Incidental Mutation 'R1534:Tiam1'
ID 166848
Institutional Source Beutler Lab
Gene Symbol Tiam1
Ensembl Gene ENSMUSG00000002489
Gene Name T cell lymphoma invasion and metastasis 1
Synonyms D16Ium10, D16Ium10e
MMRRC Submission 039573-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1534 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 89583999-89940657 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 89664396 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002588] [ENSMUST00000114124] [ENSMUST00000163370]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000002588
SMART Domains Protein: ENSMUSP00000002588
Gene: ENSMUSG00000002489

DomainStartEndE-ValueType
low complexity region 52 67 N/A INTRINSIC
low complexity region 178 189 N/A INTRINSIC
low complexity region 367 377 N/A INTRINSIC
PH 434 549 1.32e-13 SMART
low complexity region 573 586 N/A INTRINSIC
low complexity region 683 695 N/A INTRINSIC
RBD 765 832 1.76e-22 SMART
PDZ 856 928 1.15e-5 SMART
low complexity region 1013 1028 N/A INTRINSIC
RhoGEF 1044 1233 1.42e-63 SMART
PH 1262 1397 9.58e-2 SMART
low complexity region 1445 1454 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000114124
SMART Domains Protein: ENSMUSP00000109759
Gene: ENSMUSG00000002489

DomainStartEndE-ValueType
low complexity region 52 67 N/A INTRINSIC
low complexity region 178 189 N/A INTRINSIC
low complexity region 367 377 N/A INTRINSIC
PH 434 549 1.32e-13 SMART
low complexity region 573 586 N/A INTRINSIC
low complexity region 683 695 N/A INTRINSIC
RBD 765 832 1.76e-22 SMART
PDZ 856 928 1.15e-5 SMART
low complexity region 1013 1028 N/A INTRINSIC
RhoGEF 1044 1233 1.42e-63 SMART
PH 1262 1397 9.58e-2 SMART
low complexity region 1445 1454 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000163370
SMART Domains Protein: ENSMUSP00000132137
Gene: ENSMUSG00000002489

DomainStartEndE-ValueType
low complexity region 52 67 N/A INTRINSIC
low complexity region 178 189 N/A INTRINSIC
low complexity region 367 377 N/A INTRINSIC
PH 434 549 1.32e-13 SMART
low complexity region 573 586 N/A INTRINSIC
low complexity region 683 695 N/A INTRINSIC
RBD 765 832 1.76e-22 SMART
PDZ 856 928 1.15e-5 SMART
low complexity region 1013 1028 N/A INTRINSIC
RhoGEF 1044 1233 1.42e-63 SMART
PH 1262 1397 9.58e-2 SMART
low complexity region 1445 1454 N/A INTRINSIC
Meta Mutation Damage Score 0.9498 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency 98% (52/53)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null allele display resistance to chemically-induced tumors, however, tumors that do develop progress to malignancy. Mice homozygous for a gene trap allele display anencephaly, exencephaly and/or neural tube defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy10 T C 1: 165,345,881 (GRCm39) I310T probably damaging Het
Adcy5 T C 16: 35,073,629 (GRCm39) V469A possibly damaging Het
Agrn C T 4: 156,261,141 (GRCm39) C652Y probably damaging Het
Ankfn1 C T 11: 89,413,977 (GRCm39) V133M probably damaging Het
Ankrd13c A G 3: 157,706,757 (GRCm39) T448A probably benign Het
Atp8b1 C T 18: 64,678,335 (GRCm39) V854M probably damaging Het
B4galt2 T C 4: 117,734,669 (GRCm39) H233R probably damaging Het
Bpifb5 T G 2: 154,071,419 (GRCm39) Y249D possibly damaging Het
Brd1 T C 15: 88,573,866 (GRCm39) I1078V possibly damaging Het
Celsr3 A G 9: 108,726,083 (GRCm39) E3104G probably damaging Het
Cyp2c69 T A 19: 39,839,593 (GRCm39) K343N probably benign Het
Cyp4f18 T A 8: 72,746,799 (GRCm39) D331V probably damaging Het
D130040H23Rik T C 8: 69,755,378 (GRCm39) V261A possibly damaging Het
Dchs1 T C 7: 105,421,247 (GRCm39) D391G probably damaging Het
Diaph1 A G 18: 38,029,146 (GRCm39) probably null Het
