Incidental Mutation 'R1534:Or5w22'
ID 166804
Institutional Source Beutler Lab
Gene Symbol Or5w22
Ensembl Gene ENSMUSG00000061520
Gene Name olfactory receptor family 5 subfamily W member 22
Synonyms Olfr4-2, V5, GA_x6K02T2Q125-49033418-49034341, MOR177-5, Olfr153
MMRRC Submission 039573-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R1534 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87362379-87363302 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87363016 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 213 (V213D)
Ref Sequence ENSEMBL: ENSMUSP00000149859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077471] [ENSMUST00000217113]
AlphaFold Q7TR48
Predicted Effect probably damaging
Transcript: ENSMUST00000077471
AA Change: V213D

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076681
Gene: ENSMUSG00000075151
AA Change: V213D

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 6e-48 PFAM
Pfam:7tm_1 40 289 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217113
AA Change: V213D

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Meta Mutation Damage Score 0.2896 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy10 T C 1: 165,345,881 (GRCm39) I310T probably damaging Het
Adcy5 T C 16: 35,073,629 (GRCm39) V469A possibly damaging Het
Agrn C T 4: 156,261,141 (GRCm39) C652Y probably damaging Het
Ankfn1 C T 11: 89,413,977 (GRCm39) V133M probably damaging Het
Ankrd13c A G 3: 157,706,757 (GRCm39) T448A probably benign Het
Atp8b1 C T 18: 64,678,335 (GRCm39) V854M probably damaging Het
B4galt2 T C 4: 117,734,669 (GRCm39) H233R probably damaging Het
Bpifb5 T G 2: 154,071,419 (GRCm39) Y249D possibly damaging Het
Brd1 T C 15: 88,573,866 (GRCm39) I1078V possibly damaging Het
Celsr3 A G 9: 108,726,083 (GRCm39) E3104G probably damaging Het
Cyp2c69 T A 19: 39,839,593 (GRCm39) K343N probably benign Het
Cyp4f18 T A 8: 72,746,799 (GRCm39) D331V probably damaging Het
D130040H23Rik T C 8: 69,755,378 (GRCm39) V261A possibly damaging Het
Dchs1 T C 7: 105,421,247 (GRCm39) D391G probably damaging Het
Diaph1 A G 18: 38,029,146 (GRCm39) probably null Het
Fat4 T C 3: 38,944,238 (GRCm39) F1044L probably damaging Het
Frrs1 A T 3: 116,672,057 (GRCm39) T52S probably benign Het
Gan G A 8: 117,914,168 (GRCm39) V189I probably benign Het
Hnf1b A G 11: 83,784,409 (GRCm39) probably benign Het
Itgae T C 11: 73,036,431 (GRCm39) I1123T possibly damaging Het
Klra3 G C 6: 130,310,107 (GRCm39) R138G probably benign Het
Lrrc18 A G 14: 32,730,478 (GRCm39) K6E possibly damaging Het
Map2 G A 1: 66,452,339 (GRCm39) V492I probably benign Het
Mtr A T 13: 12,250,430 (GRCm39) probably benign Het
Ncor1 G T 11: 62,269,330 (GRCm39) A689E possibly damaging Het
Or52n2c G A 7: 104,574,621 (GRCm39) L117F possibly damaging Het
Palm T G 10: 79,652,737 (GRCm39) V42G probably damaging Het
Pcm1 G A 8: 41,740,738 (GRCm39) V995I probably benign Het
Pfkp A G 13: 6,669,574 (GRCm39) V215A probably damaging Het
Prkg2 T C 5: 99,142,420 (GRCm39) Y238C probably damaging Het
Prr14 C T 7: 127,073,154 (GRCm39) A167V probably benign Het
