Incidental Mutation 'R1466:Myg1'
ID 166094
Institutional Source Beutler Lab
Gene Symbol Myg1
Ensembl Gene ENSMUSG00000001285
Gene Name melanocyte proliferating gene 1
Synonyms Gamm1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.193) question?
Stock # R1466 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 102331709-102338139 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 102337390 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 275 (L275Q)
Ref Sequence ENSEMBL: ENSMUSP00000109312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001331] [ENSMUST00000041208] [ENSMUST00000113682] [ENSMUST00000228959] [ENSMUST00000229900] [ENSMUST00000231061] [ENSMUST00000230481]
AlphaFold Q9JK81
Predicted Effect probably damaging
Transcript: ENSMUST00000001331
AA Change: L221Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000001331
Gene: ENSMUSG00000001285
AA Change: L221Q

DomainStartEndE-ValueType
Pfam:UPF0160 41 161 4.8e-54 PFAM
Pfam:UPF0160 158 312 1.3e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000041208
SMART Domains Protein: ENSMUSP00000044604
Gene: ENSMUSG00000036678

DomainStartEndE-ValueType
WD40 136 179 3.7e0 SMART
WD40 181 221 4.75e1 SMART
WD40 232 273 1.17e-5 SMART
WD40 278 315 2.66e0 SMART
Blast:WD40 319 357 2e-15 BLAST
low complexity region 534 545 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000113682
AA Change: L275Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000109312
Gene: ENSMUSG00000001285
AA Change: L275Q

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:UPF0160 45 365 1.5e-143 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164019
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164961
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168547
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170078
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170281
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170713
Predicted Effect unknown
Transcript: ENSMUST00000171244
AA Change: L229Q
SMART Domains Protein: ENSMUSP00000129494
Gene: ENSMUSG00000001285
AA Change: L229Q

