Mutagenetix > Incidental Mutations

Incidental Mutation 'R1527:Tas2r126'

166283

Institutional Source

Beutler Lab

Gene Symbol

Tas2r126

Ensembl Gene

ENSMUSG00000048284

Gene Name

taste receptor, type 2, member 126

Synonyms

T2R12, mt2r35, T2R26, mGR26, Tas2r26

MMRRC Submission

039567-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R1527 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

42434535-42435464 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 42435136 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 201 (I201T)

Ref Sequence

ENSEMBL: ENSMUSP00000056581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059534]

Predicted Effect

probably benign
Transcript: ENSMUST00000059534
AA Change: I201T

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000056581
Gene: ENSMUSG00000048284
AA Change: I201T

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	303	2.5e-97	PFAM

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.3%
20x: 89.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110059E24Rik	C	A	19: 21,598,269	C130F	probably damaging	Het
4933402N03Rik	T	C	7: 131,138,860	D209G	probably benign	Het
Adam7	A	G	14: 68,501,521	V744A	probably benign	Het
Atr	G	T	9: 95,870,043	R571I	possibly damaging	Het
C5ar1	A	G	7: 16,248,193	Y301H	probably damaging	Het
Cacna1d	A	G	14: 30,107,796	I954T	probably damaging	Het
Ccdc157	A	G	11: 4,151,795	F42S	probably damaging	Het
Chd2	A	T	7: 73,490,614	L622*	probably null	Het
Csmd3	T	C	15: 47,948,087	T1203A	probably benign	Het
Cxcl17	A	G	7: 25,402,211	V67A	possibly damaging	Het
Ddx4	T	C	13: 112,622,239	T263A	possibly damaging	Het
Eps8l1	A	G	7: 4,471,394	D288G	probably benign	Het
Fam208a	T	C	14: 27,480,093		probably null	Het
Fbxl4	A	G	4: 22,386,154	K254E	probably benign	Het
Glis1	T	C	4: 107,567,926	S245P	probably damaging	Het
Gm11111	T	C	5: 98,553,528		probably benign	Het
Haus3	A	T	5: 34,154,053	H544Q	probably benign	Het
Hmcn1	A	G	1: 150,773,803	V644A	probably benign	Het
Lmo7	T	C	14: 101,876,828	L2P	probably damaging	Het
Lonrf2	G	A	1: 38,813,276	P165S	probably benign	Het
Mga	A	G	2: 119,916,597	T410A	probably damaging	Het
Mical3	T	C	6: 121,024,779	D584G	probably damaging	Het
Miga1	A	T	3: 152,317,663	F250L	possibly damaging	Het
Mroh1	A	G	15: 76,452,263	D1553G	probably benign	Het
Myof	T	C	19: 37,924,619	Y1462C	probably damaging	Het
Notch4	T	C	17: 34,565,744	C144R	probably damaging	Het
Obox1	T	C	7: 15,555,325	V55A	probably damaging	Het
Olfr1241	C	T	2: 89,482,532	G201D	probably benign	Het
Olfr761	T	A	17: 37,952,829	H65L	possibly damaging	Het
Olfr822	T	A	10: 130,075,192	S261T	probably damaging	Het
Pclo	T	C	5: 14,679,648		probably benign	Het
Prr14l	C	T	5: 32,827,949	V1401I	possibly damaging	Het
Rad51ap1	T	C	6: 126,928,167		probably null	Het
Rev3l	T	A	10: 39,822,822	V1105D	probably damaging	Het
Rif1	GCCACCA	GCCA	2: 52,110,324		probably benign	Het
Sgsm2	A	T	11: 74,853,848	C848*	probably null	Het
Slc39a10	A	T	1: 46,819,262	V625E	probably benign	Het
Spry4	C	T	18: 38,590,577	M44I	probably benign	Het
Stat5b	A	T	11: 100,808,394		probably null	Het
Tex44	A	G	1: 86,427,646	T426A	probably benign	Het
Tln2	T	C	9: 67,272,668	D807G	possibly damaging	Het
Tlr9	A	G	9: 106,223,750	N80S	probably benign	Het
Trpm7	A	C	2: 126,830,162	H579Q	probably benign	Het
Ufd1	T	C	16: 18,814,911	S29P	probably damaging	Het
Ugt2a3	G	T	5: 87,325,598	Q487K	probably damaging	Het
Wdr66	T	C	5: 123,287,345	V789A	probably benign	Het
Zfyve9	A	G	4: 108,695,767		probably null	Het

Other mutations in Tas2r126

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00915:Tas2r126	APN	6	42435349	missense	possibly damaging	0.67
IGL01327:Tas2r126	APN	6	42434750	missense	probably benign	0.09
IGL01690:Tas2r126	APN	6	42435307	missense	probably benign	0.02
IGL02153:Tas2r126	APN	6	42434664	missense	probably benign	0.32
IGL02291:Tas2r126	APN	6	42435287	missense	probably benign	0.00
IGL03365:Tas2r126	APN	6	42435457	missense	probably benign	0.36
R0091:Tas2r126	UTSW	6	42435102	missense	probably benign
R0486:Tas2r126	UTSW	6	42435291	missense	probably benign	0.01
R0611:Tas2r126	UTSW	6	42435091	missense	probably damaging	0.99
R1529:Tas2r126	UTSW	6	42434568	missense	probably benign	0.00
R1883:Tas2r126	UTSW	6	42435027	missense	probably benign
R1884:Tas2r126	UTSW	6	42435027	missense	probably benign
R2039:Tas2r126	UTSW	6	42434623	missense	probably benign	0.22
R4863:Tas2r126	UTSW	6	42435390	missense	probably benign	0.02
R5975:Tas2r126	UTSW	6	42435000	missense	possibly damaging	0.69
R7127:Tas2r126	UTSW	6	42434805	missense	probably damaging	1.00
R7351:Tas2r126	UTSW	6	42435306	missense	probably benign	0.02
R7714:Tas2r126	UTSW	6	42435097	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- CTGGGACTTCTTGAACTCAGCCAC -3'
(R):5'- TTTGCCAGGGCCAATACCACAC -3'

Sequencing Primer
(F):5'- TTGAAGTGGAGATTCCCAGC -3'
(R):5'- CCACACATTATCTGAGGAGATGAAG -3'

Posted On

2014-04-13