Mutagenetix > Incidental Mutation

Incidental Mutation 'R1533:Vmn2r103'

166781

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

039572-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R1533 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19773400 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 13 (I13T)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: I13T

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: I13T

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	G	T	3: 37,041,375	G4509V	probably damaging	Het
Abca4	G	C	3: 122,135,158	G1340A	probably benign	Het
Ambra1	T	A	2: 91,886,865	Y836N	probably damaging	Het
Arhgap26	A	T	18: 39,371,077	H144L	probably benign	Het
B3gnt5	A	G	16: 19,769,614	I194M	probably damaging	Het
Bod1l	A	T	5: 41,822,155	C605*	probably null	Het
C2cd3	G	T	7: 100,406,077	K482N	possibly damaging	Het
Ccdc114	T	A	7: 45,942,858	M354K	probably benign	Het
Cd300lg	T	A	11: 102,043,221	L98Q	probably damaging	Het
Cerkl	T	A	2: 79,341,357	I386F	possibly damaging	Het
Cfh	T	A	1: 140,100,978	D466V	possibly damaging	Het
Crtc1	A	T	8: 70,398,299	I221N	probably damaging	Het
Ctnnbl1	T	C	2: 157,836,643	S389P	probably benign	Het
Ctsb	A	T	14: 63,139,095	D258V	probably damaging	Het
Cuzd1	G	T	7: 131,311,703	T395N	probably damaging	Het
Dnah6	T	C	6: 73,151,553	T1240A	probably benign	Het
Dok7	T	A	5: 35,064,327		probably null	Het
Dscaml1	T	C	9: 45,450,584	V214A	probably damaging	Het
Enpp6	A	T	8: 47,065,434	Y199F	probably benign	Het
Entpd5	C	A	12: 84,394,660	K111N	probably damaging	Het
Fam98a	A	G	17: 75,541,281	L146S	probably damaging	Het
Fhod3	A	T	18: 25,115,864	I1367F	probably damaging	Het
Fmnl2	A	G	2: 53,105,537	E424G	probably damaging	Het
Fpr3	T	A	17: 17,970,660	Y64*	probably null	Het
Fzd6	A	T	15: 39,031,624	H395L	probably damaging	Het
Gcsh	T	A	8: 116,989,182	H54L	probably damaging	Het
Gsdma	T	A	11: 98,676,384	S437T	unknown	Het
Gzmc	A	G	14: 56,233,919	V55A	probably damaging	Het
Hecw2	T	A	1: 53,926,545		probably null	Het
Ifi207	A	G	1: 173,727,740	V792A	probably benign	Het
Itpr3	C	A	17: 27,095,560	N661K	possibly damaging	Het
Jmy	A	T	13: 93,441,311	I783N	probably benign	Het
Kcmf1	T	C	6: 72,843,020	E281G	possibly damaging	Het
Klra3	G	C	6: 130,333,144	R138G	probably benign	Het
Lgr6	T	A	1: 135,104,932	Y70F	possibly damaging	Het
Lnx1	T	G	5: 74,620,017	D330A	probably damaging	Het
Lrp5	T	C	19: 3,614,234	N106S	probably benign	Het
Mamdc4	C	A	2: 25,569,747	R135L	possibly damaging	Het
Mcm3ap	A	G	10: 76,504,287	E1464G	probably damaging	Het
Megf8	T	C	7: 25,334,855	V666A	possibly damaging	Het
Mettl3	T	A	14: 52,296,928	E331D	probably benign	Het
Mphosph9	T	C	5: 124,267,141	K789R	probably damaging	Het
Mtf2	T	C	5: 108,092,129	L234P	probably damaging	Het
Ncdn	C	A	4: 126,748,698	E389*	probably null	Het
Ndor1	A	G	2: 25,249,267	S231P	probably damaging	Het
Nelfa	T	G	5: 33,898,871	K483Q	probably damaging	Het
Olfr311	A	G	11: 58,841,966	N284S	probably damaging	Het
Olfr538	T	A	7: 140,575,121		probably null	Het
Opn1sw	C	T	6: 29,378,924	R243Q	probably benign	Het
Pik3cd	T	C	4: 149,655,196	E584G	probably damaging	Het
Plcb3	A	T	19: 6,957,673	M870K	possibly damaging	Het
Poc5	A	G	13: 96,391,644	D16G	probably damaging	Het
Prpf40a	A	G	2: 53,145,840	I633T	probably damaging	Het
Ptpn13	G	T	5: 103,556,178	E1359*	probably null	Het
Ptprr	C	A	10: 116,188,208	Y4*	probably null	Het
Rbm45	T	C	2: 76,372,159		probably null	Het
Rfng	C	T	11: 120,781,861	W320*	probably null	Het
Rgs6	G	T	12: 83,091,773	V294L	probably benign	Het
Rufy4	T	C	1: 74,129,843		probably null	Het
Ruvbl2	T	A	7: 45,424,142	N313I	probably damaging	Het
Sema4g	G	A	19: 44,992,817	V70M	probably damaging	Het
Siglec1	T	C	2: 131,076,158	T969A	probably benign	Het
Slc22a27	T	A	19: 7,866,983	T431S	possibly damaging	Het
Slc25a16	G	A	10: 62,920,864	R38H	probably damaging	Het
Slc38a6	T	C	12: 73,344,852	V296A	probably benign	Het
Slc39a11	C	T	11: 113,305,922	V212I	probably damaging	Het
Sltm	A	G	9: 70,586,666	K782E	probably damaging	Het
Styxl1	T	A	5: 135,770,321	Y23F	probably damaging	Het
Svs4	T	C	2: 164,278,228	I20V	unknown	Het
Syt14	G	T	1: 192,930,776	T572K	possibly damaging	Het
Tbc1d5	A	T	17: 50,920,575	I214N	possibly damaging	Het
Tm9sf3	A	G	19: 41,238,784	S283P	probably benign	Het
Tmtc1	C	T	6: 148,245,710		probably null	Het
Ttll7	T	A	3: 146,896,667	N73K	probably damaging	Het
Ttn	T	A	2: 76,772,458	K18473N	probably damaging	Het
Ubr2	A	C	17: 46,967,247	Y721*	probably null	Het
Vmn1r14	T	A	6: 57,234,301	I288N	probably damaging	Het
Vps13a	A	T	19: 16,701,130	Y1162*	probably null	Het
Vps51	C	A	19: 6,071,467	R175L	probably benign	Het
Zfp523	C	A	17: 28,204,499	S149R	probably benign	Het
Zik1	A	G	7: 10,490,126	I348T	possibly damaging	Het
Znfx1	T	A	2: 167,056,788	H72L	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19811659	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19793765	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19799263	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19812213	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- CGAAATTCCCAATGGCATTCTCAATCC -3'
(R):5'- CAGACATTGTGGCATAACAAGAATGGC -3'

Sequencing Primer
(F):5'- AATGGCATTCTCAATCCCTTGG -3'
(R):5'- CTGCCTGAGTGAGGAAAATGTTC -3'

Posted On

2014-04-13