DomainStartEndE-ValueType
Pfam:UPF0160 41 209 1.7e-76 PFAM
Pfam:UPF0160 204 306 3.3e-43 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171733
Predicted Effect probably benign
Transcript: ENSMUST00000228959
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229315
Predicted Effect probably benign
Transcript: ENSMUST00000230406
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230812
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231099
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229589
Predicted Effect probably benign
Transcript: ENSMUST00000229900
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230710
Predicted Effect probably benign
Transcript: ENSMUST00000231061
Predicted Effect probably benign
Transcript: ENSMUST00000230481
Predicted Effect probably benign
Transcript: ENSMUST00000230239
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 97.9%
  • 10x: 90.8%
  • 20x: 71.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display no gross abnormalities but altered sex-dependent anxiety-like behaviors in different tests. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 108 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd15 C T 11: 77,515,410 (GRCm38) A71V probably damaging Het
Adamts12 T C 15: 11,311,359 (GRCm38) F1234S probably benign Het
Ahnak A G 19: 9,015,875 (GRCm38) D4841G probably damaging Het
Akap13 T C 7: 75,729,049 (GRCm38) S2095P possibly damaging Het
Ampd2 T C 3: 108,080,337 (GRCm38) probably null Het
Arhgef17 G T 7: 100,929,659 (GRCm38) P694Q possibly damaging Het
Arrdc1 T C 2: 24,925,795 (GRCm38) I398V probably benign Het
Ash1l T C 3: 89,052,065 (GRCm38) Y2250H probably damaging Het
Aspg A G 12: 112,121,852 (GRCm38) N385D probably benign Het
Atxn3 G A 12: 101,926,499 (GRCm38) R319C possibly damaging Het
Brca2 G A 5: 150,552,258 (GRCm38) A2478T probably damaging Het
C1s1 C T 6: 124,531,131 (GRCm38) C633Y probably damaging Het
C8g C T 2: 25,500,216 (GRCm38) A6T probably benign Het
Cbl A T 9: 44,154,244 (GRCm38) V706E probably benign Het
Ccdc121rt3 C T 5: 112,354,764 (GRCm38) G358D probably benign Het
Cfhr1 C T 1: 139,557,574 (GRCm38) E45K probably benign Het
Chd7 G A 4: 8,840,561 (GRCm38) probably null Het
Chek1 G T 9: 36,725,857 (GRCm38) A2E probably damaging Het
Cntnap1 C A 11: 101,180,360 (GRCm38) F366L probably damaging Het
Corin C T 5: 72,302,790 (GRCm38) probably null Het
Crb2 T C 2: 37,783,388 (GRCm38) Y99H probably damaging Het
Ctdspl2 G A 2: 122,003,929 (GRCm38) R332K probably benign Het
Cym G A 3: 107,213,458 (GRCm38) T277I probably damaging Het
Cyp2d11 C T 15: 82,391,735 (GRCm38) C215Y probably benign Het
Dido1 G A 2: 180,662,328 (GRCm38) P1261L probably damaging Het
Dnah10 T A 5: 124,763,096 (GRCm38) Y1265N probably benign Het
Dtx3l G A 16: 35,932,728 (GRCm38) L503F probably damaging Het
Efhb A G 17: 53,437,178 (GRCm38) F462L probably damaging Het
Enpep T A 3: 129,319,448 (GRCm38) T203S probably damaging Het
Fat3 A C 9: 16,375,482 (GRCm38) V915G probably damaging Het
Fbln7 A G 2: 128,877,429 (GRCm38) T49A probably benign Het
Fcho1 C T 8: 71,712,560 (GRCm38) A418T probably benign Het
Fgf14 T A 14: 124,676,539 (GRCm38) K60M probably benign Het
Galnt4 A G 10: 99,108,709 (GRCm38) R99G probably benign Het
Gimap4 C A 6: 48,691,282 (GRCm38) Q196K probably benign Het
Glcci1 C T 6: 8,537,964 (GRCm38) T6I probably damaging Het
Gm10110 A T 14: 89,898,075 (GRCm38) noncoding transcript Het
Gm4884 A G 7: 41,043,128 (GRCm38) K174E probably damaging Het
Grip2 A T 6: 91,788,443 (GRCm38) D19E probably damaging Het
Grk4 T C 5: 34,694,750 (GRCm38) S113P probably benign Het
Hectd3 G A 4: 116,996,566 (GRCm38) E220K probably damaging Het
Helz2 G A 2: 181,236,297 (GRCm38) P903S probably damaging Het
Hydin T A 8: 110,532,953 (GRCm38) V2519E possibly damaging Het
Ints11 G A 4: 155,888,110 (GRCm38) probably null Het
Kif1a A G 1: 93,054,929 (GRCm38) W718R possibly damaging Het
Kif1b A T 4: 149,223,252 (GRCm38) Y839N probably damaging Het
Kif20b T A 19: 34,950,599 (GRCm38) V1047D probably benign Het
Klhl23 T C 2: 69,833,888 (GRCm38) I527T probably damaging Het
Klra10 T A 6: 130,279,315 (GRCm38) R125S probably damaging Het
Klra10 T C 6: 130,279,431 (GRCm38) N87D probably damaging Het
Lars1 G A 18: 42,210,050 (GRCm38) R1101C probably damaging Het
Lcn4 G A 2: 26,668,576 (GRCm38) P166L probably damaging Het
Letmd1 T A 15: 100,472,542 (GRCm38) probably null Het
Map4k2 G T 19: 6,341,917 (GRCm38) W87L probably damaging Het
Mccc1 A G 3: 35,974,286 (GRCm38) V457A probably benign Het
Mdn1 T A 4: 32,730,788 (GRCm38) S2886T probably benign Het
Mroh2b G T 15: 4,925,684 (GRCm38) D720Y probably damaging Het
Mrpl24 T A 3: 87,921,928 (GRCm38) Y21* probably null Het
Mrps35 C T 6: 147,055,984 (GRCm38) T169M probably damaging Het
Mtcl1 T A 17: 66,380,435 (GRCm38) D492V probably damaging Het
