Incidental Mutation 'R1533:Rgs6'
| ID |
166769 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rgs6
|
| Ensembl Gene |
ENSMUSG00000021219 |
| Gene Name |
regulator of G-protein signaling 6 |
| Synonyms |
|
| MMRRC Submission |
039572-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.147)
|
| Stock # |
R1533 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
82663325-83208835 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 83138547 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Leucine
at position 294
(V294L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125256
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000101234]
[ENSMUST00000161801]
[ENSMUST00000185665]
[ENSMUST00000185674]
[ENSMUST00000186081]
[ENSMUST00000186309]
[ENSMUST00000186323]
[ENSMUST00000191311]
[ENSMUST00000186458]
[ENSMUST00000202210]
[ENSMUST00000186848]
[ENSMUST00000191107]
[ENSMUST00000191352]
[ENSMUST00000200911]
|
| AlphaFold |
Q9Z2H2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101234
AA Change: V294L
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000098793
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
3.28e-24 |
SMART |
|
G_gamma
|
255 |
319 |
2.23e-23 |
SMART |
|
GGL
|
258 |
319 |
1.38e-27 |
SMART |
|
RGS
|
336 |
451 |
2.05e-47 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161801
AA Change: V294L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000125256
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
3.28e-24 |
SMART |
|
G_gamma
|
255 |
319 |
2.23e-23 |
SMART |
|
GGL
|
258 |
319 |
1.38e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185665
AA Change: V294L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000139566
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
G_gamma
|
255 |
319 |
1e-27 |
SMART |
|
GGL
|
258 |
319 |
8.7e-30 |
SMART |
|
RGS
|
336 |
451 |
7.5e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185674
|
| SMART Domains |
Protein: ENSMUSP00000139940
Gene: ENSMUSG00000021219
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
RGS
|
299 |
414 |
7.5e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186081
AA Change: V294L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000140188
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
RGS
|
299 |
414 |
7.5e-50 |
SMART |
|
low complexity region
|
417 |
425 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186309
AA Change: V294L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000140701
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
G_gamma
|
255 |
319 |
1e-27 |
SMART |
|
GGL
|
258 |
319 |
8.7e-30 |
SMART |
|
RGS
|
336 |
451 |
7.5e-50 |
SMART |
|
low complexity region
|
494 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
511 |
523 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186323
|
| SMART Domains |
Protein: ENSMUSP00000141079
Gene: ENSMUSG00000021219
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
RGS
|
299 |
414 |
7.5e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191311
AA Change: V294L
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000140723
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
G_gamma
|
255 |
319 |
1e-27 |
SMART |
|
GGL
|
258 |
319 |
8.7e-30 |
SMART |
|
RGS
|
336 |
451 |
7.5e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186458
AA Change: V294L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000139735
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
3.28e-24 |
SMART |
|
G_gamma
|
255 |
319 |
2.23e-23 |
SMART |
|
GGL
|
258 |
319 |
1.38e-27 |
SMART |
|
RGS
|
336 |
451 |
2.05e-47 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000202210
AA Change: V294L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000143961
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
3.28e-24 |
SMART |
|
G_gamma
|
255 |
319 |
2.23e-23 |
SMART |
|
GGL
|
258 |
319 |
1.38e-27 |
SMART |