Fat4 T C 3: 38,944,238 (GRCm39) F1044L probably damaging Het
Frrs1 A T 3: 116,672,057 (GRCm39) T52S probably benign Het
Gan G A 8: 117,914,168 (GRCm39) V189I probably benign Het
Hnf1b A G 11: 83,784,409 (GRCm39) probably benign Het
Itgae T C 11: 73,036,431 (GRCm39) I1123T possibly damaging Het
Klra3 G C 6: 130,310,107 (GRCm39) R138G probably benign Het
Lrrc18 A G 14: 32,730,478 (GRCm39) K6E possibly damaging Het
Map2 G A 1: 66,452,339 (GRCm39) V492I probably benign Het
Mtr A T 13: 12,250,430 (GRCm39) probably benign Het
Ncor1 G T 11: 62,269,330 (GRCm39) A689E possibly damaging Het
Or52n2c G A 7: 104,574,621 (GRCm39) L117F possibly damaging Het
Or5w22 T A 2: 87,363,016 (GRCm39) V213D probably damaging Het
Palm T G 10: 79,652,737 (GRCm39) V42G probably damaging Het
Pcm1 G A 8: 41,740,738 (GRCm39) V995I probably benign Het
Pfkp A G 13: 6,669,574 (GRCm39) V215A probably damaging Het
Prkg2 T C 5: 99,142,420 (GRCm39) Y238C probably damaging Het
Prr14 C T 7: 127,073,154 (GRCm39) A167V probably benign Het
Ptprn A C 1: 75,234,587 (GRCm39) probably null Het
Rexo2 A T 9: 48,380,190 (GRCm39) I214N probably damaging Het
Rrbp1 A G 2: 143,830,233 (GRCm39) S645P probably damaging Het
Rsf1 G GACGGCGGCA 7: 97,229,116 (GRCm39) probably benign Het
Satb2 A T 1: 56,987,392 (GRCm39) C64* probably null Het
Sez6 A G 11: 77,853,871 (GRCm39) Y347C probably damaging Het
Sos2 A G 12: 69,663,729 (GRCm39) I585T probably damaging Het
Spg11 G A 2: 121,922,806 (GRCm39) T881M probably damaging Het
Tlcd5 A G 9: 43,022,923 (GRCm39) W126R probably damaging Het
Top1 T C 2: 160,556,152 (GRCm39) I537T probably damaging Het
Trappc6a A G 7: 19,248,138 (GRCm39) S33G probably benign Het
Tspan11 G C 6: 127,926,768 (GRCm39) V239L probably benign Het
Ubr4 T C 4: 139,155,462 (GRCm39) V2190A possibly damaging Het
Usp28 A G 9: 48,896,806 (GRCm39) D9G possibly damaging Het
Uty A G Y: 1,245,440 (GRCm39) V35A probably benign Het
Vmn2r56 A G 7: 12,427,954 (GRCm39) S771P probably benign Het
Wars2 C T 3: 99,124,177 (GRCm39) A346V probably damaging Het
Wdr87-ps G T 7: 29,229,854 (GRCm39) noncoding transcript Het
Zfp142 G T 1: 74,611,247 (GRCm39) N849K probably benign Het
Zfp180 A T 7: 23,800,948 (GRCm39) N66I probably benign Het
Other mutations in Tiam1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00929:Tiam1 APN 16 89,591,627 (GRCm39) missense probably damaging 1.00
IGL01356:Tiam1 APN 16 89,634,676 (GRCm39) missense probably damaging 0.99
IGL01583:Tiam1 APN 16 89,586,168 (GRCm39) missense probably damaging 1.00
IGL01626:Tiam1 APN 16 89,609,856 (GRCm39) missense probably damaging 1.00
IGL01802:Tiam1 APN 16 89,695,260 (GRCm39) missense possibly damaging 0.94
IGL01818:Tiam1 APN 16 89,664,592 (GRCm39) missense probably damaging 1.00
IGL02146:Tiam1 APN 16 89,646,569 (GRCm39) missense probably benign 0.20
IGL02329:Tiam1 APN 16 89,596,924 (GRCm39) missense probably benign 0.08
IGL02341:Tiam1 APN 16 89,695,257 (GRCm39) missense probably damaging 1.00
IGL02622:Tiam1 APN 16 89,595,588 (GRCm39) missense possibly damaging 0.59
F5770:Tiam1 UTSW 16 89,662,159 (GRCm39) missense probably damaging 1.00
PIT4515001:Tiam1 UTSW 16 89,657,130 (GRCm39) missense probably damaging 0.99
R0130:Tiam1 UTSW 16 89,694,642 (GRCm39) missense probably benign 0.01
R0143:Tiam1 UTSW 16 89,695,088 (GRCm39) missense probably benign 0.01
R0158:Tiam1 UTSW 16 89,589,889 (GRCm39) critical splice donor site probably benign
R0413:Tiam1 UTSW 16 89,606,253 (GRCm39) splice site probably benign
R0449:Tiam1 UTSW 16 89,634,715 (GRCm39) missense possibly damaging 0.75
R0520:Tiam1 UTSW 16 89,614,839 (GRCm39) splice site probably benign
R0667:Tiam1 UTSW 16 89,694,872 (GRCm39) missense probably damaging 1.00
R0787:Tiam1 UTSW 16 89,586,449 (GRCm39) missense probably damaging 1.00
R1355:Tiam1 UTSW 16 89,695,109 (GRCm39) missense probably benign 0.09
R1370:Tiam1 UTSW 16 89,695,109 (GRCm39) missense probably benign 0.09
R1769:Tiam1 UTSW 16 89,657,167 (GRCm39) missense probably damaging 1.00
R1831:Tiam1 UTSW 16 89,657,182 (GRCm39) missense probably benign 0.01
R1913:Tiam1 UTSW 16 89,595,582 (GRCm39) missense probably damaging 1.00
R2022:Tiam1 UTSW 16 89,674,075 (GRCm39) missense probably benign
R2140:Tiam1 UTSW 16 89,646,533 (GRCm39) splice site probably benign
R2383:Tiam1 UTSW 16 89,595,572 (GRCm39) missense probably benign 0.29
R2697:Tiam1 UTSW 16 89,590,052 (GRCm39) missense probably benign 0.00
R4118:Tiam1 UTSW 16 89,673,921 (GRCm39) splice site probably null
R4327:Tiam1 UTSW 16 89,652,779 (GRCm39) missense possibly damaging 0.80
R4693:Tiam1 UTSW 16 89,640,170 (GRCm39) missense possibly damaging 0.87
R5104:Tiam1 UTSW 16 89,614,929 (GRCm39) missense probably benign 0.00
R5412:Tiam1 UTSW 16 89,681,753 (GRCm39) missense possibly damaging 0.52
R5426:Tiam1 UTSW 16 89,662,280 (GRCm39) missense possibly damaging 0.58
R5600:Tiam1 UTSW 16 89,662,253 (GRCm39) missense probably damaging 1.00
R5842:Tiam1 UTSW 16 89,652,887 (GRCm39) missense probably benign
R5986:Tiam1 UTSW 16 89,586,074 (GRCm39) missense probably benign 0.31
R6077:Tiam1 UTSW 16 89,594,918 (GRCm39) critical splice donor site probably null
R6419:Tiam1 UTSW 16 89,694,912 (GRCm39) nonsense probably null
R6525:Tiam1 UTSW 16 89,655,485 (GRCm39) critical splice donor site probably null
R6950:Tiam1 UTSW 16 89,657,092 (GRCm39) critical splice donor site probably null
R7127:Tiam1 UTSW 16 89,657,148 (GRCm39) missense probably damaging 1.00
R7197:Tiam1 UTSW 16 89,681,826 (GRCm39) missense probably damaging 1.00
R7249:Tiam1 UTSW 16 89,640,143 (GRCm39) missense probably damaging 1.00
R7490:Tiam1 UTSW 16 89,695,083 (GRCm39) missense probably benign 0.01
R7825:Tiam1 UTSW 16 89,694,977 (GRCm39) missense probably benign 0.07
R8047:Tiam1 UTSW 16 89,694,672 (GRCm39) missense probably benign 0.00
R8069:Tiam1 UTSW 16 89,586,146 (GRCm39) missense probably benign
R8247:Tiam1 UTSW 16 89,695,037 (GRCm39) missense probably benign 0.26
R8490:Tiam1 UTSW 16 89,681,932 (GRCm39) missense probably damaging 0.99
R8678:Tiam1 UTSW 16 89,681,709 (GRCm39) nonsense probably null
R8690:Tiam1 UTSW 16 89,694,900 (GRCm39) missense probably damaging 1.00
R8839:Tiam1 UTSW 16 89,681,827 (GRCm39) missense probably damaging 1.00
R8857:Tiam1 UTSW 16 89,662,145 (GRCm39) missense probably damaging 0.97
R8935:Tiam1 UTSW 16 89,681,821 (GRCm39) missense probably damaging 1.00
R8972:Tiam1 UTSW 16 89,609,894 (GRCm39) missense probably damaging 1.00
R9047:Tiam1 UTSW 16 89,601,776 (GRCm39) intron probably benign
R9131:Tiam1 UTSW 16 89,657,155 (GRCm39) missense probably damaging 1.00
R9229:Tiam1 UTSW 16 89,634,719 (GRCm39) missense possibly damaging 0.94
R9383:Tiam1 UTSW 16 89,655,561 (GRCm39) missense probably damaging 1.00
R9431:Tiam1 UTSW 16 89,594,918 (GRCm39) critical splice donor site probably null
R9519:Tiam1 UTSW 16 89,608,822 (GRCm39) missense probably benign 0.06
R9567:Tiam1 UTSW 16 89,591,653 (GRCm39) missense probably damaging 1.00
R9656:Tiam1 UTSW 16 89,664,459 (GRCm39) missense probably damaging 1.00
R9714:Tiam1 UTSW 16 89,694,647 (GRCm39) missense probably benign 0.00
R9750:Tiam1 UTSW 16 89,695,394 (GRCm39) missense probably damaging 1.00
V7582:Tiam1 UTSW 16 89,662,159 (GRCm39) missense probably damaging 1.00
Z1176:Tiam1 UTSW 16 89,662,163 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGGCACAGATTCCCCTGGAAAC -3'
(R):5'- ACAGAGCTGGAGAACTGGATCACC -3'

Sequencing Primer
(F):5'- AAGGATTCGGAAGGCCCTC -3'
(R):5'- GAACTGGATCACCGCCATC -3'
Posted On 2014-04-13