Incidental Mutation 'R1525:Or1j21'
ID 167760
Institutional Source Beutler Lab
Gene Symbol Or1j21
Ensembl Gene ENSMUSG00000111021
Gene Name olfactory receptor family 1 subfamily J member 21
Synonyms MOR136-6, GA_x6K02T2NLDC-33487752-33488690, ID3, Olfr50
MMRRC Submission 040872-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.325) question?
Stock # R1525 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 36683250-36684188 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36684155 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 302 (R302S)
Ref Sequence ENSEMBL: ENSMUSP00000108572 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072114] [ENSMUST00000112950] [ENSMUST00000213498] [ENSMUST00000214909] [ENSMUST00000215199] [ENSMUST00000216753] [ENSMUST00000217041]
AlphaFold Q8VGK5
Predicted Effect probably null
Transcript: ENSMUST00000072114
AA Change: R302S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000071985
Gene: ENSMUSG00000068950
AA Change: R302S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.3e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-8 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000112950
AA Change: R302S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000108572
Gene: ENSMUSG00000111021
AA Change: R302S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 36 306 3e-6 PFAM
Pfam:7tm_1 42 291 3.5e-34 PFAM
Pfam:7tm_4 140 284 3.9e-40 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213498
Predicted Effect probably null
Transcript: ENSMUST00000214909
Predicted Effect probably null
Transcript: ENSMUST00000215199
Predicted Effect probably benign
Transcript: ENSMUST00000216753
AA Change: R302S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000217041
AA Change: R302S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 A T 11: 94,252,062 (GRCm39) H840Q probably benign Het
Amotl2 C T 9: 102,605,767 (GRCm39) R540C probably damaging Het
Brpf1 A G 6: 113,294,115 (GRCm39) E605G probably damaging Het
Cacna2d3 T C 14: 28,694,199 (GRCm39) I865V probably benign Het
Cdh24 A T 14: 54,876,046 (GRCm39) F199I probably damaging Het
Cdk9 A G 2: 32,600,521 (GRCm39) V27A probably damaging Het
Cfap69 G T 5: 5,690,230 (GRCm39) probably null Het
Cyp2d11 G T 15: 82,273,498 (GRCm39) L458I probably damaging Het
Dchs1 T C 7: 105,408,138 (GRCm39) E1898G probably damaging Het
Dennd4b G T 3: 90,178,177 (GRCm39) L456F probably damaging Het
Dgat1 T C 15: 76,395,786 (GRCm39) T66A probably benign Het
Dock10 C A 1: 80,583,881 (GRCm39) probably null Het
Fam110b A G 4: 5,799,578 (GRCm39) D332G possibly damaging Het
Fem1al A C 11: 29,773,994 (GRCm39) Y488D probably benign Het
Frmd4b G A 6: 97,273,347 (GRCm39) P628S probably damaging Het
Ice1 A T 13: 70,753,529 (GRCm39) H852Q probably benign Het
Il17ra T C 6: 120,450,751 (GRCm39) V116A probably damaging Het
Ints9 T C 14: 65,232,460 (GRCm39) I173T probably benign Het
Kctd14 A T 7: 97,107,074 (GRCm39) M110L probably benign Het
Krt6a T G 15: 101,602,637 (GRCm39) Y16S probably benign Het
Lamc2 T C 1: 153,006,502 (GRCm39) N883S probably benign Het
Larp4b C T 13: 9,195,486 (GRCm39) T195M probably damaging Het
Lrp1 A G 10: 127,375,398 (GRCm39) L4432P probably damaging Het
Mei4 T C 9: 81,772,252 (GRCm39) S22P probably damaging Het
Mep1a T C 17: 43,802,527 (GRCm39) Q166R probably damaging Het
Mroh2b C A 15: 4,980,612 (GRCm39) probably null Het
Myoc T G 1: 162,476,220 (GRCm39) L308R probably damaging Het
Ndn C T 7: 61,998,256 (GRCm39) P34L probably benign Het
Or2t6 T A 14: 14,175,725 (GRCm38) Y119F probably damaging Het
Or4c101 C G 2: 88,389,985 (GRCm39) S57R probably damaging Het
Pdilt T A 7: 119,087,217 (GRCm39) T478S probably damaging Het
Pias1 T C 9: 62,827,769 (GRCm39) K222E probably damaging Het
Prss16 A C 13: 22,193,613 (GRCm39) L61V possibly damaging Het
Pttg1ip2 C A 5: 5,502,019 (GRCm39) W144C probably benign Het
Pvr G A 7: 19,644,551 (GRCm39) Q328* probably null Het
Ranbp3 A G 17: 57,017,865 (GRCm39) D481G possibly damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,115 (GRCm39) probably benign Het
Ryr3 G T 2: 112,508,435 (GRCm39) D3419E probably damaging Het
Scn1a C T 2: 66,149,806 (GRCm39) W946* probably null Het
Sh3pxd2a T C 19: 47,266,864 (GRCm39) K242E probably damaging Het
Slc34a2 A G 5: 53,226,848 (GRCm39) D657G probably benign Het
Stard9 T A 2: 120,532,533 (GRCm39) I2930K probably benign Het
Syna T C 5: 134,588,112 (GRCm39) D279G probably benign Het
Tfr2 T C 5: 137,577,292 (GRCm39) F415L probably benign Het
Tmem97 T A 11: 78,433,586 (GRCm39) Y103F probably damaging Het
Tmem97 A T 11: 78,433,587 (GRCm39) Y103N probably damaging Het
Txndc2 T A 17: 65,945,310 (GRCm39) D289V probably damaging Het
Zbtb1 T G 12: 76,433,206 (GRCm39) D397E probably benign Het
Zc3h18 T C 8: 123,140,677 (GRCm39) S847P probably benign Het
Zfp382 G A 7: 29,833,144 (GRCm39) G265E probably damaging Het
Zfp410 T C 12: 84,369,740 (GRCm39) L39S probably damaging Het
Zfp729a G T 13: 67,767,440 (GRCm39) P930T probably benign Het
Other mutations in Or1j21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or1j21 APN 2 36,684,012 (GRCm39) missense probably benign 0.05
IGL02316:Or1j21 APN 2 36,683,632 (GRCm39) missense probably damaging 0.98
IGL02330:Or1j21 APN 2 36,683,907 (GRCm39) missense probably benign 0.00
IGL03144:Or1j21 APN 2 36,684,093 (GRCm39) missense probably benign 0.44
R0092:Or1j21 UTSW 2 36,683,508 (GRCm39) missense probably benign 0.06
R0113:Or1j21 UTSW 2 36,684,007 (GRCm39) missense probably damaging 0.99
R0113:Or1j21 UTSW 2 36,684,006 (GRCm39) missense probably damaging 0.98
R0604:Or1j21 UTSW 2 36,684,119 (GRCm39) nonsense probably null
R0932:Or1j21 UTSW 2 36,683,903 (GRCm39) nonsense probably null
R1191:Or1j21 UTSW 2 36,683,350 (GRCm39) missense probably damaging 0.97
R1238:Or1j21 UTSW 2 36,683,601 (GRCm39) missense probably damaging 1.00
R3103:Or1j21 UTSW 2 36,683,574 (GRCm39) missense possibly damaging 0.80
R3955:Or1j21 UTSW 2 36,683,565 (GRCm39) missense probably benign 0.34
R4573:Or1j21 UTSW 2 36,683,491 (GRCm39) missense probably damaging 1.00
R5256:Or1j21 UTSW 2 36,683,685 (GRCm39) missense probably benign
R5650:Or1j21 UTSW 2 36,683,277 (GRCm39) missense probably benign 0.36
R6130:Or1j21 UTSW 2 36,684,055 (GRCm39) missense probably benign 0.01
R6175:Or1j21 UTSW 2 36,683,980 (GRCm39) missense probably damaging 1.00
R6320:Or1j21 UTSW 2 36,683,585 (GRCm39) missense possibly damaging 0.90
R6481:Or1j21 UTSW 2 36,683,789 (GRCm39) missense possibly damaging 0.63
R7164:Or1j21 UTSW 2 36,683,709 (GRCm39) missense probably benign 0.34
R7622:Or1j21 UTSW 2 36,683,943 (GRCm39) missense probably benign 0.06
R8391:Or1j21 UTSW 2 36,684,096 (GRCm39) missense probably damaging 0.99
R8846:Or1j21 UTSW 2 36,683,689 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGGGCCACTATCCTAAGAACTCCA -3'
(R):5'- CAGGGCTGAGATGAAACAGGCTG -3'

Sequencing Primer
(F):5'- TCCATCAAGGGTATCTGCAAAG -3'
(R):5'- CTGAGATGAAACAGGCTGAAAAAATC -3'
Posted On 2014-04-13