Incidental Mutation 'R1521:Ncoa6'
| ID |
166952 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ncoa6
|
| Ensembl Gene |
ENSMUSG00000038369 |
| Gene Name |
nuclear receptor coactivator 6 |
| Synonyms |
ASC-2, RAP250, NRC, AIB3, ASC2, PRIP |
| MMRRC Submission |
040870-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1521 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
155232585-155315741 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 155257142 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Arginine
at position 800
(S800R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118113
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043126]
[ENSMUST00000109670]
[ENSMUST00000123293]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000043126
AA Change: S800R
PolyPhen 2
Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000045386
Gene: ENSMUSG00000038369
AA Change: S800R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
47 |
190 |
3.3e-55 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109670
AA Change: S800R
PolyPhen 2
Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000105295
Gene: ENSMUSG00000038369
AA Change: S800R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
3.6e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000123293
AA Change: S800R
PolyPhen 2
Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000118113
Gene: ENSMUSG00000038369
AA Change: S800R
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
2.4e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
low complexity region
|
564 |
573 |
N/A |
INTRINSIC |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141928
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adat1 |
A |
G |
8: 112,713,867 (GRCm39) |
L104P |
possibly damaging |
Het |
| Adgrf5 |
T |
C |
17: 43,741,443 (GRCm39) |
V360A |
probably benign |
Het |
| Ahnak |
G |
A |
19: 8,982,092 (GRCm39) |
M1125I |
probably benign |
Het |
| Akap12 |
T |
C |
10: 4,304,804 (GRCm39) |
V538A |
probably benign |
Het |
| Arhgef10l |
T |
C |
4: 140,242,749 (GRCm39) |
D1088G |
possibly damaging |
Het |
| Atp7b |
A |
T |
8: 22,517,689 (GRCm39) |
L268Q |
probably damaging |
Het |
| Atxn2 |
A |
C |
5: 121,917,654 (GRCm39) |
N516T |
probably damaging |
Het |
| Cacna1h |
T |
C |
17: 25,616,328 (GRCm39) |
M184V |
possibly damaging |
Het |
| Cacnb2 |
G |
T |
2: 14,619,163 (GRCm39) |
R66L |
probably benign |
Het |
| Casp8ap2 |
A |
G |
4: 32,631,867 (GRCm39) |
E96G |
probably damaging |
Het |
| Ccdc78 |
G |
T |
17: 26,007,755 (GRCm39) |
R264L |
probably damaging |
Het |
| Cdh4 |
G |
A |
2: 179,439,351 (GRCm39) |
R166H |
probably damaging |
Het |
| Cog7 |
C |
T |
7: 121,529,797 (GRCm39) |
D615N |
possibly damaging |
Het |
| Crtc2 |
T |
C |
3: 90,164,690 (GRCm39) |
V115A |
probably benign |
Het |
| Crybg1 |
A |
G |
10: 43,874,412 (GRCm39) |
S899P |
probably damaging |
Het |
| Ctdnep1 |
T |
A |
11: 69,879,461 (GRCm39) |
V128E |
probably damaging |
Het |
| Ctnna3 |
A |
G |
10: 64,795,621 (GRCm39) |
K780E |
probably benign |
Het |
| Cul7 |
T |
A |
17: 46,974,116 (GRCm39) |
L1467H |
probably damaging |
Het |
| Dazap2 |
T |
A |
15: 100,515,946 (GRCm39) |
Y91* |
probably null |
Het |
| Dcdc5 |
T |
C |
2: 106,182,014 (GRCm39) |
|
noncoding transcript |
Het |
| Dppa1 |
T |
A |
11: 46,501,300 (GRCm39) |
R74S |
possibly damaging |
Het |
| Elovl1 |
A |
T |
4: 118,289,197 (GRCm39) |
T241S |
probably benign |
Het |
| Eya1 |
G |
T |
1: 14,344,774 (GRCm39) |
Q86K |
probably damaging |
Het |
| Fam110d |
T |
C |
4: 133,978,661 (GRCm39) |
*272W |
probably null |
Het |
| Fancm |
A |
T |
12: 65,168,478 (GRCm39) |
M1614L |
probably benign |
Het |
| Fcgbp |
C |
T |
7: 27,774,585 (GRCm39) |
T53I |
probably benign |
Het |
| Fpr3 |
T |
A |
17: 18,191,277 (GRCm39) |
W183R |
probably damaging |
Het |
| Galnt13 |
G |
A |
2: 54,744,657 (GRCm39) |
V119I |
probably benign |
Het |
| Garin4 |
T |
A |
1: 190,896,219 (GRCm39) |
R141S |
probably benign |
Het |
| Gcfc2 |
T |
C |
6: 81,900,793 (GRCm39) |
S36P |
probably benign |
Het |
| Gdap2 |
T |
A |
3: 100,101,931 (GRCm39) |
D412E |
possibly damaging |
Het |
| Gm12258 |
T |
C |
11: 58,750,381 (GRCm39) |
C41R |
probably damaging |
Het |
| Hipk1 |
T |
G |
3: 103,685,098 (GRCm39) |
E172D |
probably benign |
Het |
| Hmgcs1 |
T |
G |
13: 120,165,127 (GRCm39) |
L326R |
probably benign |
Het |
| Hs6st1 |
C |
A |
1: 36,107,967 (GRCm39) |
R77S |
probably damaging |
Het |
| Ifit3 |
A |
T |
19: 34,564,573 (GRCm39) |
N40Y |
probably damaging |
Het |
| Il1a |
T |
A |
2: 129,146,661 (GRCm39) |
Q144L |
possibly damaging |
Het |
| Itga7 |
A |
G |
10: 128,793,680 (GRCm39) |
E1128G |
possibly damaging |
Het |
| Itih2 |
T |
C |
2: 10,111,558 (GRCm39) |
D460G |
probably damaging |
Het |
| Ivns1abp |
G |
A |
1: 151,227,309 (GRCm39) |
C39Y |
probably damaging |
Het |
| Kif22 |
G |
T |
7: 126,627,011 (GRCm39) |
A646E |
probably damaging |
Het |
| Klhl29 |
T |
C |
12: 5,141,307 (GRCm39) |
Y559C |
probably damaging |
Het |
| Klhl7 |
T |
A |
5: 24,354,108 (GRCm39) |
|
probably null |
Het |
| Klhl9 |
A |
G |
4: 88,640,230 (GRCm39) |
S4P |
probably benign |
Het |
| Klk10 |
A |
G |
7: 43,432,304 (GRCm39) |
Q79R |
probably benign |
Het |
| Klk6 |
T |
C |
7: 43,478,699 (GRCm39) |
|
probably null |
Het |
| Kpna2rt |
T |
A |
17: 90,217,734 (GRCm39) |
N4I |
possibly damaging |
Het |
| Lamc2 |
C |
T |
1: 153,042,009 (GRCm39) |
E42K |
probably benign |
Het |
| Lingo3 |
T |
C |
10: 80,671,555 (GRCm39) |
D125G |
probably benign |
Het |
| Map1b |
T |
C |
13: 99,569,247 (GRCm39) |
N1158S |
unknown |
Het |
| Masp1 |
T |
A |
16: 23,313,387 (GRCm39) |
N183Y |
probably damaging |
Het |
| Mdga2 |
A |
G |
12: 66,615,700 (GRCm39) |
Y636H |
probably benign |
Het |
| Mical2 |
T |
A |
7: 111,980,817 (GRCm39) |
S264T |
probably damaging |
Het |
| Mif |
A |
G |
10: 75,695,375 (GRCm39) |
V95A |
possibly damaging |
Het |
| Mmp17 |
G |
A |
5: 129,672,152 (GRCm39) |
|
probably null |
Het |
| Mmp23 |
T |
C |
4: 155,735,174 (GRCm39) |
R390G |
possibly damaging |
Het |
| Nfix |
G |
A |
8: 85,453,155 (GRCm39) |
R300C |
probably damaging |
Het |
| Nr2e3 |
A |
T |
9: 59,856,488 (GRCm39) |
S67R |
probably damaging |
Het |
| Odf2l |
T |
C |
3: 144,854,797 (GRCm39) |
S545P |
possibly damaging |
Het |
| Or10d3 |
A |
T |
9: 39,462,080 (GRCm39) |
V29E |
possibly damaging |
Het |
| Or4a47 |
G |
A |
2: 89,665,516 (GRCm39) |
R258* |
probably null |
Het |
| Or52s1b |
T |
A |
7: 102,822,658 (GRCm39) |
Y62F |
probably benign |
Het |
| Or5k1b |
C |
T |
16: 58,581,216 (GRCm39) |
E108K |
probably damaging |
Het |
| Or7e176 |
A |
C |
9: 20,171,728 (GRCm39) |
Q197H |
possibly damaging |
Het |
| Or7g27 |
C |
T |
9: 19,249,948 (GRCm39) |
S64F |
probably benign |
Het |
| Or8b51 |
T |
G |
9: 38,569,014 (GRCm39) |
I225L |
probably damaging |
Het |
| Otog |
A |
T |
7: 45,908,688 (GRCm39) |
H562L |
possibly damaging |
Het |
| Pcdh15 |
T |
C |
10: 74,430,023 (GRCm39) |
V1250A |
probably damaging |
Het |
| Pde1c |
A |
G |
6: 56,150,592 (GRCm39) |
V309A |
possibly damaging |
Het |
| Pfkfb4 |
A |
C |
9: 108,836,373 (GRCm39) |
T134P |
probably damaging |
Het |
| Phc3 |
G |
T |
3: 30,990,724 (GRCm39) |
Q498K |
possibly damaging |
Het |
| Phlpp1 |
T |
C |
1: 106,320,049 (GRCm39) |
V1348A |
probably damaging |
Het |
| Pik3ap1 |
T |
C |
19: 41,309,997 (GRCm39) |
D441G |
probably damaging |
Het |
| Pkd1l2 |
T |
C |
8: 117,792,239 (GRCm39) |
|
probably null |
Het |
| Pla2g4a |
T |
C |
1: 149,733,437 (GRCm39) |
|
probably null |
Het |
| Pola2 |
A |
T |
19: 5,998,434 (GRCm39) |
I376N |
probably damaging |
Het |
| Pold2 |
T |
A |
11: 5,826,833 (GRCm39) |
N34Y |
probably damaging |
Het |
| Ppp2r5c |
T |
C |
12: 110,521,320 (GRCm39) |
L281P |
probably damaging |
Het |
| Prss46 |
A |
G |
9: 110,678,703 (GRCm39) |
I29V |
probably benign |
Het |
| Ranbp6 |
A |
T |
19: 29,788,846 (GRCm39) |
V502E |
probably benign |
Het |
| Rdh14 |
T |
C |
12: 10,444,613 (GRCm39) |
F155L |
probably damaging |
Het |
| Rnaseh2a |
A |
T |
8: 85,692,487 (GRCm39) |
|
probably null |
Het |
| Rpp30 |
A |
G |
19: 36,071,785 (GRCm39) |
T118A |
possibly damaging |
Het |
| Rragd |
T |
C |
4: 32,996,005 (GRCm39) |
F117L |
probably damaging |
Het |
| Rxylt1 |
A |
G |
10: 121,926,384 (GRCm39) |
W243R |
probably damaging |
Het |
| S100a2 |
T |
A |
3: 90,498,599 (GRCm39) |
|
probably null |
Het |
| Septin12 |
T |
C |
16: 4,814,340 (GRCm39) |
K43R |
probably damaging |
Het |
| Sh3tc2 |
A |
G |
18: 62,141,559 (GRCm39) |
E1080G |
probably damaging |
Het |
| Slc26a9 |
A |
G |
1: 131,678,415 (GRCm39) |
K27R |
probably damaging |
Het |
| Spata17 |
T |
A |
1: 186,926,191 (GRCm39) |
K46N |
probably damaging |
Het |
| St14 |
A |
C |
9: 31,019,511 (GRCm39) |
D103E |
probably benign |
Het |
| St6galnac2 |
T |
A |
11: 116,575,173 (GRCm39) |
Q222L |
possibly damaging |
Het |
| Tdrd9 |
T |
C |
12: 112,002,844 (GRCm39) |
V831A |
probably damaging |
Het |
| Tert |
A |
G |
13: 73,790,175 (GRCm39) |
E843G |
probably damaging |
Het |
| Tex21 |
A |
G |
12: 76,251,044 (GRCm39) |
V464A |
probably benign |
Het |
| Tmem232 |
T |
A |
17: 65,791,496 (GRCm39) |
H124L |
probably damaging |
Het |
| Tnfrsf19 |
T |
G |
14: 61,242,555 (GRCm39) |
S110R |
probably damaging |
Het |
| Tnnt3 |
A |
T |
7: 142,069,562 (GRCm39) |
K272* |
probably null |
Het |
| Tnxb |
T |
C |
17: 34,930,477 (GRCm39) |
L2054P |
probably damaging |
Het |
| Trcg1 |
A |
C |
9: 57,149,748 (GRCm39) |
D440A |
probably benign |
Het |
| Trpm3 |
A |
G |
19: 22,878,585 (GRCm39) |
E504G |
probably damaging |
Het |
| Trpm5 |
C |
T |
7: 142,636,626 (GRCm39) |
R437H |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,571,511 (GRCm39) |
R18134G |
probably damaging |
Het |
| Uchl5 |
A |
C |
1: 143,674,160 (GRCm39) |
M64L |
possibly damaging |
Het |
| Urb1 |
G |
A |
16: 90,550,751 (GRCm39) |
R2034W |
probably damaging |
Het |
| Usp44 |
T |
A |
10: 93,683,048 (GRCm39) |
C452* |
probably null |
Het |
| Uvssa |
G |
A |
5: 33,571,278 (GRCm39) |
A641T |
probably damaging |
Het |
| Vmn1r204 |
T |
A |
13: 22,741,248 (GRCm39) |
I293N |
probably benign |
Het |
| Vmn2r84 |
A |
T |
10: 130,225,137 (GRCm39) |
C458S |
probably benign |
Het |
| Vmn2r85 |
T |
G |
10: 130,261,788 (GRCm39) |
H183P |
probably damaging |
Het |
| Vps13d |
G |
T |
4: 144,832,431 (GRCm39) |
T2825K |
probably benign |
Het |
| Zc3hc1 |
T |
A |
6: 30,376,024 (GRCm39) |
I179F |
probably benign |
Het |
| Zfp112 |
A |
G |
7: 23,825,210 (GRCm39) |
N393D |
probably damaging |
Het |
| Zfp558 |
A |
G |
9: 18,367,859 (GRCm39) |
S310P |
possibly damaging |
Het |
| Zfp560 |
A |
C |
9: 20,260,071 (GRCm39) |
|
probably null |
Het |
| Zfp668 |
C |
T |
7: 127,466,252 (GRCm39) |
E311K |
probably benign |
Het |
| Zfp763 |
T |
A |
17: 33,252,276 (GRCm39) |
M1L |
probably benign |
Het |
| Zfp947 |
A |
T |
17: 22,364,813 (GRCm39) |
M287K |
probably benign |
Het |
|
| Other mutations in Ncoa6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00484:Ncoa6
|
APN |
2 |
155,248,128 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00849:Ncoa6
|
APN |
2 |
155,263,608 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00933:Ncoa6
|
APN |
2 |
155,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00981:Ncoa6
|
APN |
2 |
155,248,099 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01420:Ncoa6
|
APN |
2 |
155,249,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ncoa6
|
APN |
2 |
155,263,003 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL03049:Ncoa6
|
APN |
2 |
155,260,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03194:Ncoa6
|
APN |
2 |
155,257,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03269:Ncoa6
|
APN |
2 |
155,248,409 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03299:Ncoa6
|
APN |
2 |
155,249,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03306:Ncoa6
|
APN |
2 |
155,247,427 (GRCm39) |
missense |
probably benign |
0.30 |
|
alcoa
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
Aluminum
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
balboa
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
mauna_loa
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4466001:Ncoa6
|
UTSW |
2 |
155,247,577 (GRCm39) |
missense |
probably benign |
|
|
R0011:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0014:Ncoa6
|
UTSW |
2 |
155,279,963 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0079:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0080:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0081:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0164:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0166:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0172:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0173:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0245:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0285:Ncoa6
|
UTSW |
2 |
155,257,621 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0285:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0288:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0539:Ncoa6
|
UTSW |
2 |
155,257,617 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0652:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0781:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1053:Ncoa6
|
UTSW |
2 |
155,275,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1110:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1420:Ncoa6
|
UTSW |
2 |
155,263,073 (GRCm39) |
nonsense |
probably null |
|
|
R1541:Ncoa6
|
UTSW |
2 |
155,257,224 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1677:Ncoa6
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
R1858:Ncoa6
|
UTSW |
2 |
155,263,559 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1954:Ncoa6
|
UTSW |
2 |
155,248,741 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1955:Ncoa6
|
UTSW |
2 |
155,248,741 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2040:Ncoa6
|
UTSW |
2 |
155,248,000 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2087:Ncoa6
|
UTSW |
2 |
155,248,079 (GRCm39) |
nonsense |
probably null |
|
|
R2159:Ncoa6
|
UTSW |
2 |
155,249,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Ncoa6
|
UTSW |
2 |
155,249,570 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2696:Ncoa6
|
UTSW |
2 |
155,279,935 (GRCm39) |
missense |
probably benign |
0.45 |
|
R2891:Ncoa6
|
UTSW |
2 |
155,279,881 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3618:Ncoa6
|
UTSW |
2 |
155,249,709 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3747:Ncoa6
|
UTSW |
2 |
155,253,561 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3778:Ncoa6
|
UTSW |
2 |
155,263,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3784:Ncoa6
|
UTSW |
2 |
155,249,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3802:Ncoa6
|
UTSW |
2 |
155,247,484 (GRCm39) |
missense |
probably benign |
|
|
R3820:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3821:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3822:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3870:Ncoa6
|
UTSW |
2 |
155,257,477 (GRCm39) |
splice site |
probably null |
|
|
R4037:Ncoa6
|
UTSW |
2 |
155,249,290 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4488:Ncoa6
|
UTSW |
2 |
155,249,396 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4719:Ncoa6
|
UTSW |
2 |
155,233,081 (GRCm39) |
unclassified |
probably benign |
|
|
R4732:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4733:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ncoa6
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4835:Ncoa6
|
UTSW |
2 |
155,249,053 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4883:Ncoa6
|
UTSW |
2 |
155,248,687 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4967:Ncoa6
|
UTSW |
2 |
155,263,252 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5021:Ncoa6
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5234:Ncoa6
|
UTSW |
2 |
155,279,933 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5356:Ncoa6
|
UTSW |
2 |
155,263,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5358:Ncoa6
|
UTSW |
2 |
155,248,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5375:Ncoa6
|
UTSW |
2 |
155,275,915 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5412:Ncoa6
|
UTSW |
2 |
155,249,701 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5579:Ncoa6
|
UTSW |
2 |
155,248,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5618:Ncoa6
|
UTSW |
2 |
155,279,817 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5641:Ncoa6
|
UTSW |
2 |
155,263,756 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5757:Ncoa6
|
UTSW |
2 |
155,253,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Ncoa6
|
UTSW |
2 |
155,250,061 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5778:Ncoa6
|
UTSW |
2 |
155,248,688 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5852:Ncoa6
|
UTSW |
2 |
155,247,419 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5940:Ncoa6
|
UTSW |
2 |
155,257,785 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6155:Ncoa6
|
UTSW |
2 |
155,249,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Ncoa6
|
UTSW |
2 |
155,263,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6389:Ncoa6
|
UTSW |
2 |
155,237,736 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6669:Ncoa6
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7097:Ncoa6
|
UTSW |
2 |
155,279,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7385:Ncoa6
|
UTSW |
2 |
155,249,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7963:Ncoa6
|
UTSW |
2 |
155,247,916 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8356:Ncoa6
|
UTSW |
2 |
155,248,172 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8698:Ncoa6
|
UTSW |
2 |
155,257,041 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8859:Ncoa6
|
UTSW |
2 |
155,248,388 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8870:Ncoa6
|
UTSW |
2 |
155,263,078 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9041:Ncoa6
|
UTSW |
2 |
155,257,450 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9062:Ncoa6
|
UTSW |
2 |
155,263,348 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9088:Ncoa6
|
UTSW |
2 |
155,249,726 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9225:Ncoa6
|
UTSW |
2 |
155,249,441 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9445:Ncoa6
|
UTSW |
2 |
155,250,063 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9497:Ncoa6
|
UTSW |
2 |
155,248,238 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9514:Ncoa6
|
UTSW |
2 |
155,248,133 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9656:Ncoa6
|
UTSW |
2 |
155,274,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Ncoa6
|
UTSW |
2 |
155,250,304 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9732:Ncoa6
|
UTSW |
2 |
155,244,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF033:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF040:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF048:Ncoa6
|
UTSW |
2 |
155,263,632 (GRCm39) |
small deletion |
probably benign |
|
|
X0017:Ncoa6
|
UTSW |
2 |
155,248,460 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Ncoa6
|
UTSW |
2 |
155,263,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,263,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,248,062 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACGGGAAAGCCTGGATTTTGAC -3'
(R):5'- TGCCGGGACCAGCACAAATAATG -3'
Sequencing Primer
(F):5'- GCCTGGATTTTGACCACAAG -3'
(R):5'- TAATGAGGGGACCAACTCCG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation