824E |
possibly damaging |
Het |
| Slc25a36 |
A |
G |
9: 97,080,355 (GRCm38) |
F194L |
probably damaging |
Het |
| Slc27a4 |
T |
A |
2: 29,811,190 (GRCm38) |
V331E |
probably damaging |
Het |
| Slc7a11 |
G |
T |
3: 50,381,073 (GRCm38) |
|
probably null |
Het |
| Slco4c1 |
A |
T |
1: 96,841,172 (GRCm38) |
S322T |
probably damaging |
Het |
| Smarcc2 |
A |
T |
10: 128,474,245 (GRCm38) |
T376S |
probably damaging |
Het |
| Srebf1 |
C |
T |
11: 60,200,702 (GRCm38) |
R999H |
probably benign |
Het |
| St3gal3 |
A |
C |
4: 118,107,662 (GRCm38) |
M1R |
probably null |
Het |
| Syp |
A |
T |
X: 7,648,705 (GRCm38) |
|
probably benign |
Het |
| Tas1r2 |
A |
G |
4: 139,669,411 (GRCm38) |
D687G |
probably damaging |
Het |
| Tekt4 |
A |
T |
17: 25,472,074 (GRCm38) |
Q118L |
probably benign |
Het |
| Tph2 |
T |
C |
10: 115,079,695 (GRCm38) |
N480S |
probably benign |
Het |
| Tsc2 |
A |
T |
17: 24,608,973 (GRCm38) |
M839K |
probably damaging |
Het |
| Ttc22 |
T |
C |
4: 106,622,780 (GRCm38) |
F77S |
probably damaging |
Het |
| Uaca |
C |
T |
9: 60,854,321 (GRCm38) |
A205V |
possibly damaging |
Het |
| Uhmk1 |
A |
T |
1: 170,208,653 (GRCm38) |
|
probably null |
Het |
| Usp17lc |
A |
G |
7: 103,418,941 (GRCm38) |
H481R |
possibly damaging |
Het |
| Vwa3a |
A |
G |
7: 120,768,165 (GRCm38) |
Y181C |
probably damaging |
Het |
| Wfikkn2 |
G |
A |
11: 94,238,895 (GRCm38) |
T140I |
probably damaging |
Het |
| Zfp704 |
G |
T |
3: 9,447,348 (GRCm38) |
T288N |
possibly damaging |
Het |
| Zfp93 |
T |
C |
7: 24,276,096 (GRCm38) |
V502A |
probably damaging |
Het |
| Zzef1 |
C |
T |
11: 72,924,679 (GRCm38) |
P2942S |
probably damaging |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,304,888 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,305,011 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,338,991 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,454,487 (GRCm38) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,339,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,339,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,353,939 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,372,146 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,332,673 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,353,930 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,360,689 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,302,858 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,301,586 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,332,781 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,342,961 (GRCm38) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,503,952 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,454,473 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,332,795 (GRCm38) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,301,650 (GRCm38) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,304,933 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,302,790 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,330,895 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,302,790 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,503,952 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,358,403 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,316,051 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,504,079 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,332,711 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,339,038 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,304,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,330,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,330,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,435,298 (GRCm38) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,422,165 (GRCm38) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,372,130 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,339,879 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,358,424 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,503,883 (GRCm38) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,343,108 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,339,057 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,329,699 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,329,699 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,302,835 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,372,182 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,353,851 (GRCm38) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,339,059 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,304,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,343,019 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,316,098 (GRCm38) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,356,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,435,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,305,033 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,304,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,304,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,358,484 (GRCm38) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,316,106 (GRCm38) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,305,014 (GRCm38) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,422,154 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,435,395 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,316,389 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,360,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,372,096 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,339,045 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,301,527 (GRCm38) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,305,055 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,435,247 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,301,624 (GRCm38) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,301,500 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,422,187 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,316,103 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,358,463 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,305,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,356,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,304,931 (GRCm38) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,435,407 (GRCm38) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,435,352 (GRCm38) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,329,610 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,339,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,435,254 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,454,493 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTTATACATGGCAATGCCCTCTG -3'
(R):5'- CTTTGAACGCAGTGCCCTTTAAGC -3'
Sequencing Primer
(F):5'- CTGCTTAAGACAGTGGATTTGAAG -3'
(R):5'- GATCTGTGCTGGCTATGAGT -3'
|
| Posted On |
2014-03-28 |
Incidental Mutation