|
RGS
|
336 |
451 |
2.05e-47 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186848
AA Change: V259L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000141044
Gene: ENSMUSG00000021219
AA Change: V259L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
5 |
80 |
1.6e-26 |
SMART |
|
G_gamma
|
220 |
284 |
1.1e-27 |
SMART |
|
GGL
|
223 |
284 |
8.8e-30 |
SMART |
|
RGS
|
301 |
416 |
7.6e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191107
AA Change: V294L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000139725
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
G_gamma
|
255 |
319 |
1e-27 |
SMART |
|
GGL
|
258 |
319 |
8.7e-30 |
SMART |
|
RGS
|
336 |
451 |
7.5e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000191352
AA Change: V294L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000139718
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
1.5e-26 |
SMART |
|
G_gamma
|
255 |
319 |
1e-27 |
SMART |
|
GGL
|
258 |
319 |
8.7e-30 |
SMART |
|
RGS
|
336 |
451 |
7.5e-50 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200911
AA Change: V294L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000143801
Gene: ENSMUSG00000021219
AA Change: V294L
| Domain | Start | End | E-Value | Type |
|---|
|
DEP
|
40 |
115 |
3.28e-24 |
SMART |
|
G_gamma
|
255 |
319 |
2.23e-23 |
SMART |
|
GGL
|
258 |
319 |
1.38e-27 |
SMART |
|
RGS
|
336 |
451 |
2.05e-47 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000187556
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and GGL (G-protein gamma like)domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Mice lacking this gene exhibit decreased heart rate. Alternative splicing results in multiple transcript variants, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Sep 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased heart rate and abnormal impulse conducting system conduction. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
G |
C |
3: 121,928,807 (GRCm39) |
G1340A |
probably benign |
Het |
| Ambra1 |
T |
A |
2: 91,717,210 (GRCm39) |
Y836N |
probably damaging |
Het |
| Arhgap26 |
A |
T |
18: 39,504,130 (GRCm39) |
H144L |
probably benign |
Het |
| B3gnt5 |
A |
G |
16: 19,588,364 (GRCm39) |
I194M |
probably damaging |
Het |
| Bltp1 |
G |
T |
3: 37,095,524 (GRCm39) |
G4509V |
probably damaging |
Het |
| Bod1l |
A |
T |
5: 41,979,498 (GRCm39) |
C605* |
probably null |
Het |
| C2cd3 |
G |
T |
7: 100,055,284 (GRCm39) |
K482N |
possibly damaging |
Het |
| Cd300lg |
T |
A |
11: 101,934,047 (GRCm39) |
L98Q |
probably damaging |
Het |
| Cerkl |
T |
A |
2: 79,171,701 (GRCm39) |
I386F |
possibly damaging |
Het |
| Cfh |
T |
A |
1: 140,028,716 (GRCm39) |
D466V |
possibly damaging |
Het |
| Crtc1 |
A |
T |
8: 70,850,949 (GRCm39) |
I221N |
probably damaging |
Het |
| Ctnnbl1 |
T |
C |
2: 157,678,563 (GRCm39) |
S389P |
probably benign |
Het |
| Ctsb |
A |
T |
14: 63,376,544 (GRCm39) |
D258V |
probably damaging |
Het |
| Cuzd1 |
G |
T |
7: 130,913,432 (GRCm39) |
T395N |
probably damaging |
Het |
| Dnah6 |
T |
C |
6: 73,128,536 (GRCm39) |
T1240A |
probably benign |
Het |
| Dok7 |
T |
A |
5: 35,221,671 (GRCm39) |
|
probably null |
Het |
| Dscaml1 |
T |
C |
9: 45,361,882 (GRCm39) |
V214A |
probably damaging |
Het |
| Enpp6 |
A |
T |
8: 47,518,469 (GRCm39) |
Y199F |
probably benign |
Het |
| Entpd5 |
C |
A |
12: 84,441,434 (GRCm39) |
K111N |
probably damaging |
Het |
| Fam98a |
A |
G |
17: 75,848,276 (GRCm39) |
L146S |
probably damaging |
Het |
| Fhod3 |
A |
T |
18: 25,248,921 (GRCm39) |
I1367F |
probably damaging |
Het |
| Fmnl2 |
A |
G |
2: 52,995,549 (GRCm39) |
E424G |
probably damaging |
Het |
| Fpr3 |
T |
A |
17: 18,190,922 (GRCm39) |
Y64* |
probably null |
Het |
| Fzd6 |
A |
T |
15: 38,895,019 (GRCm39) |
H395L |
probably damaging |
Het |
| Gcsh |
T |
A |
8: 117,715,921 (GRCm39) |
H54L |
probably damaging |
Het |
| Gsdma |
