Mutagenetix > Incidental Mutation

Incidental Mutation 'R1525:Lrp1'

167793

Institutional Source

Beutler Lab

Gene Symbol

Lrp1

Ensembl Gene

ENSMUSG00000040249

Gene Name

low density lipoprotein receptor-related protein 1

Synonyms

b2b1554Clo, CD91, A2mr

MMRRC Submission

040872-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1525 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

127374030-127457017 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 127375398 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 4432 (L4432P)

Ref Sequence

ENSEMBL: ENSMUSP00000044004 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049149] [ENSMUST00000095266]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000049149
AA Change: L4432P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: L4432P

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
LDLa	27	67	1.03e-15	SMART
LDLa	72	111	1.04e-11	SMART
EGF	115	150	8.78e-2	SMART
EGF_CA	151	190	4.49e-8	SMART
low complexity region	222	232	N/A	INTRINSIC
LY	273	315	7.07e-6	SMART
LY	316	359	2.31e-10	SMART
LY	360	402	8.3e-12	SMART
EGF	478	521	9.93e-1	SMART
LY	552	594	8.84e-7	SMART
LY	595	638	6.54e-10	SMART
LY	641	690	2.5e-15	SMART
LY	691	734	1.06e-9	SMART
EGF	807	844	1.38e1	SMART
LDLa	854	893	3.39e-16	SMART
LDLa	895	934	1.73e-13	SMART
LDLa	936	974	4.47e-16	SMART
LDLa	976	1014	2.53e-15	SMART
LDLa	1015	1054	2.95e-16	SMART
LDLa	1062	1100	3.24e-13	SMART
LDLa	1104	1143	2.97e-12	SMART
LDLa	1145	1185	1.24e-9	SMART
EGF	1185	1223	4.97e-1	SMART
EGF	1227	1263	6.02e0	SMART
LY	1290	1332	3.76e-1	SMART
LY	1337	1379	8.56e-14	SMART
LY	1380	1424	8.43e-13	SMART
LY	1425	1469	3.05e-10	SMART
LY	1471	1513	3.88e-3	SMART
EGF	1540	1580	1.85e0	SMART
LY	1606	1650	2.83e-5	SMART
LY	1651	1695	2.01e-10	SMART
LY	1698	1735	1.87e-5	SMART
LY	1736	1777	3.54e-6	SMART
LY	1778	1820	4.17e1	SMART
EGF	1850	1888	1.24e-1	SMART
LY	1915	1957	3.2e-4	SMART
LY	1958	2000	2.33e-15	SMART
LY	2001	2044	7.45e-14	SMART
LY	2045	2087	3.87e-12	SMART
LY	2089	2131	1.37e0	SMART
EGF	2159	2196	1.66e1	SMART
LY	2276	2318	5.57e-4	SMART
LY	2324	2369	3.3e-6	SMART
LY	2370	2412	3.93e-13	SMART
LY	2413	2454	3.62e-3	SMART
EGF_like	2482	2519	3.16e1	SMART
LDLa	2524	2564	3.31e-10	SMART
LDLa	2566	2603	7.21e-11	SMART
LDLa	2605	2642	1.09e-10	SMART
LDLa	2660	2691	6.05e-4	SMART
LDLa	2696	2733	2.49e-14	SMART
LDLa	2734	2772	4.65e-14	SMART
LDLa	2774	2815	3.92e-12	SMART
LDLa	2818	2856	1.51e-13	SMART
LDLa	2858	2900	1.93e-11	SMART
LDLa	2904	2942	1.73e-13	SMART
EGF_CA	2941	2982	6.16e-6	SMART
EGF_CA	2983	3023	2.66e-10	SMART
LY	3050	3094	6.64e-11	SMART
LY	3095	3137	7.17e-16	SMART
LY	3138	3181	4.28e-14	SMART
LY	3182	3224	8.11e-15	SMART
LY	3225	3265	1.44e-6	SMART
EGF	3294	3332	1.02e-2	SMART
LDLa	3334	3372	2.25e-12	SMART
LDLa	3374	3411	9.81e-13	SMART
LDLa	3413	3451	9.81e-13	SMART
LDLa	3453	3492	5.67e-18	SMART
LDLa	3494	3534	7.15e-15	SMART
LDLa	3536	3573	1.79e-15	SMART
EGF_like	3575	3611	4.83e1	SMART
LDLa	3575	3612	1.92e-15	SMART
LDLa	3613	3650	1.18e-15	SMART
LDLa	3654	3693	7.55e-14	SMART
LDLa	3695	3734	1.14e-8	SMART
LDLa	3741	3779	6.28e-11	SMART
EGF	3785	3824	1.06e1	SMART
EGF	3828	3862	1.51e0	SMART
LY	3893	3935	9.43e0	SMART
LY	3951	3993	1.23e-14	SMART
LY	3994	4037	2.98e-13	SMART
LY	4038	4080	4.28e-14	SMART
EGF	4151	4184	3.76e-1	SMART
low complexity region	4185	4198	N/A	INTRINSIC
EGF	4200	4233	3.82e-2	SMART
EGF	4236	4269	4.03e-1	SMART
EGF	4272	4305	5.2e-4	SMART
EGF	4308	4341	1.22e0	SMART
EGF_like	4344	4376	4.11e1	SMART
EGF	4377	4410	5.12e-3	SMART
transmembrane domain	4423	4445	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000095266

