Incidental Mutation 'R1506:Vmn2r7'
ID 167916
Institutional Source Beutler Lab
Gene Symbol Vmn2r7
Ensembl Gene ENSMUSG00000116028
Gene Name vomeronasal 2, receptor 7
Synonyms 4933425M15Rik
MMRRC Submission 039554-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R1506 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 64598081-64627023 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 64614500 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 438 (Y438F)
Ref Sequence ENSEMBL: ENSMUSP00000131220 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161972] [ENSMUST00000168072]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000161972
AA Change: Y529F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000124192
Gene: ENSMUSG00000062200
AA Change: Y529F

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 90 507 3.8e-77 PFAM
Pfam:NCD3G 549 602 3.4e-17 PFAM
Pfam:7tm_3 635 869 1.1e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168072
AA Change: Y438F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000131220
Gene: ENSMUSG00000116028
AA Change: Y438F

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 5.1e-72 PFAM
Pfam:Peripla_BP_6 63 245 6.1e-10 PFAM
Pfam:NCD3G 458 511 1.8e-17 PFAM
Pfam:7tm_3 542 779 4.3e-76 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177146
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.7%
Validation Efficiency 98% (61/62)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 G T 11: 94,248,144 (GRCm39) T1152K possibly damaging Het
Acp3 T A 9: 104,201,373 (GRCm39) T82S probably damaging Het
Adam23 C T 1: 63,586,973 (GRCm39) P445S probably benign Het
Ap3b1 T A 13: 94,582,651 (GRCm39) probably benign Het
Artn A G 4: 117,784,058 (GRCm39) V136A probably damaging Het
Ash1l A G 3: 88,965,806 (GRCm39) T2403A probably damaging Het
Bbof1 G T 12: 84,470,273 (GRCm39) V120L probably damaging Het
Boc A G 16: 44,323,928 (GRCm39) Y158H probably damaging Het
Casp8 A G 1: 58,863,355 (GRCm39) E105G probably damaging Het
Cers4 T C 8: 4,570,557 (GRCm39) F206L probably benign Het
Chrna9 A G 5: 66,126,479 (GRCm39) T78A probably benign Het
Creb3 A T 4: 43,566,193 (GRCm39) T263S possibly damaging Het
Cyp2c40 A G 19: 39,766,443 (GRCm39) V384A probably damaging Het
Dip2b G A 15: 100,080,994 (GRCm39) V879M probably damaging Het
Dnah17 C A 11: 118,016,213 (GRCm39) V14F possibly damaging Het
Epb41l4b T A 4: 57,088,824 (GRCm39) K144N probably damaging Het
Ercc6 A T 14: 32,291,821 (GRCm39) I1062F probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fat2 C A 11: 55,175,090 (GRCm39) E1874D probably benign Het
Fbxw21 T A 9: 108,977,257 (GRCm39) I151F probably damaging Het
Fhip2a A G 19: 57,357,007 (GRCm39) I33V probably benign Het
Foxn1 A G 11: 78,256,761 (GRCm39) probably benign Het
Gpr63 G A 4: 25,008,227 (GRCm39) R317H probably damaging Het
Grip1 C A 10: 119,814,356 (GRCm39) H296N probably damaging Het
Gtdc1 A T 2: 44,465,506 (GRCm39) M288K possibly damaging Het
Guf1 T A 5: 69,724,509 (GRCm39) D488E possibly damaging Het
Gvin3 C T 7: 106,200,788 (GRCm39) D819N probably benign Het
Heatr5b C A 17: 79,060,576 (GRCm39) R2033L probably damaging Het
Hsd17b2 T A 8: 118,429,004 (GRCm39) probably null Het
Ino80 A T 2: 119,255,746 (GRCm39) L913* probably null Het
Inppl1 A C 7: 101,473,174 (GRCm39) S1159A probably benign Het
Kcnk7 G A 19: 5,756,140 (GRCm39) C122Y probably damaging Het
Mtor A G 4: 148,620,962 (GRCm39) probably benign Het
Muc4 A T 16: 32,574,033 (GRCm39) S704C possibly damaging Het
Nckap5 A T 1: 125,953,650 (GRCm39) C967* probably null Het
Nek10 T C 14: 14,999,078 (GRCm38) probably benign Het
Oas1h A T 5: 121,009,951 (GRCm39) D342V possibly damaging Het
Or10j2 A G 1: 173,098,336 (GRCm39) N198S probably benign Het
Or2ak7 T A 11: 58,575,014 (GRCm39) L105Q probably benign Het
Or2n1 A T 17: 38,486,091 (GRCm39) M39L probably benign Het
Or4m1 A G 14: 50,557,941 (GRCm39) V117A probably benign Het
Or8b1b T C 9: 38,375,439 (GRCm39) M34T probably benign Het
Prex1 A T 2: 166,429,001 (GRCm39) V694E probably damaging Het
Rad50 G A 11: 53,570,312 (GRCm39) A810V probably damaging Het
Rcor1 T C 12: 111,076,271 (GRCm39) S410P probably damaging Het
Rps14 A T 18: 60,909,551 (GRCm39) N26I probably benign Het
Slc38a1 T C 15: 96,483,431 (GRCm39) D299G probably benign Het
Slc5a1 T A 5: 33,312,052 (GRCm39) N481K possibly damaging Het
Slco3a1 A T 7: 74,009,683 (GRCm39) probably null Het
Spart T C 3: 55,024,992 (GRCm39) S196P probably damaging Het
Speg A G 1: 75,394,307 (GRCm39) T1701A probably benign Het
Sugt1 A G 14: 79,862,365 (GRCm39) N271S probably benign Het
Tbx15 A T 3: 99,259,228 (GRCm39) L366F possibly damaging Het
Tnc G A 4: 63,925,921 (GRCm39) T953I possibly damaging Het
Uqcc1 A G 2: 155,753,738 (GRCm39) S46P probably damaging Het
Vmn2r18 T C 5: 151,499,099 (GRCm39) probably null Het
Vmn2r72 T A 7: 85,398,419 (GRCm39) K520N probably benign Het
Vps52 T C 17: 34,176,868 (GRCm39) L74P probably damaging Het
Xpo5 G T 17: 46,538,814 (GRCm39) M673I probably benign Het
Zscan18 A G 7: 12,508,129 (GRCm39) V457A probably damaging Het
Other mutations in Vmn2r7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00961:Vmn2r7 APN 3 64,623,234 (GRCm39) missense possibly damaging 0.60
IGL01762:Vmn2r7 APN 3 64,598,856 (GRCm39) missense probably benign 0.39
IGL01903:Vmn2r7 APN 3 64,626,864 (GRCm39) missense probably benign 0.00
IGL02263:Vmn2r7 APN 3 64,598,868 (GRCm39) missense probably damaging 1.00
IGL02458:Vmn2r7 APN 3 64,600,446 (GRCm39) missense probably damaging 0.97
IGL02593:Vmn2r7 APN 3 64,600,443 (GRCm39) missense probably damaging 1.00
IGL02797:Vmn2r7 APN 3 64,598,666 (GRCm39) missense possibly damaging 0.80
IGL03047:Vmn2r7 UTSW 3 64,614,639 (GRCm39) missense possibly damaging 0.81
PIT4504001:Vmn2r7 UTSW 3 64,623,397 (GRCm39) missense probably benign 0.01
R0193:Vmn2r7 UTSW 3 64,598,460 (GRCm39) missense probably damaging 1.00
R0329:Vmn2r7 UTSW 3 64,598,439 (GRCm39) missense probably damaging 1.00
R0609:Vmn2r7 UTSW 3 64,623,900 (GRCm39) missense probably benign 0.44
R0735:Vmn2r7 UTSW 3 64,623,788 (GRCm39) missense probably benign 0.02
R0941:Vmn2r7 UTSW 3 64,624,000 (GRCm39) missense probably benign
R1065:Vmn2r7 UTSW 3 64,614,559 (GRCm39) missense possibly damaging 0.82
R1378:Vmn2r7 UTSW 3 64,599,025 (GRCm39) missense possibly damaging 0.59
R1445:Vmn2r7 UTSW 3 64,632,223 (GRCm39) missense probably benign 0.01
R1509:Vmn2r7 UTSW 3 64,623,881 (GRCm39) nonsense probably null
R1519:Vmn2r7 UTSW 3 64,623,876 (GRCm39) missense possibly damaging 0.95
R1706:Vmn2r7 UTSW 3 64,598,880 (GRCm39) missense possibly damaging 0.79
R2113:Vmn2r7 UTSW 3 64,599,025 (GRCm39) missense possibly damaging 0.59
R3725:Vmn2r7 UTSW 3 64,632,412 (GRCm39) missense possibly damaging 0.65
R3874:Vmn2r7 UTSW 3 64,627,032 (GRCm39) missense possibly damaging 0.69
R3902:Vmn2r7 UTSW 3 64,626,937 (GRCm39) missense possibly damaging 0.46
R4084:Vmn2r7 UTSW 3 64,600,414 (GRCm39) missense probably benign 0.08
R4117:Vmn2r7 UTSW 3 64,623,138 (GRCm39) intron probably benign
R4333:Vmn2r7 UTSW 3 64,598,199 (GRCm39) missense probably damaging 1.00
R4551:Vmn2r7 UTSW 3 64,598,110 (GRCm39) missense possibly damaging 0.86
R4643:Vmn2r7 UTSW 3 64,623,825 (GRCm39) missense probably damaging 1.00
R4654:Vmn2r7 UTSW 3 64,626,864 (GRCm39) missense probably benign 0.00
R5091:Vmn2r7 UTSW 3 64,598,205 (GRCm39) missense possibly damaging 0.63
R5109:Vmn2r7 UTSW 3 64,598,088 (GRCm39) missense probably null 0.84
R5372:Vmn2r7 UTSW 3 64,623,745 (GRCm39) missense probably damaging 1.00
R5415:Vmn2r7 UTSW 3 64,623,658 (GRCm39) missense probably benign 0.07
R5740:Vmn2r7 UTSW 3 64,614,654 (GRCm39) missense probably benign
R5977:Vmn2r7 UTSW 3 64,623,464 (GRCm39) nonsense probably null
R6019:Vmn2r7 UTSW 3 64,623,643 (GRCm39) missense probably damaging 1.00
R6058:Vmn2r7 UTSW 3 64,632,436 (GRCm39) missense probably benign 0.00
R6139:Vmn2r7 UTSW 3 64,623,339 (GRCm39) missense probably damaging 1.00
R6696:Vmn2r7 UTSW 3 64,614,495 (GRCm39) missense probably benign 0.01
R6887:Vmn2r7 UTSW 3 64,598,248 (GRCm39) missense probably damaging 1.00
R6918:Vmn2r7 UTSW 3 64,598,760 (GRCm39) missense probably benign 0.03
R6949:Vmn2r7 UTSW 3 64,598,542 (GRCm39) missense probably damaging 0.99
R6980:Vmn2r7 UTSW 3 64,623,987 (GRCm39) missense possibly damaging 0.67
R7196:Vmn2r7 UTSW 3 64,623,198 (GRCm39) missense probably benign 0.00
R7286:Vmn2r7 UTSW 3 64,598,301 (GRCm39) missense probably benign 0.00
R7455:Vmn2r7 UTSW 3 64,624,014 (GRCm39) missense probably benign
R7557:Vmn2r7 UTSW 3 64,632,394 (GRCm39) missense probably benign
R7864:Vmn2r7 UTSW 3 64,598,947 (GRCm39) missense probably benign 0.10
R8046:Vmn2r7 UTSW 3 64,614,479 (GRCm39) missense probably damaging 1.00
R8068:Vmn2r7 UTSW 3 64,623,507 (GRCm39) missense probably benign 0.01
R8252:Vmn2r7 UTSW 3 64,600,527 (GRCm39) missense probably benign 0.00
R8814:Vmn2r7 UTSW 3 64,623,984 (GRCm39) missense probably benign 0.14
R9497:Vmn2r7 UTSW 3 64,614,474 (GRCm39) missense probably benign 0.04
R9722:Vmn2r7 UTSW 3 64,598,407 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-04-13