Mutagenetix > Incidental Mutation

Incidental Mutation 'R1506:Vmn2r72'

167931

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

039554-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.139) question?

Stock #

R1506 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85749211 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 520 (K520N)

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

AlphaFold

D3Z4N8

Predicted Effect

probably benign
Transcript: ENSMUST00000063425
AA Change: K520N

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: K520N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.5%
20x: 93.7%

Validation Efficiency

98% (61/62)

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc3	G	T	11: 94,357,318	T1152K	possibly damaging	Het
Acpp	T	A	9: 104,324,174	T82S	probably damaging	Het
Adam23	C	T	1: 63,547,814	P445S	probably benign	Het
Ap3b1	T	A	13: 94,446,143		probably benign	Het
Artn	A	G	4: 117,926,861	V136A	probably damaging	Het
Ash1l	A	G	3: 89,058,499	T2403A	probably damaging	Het
Bbof1	G	T	12: 84,423,499	V120L	probably damaging	Het
Boc	A	G	16: 44,503,565	Y158H	probably damaging	Het
Casp8	A	G	1: 58,824,196	E105G	probably damaging	Het
Cers4	T	C	8: 4,520,557	F206L	probably benign	Het
Chrna9	A	G	5: 65,969,136	T78A	probably benign	Het
Creb3	A	T	4: 43,566,193	T263S	possibly damaging	Het
Cyp2c40	A	G	19: 39,777,999	V384A	probably damaging	Het
Dip2b	G	A	15: 100,183,113	V879M	probably damaging	Het
Dnah17	C	A	11: 118,125,387	V14F	possibly damaging	Het
Epb41l4b	T	A	4: 57,088,824	K144N	probably damaging	Het
Ercc6	A	T	14: 32,569,864	I1062F	probably benign	Het
Fabp3	C	T	4: 130,312,387	T57I	probably benign	Het
Fam160b1	A	G	19: 57,368,575	I33V	probably benign	Het
Fat2	C	A	11: 55,284,264	E1874D	probably benign	Het
Fbxw21	T	A	9: 109,148,189	I151F	probably damaging	Het
Foxn1	A	G	11: 78,365,935		probably benign	Het
Gm1966	C	T	7: 106,601,581	D819N	probably benign	Het
Gpr63	G	A	4: 25,008,227	R317H	probably damaging	Het
Grip1	C	A	10: 119,978,451	H296N	probably damaging	Het
Gtdc1	A	T	2: 44,575,494	M288K	possibly damaging	Het
Guf1	T	A	5: 69,567,166	D488E	possibly damaging	Het
Heatr5b	C	A	17: 78,753,147	R2033L	probably damaging	Het
Hsd17b2	T	A	8: 117,702,265		probably null	Het
Ino80	A	T	2: 119,425,265	L913*	probably null	Het
Inppl1	A	C	7: 101,823,967	S1159A	probably benign	Het
Kcnk7	G	A	19: 5,706,112	C122Y	probably damaging	Het
Mtor	A	G	4: 148,536,505		probably benign	Het
Muc4	A	T	16: 32,752,233	S704C	possibly damaging	Het
Nckap5	A	T	1: 126,025,913	C967*	probably null	Het
Nek10	T	C	14: 14,999,078		probably benign	Het
Oas1h	A	T	5: 120,871,888	D342V	possibly damaging	Het
Olfr134	A	T	17: 38,175,200	M39L	probably benign	Het
Olfr320	T	A	11: 58,684,188	L105Q	probably benign	Het
Olfr418	A	G	1: 173,270,769	N198S	probably benign	Het
Olfr734	A	G	14: 50,320,484	V117A	probably benign	Het
Olfr904	T	C	9: 38,464,143	M34T	probably benign	Het
Prex1	A	T	2: 166,587,081	V694E	probably damaging	Het
Rad50	G	A	11: 53,679,485	A810V	probably damaging	Het
Rcor1	T	C	12: 111,109,837	S410P	probably damaging	Het
Rps14	A	T	18: 60,776,479	N26I	probably benign	Het
Slc38a1	T	C	15: 96,585,550	D299G	probably benign	Het
Slc5a1	T	A	5: 33,154,708	N481K	possibly damaging	Het
Slco3a1	A	T	7: 74,359,935		probably null	Het
Speg	A	G	1: 75,417,663	T1701A	probably benign	Het
Spg20	T	C	3: 55,117,571	S196P	probably damaging	Het
Sugt1	A	G	14: 79,624,925	N271S	probably benign	Het
Tbx15	A	T	3: 99,351,912	L366F	possibly damaging	Het
Tnc	G	A	4: 64,007,684	T953I	possibly damaging	Het
Uqcc1	A	G	2: 155,911,818	S46P	probably damaging	Het
Vmn2r18	T	C	5: 151,575,634		probably null	Het
Vmn2r7	T	A	3: 64,707,079	Y438F	probably benign	Het
Vps52	T	C	17: 33,957,894	L74P	probably damaging	Het
Xpo5	G	T	17: 46,227,888	M673I	probably benign	Het
Zscan18	A	G	7: 12,774,202	V457A	probably damaging	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6354:Vmn2r72	UTSW	7	85750539	critical splice donor site	probably null
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
R8989:Vmn2r72	UTSW	7	85754926	missense	probably benign	0.10
R9015:Vmn2r72	UTSW	7	85749180	missense	probably benign	0.01
R9080:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R9269:Vmn2r72	UTSW	7	85751203	missense	probably benign	0.03
R9317:Vmn2r72	UTSW	7	85754814	missense	probably benign	0.04
R9509:Vmn2r72	UTSW	7	85754867	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- ACACTTTACTTTCCAAAATGGACATTGAGAAC -3'
(R):5'- AGGTCATCTGCCAAGTCGTCAAC -3'

Sequencing Primer
(F):5'- CATTTTCAGGGCAGGGGTTA -3'
(R):5'- atctgcctgcttctgcc -3'

Posted On

2014-04-13