|Institutional Source||Beutler Lab|
|Gene Name||non-SMC condensin II complex, subunit G2|
|Synonyms||Luzp5, 5830426I05Rik, mCAP-G2, Mtb|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R1507 (G1)|
|Chromosomal Location||116405402-116463731 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 116460566 bp|
|Amino Acid Change||Phenylalanine to Serine at position 1123 (F1123S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000081889 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000084828]|
|Predicted Effect||probably benign
AA Change: F1123S
PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
AA Change: F1123S
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.1123|
|Coding Region Coverage||
|Validation Efficiency||100% (66/66)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ncapg2||
(F):5'- GGGTGCTGAGCCTGTTTACCTTTAC -3'
(R):5'- TGCCCATGCCACAGTTCCTACAAG -3'
(F):5'- CGGCTGTGAAACTTGTGCTC -3'
(R):5'- CACCCAGTGTTTTTGACGGT -3'