Ptprn A C 1: 75,234,587 (GRCm39) probably null Het
Rexo2 A T 9: 48,380,190 (GRCm39) I214N probably damaging Het
Rrbp1 A G 2: 143,830,233 (GRCm39) S645P probably damaging Het
Rsf1 G GACGGCGGCA 7: 97,229,116 (GRCm39) probably benign Het
Satb2 A T 1: 56,987,392 (GRCm39) C64* probably null Het
Sez6 A G 11: 77,853,871 (GRCm39) Y347C probably damaging Het
Sos2 A G 12: 69,663,729 (GRCm39) I585T probably damaging Het
Spg11 G A 2: 121,922,806 (GRCm39) T881M probably damaging Het
Tiam1 A T 16: 89,664,396 (GRCm39) probably null Het
Tlcd5 A G 9: 43,022,923 (GRCm39) W126R probably damaging Het
Top1 T C 2: 160,556,152 (GRCm39) I537T probably damaging Het
Trappc6a A G 7: 19,248,138 (GRCm39) S33G probably benign Het
Tspan11 G C 6: 127,926,768 (GRCm39) V239L probably benign Het
Ubr4 T C 4: 139,155,462 (GRCm39) V2190A possibly damaging Het
Usp28 A G 9: 48,896,806 (GRCm39) D9G possibly damaging Het
Uty A G Y: 1,245,440 (GRCm39) V35A probably benign Het
Vmn2r56 A G 7: 12,427,954 (GRCm39) S771P probably benign Het
Wars2 C T 3: 99,124,177 (GRCm39) A346V probably damaging Het
Wdr87-ps G T 7: 29,229,854 (GRCm39) noncoding transcript Het
Zfp142 G T 1: 74,611,247 (GRCm39) N849K probably benign Het
Zfp180 A T 7: 23,800,948 (GRCm39) N66I probably benign Het
Other mutations in Or5w22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01320:Or5w22 APN 2 87,362,629 (GRCm39) missense probably benign 0.01
IGL02102:Or5w22 APN 2 87,362,805 (GRCm39) missense probably benign
IGL02604:Or5w22 APN 2 87,362,949 (GRCm39) missense probably damaging 0.98
IGL02695:Or5w22 APN 2 87,362,461 (GRCm39) missense probably benign 0.00
IGL02961:Or5w22 APN 2 87,363,028 (GRCm39) missense probably damaging 0.98
PIT4696001:Or5w22 UTSW 2 87,363,124 (GRCm39) missense probably damaging 1.00
R0727:Or5w22 UTSW 2 87,363,245 (GRCm39) nonsense probably null
R1699:Or5w22 UTSW 2 87,362,427 (GRCm39) missense probably benign 0.07
R1885:Or5w22 UTSW 2 87,363,168 (GRCm39) missense probably damaging 0.99
R3705:Or5w22 UTSW 2 87,362,412 (GRCm39) missense probably benign 0.01
R5664:Or5w22 UTSW 2 87,363,178 (GRCm39) missense probably benign 0.35
R6492:Or5w22 UTSW 2 87,363,085 (GRCm39) missense possibly damaging 0.66
R6808:Or5w22 UTSW 2 87,363,285 (GRCm39) missense probably benign
R7432:Or5w22 UTSW 2 87,362,784 (GRCm39) missense probably damaging 1.00
R7477:Or5w22 UTSW 2 87,362,431 (GRCm39) missense probably benign 0.00
R8014:Or5w22 UTSW 2 87,362,508 (GRCm39) missense probably benign 0.13
R8345:Or5w22 UTSW 2 87,362,691 (GRCm39) missense probably benign 0.01
R8887:Or5w22 UTSW 2 87,363,187 (GRCm39) missense possibly damaging 0.95
R8971:Or5w22 UTSW 2 87,362,580 (GRCm39) missense probably benign 0.19
R9311:Or5w22 UTSW 2 87,362,358 (GRCm39) start gained probably benign
R9690:Or5w22 UTSW 2 87,362,759 (GRCm39) missense probably benign 0.03
X0028:Or5w22 UTSW 2 87,362,383 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCTGGTGGGAACATCAGATGCTTTG -3'
(R):5'- AGACTACGCCTTGCTCTGTTATGC -3'

Sequencing Primer
(F):5'- GATACATACAACTTTGGCATTCCG -3'
(R):5'- tcacaatttcaaagccagcc -3'
Posted On 2014-04-13