Incidental Mutation 'R1510:Triobp'
| ID |
167882 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Triobp
|
| Ensembl Gene |
ENSMUSG00000033088 |
| Gene Name |
TRIO and F-actin binding protein |
| Synonyms |
EST478828, Mus EST 478828, Tara |
| MMRRC Submission |
039557-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1510 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
78831924-78890069 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 78887967 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glutamine
at position 1908
(R1908Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105311
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109687]
[ENSMUST00000109688]
[ENSMUST00000109689]
[ENSMUST00000109690]
|
| AlphaFold |
Q99KW3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109687
AA Change: R567Q
PolyPhen 2
Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000105309
Gene: ENSMUSG00000033088
AA Change: R567Q
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
7 |
104 |
6.2e-19 |
SMART |
|
coiled coil region
|
277 |
304 |
N/A |
INTRINSIC |
|
coiled coil region
|
339 |
377 |
N/A |
INTRINSIC |
|
coiled coil region
|
401 |
463 |
N/A |
INTRINSIC |
|
coiled coil region
|
497 |
576 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000109688
|
| SMART Domains |
Protein: ENSMUSP00000105310
Gene: ENSMUSG00000033088
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
30 |
47 |
N/A |
INTRINSIC |
|
PH
|
54 |
151 |
6.2e-19 |
SMART |
|
coiled coil region
|
324 |
351 |
N/A |
INTRINSIC |
|
coiled coil region
|
386 |
424 |
N/A |
INTRINSIC |
|
coiled coil region
|
448 |
510 |
N/A |
INTRINSIC |
|
coiled coil region
|
544 |
623 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109689
AA Change: R1908Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105311
Gene: ENSMUSG00000033088
AA Change: R1908Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
7.43e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
7.43e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1395 |
1492 |
6.2e-19 |
SMART |
|
coiled coil region
|
1665 |
1692 |
N/A |
INTRINSIC |
|
coiled coil region
|
1727 |
1765 |
N/A |
INTRINSIC |
|
coiled coil region
|
1789 |
1851 |
N/A |
INTRINSIC |
|
coiled coil region
|
1885 |
1964 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109690
AA Change: R1954Q
PolyPhen 2
Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000105312
Gene: ENSMUSG00000033088
AA Change: R1954Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
130 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
291 |
311 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
312 |
394 |
9.24e-13 |
PROSPERO |
|
internal_repeat_1
|
390 |
540 |
9.24e-13 |
PROSPERO |
|
low complexity region
|
585 |
600 |
N/A |
INTRINSIC |
|
low complexity region
|
638 |
657 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
767 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
903 |
923 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1017 |
N/A |
INTRINSIC |
|
low complexity region
|
1054 |
1068 |
N/A |
INTRINSIC |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
PH
|
1441 |
1538 |
6.2e-19 |
SMART |
|
coiled coil region
|
1711 |
1738 |
N/A |
INTRINSIC |
|
coiled coil region
|
1773 |
1811 |
N/A |
INTRINSIC |
|
coiled coil region
|
1835 |
1897 |
N/A |
INTRINSIC |
|
coiled coil region
|
1931 |
2010 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129922
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183598
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229535
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230425
|
| Meta Mutation Damage Score |
0.0956 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.8%
|
| Validation Efficiency |
100% (79/79) |
| MGI Phenotype |
FUNCTION: This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. The encoded protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in the human gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants have been described [provided by RefSeq, Sep 2012]
PHENOTYPE: Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcd2 |
A |
G |
15: 91,073,181 (GRCm39) |
L326S |
probably damaging |
Het |
| Adam18 |
T |
A |
8: 25,115,847 (GRCm39) |
T616S |
probably benign |
Het |
| Adam22 |
T |
C |
5: 8,202,408 (GRCm39) |
K215E |
probably benign |
Het |
| Ahi1 |
T |
G |
10: 20,835,699 (GRCm39) |
S11A |
probably benign |
Het |
| Asb18 |
T |
C |
1: 89,923,976 (GRCm39) |
M96V |
possibly damaging |
Het |
| Baz2b |
T |
C |
2: 59,752,553 (GRCm39) |
D1149G |
probably damaging |
Het |
