Mutagenetix > Incidental Mutation

Incidental Mutation 'R1529:Tas2r126'

166450

Institutional Source

Beutler Lab

Gene Symbol

Tas2r126

Ensembl Gene

ENSMUSG00000048284

Gene Name

taste receptor, type 2, member 126

Synonyms

T2R12, mt2r35, T2R26, mGR26, Tas2r26

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R1529 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

42434535-42435464 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42434568 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 12 (T12A)

Ref Sequence

ENSEMBL: ENSMUSP00000056581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059534]

AlphaFold

P59532

Predicted Effect

probably benign
Transcript: ENSMUST00000059534
AA Change: T12A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000056581
Gene: ENSMUSG00000048284
AA Change: T12A

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	303	2.5e-97	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001C19Rik	G	A	17: 47,413,890	S102L	probably benign	Het
A430105I19Rik	T	A	2: 118,761,760		probably null	Het
Adam11	T	C	11: 102,775,113		probably null	Het
AI314180	T	C	4: 58,832,701		probably null	Het
Amd1	A	T	10: 40,290,505	M194K	probably benign	Het
Ap1b1	T	G	11: 5,039,547	F793C	probably damaging	Het
Arfgef3	G	A	10: 18,613,222	R1292*	probably null	Het
Arhgef5	C	A	6: 43,279,515	H1186N	probably damaging	Het
Atad1	A	G	19: 32,706,921	F26L	probably benign	Het
Atg2b	C	T	12: 105,661,133	V532I	probably benign	Het
Atp2b4	A	G	1: 133,717,988	F943L	probably damaging	Het
Atp7b	G	A	8: 22,028,724	L21F	possibly damaging	Het
Cenpf	A	T	1: 189,660,038	D532E	probably benign	Het
Ckmt2	A	T	13: 91,861,201	D202E	probably benign	Het
Crim1	A	C	17: 78,367,954	K864T	probably benign	Het
Ctnnd2	A	G	15: 30,887,121	R765G	possibly damaging	Het
Ddx10	T	A	9: 53,117,199	R802*	probably null	Het
Dnah7b	T	A	1: 46,177,281	F1152L	probably damaging	Het
Dsg1c	T	C	18: 20,282,023	L659P	probably damaging	Het
Dzank1	A	G	2: 144,482,188	F577L	probably benign	Het
Eci3	T	C	13: 34,956,920	D93G	probably benign	Het
Ep400	C	A	5: 110,739,445	V591L	probably benign	Het
Fam126b	A	T	1: 58,539,607	D261E	probably benign	Het
Fgd3	T	C	13: 49,266,694	N569S	probably benign	Het
Ghsr	T	A	3: 27,372,482	V229E	probably damaging	Het
Gm8298	T	C	3: 59,861,112	I21T	probably benign	Het
Gna15	T	A	10: 81,509,342	I230F	probably damaging	Het
Gnl2	A	G	4: 125,046,306	S324G	probably damaging	Het
Grid1	T	C	14: 35,309,293	V281A	probably benign	Het
Hebp2	G	A	10: 18,545,761	A12V	possibly damaging	Het
Hfm1	T	C	5: 106,853,123	D1254G	probably benign	Het
Hif3a	A	C	7: 17,042,639	S459A	probably benign	Het
Hnrnpl	T	A	7: 28,813,923	N149K	possibly damaging	Het
Hoxc10	A	T	15: 102,967,200	S115C	probably damaging	Het
Ifnab	T	C	4: 88,691,055	D58G	possibly damaging	Het
Itfg1	T	C	8: 85,810,614	T195A	probably benign	Het
Itpr3	T	A	17: 27,105,485		probably null	Het
Iws1	A	G	18: 32,080,281	D254G	probably benign	Het
Kl	C	A	5: 150,988,941	D718E	probably benign	Het
Lrit2	A	G	14: 37,068,827	I154M	probably benign	Het
Lrp2	T	C	2: 69,523,182	D578G	probably damaging	Het
Lss	T	G	10: 76,536,289	Y159*	probably null	Het
Mab21l1	C	A	3: 55,783,833	Y280*	probably null	Het
Maf	A	T	8: 115,693,170	S378T	probably benign	Het
Mast2	C	T	4: 116,430,519	V59I	probably benign	Het
Nisch	C	T	14: 31,180,938		probably benign	Het
Nova2	A	T	7: 18,957,554	N139Y	probably damaging	Het
Nup210	C	A	6: 91,036,376	D434Y	probably damaging	Het
Nvl	C	T	1: 181,109,159		probably null	Het
Olfr1049	A	T	2: 86,255,241	Y151N	probably damaging	Het
Olfr1087	A	G	2: 86,690,333	V214A	possibly damaging	Het
Olfr577	A	G	7: 102,973,879	Y38H	probably damaging	Het
Olfr657	A	G	7: 104,636,489	T272A	probably benign	Het
Olfr743	T	C	14: 50,533,702	S97P	possibly damaging	Het
Pbx3	T	C	2: 34,204,859	Y255C	probably damaging	Het
Pcyt1a	G	A	16: 32,451,793	E27K	possibly damaging	Het
Pex6	A	T	17: 46,714,064	T348S	probably benign	Het
Phf21b	A	G	15: 84,797,396	I251T	probably damaging	Het
Pkd2l2	T	C	18: 34,430,702	I490T	probably damaging	Het
Pla2g12a	T	A	3: 129,878,885	L56Q	probably damaging	Het
Plk4	A	G	3: 40,806,536	T434A	probably benign	Het
Ptpn13	A	G	5: 103,564,132	N1632S	probably benign	Het
Rfpl4	C	T	7: 5,110,712	V151M	probably damaging	Het
Rpain	G	C	11: 70,974,915	E169Q	probably damaging	Het
Samd8	T	A	14: 21,775,159	V124D	possibly damaging	Het
Sdk2	C	T	11: 113,838,646		silent	Het
Slc12a1	C	T	2: 125,190,295	T622I	probably damaging	Het
Slc17a3	T	A	13: 23,845,445	V67D	probably damaging	Het
Slc41a3	G	T	6: 90,644,216	V387L	probably damaging	Het
Slitrk1	T	A	14: 108,913,277	M1L	probably benign	Het
Stat4	T	C	1: 52,011,793	W4R	probably damaging	Het
Tbc1d24	A	G	17: 24,185,979	C64R	probably damaging	Het
Tcaf2	T	C	6: 42,629,506	S505G	probably benign	Het
Tiam2	T	C	17: 3,516,703	V1506A	probably benign	Het
Tmem9b	A	C	7: 109,736,949	S163A	probably benign	Het
Tmtc2	G	A	10: 105,303,658	S669L	probably damaging	Het
Tnpo3	A	T	6: 29,560,221	I641K	possibly damaging	Het
Ttn	C	T	2: 76,735,367	A28214T	probably damaging	Het
Utp11	G	A	4: 124,683,239	A113V	probably benign	Het
Utp20	G	A	10: 88,753,006	R2434C	probably damaging	Het
Vmn1r60	A	T	7: 5,544,903	I66N	probably benign	Het
Zeb2	T	C	2: 44,997,194	E572G	probably damaging	Het

Other mutations in Tas2r126

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00915:Tas2r126	APN	6	42435349	missense	possibly damaging	0.67
IGL01327:Tas2r126	APN	6	42434750	missense	probably benign	0.09
IGL01690:Tas2r126	APN	6	42435307	missense	probably benign	0.02
IGL02153:Tas2r126	APN	6	42434664	missense	probably benign	0.32
IGL02291:Tas2r126	APN	6	42435287	missense	probably benign	0.00
IGL03365:Tas2r126	APN	6	42435457	missense	probably benign	0.36
R0091:Tas2r126	UTSW	6	42435102	missense	probably benign
R0486:Tas2r126	UTSW	6	42435291	missense	probably benign	0.01
R0611:Tas2r126	UTSW	6	42435091	missense	probably damaging	0.99
R1527:Tas2r126	UTSW	6	42435136	missense	probably benign	0.03
R1883:Tas2r126	UTSW	6	42435027	missense	probably benign
R1884:Tas2r126	UTSW	6	42435027	missense	probably benign
R2039:Tas2r126	UTSW	6	42434623	missense	probably benign	0.22
R4863:Tas2r126	UTSW	6	42435390	missense	probably benign	0.02
R5975:Tas2r126	UTSW	6	42435000	missense	possibly damaging	0.69
R7127:Tas2r126	UTSW	6	42434805	missense	probably damaging	1.00
R7351:Tas2r126	UTSW	6	42435306	missense	probably benign	0.02
R7714:Tas2r126	UTSW	6	42435097	missense	probably benign	0.12
R9154:Tas2r126	UTSW	6	42435240	missense	probably benign	0.25
R9336:Tas2r126	UTSW	6	42434943	missense	probably benign	0.45
R9516:Tas2r126	UTSW	6	42435373	missense	probably null	0.98

Predicted Primers

PCR Primer
(F):5'- TCTGGCTCACATGCAGAATCCAAC -3'
(R):5'- GCTGGGAATCTCCACTTCAACCAC -3'

Sequencing Primer
(F):5'- GCAGAATCCAACCATTTATCTCCTG -3'
(R):5'- TCTTGATACAGAACAGGACGCTG -3'

Posted On

2014-04-13