Mutagenetix > Incidental Mutation

Incidental Mutation 'R1521:Arhgef10l'

166968

Institutional Source

Beutler Lab

Gene Symbol

Arhgef10l

Ensembl Gene

ENSMUSG00000040964

Gene Name

Rho guanine nucleotide exchange factor (GEF) 10-like

Synonyms

2810441C07Rik

MMRRC Submission

040870-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R1521 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

140514485-140666012 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 140515438 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 1088 (D1088G)

Ref Sequence

ENSEMBL: ENSMUSP00000095431 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039204] [ENSMUST00000069623] [ENSMUST00000097820] [ENSMUST00000105797] [ENSMUST00000105798] [ENSMUST00000105799]

AlphaFold

A2AWP8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000039204
AA Change: D1127G

PolyPhen 2 Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000040531
Gene: ENSMUSG00000040964
AA Change: D1127G

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	318	500	1.95e-52	SMART
Blast:PH	535	748	3e-82	BLAST
low complexity region	821	833	N/A	INTRINSIC
low complexity region	864	876	N/A	INTRINSIC
Blast:WD40	1217	1270	8e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000069623
AA Change: D1093G

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000066249
Gene: ENSMUSG00000040964
AA Change: D1093G

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	279	461	1.95e-52	SMART
Blast:PH	496	714	5e-80	BLAST
low complexity region	787	799	N/A	INTRINSIC
low complexity region	830	842	N/A	INTRINSIC
Blast:WD40	1183	1236	7e-18	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000097820
AA Change: D1088G

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000095431
Gene: ENSMUSG00000040964
AA Change: D1088G

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	279	461	1.95e-52	SMART
Blast:PH	496	709	3e-82	BLAST
low complexity region	782	794	N/A	INTRINSIC
low complexity region	825	837	N/A	INTRINSIC
Blast:WD40	1178	1231	6e-18	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000105797
AA Change: D840G

PolyPhen 2 Score 0.751 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000101423
Gene: ENSMUSG00000040964
AA Change: D840G

Domain	Start	End	E-Value	Type
low complexity region	50	62	N/A	INTRINSIC
Pfam:RhoGEF	101	183	7.1e-15	PFAM
low complexity region	195	213	N/A	INTRINSIC
Blast:PH	248	461	7e-83	BLAST
low complexity region	534	546	N/A	INTRINSIC
low complexity region	577	589	N/A	INTRINSIC
Blast:WD40	618	656	6e-15	BLAST
Blast:WD40	930	983	1e-17	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000105798
AA Change: D892G

PolyPhen 2 Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000101424
Gene: ENSMUSG00000040964
AA Change: D892G

Domain	Start	End	E-Value	Type
RhoGEF	78	260	1.95e-52	SMART
Blast:PH	295	513	8e-81	BLAST
low complexity region	586	598	N/A	INTRINSIC
low complexity region	629	641	N/A	INTRINSIC
Blast:WD40	982	1035	6e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000105799
AA Change: D1132G

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000101425
Gene: ENSMUSG00000040964
AA Change: D1132G

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	318	500	1.95e-52	SMART
Blast:PH	535	753	5e-80	BLAST
low complexity region	826	838	N/A	INTRINSIC
low complexity region	869	881	N/A	INTRINSIC
Blast:WD40	1222	1275	8e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000138493

SMART Domains

Protein: ENSMUSP00000119471
Gene: ENSMUSG00000040964

Domain	Start	End	E-Value	Type
Pfam:RhoGEF	1	46	3.1e-11	PFAM
Blast:PH	81	294	3e-86	BLAST
low complexity region	367	379	N/A	INTRINSIC
Blast:WD40	387	446	8e-6	BLAST
Blast:WD40	451	489	3e-15	BLAST

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 118 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adat1	A	G	8: 111,987,235 (GRCm38)	L104P	possibly damaging	Het
Adgrf5	T	C	17: 43,430,552 (GRCm38)	V360A	probably benign	Het
Ahnak	G	A	19: 9,004,728 (GRCm38)	M1125I	probably benign	Het
Akap12	T	C	10: 4,354,804 (GRCm38)	V538A	probably benign	Het
Atp7b	A	T	8: 22,027,673 (GRCm38)	L268Q	probably damaging	Het
Atxn2	A	C	5: 121,779,591 (GRCm38)	N516T	probably damaging	Het
Cacna1h	T	C	17: 25,397,354 (GRCm38)	M184V	possibly damaging	Het
Cacnb2	G	T	2: 14,614,352 (GRCm38)	R66L	probably benign	Het
Casp8ap2	A	G	4: 32,631,867 (GRCm38)	E96G	probably damaging	Het
Ccdc78	G	T	17: 25,788,781 (GRCm38)	R264L	probably damaging	Het
Cdh4	G	A	2: 179,797,558 (GRCm38)	R166H	probably damaging	Het
Cog7	C	T	7: 121,930,574 (GRCm38)	D615N	possibly damaging	Het
Crtc2	T	C	3: 90,257,383 (GRCm38)	V115A	probably benign	Het
Crybg1	A	G	10: 43,998,416 (GRCm38)	S899P	probably damaging	Het
Ctdnep1	T	A	11: 69,988,635 (GRCm38)	V128E	probably damaging	Het
Ctnna3	A	G	10: 64,959,842 (GRCm38)	K780E	probably benign	Het
Cul7	T	A	17: 46,663,190 (GRCm38)	L1467H	probably damaging	Het
Dazap2	T	A	15: 100,618,065 (GRCm38)	Y91*	probably null	Het
Dcdc5	T	C	2: 106,351,669 (GRCm38)		noncoding transcript	Het
Dppa1	T	A	11: 46,610,473 (GRCm38)	R74S	possibly damaging	Het
Elovl1	A	T	4: 118,432,000 (GRCm38)	T241S	probably benign	Het
Eya1	G	T	1: 14,274,550 (GRCm38)	Q86K	probably damaging	Het
Fam71a	T	A	1: 191,164,022 (GRCm38)	R141S	probably benign	Het
Fancm	A	T	12: 65,121,704 (GRCm38)	M1614L	probably benign	Het
Fcgbp	C	T	7: 28,075,160 (GRCm38)	T53I	probably benign	Het
Fpr3	T	A	17: 17,971,015 (GRCm38)	W183R	probably damaging	Het
Galnt13	G	A	2: 54,854,645 (GRCm38)	V119I	probably benign	Het
Gcfc2	T	C	6: 81,923,812 (GRCm38)	S36P	probably benign	Het
Gdap2	T	A	3: 100,194,615 (GRCm38)	D412E	possibly damaging	Het
Gm10184	T	A	17: 89,910,306 (GRCm38)	N4I	possibly damaging	Het
Gm12258	T	C	11: 58,859,555 (GRCm38)	C41R	probably damaging	Het
Grrp1	T	C	4: 134,251,350 (GRCm38)	*272W	probably null	Het
Hipk1	T	G	3: 103,777,782 (GRCm38)	E172D	probably benign	Het
Hmgcs1	T	G	13: 119,703,591 (GRCm38)	L326R	probably benign	Het
Hs6st1	C	A	1: 36,068,886 (GRCm38)	R77S	probably damaging	Het
Ifit3	A	T	19: 34,587,173 (GRCm38)	N40Y	probably damaging	Het
Il1a	T	A	2: 129,304,741 (GRCm38)	Q144L	possibly damaging	Het
Itga7	A	G	10: 128,957,811 (GRCm38)	E1128G	possibly damaging	Het
Itih2	T	C	2: 10,106,747 (GRCm38)	D460G	probably damaging	Het
Ivns1abp	G	A	1: 151,351,558 (GRCm38)	C39Y	probably damaging	Het
Kif22	G	T	7: 127,027,839 (GRCm38)	A646E	probably damaging	Het
Klhl29	T	C	12: 5,091,307 (GRCm38)	Y559C	probably damaging	Het
Klhl7	T	A	5: 24,149,110 (GRCm38)		probably null	Het
Klhl9	A	G	4: 88,721,993 (GRCm38)	S4P	probably benign	Het
Klk10	A	G	7: 43,782,880 (GRCm38)	Q79R	probably benign	Het
Klk6	T	C	7: 43,829,275 (GRCm38)		probably null	Het
Lamc2	C	T	1: 153,166,263 (GRCm38)	E42K	probably benign	Het
Lingo3	T	C	10: 80,835,721 (GRCm38)	D125G	probably benign	Het
Map1b	T	C	13: 99,432,739 (GRCm38)	N1158S	unknown	Het
Masp1	T	A	16: 23,494,637 (GRCm38)	N183Y	probably damaging	Het
Mdga2	A	G	12: 66,568,926 (GRCm38)	Y636H	probably benign	Het
Micalcl	T	A	7: 112,381,610 (GRCm38)	S264T	probably damaging	Het
Mif	A	G	10: 75,859,541 (GRCm38)	V95A	possibly damaging	Het
Mmp17	G	A	5: 129,595,088 (GRCm38)		probably null	Het
Mmp23	T	C	4: 155,650,717 (GRCm38)	R390G	possibly damaging	Het
Ncoa6	A	C	2: 155,415,222 (GRCm38)	S800R	possibly damaging	Het
Nfix	G	A	8: 84,726,526 (GRCm38)	R300C	probably damaging	Het
Nr2e3	A	T	9: 59,949,205 (GRCm38)	S67R	probably damaging	Het
Odf2l	T	C	3: 145,149,036 (GRCm38)	S545P	possibly damaging	Het
Olfr1256	G	A	2: 89,835,172 (GRCm38)	R258*	probably null	Het
Olfr172	C	T	16: 58,760,853 (GRCm38)	E108K	probably damaging	Het
Olfr591	T	A	7: 103,173,451 (GRCm38)	Y62F	probably benign	Het
Olfr845	C	T	9: 19,338,652 (GRCm38)	S64F	probably benign	Het
Olfr872	A	C	9: 20,260,432 (GRCm38)	Q197H	possibly damaging	Het
Olfr916	T	G	9: 38,657,718 (GRCm38)	I225L	probably damaging	Het
Olfr958	A	T	9: 39,550,784 (GRCm38)	V29E	possibly damaging	Het
Otog	A	T	7: 46,259,264 (GRCm38)	H562L	possibly damaging	Het
Pcdh15	T	C	10: 74,594,191 (GRCm38)	V1250A	probably damaging	Het
Pde1c	A	G	6: 56,173,607 (GRCm38)	V309A	possibly damaging	Het
Pfkfb4	A	C	9: 109,007,305 (GRCm38)	T134P	probably damaging	Het
Phc3	G	T	3: 30,936,575 (GRCm38)	Q498K	possibly damaging	Het
Phlpp1	T	C	1: 106,392,319 (GRCm38)	V1348A	probably damaging	Het
Pik3ap1	T	C	19: 41,321,558 (GRCm38)	D441G	probably damaging	Het
Pkd1l2	T	C	8: 117,065,500 (GRCm38)		probably null	Het
Pla2g4a	T	C	1: 149,857,686 (GRCm38)		probably null	Het
Pola2	A	T	19: 5,948,406 (GRCm38)	I376N	probably damaging	Het
Pold2	T	A	11: 5,876,833 (GRCm38)	N34Y	probably damaging	Het
Ppp2r5c	T	C	12: 110,554,886 (GRCm38)	L281P	probably damaging	Het
Prss46	A	G	9: 110,849,635 (GRCm38)	I29V	probably benign	Het
Ranbp6	A	T	19: 29,811,446 (GRCm38)	V502E	probably benign	Het
Rdh14	T	C	12: 10,394,613 (GRCm38)	F155L	probably damaging	Het
Rnaseh2a	A	T	8: 84,965,858 (GRCm38)		probably null	Het
Rpp30	A	G	19: 36,094,385 (GRCm38)	T118A	possibly damaging	Het
Rragd	T	C	4: 32,996,005 (GRCm38)	F117L	probably damaging	Het
S100a2	T	A	3: 90,591,292 (GRCm38)		probably null	Het
Sept12	T	C	16: 4,996,476 (GRCm38)	K43R	probably damaging	Het
Sh3tc2	A	G	18: 62,008,488 (GRCm38)	E1080G	probably damaging	Het
Slc26a9	A	G	1: 131,750,677 (GRCm38)	K27R	probably damaging	Het
Spata17	T	A	1: 187,193,994 (GRCm38)	K46N	probably damaging	Het
St14	A	C	9: 31,108,215 (GRCm38)	D103E	probably benign	Het
St6galnac2	T	A	11: 116,684,347 (GRCm38)	Q222L	possibly damaging	Het
Tdrd9	T	C	12: 112,036,410 (GRCm38)	V831A	probably damaging	Het
Tert	A	G	13: 73,642,056 (GRCm38)	E843G	probably damaging	Het
Tex21	A	G	12: 76,204,270 (GRCm38)	V464A	probably benign	Het
Tmem232	T	A	17: 65,484,501 (GRCm38)	H124L	probably damaging	Het
Tmem5	A	G	10: 122,090,479 (GRCm38)	W243R	probably damaging	Het
Tnfrsf19	T	G	14: 61,005,106 (GRCm38)	S110R	probably damaging	Het
Tnnt3	A	T	7: 142,515,825 (GRCm38)	K272*	probably null	Het
Tnxb	T	C	17: 34,711,503 (GRCm38)	L2054P	probably damaging	Het
Trcg1	A	C	9: 57,242,465 (GRCm38)	D440A	probably benign	Het
Trpm3	A	G	19: 22,901,221 (GRCm38)	E504G	probably damaging	Het
Trpm5	C	T	7: 143,082,889 (GRCm38)	R437H	probably benign	Het
Ttn	T	C	2: 76,741,167 (GRCm38)	R18134G	probably damaging	Het
Uchl5	A	C	1: 143,798,422 (GRCm38)	M64L	possibly damaging	Het
Urb1	G	A	16: 90,753,863 (GRCm38)	R2034W	probably damaging	Het
Usp44	T	A	10: 93,847,186 (GRCm38)	C452*	probably null	Het
Uvssa	G	A	5: 33,413,934 (GRCm38)	A641T	probably damaging	Het
Vmn1r204	T	A	13: 22,557,078 (GRCm38)	I293N	probably benign	Het
Vmn2r84	A	T	10: 130,389,268 (GRCm38)	C458S	probably benign	Het
Vmn2r85	T	G	10: 130,425,919 (GRCm38)	H183P	probably damaging	Het
Vps13d	G	T	4: 145,105,861 (GRCm38)	T2825K	probably benign	Het
Zc3hc1	T	A	6: 30,376,025 (GRCm38)	I179F	probably benign	Het
Zfp112	A	G	7: 24,125,785 (GRCm38)	N393D	probably damaging	Het
Zfp558	A	G	9: 18,456,563 (GRCm38)	S310P	possibly damaging	Het
Zfp560	A	C	9: 20,348,775 (GRCm38)		probably null	Het
Zfp668	C	T	7: 127,867,080 (GRCm38)	E311K	probably benign	Het
Zfp763	T	A	17: 33,033,302 (GRCm38)	M1L	probably benign	Het
Zfp947	A	T	17: 22,145,832 (GRCm38)	M287K	probably benign	Het

Other mutations in Arhgef10l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01420:Arhgef10l	APN	4	140,570,338 (GRCm38)	missense	probably damaging	0.98
IGL01732:Arhgef10l	APN	4	140,580,415 (GRCm38)	missense	probably damaging	0.99
IGL01988:Arhgef10l	APN	4	140,578,361 (GRCm38)	splice site	probably benign
IGL02031:Arhgef10l	APN	4	140,575,345 (GRCm38)	missense	probably damaging	1.00
IGL02253:Arhgef10l	APN	4	140,544,284 (GRCm38)	nonsense	probably null
IGL02445:Arhgef10l	APN	4	140,547,007 (GRCm38)	missense	probably benign	0.19
IGL02619:Arhgef10l	APN	4	140,594,193 (GRCm38)	missense	probably benign	0.07
IGL02798:Arhgef10l	APN	4	140,565,130 (GRCm38)	critical splice donor site	probably null
IGL03064:Arhgef10l	APN	4	140,579,279 (GRCm38)	missense	probably damaging	1.00
IGL03178:Arhgef10l	APN	4	140,544,428 (GRCm38)	missense	possibly damaging	0.92
IGL03236:Arhgef10l	APN	4	140,611,360 (GRCm38)	missense	probably damaging	1.00
IGL03352:Arhgef10l	APN	4	140,583,931 (GRCm38)	start codon destroyed	probably null	0.99
PIT4494001:Arhgef10l	UTSW	4	140,565,211 (GRCm38)	missense	probably damaging	0.98
R0057:Arhgef10l	UTSW	4	140,611,218 (GRCm38)	splice site	probably benign
R0062:Arhgef10l	UTSW	4	140,552,532 (GRCm38)	missense	probably damaging	1.00
R0109:Arhgef10l	UTSW	4	140,578,294 (GRCm38)	missense	probably benign	0.02
R0109:Arhgef10l	UTSW	4	140,578,294 (GRCm38)	missense	probably benign	0.02
R0114:Arhgef10l	UTSW	4	140,583,883 (GRCm38)	missense	probably benign	0.17
R0334:Arhgef10l	UTSW	4	140,583,926 (GRCm38)	nonsense	probably null
R0742:Arhgef10l	UTSW	4	140,536,845 (GRCm38)	missense	probably damaging	1.00
R1017:Arhgef10l	UTSW	4	140,515,306 (GRCm38)	missense	probably damaging	0.99
R1166:Arhgef10l	UTSW	4	140,575,270 (GRCm38)	unclassified	probably benign
R1397:Arhgef10l	UTSW	4	140,544,443 (GRCm38)	missense	probably damaging	0.98
R1707:Arhgef10l	UTSW	4	140,564,289 (GRCm38)	missense	probably damaging	1.00
R1793:Arhgef10l	UTSW	4	140,515,373 (GRCm38)	missense	probably damaging	0.97
R2018:Arhgef10l	UTSW	4	140,544,384 (GRCm38)	missense	probably damaging	1.00
R2093:Arhgef10l	UTSW	4	140,570,290 (GRCm38)	missense	possibly damaging	0.57
R2098:Arhgef10l	UTSW	4	140,579,432 (GRCm38)	missense	probably damaging	1.00
R2310:Arhgef10l	UTSW	4	140,593,118 (GRCm38)	missense	probably damaging	1.00
R2879:Arhgef10l	UTSW	4	140,515,287 (GRCm38)	missense	probably benign	0.09
R2883:Arhgef10l	UTSW	4	140,516,802 (GRCm38)	missense	probably benign	0.02
R3732:Arhgef10l	UTSW	4	140,581,619 (GRCm38)	small deletion	probably benign
R3732:Arhgef10l	UTSW	4	140,581,619 (GRCm38)	small deletion	probably benign
R3861:Arhgef10l	UTSW	4	140,515,487 (GRCm38)	missense	possibly damaging	0.94
R4049:Arhgef10l	UTSW	4	140,515,451 (GRCm38)	missense	probably benign	0.05
R4322:Arhgef10l	UTSW	4	140,542,726 (GRCm38)	missense	probably benign	0.07
R4707:Arhgef10l	UTSW	4	140,536,883 (GRCm38)	missense	possibly damaging	0.63
R5395:Arhgef10l	UTSW	4	140,570,290 (GRCm38)	missense	probably benign	0.16
R5720:Arhgef10l	UTSW	4	140,581,619 (GRCm38)	small deletion	probably benign
R6066:Arhgef10l	UTSW	4	140,577,080 (GRCm38)	missense	probably damaging	1.00
R6190:Arhgef10l	UTSW	4	140,542,762 (GRCm38)	missense	possibly damaging	0.90
R6464:Arhgef10l	UTSW	4	140,586,815 (GRCm38)	missense	probably benign	0.05
R6476:Arhgef10l	UTSW	4	140,611,382 (GRCm38)	missense	probably damaging	1.00
R6478:Arhgef10l	UTSW	4	140,542,757 (GRCm38)	missense	possibly damaging	0.91
R6483:Arhgef10l	UTSW	4	140,616,915 (GRCm38)	missense	probably damaging	0.99
R6631:Arhgef10l	UTSW	4	140,517,747 (GRCm38)	intron	probably benign
R6721:Arhgef10l	UTSW	4	140,570,344 (GRCm38)	missense	probably damaging	1.00
R6890:Arhgef10l	UTSW	4	140,544,419 (GRCm38)	missense	probably damaging	1.00
R7098:Arhgef10l	UTSW	4	140,580,911 (GRCm38)	missense	probably benign	0.01
R7100:Arhgef10l	UTSW	4	140,516,815 (GRCm38)	missense	possibly damaging	0.60
R7117:Arhgef10l	UTSW	4	140,564,186 (GRCm38)	critical splice donor site	probably null
R7195:Arhgef10l	UTSW	4	140,611,410 (GRCm38)	missense	probably benign
R7222:Arhgef10l	UTSW	4	140,521,269 (GRCm38)	missense	probably damaging	1.00
R7397:Arhgef10l	UTSW	4	140,562,804 (GRCm38)	missense	probably damaging	1.00
R7776:Arhgef10l	UTSW	4	140,575,331 (GRCm38)	missense	probably damaging	1.00
R7801:Arhgef10l	UTSW	4	140,544,267 (GRCm38)	missense	probably benign	0.00
R7811:Arhgef10l	UTSW	4	140,515,024 (GRCm38)	missense	possibly damaging	0.63
R7832:Arhgef10l	UTSW	4	140,578,305 (GRCm38)	missense	possibly damaging	0.90
R7849:Arhgef10l	UTSW	4	140,583,934 (GRCm38)	critical splice acceptor site	probably null
R7963:Arhgef10l	UTSW	4	140,579,425 (GRCm38)	missense	probably damaging	1.00
R8434:Arhgef10l	UTSW	4	140,564,271 (GRCm38)	missense	possibly damaging	0.89
R8943:Arhgef10l	UTSW	4	140,565,239 (GRCm38)	missense	probably damaging	0.99
R9004:Arhgef10l	UTSW	4	140,552,610 (GRCm38)	missense	probably damaging	0.98
R9006:Arhgef10l	UTSW	4	140,544,348 (GRCm38)	missense	probably benign	0.04
R9033:Arhgef10l	UTSW	4	140,594,152 (GRCm38)	missense	probably damaging	0.99
R9302:Arhgef10l	UTSW	4	140,515,237 (GRCm38)	missense	probably benign	0.04
R9337:Arhgef10l	UTSW	4	140,611,313 (GRCm38)	missense	probably damaging	1.00
R9375:Arhgef10l	UTSW	4	140,591,954 (GRCm38)	missense	probably benign
R9454:Arhgef10l	UTSW	4	140,580,925 (GRCm38)	nonsense	probably null
Z1088:Arhgef10l	UTSW	4	140,581,735 (GRCm38)	missense	possibly damaging	0.53
Z1177:Arhgef10l	UTSW	4	140,516,772 (GRCm38)	missense	probably benign	0.28

Predicted Primers

PCR Primer
(F):5'- TGTCCACCAGAGATGATAGCCACAG -3'
(R):5'- CTTGGAGATGGAGAATGCCTCCAC -3'

Sequencing Primer
(F):5'- ACAGAGCAGATCTCCTTGCG -3'
(R):5'- GATCCTATAGCCTCTGATAAGGTGC -3'

Posted On

2014-04-13