| C1qtnf3 |
A |
G |
15: 10,975,722 (GRCm39) |
E176G |
probably benign |
Het |
| Cd151 |
T |
A |
7: 141,050,280 (GRCm39) |
S172T |
probably benign |
Het |
| Cdh2 |
G |
T |
18: 16,781,651 (GRCm39) |
L90I |
probably benign |
Het |
| Cdkl3 |
T |
C |
11: 51,924,341 (GRCm39) |
V55A |
possibly damaging |
Het |
| Cfap90 |
T |
A |
13: 68,745,596 (GRCm39) |
M1K |
probably null |
Het |
| Chst8 |
T |
A |
7: 34,374,693 (GRCm39) |
H382L |
probably benign |
Het |
| Cyb5r4 |
T |
C |
9: 86,948,696 (GRCm39) |
|
probably benign |
Het |
| Cyp2j13 |
T |
C |
4: 95,950,209 (GRCm39) |
D264G |
possibly damaging |
Het |
| Daam1 |
A |
G |
12: 72,024,500 (GRCm39) |
M814V |
probably damaging |
Het |
| Ddx19b |
A |
G |
8: 111,742,285 (GRCm39) |
I150T |
probably damaging |
Het |
| Dync1li1 |
T |
G |
9: 114,518,278 (GRCm39) |
S50A |
possibly damaging |
Het |
| Fat3 |
A |
T |
9: 15,871,351 (GRCm39) |
L3680Q |
probably damaging |
Het |
| Fermt1 |
C |
T |
2: 132,766,942 (GRCm39) |
E342K |
probably benign |
Het |
| Gm21286 |
T |
G |
4: 60,794,931 (GRCm39) |
|
noncoding transcript |
Het |
| Il6 |
T |
C |
5: 30,223,060 (GRCm39) |
Y126H |
probably damaging |
Het |
| Inhba |
G |
T |
13: 16,201,607 (GRCm39) |
V390L |
probably damaging |
Het |
| Ino80 |
C |
T |
2: 119,280,530 (GRCm39) |
R278H |
probably damaging |
Het |
| Jade3 |
T |
G |
X: 20,384,057 (GRCm39) |
N799K |
probably benign |
Het |
| Kcnn1 |
G |
A |
8: 71,316,714 (GRCm39) |
|
probably benign |
Het |
| Klhl6 |
T |
C |
16: 19,765,848 (GRCm39) |
T585A |
probably damaging |
Het |
| Kmt2d |
T |
A |
15: 98,754,258 (GRCm39) |
|
probably benign |
Het |
| Krt17 |
C |
T |
11: 100,148,365 (GRCm39) |
E359K |
possibly damaging |
Het |
| Lce1b |
T |
G |
3: 92,563,283 (GRCm39) |
R83S |
unknown |
Het |
| Lck |
T |
C |
4: 129,449,461 (GRCm39) |
S290G |
possibly damaging |
Het |
| Ltbp3 |
T |
C |
19: 5,798,915 (GRCm39) |
S544P |
probably benign |
Het |
| Lypd6b |
T |
A |
2: 49,824,831 (GRCm39) |
S4R |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,328,555 (GRCm39) |
D4724G |
probably null |
Het |
| Mcoln2 |
A |
G |
3: 145,882,365 (GRCm39) |
T255A |
probably benign |
Het |
| Mcph1 |
T |
A |
8: 18,682,703 (GRCm39) |
|
probably null |
Het |
| Mki67 |
C |
A |
7: 135,297,900 (GRCm39) |
R2378L |
probably benign |
Het |
| Mxd1 |
A |
G |
6: 86,630,137 (GRCm39) |
V27A |
possibly damaging |
Het |
| Myo5a |
T |
C |
9: 75,078,833 (GRCm39) |
Y864H |
probably benign |
Het |
| Ndel1 |
A |
T |
11: 68,713,482 (GRCm39) |
N318K |
possibly damaging |
Het |
| Oasl1 |
A |
G |
5: 115,066,167 (GRCm39) |
Q95R |
probably benign |
Het |
| Or5ac16 |
A |
T |
16: 59,022,546 (GRCm39) |
M81K |
probably damaging |
Het |
| Or5j3 |
T |
C |
2: 86,128,715 (GRCm39) |
L185P |
probably damaging |
Het |
| Or5p57 |
T |
C |
7: 107,665,735 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or6b2b |
A |
T |
1: 92,419,339 (GRCm39) |
I46N |
probably damaging |
Het |
| Parp10 |
T |
A |
15: 76,125,617 (GRCm39) |
Q487L |
probably damaging |
Het |
| Pcdh10 |
C |
T |
3: 45,333,838 (GRCm39) |
R51C |
probably damaging |
Het |
| Pdpr |
A |
T |
8: 111,851,107 (GRCm39) |
|
probably benign |
Het |
| Pfpl |
A |
T |
19: 12,407,060 (GRCm39) |
D437V |
probably benign |
Het |
| Pik3c2a |
G |
A |
7: 115,987,280 (GRCm39) |
T547I |
probably benign |
Het |
| Pkdrej |
A |
C |
15: 85,700,963 (GRCm39) |
S1658A |
possibly damaging |
Het |
| Pkn3 |
T |
C |
2: 29,969,776 (GRCm39) |
|
probably null |
Het |
| Plekhh2 |
A |
G |
17: 84,867,004 (GRCm39) |
|
probably null |
Het |
| Plxdc1 |
A |
T |
11: 97,823,150 (GRCm39) |
C357S |
probably damaging |
Het |
| Pnp |
A |
G |
14: 51,188,042 (GRCm39) |
T132A |
possibly damaging |
Het |
| Prorp |
A |
T |
12: 55,350,997 (GRCm39) |
Q102L |
probably benign |
Het |
| Rcan2 |
A |
G |
17: 44,147,315 (GRCm39) |
D51G |
probably damaging |
Het |
| Rcn1 |
T |
C |
2: 105,219,434 (GRCm39) |
N253S |
probably damaging |
Het |
| Rreb1 |
T |
A |
13: 38,115,860 (GRCm39) |
I1073N |
probably benign |
Het |
| Scaf4 |
G |
T |
16: 90,042,282 (GRCm39) |
D686E |
unknown |
Het |
| Sfxn5 |
A |
C |
6: 85,213,907 (GRCm39) |
M221R |
probably damaging |
Het |
| Slc38a1 |
A |
G |
15: 96,507,741 (GRCm39) |
F104L |
probably damaging |
Het |
| Slc8a1 |
A |
T |
17: 81,955,547 (GRCm39) |
V497D |
probably damaging |
Het |
| Spryd3 |
C |
A |
15: 102,027,396 (GRCm39) |
G290C |
probably damaging |
Het |
| Stc2 |
A |
T |
11: 31,315,418 (GRCm39) |
Y140* |
probably null |
Het |
| Stfa2 |
A |
T |
16: 36,228,673 (GRCm39) |
I8K |
possibly damaging |
Het |
| Sult3a2 |
A |
T |
10: 33,658,026 (GRCm39) |
M29K |