Muc2 A G 7: 141,748,974 (GRCm38) Y457C probably damaging Het
Muc4 G A 16: 32,753,595 (GRCm38) G1157D probably benign Het
Naga T A 15: 82,334,788 (GRCm38) M237L probably null Het
Oc90 T A 15: 65,897,720 (GRCm38) Y96F probably damaging Het
Or12d13 A T 17: 37,336,956 (GRCm38) L92H probably benign Het
Or13a18 A G 7: 140,610,969 (GRCm38) I268V probably benign Het
Or4a80 C T 2: 89,752,267 (GRCm38) C187Y probably damaging Het
Or5m11b T A 2: 85,975,995 (GRCm38) F251I probably damaging Het
Or6ae1 A G 7: 140,162,203 (GRCm38) V249A probably damaging Het
Orc4 A T 2: 48,909,494 (GRCm38) C324S possibly damaging Het
Pcdh10 T G 3: 45,379,974 (GRCm38) L241R probably damaging Het
Pdzrn4 T C 15: 92,770,537 (GRCm38) S857P probably benign Het
Plec C T 15: 76,185,908 (GRCm38) E1000K possibly damaging Het
Plvap A T 8: 71,508,481 (GRCm38) V149D probably benign Het
Ppef1 C A X: 160,625,674 (GRCm38) probably null Het
Prkaa1 C A 15: 5,178,798 (GRCm38) P507T probably benign Het
Ptch1 A G 13: 63,524,969 (GRCm38) Y804H probably benign Het
R3hdm2 A G 10: 127,476,690 (GRCm38) I434V probably benign Het
Rfx5 T A 3: 94,956,303 (GRCm38) Y88N probably damaging Het
Rnase2b A T 14: 51,162,839 (GRCm38) K126* probably null Het
Rpl3l A G 17: 24,730,871 (GRCm38) I15V probably benign Het
Saal1 G T 7: 46,702,545 (GRCm38) probably null Het
Sbpl A C 17: 23,953,254 (GRCm38) D230E unknown Het
Scn10a T C 9: 119,666,490 (GRCm38) Y322C probably damaging Het
Sec16a A T 2: 26,431,157 (GRCm38) Y1308N probably damaging Het
Sis A T 3: 72,932,060 (GRCm38) D824E possibly damaging Het
Slc25a36 A G 9: 97,080,355 (GRCm38) F194L probably damaging Het
Slc27a4 T A 2: 29,811,190 (GRCm38) V331E probably damaging Het
Slc7a11 G T 3: 50,381,073 (GRCm38) probably null Het
Slco4c1 A T 1: 96,841,172 (GRCm38) S322T probably damaging Het
Smarcc2 A T 10: 128,474,245 (GRCm38) T376S probably damaging Het
Srebf1 C T 11: 60,200,702 (GRCm38) R999H probably benign Het
St3gal3 A C 4: 118,107,662 (GRCm38) M1R probably null Het
Syp A T X: 7,648,705 (GRCm38) probably benign Het
Tas1r2 A G 4: 139,669,411 (GRCm38) D687G probably damaging Het
Tekt4 A T 17: 25,472,074 (GRCm38) Q118L probably benign Het
Thoc2l T A 5: 104,518,257 (GRCm38) I215N probably damaging Het
Tph2 T C 10: 115,079,695 (GRCm38) N480S probably benign Het
Tsc2 A T 17: 24,608,973 (GRCm38) M839K probably damaging Het
Ttc22 T C 4: 106,622,780 (GRCm38) F77S probably damaging Het
Uaca C T 9: 60,854,321 (GRCm38) A205V possibly damaging Het
Uhmk1 A T 1: 170,208,653 (GRCm38) probably null Het
Usp17lc A G 7: 103,418,941 (GRCm38) H481R possibly damaging Het
Vwa3a A G 7: 120,768,165 (GRCm38) Y181C probably damaging Het
Wfikkn2 G A 11: 94,238,895 (GRCm38) T140I probably damaging Het
Zfp704 G T 3: 9,447,348 (GRCm38) T288N possibly damaging Het
Zfp93 T C 7: 24,276,096 (GRCm38) V502A probably damaging Het
Zzef1 C T 11: 72,924,679 (GRCm38) P2942S probably damaging Het
Other mutations in Myg1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01369:Myg1 APN 15 102,334,338 (GRCm38) missense probably benign 0.00
IGL02188:Myg1 APN 15 102,337,441 (GRCm38) missense probably benign 0.08
IGL02373:Myg1 APN 15 102,336,833 (GRCm38) missense probably damaging 0.99
IGL02885:Myg1 APN 15 102,332,159 (GRCm38) missense probably damaging 1.00
IGL03066:Myg1 APN 15 102,334,366 (GRCm38) unclassified probably benign
R0583:Myg1 UTSW 15 102,337,790 (GRCm38) nonsense probably null
R0631:Myg1 UTSW 15 102,331,849 (GRCm38) missense probably benign 0.00
R0835:Myg1 UTSW 15 102,332,102 (GRCm38) missense probably damaging 1.00
R1016:Myg1 UTSW 15 102,334,351 (GRCm38) missense possibly damaging 0.50
R1466:Myg1 UTSW 15 102,337,390 (GRCm38) missense probably damaging 1.00
R1757:Myg1 UTSW 15 102,331,829 (GRCm38) missense probably benign
R2400:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R2428:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R2429:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R2431:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R2997:Myg1 UTSW 15 102,337,510 (GRCm38) missense probably null 1.00
R3683:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R3826:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R3827:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R3829:Myg1 UTSW 15 102,337,736 (GRCm38) missense probably damaging 1.00
R4923:Myg1 UTSW 15 102,331,853 (GRCm38) missense probably benign
R5363:Myg1 UTSW 15 102,337,824 (GRCm38) missense probably benign 0.00
R5419:Myg1 UTSW 15 102,336,962 (GRCm38) missense probably damaging 0.99
R9389:Myg1 UTSW 15 102,336,937 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGGCCCAGAGATTCAAGGTAGAC -3'
(R):5'- ACCAATGAAGCCACTGGCATGGAC -3'

Sequencing Primer
(F):5'- TAGACCTGGGAGGTGGC -3'
(R):5'- GGCAAGGGTAGCCTACAC -3'
Posted On 2014-03-28