SMART Domains

Protein: ENSMUSP00000092900
Gene: ENSMUSG00000040258

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:Neurexophilin	70	166	3e-32	PFAM
Pfam:Neurexophilin	217	304	1e-37	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135188

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000140269

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145947

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]

Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc3	A	T	11: 94,252,062 (GRCm39)	H840Q	probably benign	Het
Amotl2	C	T	9: 102,605,767 (GRCm39)	R540C	probably damaging	Het
Brpf1	A	G	6: 113,294,115 (GRCm39)	E605G	probably damaging	Het
Cacna2d3	T	C	14: 28,694,199 (GRCm39)	I865V	probably benign	Het
Cdh24	A	T	14: 54,876,046 (GRCm39)	F199I	probably damaging	Het
Cdk9	A	G	2: 32,600,521 (GRCm39)	V27A	probably damaging	Het
Cfap69	G	T	5: 5,690,230 (GRCm39)		probably null	Het
Cyp2d11	G	T	15: 82,273,498 (GRCm39)	L458I	probably damaging	Het
Dchs1	T	C	7: 105,408,138 (GRCm39)	E1898G	probably damaging	Het
Dennd4b	G	T	3: 90,178,177 (GRCm39)	L456F	probably damaging	Het
Dgat1	T	C	15: 76,395,786 (GRCm39)	T66A	probably benign	Het
Dock10	C	A	1: 80,583,881 (GRCm39)		probably null	Het
Fam110b	A	G	4: 5,799,578 (GRCm39)	D332G	possibly damaging	Het
Fem1al	A	C	11: 29,773,994 (GRCm39)	Y488D	probably benign	Het
Frmd4b	G	A	6: 97,273,347 (GRCm39)	P628S	probably damaging	Het
Ice1	A	T	13: 70,753,529 (GRCm39)	H852Q	probably benign	Het
Il17ra	T	C	6: 120,450,751 (GRCm39)	V116A	probably damaging	Het
Ints9	T	C	14: 65,232,460 (GRCm39)	I173T	probably benign	Het
Kctd14	A	T	7: 97,107,074 (GRCm39)	M110L	probably benign	Het
Krt6a	T	G	15: 101,602,637 (GRCm39)	Y16S	probably benign	Het
Lamc2	T	C	1: 153,006,502 (GRCm39)	N883S	probably benign	Het
Larp4b	C	T	13: 9,195,486 (GRCm39)	T195M	probably damaging	Het
Mei4	T	C	9: 81,772,252 (GRCm39)	S22P	probably damaging	Het
Mep1a	T	C	17: 43,802,527 (GRCm39)	Q166R	probably damaging	Het
Mroh2b	C	A	15: 4,980,612 (GRCm39)		probably null	Het
Myoc	T	G	1: 162,476,220 (GRCm39)	L308R	probably damaging	Het
Ndn	C	T	7: 61,998,256 (GRCm39)	P34L	probably benign	Het
Or1j21	A	T	2: 36,684,155 (GRCm39)	R302S	probably null	Het
Or2t6	T	A	14: 14,175,725 (GRCm38)	Y119F	probably damaging	Het
Or4c101	C	G	2: 88,389,985 (GRCm39)	S57R	probably damaging	Het
Pdilt	T	A	7: 119,087,217 (GRCm39)	T478S	probably damaging	Het
Pias1	T	C	9: 62,827,769 (GRCm39)	K222E	probably damaging	Het
Prss16	A	C	13: 22,193,613 (GRCm39)	L61V	possibly damaging	Het
Pttg1ip2	C	A	5: 5,502,019 (GRCm39)	W144C	probably benign	Het
Pvr	G	A	7: 19,644,551 (GRCm39)	Q328*	probably null	Het
Ranbp3	A	G	17: 57,017,865 (GRCm39)	D481G	possibly damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,229,115 (GRCm39)		probably benign	Het
Ryr3	G	T	2: 112,508,435 (GRCm39)	D3419E	probably damaging	Het
Scn1a	C	T	2: 66,149,806 (GRCm39)	W946*	probably null	Het
Sh3pxd2a	T	C	19: 47,266,864 (GRCm39)	K242E	probably damaging	Het
Slc34a2	A	G	5: 53,226,848 (GRCm39)	D657G	probably benign	Het
Stard9	T	A	2: 120,532,533 (GRCm39)	I2930K	probably benign	Het
Syna	T	C	5: 134,588,112 (GRCm39)	D279G	probably benign	Het
Tfr2	T	C	5: 137,577,292 (GRCm39)	F415L	probably benign	Het
Tmem97	T	A	11: 78,433,586 (GRCm39)	Y103F	probably damaging	Het
Tmem97	A	T	11: 78,433,587 (GRCm39)	Y103N	probably damaging	Het
Txndc2	T	A	17: 65,945,310 (GRCm39)	D289V	probably damaging	Het
Zbtb1	T	G	12: 76,433,206 (GRCm39)	D397E	probably benign	Het
Zc3h18	T	C	8: 123,140,677 (GRCm39)	S847P	probably benign	Het
Zfp382	G	A	7: 29,833,144 (GRCm39)	G265E	probably damaging	Het
Zfp410	T	C	12: 84,369,740 (GRCm39)	L39S	probably damaging	Het
Zfp729a	G	T	13: 67,767,440 (GRCm39)	P930T	probably benign	Het

Other mutations in Lrp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00793:Lrp1	APN	10	127,378,074 (GRCm39)	missense	possibly damaging	0.89
IGL01065:Lrp1	APN	10	127,410,907 (GRCm39)	missense	probably benign	0.10
IGL01121:Lrp1	APN	10	127,419,722 (GRCm39)	nonsense	probably null
IGL01360:Lrp1	APN	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
IGL01402:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01404:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01411:Lrp1	APN	10	127,417,634 (GRCm39)	nonsense	probably null
IGL01469:Lrp1	APN	10	127,420,283 (GRCm39)	missense	probably damaging	1.00
IGL01552:Lrp1	APN	10	127,424,379 (GRCm39)	nonsense	probably null
IGL01682:Lrp1	APN	10	127,410,847 (GRCm39)	missense	probably benign	0.00
IGL01760:Lrp1	APN	10	127,409,370 (GRCm39)	missense	probably benign	0.00
IGL01918:Lrp1	APN	10	127,390,458 (GRCm39)	missense	probably damaging	0.99
IGL01989:Lrp1	APN	10	127,413,998 (GRCm39)	missense	probably damaging	1.00
IGL02105:Lrp1	APN	10	127,380,448 (GRCm39)	missense	probably damaging	1.00
IGL02158:Lrp1	APN	10	127,390,140 (GRCm39)	missense	probably benign	0.02
IGL02164:Lrp1	APN	10	127,399,536 (GRCm39)	missense	probably benign	0.39
IGL02337:Lrp1	APN	10	127,412,756 (GRCm39)	missense	possibly damaging	0.87
IGL02425:Lrp1	APN	10	127,407,756 (GRCm39)	critical splice donor site	probably null
IGL02493:Lrp1	APN	10	127,417,647 (GRCm39)	missense	probably damaging	0.99
IGL02563:Lrp1	APN	10	127,387,555 (GRCm39)	missense	probably damaging	1.00
IGL02590:Lrp1	APN	10	127,388,660 (GRCm39)	missense	probably damaging	1.00
IGL02624:Lrp1	APN	10	127,408,291 (GRCm39)	missense	probably damaging	0.98
IGL02625:Lrp1	APN	10	127,410,355 (GRCm39)	missense	probably damaging	1.00
IGL02825:Lrp1	APN	10	127,378,474 (GRCm39)	missense	probably damaging	1.00
IGL02880:Lrp1	APN	10	127,376,091 (GRCm39)	missense	probably benign	0.12
IGL02900:Lrp1	APN	10	127,412,516 (GRCm39)	splice site	probably benign
IGL02956:Lrp1	APN	10	127,380,428 (GRCm39)	missense	probably benign	0.00
IGL02974:Lrp1	APN	10	127,390,885 (GRCm39)	missense	probably damaging	0.99
IGL02983:Lrp1	APN	10	127,386,068 (GRCm39)	missense	probably damaging	1.00
IGL03002:Lrp1	APN	10	127,425,505 (GRCm39)	missense	probably damaging	1.00
IGL03091:Lrp1	APN	10	127,394,993 (GRCm39)	missense	probably benign	0.30
IGL03109:Lrp1	APN	10	127,402,514 (GRCm39)	missense	probably benign
IGL03194:Lrp1	APN	10	127,404,554 (GRCm39)	missense	probably damaging	1.00
IGL03232:Lrp1	APN	10	127,375,245 (GRCm39)	missense	probably damaging	1.00
calculus	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
Delimiter	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
extremis	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
Jockey	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
peripheral	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
tangential	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
P0015:Lrp1	UTSW	10	127,402,532 (GRCm39)	missense	probably damaging	0.99
PIT4519001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
PIT4520001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
R0004:Lrp1	UTSW	10	127,377,694 (GRCm39)	splice site	probably null
R0034:Lrp1	UTSW	10	127,381,520 (GRCm39)	missense	probably benign	0.42
R0091:Lrp1	UTSW	10	127,376,848 (GRCm39)	missense	probably damaging	1.00
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0143:Lrp1	UTSW	10	127,429,811 (GRCm39)	missense	probably damaging	1.00
R0372:Lrp1	UTSW	10	127,428,005 (GRCm39)	missense	probably damaging	1.00
R0379:Lrp1	UTSW	10	127,430,838 (GRCm39)	missense	probably damaging	1.00
R0445:Lrp1	UTSW	10	127,426,505 (GRCm39)	nonsense	probably null
R0529:Lrp1	UTSW	10	127,377,463 (GRCm39)	splice site	probably null
R0551:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R0570:Lrp1	UTSW	10	127,390,878 (GRCm39)	nonsense	probably null
R0600:Lrp1	UTSW	10	127,403,252 (GRCm39)	missense	probably benign	0.00
R0626:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0647:Lrp1	UTSW	10	127,407,346 (GRCm39)	missense	probably damaging	1.00
R0680:Lrp1	UTSW	10	127,425,530 (GRCm39)	missense	probably damaging	1.00
R0792:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R0792:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0848:Lrp1	UTSW	10	127,389,231 (GRCm39)	splice site	probably null
R0866:Lrp1	UTSW	10	127,375,147 (GRCm39)	missense	probably damaging	1.00
R0918:Lrp1	UTSW	10	127,429,834 (GRCm39)	missense	probably damaging	1.00
R1076:Lrp1	UTSW	10	127,399,666 (GRCm39)	splice site	probably benign
R1107:Lrp1	UTSW	10	127,393,304 (GRCm39)	missense	probably damaging	1.00
R1346:Lrp1	UTSW	10	127,441,735 (GRCm39)	missense	probably damaging	1.00
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1496:Lrp1	UTSW	10	127,374,880 (GRCm39)	missense	probably damaging	1.00
R1522:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R1522:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R1539:Lrp1	UTSW	10	127,420,250 (GRCm39)	splice site	probably null
R1589:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1591:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1663:Lrp1	UTSW	10	127,392,790 (GRCm39)	missense	probably damaging	1.00
R1682:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R1717:Lrp1	UTSW	10	127,399,534 (GRCm39)	missense	probably damaging	1.00
R1717:Lrp1	UTSW	10	127,392,138 (GRCm39)	missense	possibly damaging	0.59
R1758:Lrp1	UTSW	10	127,424,453 (GRCm39)	missense	possibly damaging	0.76
R1826:Lrp1	UTSW	10	127,389,576 (GRCm39)	missense	probably damaging	1.00
R1842:Lrp1	UTSW	10	127,409,337 (GRCm39)	missense	possibly damaging	0.93
R1844:Lrp1	UTSW	10	127,431,152 (GRCm39)	critical splice donor site	probably null
R1845:Lrp1	UTSW	10	127,414,542 (GRCm39)	missense	probably damaging	1.00
R1896:Lrp1	UTSW	10	127,395,867 (GRCm39)	missense	possibly damaging	0.64
R1952:Lrp1	UTSW	10	127,403,300 (GRCm39)	missense	probably damaging	1.00
R2009:Lrp1	UTSW	10	127,380,385 (GRCm39)	missense	probably damaging	1.00
R2015:Lrp1	UTSW	10	127,376,563 (GRCm39)	missense	probably benign	0.00
R2116:Lrp1	UTSW	10	127,412,362 (GRCm39)	nonsense	probably null
R2161:Lrp1	UTSW	10	127,391,607 (GRCm39)	missense	probably damaging	1.00
R2199:Lrp1	UTSW	10	127,382,709 (GRCm39)	missense	probably damaging	1.00
R2213:Lrp1	UTSW	10	127,376,571 (GRCm39)	missense	probably damaging	1.00
R2300:Lrp1	UTSW	10	127,392,784 (GRCm39)	nonsense	probably null
R2324:Lrp1	UTSW	10	127,402,455 (GRCm39)	missense	possibly damaging	0.92
R2849:Lrp1	UTSW	10	127,378,165 (GRCm39)	missense	probably damaging	1.00
R2926:Lrp1	UTSW	10	127,423,982 (GRCm39)	missense	probably damaging	0.98
R2993:Lrp1	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
R3522:Lrp1	UTSW	10	127,389,424 (GRCm39)	missense	probably damaging	1.00
R3702:Lrp1	UTSW	10	127,430,972 (GRCm39)	missense	probably damaging	1.00
R3789:Lrp1	UTSW	10	127,407,838 (GRCm39)	missense	possibly damaging	0.94
R3898:Lrp1	UTSW	10	127,427,969 (GRCm39)	nonsense	probably null
R3941:Lrp1	UTSW	10	127,389,265 (GRCm39)	missense	probably damaging	1.00
R3958:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R4369:Lrp1	UTSW	10	127,386,155 (GRCm39)	missense	possibly damaging	0.87
R4510:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4511:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4576:Lrp1	UTSW	10	127,376,057 (GRCm39)	small deletion	probably benign
R4583:Lrp1	UTSW	10	127,377,241 (GRCm39)	missense	probably benign	0.00
R4662:Lrp1	UTSW	10	127,388,054 (GRCm39)	nonsense	probably null
R4721:Lrp1	UTSW	10	127,390,928 (GRCm39)	missense	possibly damaging	0.58
R4728:Lrp1	UTSW	10	127,399,606 (GRCm39)	missense	probably damaging	1.00
R4745:Lrp1	UTSW	10	127,385,813 (GRCm39)	missense	probably benign	0.20
R4785:Lrp1	UTSW	10	127,394,002 (GRCm39)	missense	probably benign	0.12
R4841:Lrp1	UTSW	10	127,419,805 (GRCm39)	missense	probably damaging	1.00
R4842:Lrp1	UTSW	10	127,419,805 (GRCm39)	missense	probably damaging	1.00
R4855:Lrp1	UTSW	10	127,446,311 (GRCm39)	missense	probably benign	0.03
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4891:Lrp1	UTSW	10	127,377,621 (GRCm39)	missense	probably damaging	1.00
R4925:Lrp1	UTSW	10	127,410,944 (GRCm39)	nonsense	probably null
R4970:Lrp1	UTSW	10	127,375,389 (GRCm39)	missense	probably benign	0.11
R4999:Lrp1	UTSW	10	127,389,648 (GRCm39)	missense	probably damaging	1.00
R5044:Lrp1	UTSW	10	127,403,364 (GRCm39)	missense	probably damaging	1.00
R5127:Lrp1	UTSW	10	127,375,503 (GRCm39)	intron	probably benign
R5188:Lrp1	UTSW	10	127,443,821 (GRCm39)	missense	probably damaging	1.00
R5218:Lrp1	UTSW	10	127,384,488 (GRCm39)	missense	probably damaging	1.00
R5225:Lrp1	UTSW	10	127,391,965 (GRCm39)	missense	probably benign	0.04
R5291:Lrp1	UTSW	10	127,429,747 (GRCm39)	missense	probably damaging	1.00
R5386:Lrp1	UTSW	10	127,427,983 (GRCm39)	missense	probably damaging	1.00
R5395:Lrp1	UTSW	10	127,431,166 (GRCm39)	missense	probably damaging	1.00
R5413:Lrp1	UTSW	10	127,423,936 (GRCm39)	critical splice donor site	probably null
R5430:Lrp1	UTSW	10	127,376,930 (GRCm39)	missense	probably damaging	0.99
R5499:Lrp1	UTSW	10	127,408,813 (GRCm39)	missense	possibly damaging	0.58
R5526:Lrp1	UTSW	10	127,391,593 (GRCm39)	missense	probably benign	0.37
R5580:Lrp1	UTSW	10	127,424,389 (GRCm39)	missense	probably benign
R5583:Lrp1	UTSW	10	127,424,332 (GRCm39)	missense	probably benign	0.08
R5599:Lrp1	UTSW	10	127,429,738 (GRCm39)	missense	probably damaging	1.00
R5639:Lrp1	UTSW	10	127,429,708 (GRCm39)	missense	probably damaging	0.99
R5677:Lrp1	UTSW	10	127,410,298 (GRCm39)	missense	probably damaging	1.00
R5730:Lrp1	UTSW	10	127,419,703 (GRCm39)	missense	probably benign	0.00
R5742:Lrp1	UTSW	10	127,384,216 (GRCm39)	missense	probably damaging	0.98
R5764:Lrp1	UTSW	10	127,431,187 (GRCm39)	missense	probably benign	0.41
R5864:Lrp1	UTSW	10	127,403,374 (GRCm39)	missense	possibly damaging	0.58
R5937:Lrp1	UTSW	10	127,419,745 (GRCm39)	missense	possibly damaging	0.93
R5947:Lrp1	UTSW	10	127,425,423 (GRCm39)	critical splice donor site	probably null
R5976:Lrp1	UTSW	10	127,419,770 (GRCm39)	missense	probably damaging	1.00
R6021:Lrp1	UTSW	10	127,413,883 (GRCm39)	missense	probably damaging	1.00
R6026:Lrp1	UTSW	10	127,409,272 (GRCm39)	missense	probably damaging	1.00
R6045:Lrp1	UTSW	10	127,402,469 (GRCm39)	missense	probably damaging	0.98
R6057:Lrp1	UTSW	10	127,403,359 (GRCm39)	missense	probably damaging	1.00
R6084:Lrp1	UTSW	10	127,396,422 (GRCm39)	missense	probably benign	0.09
R6131:Lrp1	UTSW	10	127,396,026 (GRCm39)	missense	probably benign
R6235:Lrp1	UTSW	10	127,424,046 (GRCm39)	missense	probably damaging	1.00
R6280:Lrp1	UTSW	10	127,425,453 (GRCm39)	missense	probably benign	0.04
R6307:Lrp1	UTSW	10	127,427,944 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,385,276 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,377,551 (GRCm39)	missense	probably damaging	1.00
R6536:Lrp1	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
R6605:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6607:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6631:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R6676:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6678:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6809:Lrp1	UTSW	10	127,390,925 (GRCm39)	missense	probably benign	0.04
R6884:Lrp1	UTSW	10	127,394,986 (GRCm39)	missense	probably benign	0.00
R6925:Lrp1	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
R6987:Lrp1	UTSW	10	127,410,874 (GRCm39)	missense	probably damaging	1.00
R7016:Lrp1	UTSW	10	127,395,836 (GRCm39)	critical splice donor site	probably null
R7030:Lrp1	UTSW	10	127,388,745 (GRCm39)	missense	probably damaging	0.97
R7053:Lrp1	UTSW	10	127,376,963 (GRCm39)	missense	probably damaging	1.00
R7076:Lrp1	UTSW	10	127,386,052 (GRCm39)	critical splice donor site	probably null
R7136:Lrp1	UTSW	10	127,394,491 (GRCm39)	missense	probably damaging	1.00
R7180:Lrp1	UTSW	10	127,392,834 (GRCm39)	missense	probably damaging	1.00
R7199:Lrp1	UTSW	10	127,409,325 (GRCm39)	missense	probably damaging	0.99
R7219:Lrp1	UTSW	10	127,393,097 (GRCm39)	missense	probably benign	0.40
R7233:Lrp1	UTSW	10	127,430,930 (GRCm39)	missense	probably damaging	1.00
R7251:Lrp1	UTSW	10	127,408,423 (GRCm39)	missense	probably damaging	1.00
R7264:Lrp1	UTSW	10	127,427,962 (GRCm39)	missense	probably damaging	1.00
R7302:Lrp1	UTSW	10	127,374,856 (GRCm39)	missense	probably benign	0.01
R7313:Lrp1	UTSW	10	127,389,337 (GRCm39)	missense	probably damaging	1.00
R7322:Lrp1	UTSW	10	127,381,433 (GRCm39)	missense	probably benign	0.24
R7354:Lrp1	UTSW	10	127,407,277 (GRCm39)	missense	probably damaging	1.00
R7375:Lrp1	UTSW	10	127,375,217 (GRCm39)	missense	probably damaging	1.00
R7388:Lrp1	UTSW	10	127,419,766 (GRCm39)	nonsense	probably null
R7404:Lrp1	UTSW	10	127,418,577 (GRCm39)	missense
R7405:Lrp1	UTSW	10	127,417,620 (GRCm39)	missense	possibly damaging	0.93
R7477:Lrp1	UTSW	10	127,404,789 (GRCm39)	missense	probably damaging	1.00
R7555:Lrp1	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
R7600:Lrp1	UTSW	10	127,391,575 (GRCm39)	missense	probably benign
R7678:Lrp1	UTSW	10	127,409,922 (GRCm39)	missense	probably damaging	1.00
R7679:Lrp1	UTSW	10	127,424,297 (GRCm39)	nonsense	probably null
R7951:Lrp1	UTSW	10	127,374,933 (GRCm39)	nonsense	probably null
R7964:Lrp1	UTSW	10	127,410,913 (GRCm39)	missense	possibly damaging	0.94
R8006:Lrp1	UTSW	10	127,425,488 (GRCm39)	missense	probably damaging	1.00
R8021:Lrp1	UTSW	10	127,384,215 (GRCm39)	missense	possibly damaging	0.92
R8098:Lrp1	UTSW	10	127,410,324 (GRCm39)	missense	possibly damaging	0.78
R8112:Lrp1	UTSW	10	127,441,715 (GRCm39)	missense	probably damaging	1.00
R8210:Lrp1	UTSW	10	127,412,354 (GRCm39)	missense	probably damaging	1.00
R8249:Lrp1	UTSW	10	127,441,412 (GRCm39)	missense	probably benign
R8291:Lrp1	UTSW	10	127,425,572 (GRCm39)	missense	probably damaging	1.00
R8332:Lrp1	UTSW	10	127,407,805 (GRCm39)	missense	probably damaging	1.00
R8435:Lrp1	UTSW	10	127,392,199 (GRCm39)	missense	probably damaging	0.97
R8467:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8468:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8474:Lrp1	UTSW	10	127,375,572 (GRCm39)	missense	probably damaging	1.00
R8481:Lrp1	UTSW	10	127,404,779 (GRCm39)	missense	probably damaging	1.00
R8483:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8485:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8488:Lrp1	UTSW	10	127,396,356 (GRCm39)	missense	probably damaging	1.00
R8715:Lrp1	UTSW	10	127,396,490 (GRCm39)	missense	possibly damaging	0.77
R8790:Lrp1	UTSW	10	127,374,946 (GRCm39)	missense	probably damaging	1.00
R8854:Lrp1	UTSW	10	127,378,968 (GRCm39)	missense	probably damaging	1.00
R8926:Lrp1	UTSW	10	127,381,671 (GRCm39)	missense	probably benign
R8949:Lrp1	UTSW	10	127,425,405 (GRCm39)	intron	probably benign
R8971:Lrp1	UTSW	10	127,391,896 (GRCm39)	missense	possibly damaging	0.94
R9103:Lrp1	UTSW	10	127,430,979 (GRCm39)	nonsense	probably null
R9108:Lrp1	UTSW	10	127,390,206 (GRCm39)	missense	probably damaging	0.99
R9130:Lrp1	UTSW	10	127,382,281 (GRCm39)	missense	probably benign	0.18
R9157:Lrp1	UTSW	10	127,410,209 (GRCm39)	missense	probably damaging	1.00
R9162:Lrp1	UTSW	10	127,441,368 (GRCm39)	missense	probably benign	0.32
R9205:Lrp1	UTSW	10	127,430,850 (GRCm39)	nonsense	probably null
R9228:Lrp1	UTSW	10	127,382,807 (GRCm39)	missense	probably damaging	0.98
R9231:Lrp1	UTSW	10	127,382,268 (GRCm39)	missense	probably benign	0.06
R9287:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R9381:Lrp1	UTSW	10	127,441,337 (GRCm39)	missense	probably benign	0.17
R9412:Lrp1	UTSW	10	127,409,287 (GRCm39)	missense	probably damaging	1.00
R9434:Lrp1	UTSW	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
R9463:Lrp1	UTSW	10	127,429,334 (GRCm39)	nonsense	probably null
R9526:Lrp1	UTSW	10	127,431,229 (GRCm39)	missense	probably damaging	0.96
R9548:Lrp1	UTSW	10	127,388,733 (GRCm39)	missense	probably damaging	0.99
R9599:Lrp1	UTSW	10	127,410,246 (GRCm39)	missense	probably damaging	1.00
R9649:Lrp1	UTSW	10	127,409,368 (GRCm39)	missense	probably benign	0.14
R9687:Lrp1	UTSW	10	127,402,562 (GRCm39)	missense	probably damaging	1.00
R9707:Lrp1	UTSW	10	127,408,414 (GRCm39)	missense	probably benign	0.08
R9770:Lrp1	UTSW	10	127,420,268 (GRCm39)	missense	probably damaging	1.00
V3553:Lrp1	UTSW	10	127,407,311 (GRCm39)	missense	probably damaging	1.00
Y5406:Lrp1	UTSW	10	127,390,152 (GRCm39)	missense	probably damaging	1.00
Z1088:Lrp1	UTSW	10	127,420,248 (GRCm39)	missense	probably damaging	1.00
Z1176:Lrp1	UTSW	10	127,390,831 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCCTTTGATCCTGTTCCAGAAGCC -3'
(R):5'- ATGCCCACCCACTGAGTTTTGC -3'

Sequencing Primer
(F):5'- AGGTAGGGTTTCCAATTTCCAC -3'
(R):5'- ATATGACAGGACCCCGGTG -3'

Posted On

2014-04-13