probably benign |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Trpm2 |
T |
A |
10: 77,802,828 (GRCm39) |
R7* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,782,501 (GRCm39) |
I912V |
probably benign |
Het |
| Tusc2 |
T |
A |
9: 107,442,080 (GRCm39) |
V93E |
probably damaging |
Het |
| Uhrf2 |
T |
A |
19: 30,016,461 (GRCm39) |
|
probably benign |
Het |
| Umodl1 |
G |
A |
17: 31,178,203 (GRCm39) |
V60M |
probably damaging |
Het |
| Ush2a |
A |
T |
1: 188,380,501 (GRCm39) |
D2270V |
probably damaging |
Het |
| Vmn2r80 |
A |
G |
10: 79,005,553 (GRCm39) |
T397A |
possibly damaging |
Het |
| Wbp2 |
A |
G |
11: 115,977,708 (GRCm39) |
V15A |
probably benign |
Het |
| Zfp182 |
T |
A |
X: 20,896,446 (GRCm39) |
R617W |
probably damaging |
Het |
| Zfp82 |
C |
A |
7: 29,756,047 (GRCm39) |
R345L |
probably damaging |
Het |
| Zfp85 |
T |
C |
13: 67,903,084 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Triobp |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01634:Triobp
|
APN |
15 |
78,877,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01904:Triobp
|
APN |
15 |
78,851,564 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01957:Triobp
|
APN |
15 |
78,856,847 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02085:Triobp
|
APN |
15 |
78,858,497 (GRCm39) |
splice site |
probably benign |
|
|
IGL02260:Triobp
|
APN |
15 |
78,850,562 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02498:Triobp
|
APN |
15 |
78,845,243 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02551:Triobp
|
APN |
15 |
78,857,689 (GRCm39) |
missense |
probably benign |
|
|
IGL02740:Triobp
|
APN |
15 |
78,850,889 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL02810:Triobp
|
APN |
15 |
78,886,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03063:Triobp
|
APN |
15 |
78,875,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4304:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
FR4340:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4342:Triobp
|
UTSW |
15 |
78,877,592 (GRCm39) |
unclassified |
probably benign |
|
|
FR4449:Triobp
|
UTSW |
15 |
78,877,589 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,590 (GRCm39) |
unclassified |
probably benign |
|
|
FR4548:Triobp
|
UTSW |
15 |
78,877,587 (GRCm39) |
unclassified |
probably benign |
|
|
R0276:Triobp
|
UTSW |
15 |
78,857,876 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0309:Triobp
|
UTSW |
15 |
78,860,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Triobp
|
UTSW |
15 |
78,852,401 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0464:Triobp
|
UTSW |
15 |
78,851,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0525:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0665:Triobp
|
UTSW |
15 |
78,858,098 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0689:Triobp
|
UTSW |
15 |
78,844,188 (GRCm39) |
nonsense |
probably null |
|
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1149:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1151:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1152:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1519:Triobp
|
UTSW |
15 |
78,857,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1642:Triobp
|
UTSW |
15 |
78,886,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1732:Triobp
|
UTSW |
15 |
78,851,428 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R1755:Triobp
|
UTSW |
15 |
78,850,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1975:Triobp
|
UTSW |
15 |
78,850,908 (GRCm39) |
missense |
probably benign |
|
|
R2051:Triobp
|
UTSW |
15 |
78,888,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Triobp
|
UTSW |
15 |
78,858,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2260:Triobp
|
UTSW |
15 |
78,875,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2351:Triobp
|
UTSW |
15 |
78,888,780 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2902:Triobp
|
UTSW |
15 |
78,857,618 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3801:Triobp
|
UTSW |
15 |
78,857,900 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3959:Triobp
|
UTSW |
15 |
78,886,589 (GRCm39) |
nonsense |
probably null |
|
|
R4003:Triobp
|
UTSW |
15 |
78,844,177 (GRCm39) |
unclassified |
probably benign |
|
|
R4084:Triobp
|
UTSW |
15 |
78,857,871 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4482:Triobp
|
UTSW |
15 |
78,850,763 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4592:Triobp
|
UTSW |
15 |
78,851,295 (GRCm39) |
missense |
probably benign |
|
|
R4662:Triobp
|
UTSW |
15 |
78,877,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Triobp
|
UTSW |
15 |
78,851,313 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4789:Triobp
|
UTSW |
15 |
78,875,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Triobp
|
UTSW |
15 |
78,850,816 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4990:Triobp
|
UTSW |
15 |
78,851,205 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5129:Triobp
|
UTSW |
15 |
78,845,296 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5181:Triobp
|
UTSW |
15 |
78,851,954 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5279:Triobp
|
UTSW |
15 |
78,878,591 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5584:Triobp
|
UTSW |
15 |
78,852,332 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5601:Triobp
|
UTSW |
15 |
78,857,833 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Triobp
|
UTSW |
15 |
78,852,467 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5969:Triobp
|
UTSW |
15 |
78,851,740 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6722:Triobp
|
UTSW |
15 |
78,885,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Triobp
|
UTSW |
15 |
78,850,566 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6810:Triobp
|
UTSW |
15 |
78,850,815 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7011:Triobp
|
UTSW |
15 |
78,862,923 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7015:Triobp
|
UTSW |
15 |
78,878,260 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7200:Triobp
|
UTSW |
15 |
78,851,042 (GRCm39) |
small deletion |
probably benign |
|
|
R7294:Triobp
|
UTSW |
15 |
78,858,176 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7688:Triobp
|
UTSW |
15 |
78,845,311 (GRCm39) |
splice site |
probably null |
|
|
R7805:Triobp
|
UTSW |
15 |
78,858,204 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7972:Triobp
|
UTSW |
15 |
78,852,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7977:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7987:Triobp
|
UTSW |
15 |
78,885,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Triobp
|
UTSW |
15 |
78,844,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8344:Triobp
|
UTSW |
15 |
78,842,475 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8348:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8446:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8448:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8469:Triobp
|
UTSW |
15 |
78,851,219 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8491:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8492:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8493:Triobp
|
UTSW |
15 |
78,878,326 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9424:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9495:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9514:Triobp
|
UTSW |
15 |
78,877,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Triobp
|
UTSW |
15 |
78,886,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Triobp
|
UTSW |
15 |
78,858,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9576:Triobp
|
UTSW |
15 |
78,844,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Triobp
|
UTSW |
15 |
78,887,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Triobp
|
UTSW |
15 |
78,851,227 (GRCm39) |
small insertion |
probably benign |
|
|
RF005:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF007:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
RF022:Triobp
|
UTSW |
15 |
78,858,482 (GRCm39) |
missense |
probably benign |
0.05 |
|
RF028:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF032:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF035:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,239 (GRCm39) |
small insertion |
probably benign |
|
|
RF039:Triobp
|
UTSW |
15 |
78,851,236 (GRCm39) |
small insertion |
probably benign |
|
|
RF040:Triobp
|
UTSW |
15 |
78,851,263 (GRCm39) |
small insertion |
probably benign |
|
|
RF049:Triobp
|
UTSW |
15 |
78,851,261 (GRCm39) |
small insertion |
probably benign |
|
|
RF051:Triobp
|
UTSW |
15 |
78,851,234 (GRCm39) |
small insertion |
probably benign |
|
|
RF058:Triobp
|
UTSW |
15 |
78,851,244 (GRCm39) |
small insertion |
probably benign |
|
|
X0026:Triobp
|
UTSW |
15 |
78,844,223 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Triobp
|
UTSW |
15 |
78,886,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCCCACCACATTGATAGAGCTAC -3'
(R):5'- AGGCTTTTCCAATTCCCAGCTACAC -3'
Sequencing Primer
(F):5'- GAGCTACAGTTCACAGTAGAGCC -3'
(R):5'- TTGGAATCGACCCACTGC -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation