Incidental Mutation 'V5622:Zfp180'
ID 166128
Institutional Source Beutler Lab
Gene Symbol Zfp180
Ensembl Gene ENSMUSG00000057101
Gene Name zinc finger protein 180
Synonyms HHZ168, D130011P11, 2310040I01Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.582) question?
Stock # V5622 () of strain 521
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23781349-23807138 bp(+) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) A to G at 23781456 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146219 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068975] [ENSMUST00000203854] [ENSMUST00000206184] [ENSMUST00000207002]
AlphaFold Q6NZI9
Predicted Effect probably benign
Transcript: ENSMUST00000068975
SMART Domains Protein: ENSMUSP00000064611
Gene: ENSMUSG00000057101

DomainStartEndE-ValueType
Blast:KRAB 46 103 7e-14 BLAST
ZnF_C2H2 318 340 3.21e-4 SMART
ZnF_C2H2 346 368 3.39e-3 SMART
ZnF_C2H2 374 396 1.72e-4 SMART
ZnF_C2H2 402 424 4.87e-4 SMART
ZnF_C2H2 430 452 1.58e-3 SMART
ZnF_C2H2 458 480 5.99e-4 SMART
ZnF_C2H2 486 508 2.12e-4 SMART
ZnF_C2H2 514 536 1.6e-4 SMART
ZnF_C2H2 542 564 3.95e-4 SMART
ZnF_C2H2 570 592 5.9e-3 SMART
ZnF_C2H2 598 620 1.12e-3 SMART
ZnF_C2H2 626 648 4.11e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000203854
SMART Domains Protein: ENSMUSP00000145165
Gene: ENSMUSG00000057101

DomainStartEndE-ValueType
Blast:KRAB 12 69 4e-14 BLAST
ZnF_C2H2 284 306 3.21e-4 SMART
ZnF_C2H2 312 334 3.39e-3 SMART
ZnF_C2H2 340 362 1.72e-4 SMART
ZnF_C2H2 368 390 4.87e-4 SMART
ZnF_C2H2 396 418 1.58e-3 SMART
ZnF_C2H2 424 446 5.99e-4 SMART
ZnF_C2H2 452 474 2.12e-4 SMART
ZnF_C2H2 480 502 1.6e-4 SMART
ZnF_C2H2 508 530 3.95e-4 SMART
ZnF_C2H2 536 558 5.9e-3 SMART
ZnF_C2H2 564 586 1.12e-3 SMART
ZnF_C2H2 592 614 4.11e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000206184
Predicted Effect probably benign
Transcript: ENSMUST00000207002
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207254
Coding Region Coverage
  • 1x: 94.1%
  • 3x: 94.1%
  • 10x: 94.0%
  • 20x: 93.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik C T 4: 148,026,233 (GRCm39) S251F probably benign Het
Ccar2 G T 14: 70,388,738 (GRCm39) L158I probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Gm10719 A G 9: 3,021,253 (GRCm39) probably null Het
Gm10720 A C 9: 3,015,669 (GRCm39) N6H probably benign Het
Gm21738 C T 14: 19,417,180 (GRCm38) C116Y probably damaging Het
Gm8688 T G 8: 100,391,152 (GRCm39) noncoding transcript Het
Hjurp A G 1: 88,205,247 (GRCm39) probably benign Het
Hspg2 C A 4: 137,261,049 (GRCm39) Q1648K probably damaging Het
Hvcn1 TGAGGAGGAGGAGGAGGAG TGAGGAGGAGGAGGAG 5: 122,371,602 (GRCm39) probably benign Het
Megf11 C A 9: 64,597,351 (GRCm39) C674* probably null Het
Mroh2a C T 1: 88,154,813 (GRCm39) probably benign Het
Muc4 T C 16: 32,570,643 (GRCm39) S568P probably benign Het
Naip2 A T 13: 100,291,529 (GRCm39) D1136E probably benign Het
Npm1 C T 11: 33,111,186 (GRCm39) V60I probably benign Het
Ppp2r5a G A 1: 191,091,189 (GRCm39) R213W probably damaging Het
Ppp2r5a C T 1: 191,091,198 (GRCm39) V210I probably benign Het
Trim43b T C 9: 88,974,598 (GRCm39) probably benign Het
Vmn2r115 T C 17: 23,565,201 (GRCm39) S363P probably damaging Het
Vmn2r115 T C 17: 23,578,333 (GRCm39) I602T probably benign Het
Vmn2r117 C T 17: 23,696,814 (GRCm39) A198T probably damaging Het
Vmn2r117 C G 17: 23,698,479 (GRCm39) Q31H possibly damaging Het
Vmn2r88 C G 14: 51,650,584 (GRCm39) T99S probably benign Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Zbtb12 C A 17: 35,115,277 (GRCm39) A354E possibly damaging Het
Zfp268 C T 4: 145,311,891 (GRCm39) probably benign Het
Other mutations in Zfp180
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Zfp180 APN 7 23,784,894 (GRCm39) missense probably damaging 0.98
IGL00990:Zfp180 APN 7 23,803,841 (GRCm39) missense possibly damaging 0.83
IGL00990:Zfp180 APN 7 23,804,255 (GRCm39) missense probably benign 0.42
IGL00990:Zfp180 APN 7 23,804,420 (GRCm39) missense possibly damaging 0.60
IGL01061:Zfp180 APN 7 23,804,170 (GRCm39) missense possibly damaging 0.50
IGL01328:Zfp180 APN 7 23,800,904 (GRCm39) missense probably benign 0.01
IGL03134:Zfp180 UTSW 7 23,804,170 (GRCm39) missense possibly damaging 0.50
R0137:Zfp180 UTSW 7 23,805,158 (GRCm39) missense possibly damaging 0.93
R0390:Zfp180 UTSW 7 23,804,132 (GRCm39) missense possibly damaging 0.95
R1451:Zfp180 UTSW 7 23,804,643 (GRCm39) missense probably benign 0.00
R1534:Zfp180 UTSW 7 23,800,948 (GRCm39) missense probably benign 0.31
R1555:Zfp180 UTSW 7 23,800,999 (GRCm39) intron probably benign
R1577:Zfp180 UTSW 7 23,805,333 (GRCm39) missense probably damaging 1.00
R1605:Zfp180 UTSW 7 23,804,049 (GRCm39) missense probably benign 0.00
R1633:Zfp180 UTSW 7 23,804,226 (GRCm39) missense probably benign 0.07
R1817:Zfp180 UTSW 7 23,804,652 (GRCm39) missense probably damaging 1.00
R2012:Zfp180 UTSW 7 23,803,943 (GRCm39) missense probably benign 0.01
R2076:Zfp180 UTSW 7 23,804,528 (GRCm39) missense probably damaging 1.00
R2151:Zfp180 UTSW 7 23,804,685 (GRCm39) missense probably damaging 1.00
R2262:Zfp180 UTSW 7 23,804,049 (GRCm39) missense probably benign 0.32
R3081:Zfp180 UTSW 7 23,804,928 (GRCm39) missense probably damaging 1.00
R3402:Zfp180 UTSW 7 23,805,170 (GRCm39) missense probably benign 0.30
R4551:Zfp180 UTSW 7 23,803,998 (GRCm39) missense possibly damaging 0.87
R4747:Zfp180 UTSW 7 23,805,246 (GRCm39) missense probably damaging 1.00
R4983:Zfp180 UTSW 7 23,805,503 (GRCm39) missense probably damaging 0.98
R5610:Zfp180 UTSW 7 23,804,315 (GRCm39) missense probably benign 0.00
R5764:Zfp180 UTSW 7 23,800,909 (GRCm39) missense possibly damaging 0.71
R5987:Zfp180 UTSW 7 23,804,859 (GRCm39) missense probably damaging 1.00
R6207:Zfp180 UTSW 7 23,804,510 (GRCm39) nonsense probably null
R6247:Zfp180 UTSW 7 23,804,530 (GRCm39) missense probably damaging 1.00
R6328:Zfp180 UTSW 7 23,804,981 (GRCm39) missense probably damaging 1.00
R6708:Zfp180 UTSW 7 23,805,521 (GRCm39) missense probably damaging 0.98
R6814:Zfp180 UTSW 7 23,805,306 (GRCm39) missense probably damaging 1.00
R6872:Zfp180 UTSW 7 23,805,306 (GRCm39) missense probably damaging 1.00
R7006:Zfp180 UTSW 7 23,804,537 (GRCm39) nonsense probably null
R7084:Zfp180 UTSW 7 23,804,686 (GRCm39) missense probably damaging 1.00
R7101:Zfp180 UTSW 7 23,803,958 (GRCm39) missense probably benign 0.00
R7213:Zfp180 UTSW 7 23,803,938 (GRCm39) missense possibly damaging 0.87
R7263:Zfp180 UTSW 7 23,805,125 (GRCm39) nonsense probably null
R7360:Zfp180 UTSW 7 23,804,915 (GRCm39) missense probably damaging 1.00
R7487:Zfp180 UTSW 7 23,805,525 (GRCm39) missense probably damaging 1.00
R7766:Zfp180 UTSW 7 23,804,084 (GRCm39) missense probably benign 0.37
R7816:Zfp180 UTSW 7 23,804,570 (GRCm39) missense probably damaging 1.00
R8086:Zfp180 UTSW 7 23,805,535 (GRCm39) missense probably benign
R8359:Zfp180 UTSW 7 23,804,337 (GRCm39) missense probably benign
R8747:Zfp180 UTSW 7 23,804,687 (GRCm39) missense possibly damaging 0.54
R8768:Zfp180 UTSW 7 23,805,161 (GRCm39) missense probably damaging 1.00
R8967:Zfp180 UTSW 7 23,804,726 (GRCm39) missense probably damaging 1.00
R9045:Zfp180 UTSW 7 23,804,315 (GRCm39) missense probably benign 0.01
R9460:Zfp180 UTSW 7 23,804,399 (GRCm39) missense probably damaging 1.00
R9480:Zfp180 UTSW 7 23,804,628 (GRCm39) missense probably benign 0.20
X0067:Zfp180 UTSW 7 23,804,897 (GRCm39) missense probably damaging 1.00
Z1177:Zfp180 UTSW 7 23,805,296 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-04-07