T |
A |
11: 98,567,210 (GRCm39) |
S437T |
unknown |
Het |
| Gzmc |
A |
G |
14: 56,471,376 (GRCm39) |
V55A |
probably damaging |
Het |
| Hecw2 |
T |
A |
1: 53,965,704 (GRCm39) |
|
probably null |
Het |
| Ifi207 |
A |
G |
1: 173,555,306 (GRCm39) |
V792A |
probably benign |
Het |
| Itpr3 |
C |
A |
17: 27,314,534 (GRCm39) |
N661K |
possibly damaging |
Het |
| Jmy |
A |
T |
13: 93,577,819 (GRCm39) |
I783N |
probably benign |
Het |
| Kcmf1 |
T |
C |
6: 72,820,003 (GRCm39) |
E281G |
possibly damaging |
Het |
| Klra3 |
G |
C |
6: 130,310,107 (GRCm39) |
R138G |
probably benign |
Het |
| Lgr6 |
T |
A |
1: 135,032,670 (GRCm39) |
Y70F |
possibly damaging |
Het |
| Lnx1 |
T |
G |
5: 74,780,678 (GRCm39) |
D330A |
probably damaging |
Het |
| Lrp5 |
T |
C |
19: 3,664,234 (GRCm39) |
N106S |
probably benign |
Het |
| Mamdc4 |
C |
A |
2: 25,459,759 (GRCm39) |
R135L |
possibly damaging |
Het |
| Mcm3ap |
A |
G |
10: 76,340,121 (GRCm39) |
E1464G |
probably damaging |
Het |
| Megf8 |
T |
C |
7: 25,034,280 (GRCm39) |
V666A |
possibly damaging |
Het |
| Mettl3 |
T |
A |
14: 52,534,385 (GRCm39) |
E331D |
probably benign |
Het |
| Mphosph9 |
T |
C |
5: 124,405,204 (GRCm39) |
K789R |
probably damaging |
Het |
| Mtf2 |
T |
C |
5: 108,239,995 (GRCm39) |
L234P |
probably damaging |
Het |
| Ncdn |
C |
A |
4: 126,642,491 (GRCm39) |
E389* |
probably null |
Het |
| Ndor1 |
A |
G |
2: 25,139,279 (GRCm39) |
S231P |
probably damaging |
Het |
| Nelfa |
T |
G |
5: 34,056,215 (GRCm39) |
K483Q |
probably damaging |
Het |
| Odad1 |
T |
A |
7: 45,592,282 (GRCm39) |
M354K |
probably benign |
Het |
| Opn1sw |
C |
T |
6: 29,378,923 (GRCm39) |
R243Q |
probably benign |
Het |
| Or13a24 |
T |
A |
7: 140,155,034 (GRCm39) |
|
probably null |
Het |
| Or9e1 |
A |
G |
11: 58,732,792 (GRCm39) |
N284S |
probably damaging |
Het |
| Pik3cd |
T |
C |
4: 149,739,653 (GRCm39) |
E584G |
probably damaging |
Het |
| Plcb3 |
A |
T |
19: 6,935,041 (GRCm39) |
M870K |
possibly damaging |
Het |
| Poc5 |
A |
G |
13: 96,528,152 (GRCm39) |
D16G |
probably damaging |
Het |
| Prpf40a |
A |
G |
2: 53,035,852 (GRCm39) |
I633T |
probably damaging |
Het |
| Ptpn13 |
G |
T |
5: 103,704,044 (GRCm39) |
E1359* |
probably null |
Het |
| Ptprr |
C |
A |
10: 116,024,113 (GRCm39) |
Y4* |
probably null |
Het |
| Rbm45 |
T |
C |
2: 76,202,503 (GRCm39) |
|
probably null |
Het |
| Rfng |
C |
T |
11: 120,672,687 (GRCm39) |
W320* |
probably null |
Het |
| Rufy4 |
T |
C |
1: 74,169,002 (GRCm39) |
|
probably null |
Het |
| Ruvbl2 |
T |
A |
7: 45,073,566 (GRCm39) |
N313I |
probably damaging |
Het |
| Sema4g |
G |
A |
19: 44,981,256 (GRCm39) |
V70M |
probably damaging |
Het |
| Siglec1 |
T |
C |
2: 130,918,078 (GRCm39) |
T969A |
probably benign |
Het |
| Slc22a27 |
T |
A |
19: 7,844,348 (GRCm39) |
T431S |
possibly damaging |
Het |
| Slc25a16 |
G |
A |
10: 62,756,643 (GRCm39) |
R38H |
probably damaging |
Het |
| Slc38a6 |
T |
C |
12: 73,391,626 (GRCm39) |
V296A |
probably benign |
Het |
| Slc39a11 |
C |
T |
11: 113,196,748 (GRCm39) |
V212I |
probably damaging |
Het |
| Sltm |
A |
G |
9: 70,493,948 (GRCm39) |
K782E |
probably damaging |
Het |
| Styxl1 |
T |
A |
5: 135,799,175 (GRCm39) |
Y23F |
probably damaging |
Het |
| Svs4 |
T |
C |
2: 164,120,148 (GRCm39) |
I20V |
unknown |
Het |
| Syt14 |
G |
T |
1: 192,613,084 (GRCm39) |
T572K |
possibly damaging |
Het |
| Tbc1d5 |
A |
T |
17: 51,227,603 (GRCm39) |
I214N |
possibly damaging |
Het |
| Tm9sf3 |
A |
G |
19: 41,227,223 (GRCm39) |
S283P |
probably benign |
Het |
| Tmtc1 |
C |
T |
6: 148,147,208 (GRCm39) |
|
probably null |
Het |
| Ttll7 |
T |
A |
3: 146,602,422 (GRCm39) |
N73K |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,602,802 (GRCm39) |
K18473N |
probably damaging |
Het |
| Ubr2 |
A |
C |
17: 47,278,173 (GRCm39) |
Y721* |
probably null |
Het |
| Vmn1r14 |
T |
A |
6: 57,211,286 (GRCm39) |
I288N |
probably damaging |
Het |
| Vmn2r103 |
T |
C |
17: 19,993,662 (GRCm39) |
I13T |
probably benign |
Het |
| Vps13a |
A |
T |
19: 16,678,494 (GRCm39) |
Y1162* |
probably null |
Het |
| Vps51 |
C |
A |
19: 6,121,497 (GRCm39) |
R175L |
probably benign |
Het |
| Zfp523 |
C |
A |
17: 28,423,473 (GRCm39) |
S149R |
probably benign |
Het |
| Zik1 |
A |
G |
7: 10,224,053 (GRCm39) |
I348T |
possibly damaging |
Het |
| Znfx1 |
T |
A |
2: 166,898,708 (GRCm39) |
H72L |
probably benign |
Het |
|
| Other mutations in Rgs6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00502:Rgs6
|
APN |
12 |
83,098,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02131:Rgs6
|
APN |
12 |
83,116,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02354:Rgs6
|
APN |
12 |
82,665,393 (GRCm39) |
intron |
probably benign |
|
|
IGL02361:Rgs6
|
APN |
12 |
82,665,393 (GRCm39) |
intron |
probably benign |
|
|
IGL02568:Rgs6
|
APN |
12 |
83,117,376 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02598:Rgs6
|
APN |
12 |
83,138,571 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03146:Rgs6
|
APN |
12 |
83,099,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03248:Rgs6
|
APN |
12 |
83,099,324 (GRCm39) |
splice site |
probably benign |
|
|
IGL03098:Rgs6
|
UTSW |
12 |
83,032,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03147:Rgs6
|
UTSW |
12 |
83,138,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4453001:Rgs6
|
UTSW |
12 |
83,138,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Rgs6
|
UTSW |
12 |
83,180,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0390:Rgs6
|
UTSW |
12 |
83,180,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0540:Rgs6
|
UTSW |
12 |
83,106,578 (GRCm39) |
nonsense |
probably null |
|
|
R0630:Rgs6
|
UTSW |
12 |
83,094,324 (GRCm39) |
splice site |
probably benign |
|
|
R1479:Rgs6
|
UTSW |
12 |
83,163,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1545:Rgs6
|
UTSW |
12 |
83,162,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2161:Rgs6
|
UTSW |
12 |
83,138,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2421:Rgs6
|
UTSW |
12 |
83,163,057 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4089:Rgs6
|
UTSW |
12 |
83,110,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Rgs6
|
UTSW |
12 |
83,112,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4821:Rgs6
|
UTSW |
12 |
83,114,185 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6228:Rgs6
|
UTSW |
12 |
83,112,738 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7023:Rgs6
|
UTSW |
12 |
83,138,878 (GRCm39) |
intron |
probably benign |
|
|
R7585:Rgs6
|
UTSW |
12 |
83,153,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7610:Rgs6
|
UTSW |
12 |
83,138,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Rgs6
|
UTSW |
12 |
83,116,293 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8003:Rgs6
|
UTSW |
12 |
83,032,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8011:Rgs6
|
UTSW |
12 |
83,163,066 (GRCm39) |
missense |
probably null |
0.32 |
|
R8081:Rgs6
|
UTSW |
12 |
83,094,347 (GRCm39) |
nonsense |
probably null |
|
|
R8248:Rgs6
|
UTSW |
12 |
83,184,478 (GRCm39) |
intron |
probably benign |
|
|
R8267:Rgs6
|
UTSW |
12 |
82,698,669 (GRCm39) |
missense |
probably benign |
|
|
R8285:Rgs6
|
UTSW |
12 |
83,162,949 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8932:Rgs6
|
UTSW |
12 |
83,112,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9398:Rgs6
|
UTSW |
12 |
82,698,615 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9415:Rgs6
|
UTSW |
12 |
83,184,166 (GRCm39) |
missense |
probably benign |
0.06 |
|
RF008:Rgs6
|
UTSW |
12 |
83,110,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTGTGACCTCTGTATTAGGCATC -3'
(R):5'- GCCATGTACAAGTCAAAGCTGCAAG -3'
Sequencing Primer
(F):5'- CTTAAGGTAACAGAGCAAACCTG -3'
(R):5'- TTAATGTGGAGGACACTTGGACC -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation