Mutagenetix > Incidental Mutation

Incidental Mutation 'R1509:Rp1'

168101

Institutional Source

Beutler Lab

Gene Symbol

Rp1

Ensembl Gene

ENSMUSG00000025900

Gene Name

retinitis pigmentosa 1 (human)

Synonyms

Dcdc3, mG145, Orp1, oxygen-regulated protein 1, Rp1h

MMRRC Submission

039556-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R1509 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

3999557-4409241 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 4347694 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Arginine at position 1065 (K1065R)

Ref Sequence

ENSEMBL: ENSMUSP00000027032 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027032] [ENSMUST00000194992] [ENSMUST00000208660]

AlphaFold

P56716

Predicted Effect

probably damaging
Transcript: ENSMUST00000027032
AA Change: K1065R

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000027032
Gene: ENSMUSG00000025900
AA Change: K1065R

Domain	Start	End	E-Value	Type
DCX	30	117	4.37e-39	SMART
low complexity region	120	133	N/A	INTRINSIC
DCX	152	236	7.17e-35	SMART
low complexity region	343	354	N/A	INTRINSIC
low complexity region	403	414	N/A	INTRINSIC
low complexity region	462	473	N/A	INTRINSIC
low complexity region	646	661	N/A	INTRINSIC
low complexity region	1113	1123	N/A	INTRINSIC
low complexity region	1396	1412	N/A	INTRINSIC
low complexity region	1434	1444	N/A	INTRINSIC
low complexity region	1648	1661	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000194992

SMART Domains

Protein: ENSMUSP00000142146
Gene: ENSMUSG00000025900

Domain	Start	End	E-Value	Type
DCX	40	127	4.37e-39	SMART
low complexity region	130	143	N/A	INTRINSIC
DCX	162	246	7.17e-35	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000208660

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000208793

Meta Mutation Damage Score

0.1179

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.4%
20x: 93.1%

Validation Efficiency

99% (89/90)

MGI Phenotype

FUNCTION: This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. Two transcript variants encoding distinct isoforms are resulted from alternative promoters and alternative splicing. [provided by RefSeq, Sep 2010]
PHENOTYPE: Mice homozygous for disruptions in this gene experience progressive degeneration in photoreceptors but are otherwise phenotypically normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 85 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	T	C	13: 77,192,647 (GRCm38)	S132P	probably benign	Het
4930430A15Rik	A	T	2: 111,218,627 (GRCm38)	M269K	probably benign	Het
AC153895.1	T	C	6: 50,043,471 (GRCm38)	R54G	unknown	Het
Acot12	G	A	13: 91,771,875 (GRCm38)		probably null	Het
Adhfe1	T	A	1: 9,553,446 (GRCm38)	D98E	probably benign	Het
Ago2	A	G	15: 73,116,364 (GRCm38)	F594S	probably damaging	Het
Aldh18a1	A	G	19: 40,557,483 (GRCm38)	I620T	probably damaging	Het
Aspscr1	C	A	11: 120,701,516 (GRCm38)	A294D	probably damaging	Het
BC067074	A	G	13: 113,368,256 (GRCm38)	N431S	probably damaging	Het
Bod1l	C	G	5: 41,819,540 (GRCm38)	R1477T	probably damaging	Het
Ccdc18	C	A	5: 108,188,978 (GRCm38)	A741D	possibly damaging	Het
Ces4a	G	A	8: 105,138,097 (GRCm38)	G69S	probably damaging	Het
Cfap52	C	T	11: 67,938,993 (GRCm38)	V317I	probably benign	Het
Cgn	A	T	3: 94,774,258 (GRCm38)	L509Q	probably benign	Het
Crb2	A	G	2: 37,786,619 (GRCm38)	H204R	probably benign	Het
Ddx39	G	A	8: 83,719,898 (GRCm38)	V99M	probably damaging	Het
Dis3l2	T	A	1: 87,021,086 (GRCm38)	C582S	possibly damaging	Het
Dmbt1	G	A	7: 131,074,331 (GRCm38)		probably benign	Het
Dnah6	T	C	6: 73,027,442 (GRCm38)	E3846G	probably damaging	Het
Dstyk	A	G	1: 132,456,346 (GRCm38)	E655G	probably damaging	Het
Epha4	T	C	1: 77,380,886 (GRCm38)	Y825C	probably damaging	Het
Esp36	T	A	17: 38,417,282 (GRCm38)	N36I	probably damaging	Het
Fabp3	C	T	4: 130,312,387 (GRCm38)	T57I	probably benign	Het
Fem1c	A	G	18: 46,524,213 (GRCm38)	S145P	probably benign	Het
Galnt13	T	C	2: 54,733,082 (GRCm38)	I80T	probably damaging	Het
Gm10125	A	G	18: 5,583,794 (GRCm38)		noncoding transcript	Het
Gm5698	T	C	1: 30,977,647 (GRCm38)	T108A	probably benign	Het
Hipk3	A	G	2: 104,441,262 (GRCm38)	S442P	probably benign	Het
Hmcn2	T	A	2: 31,314,479 (GRCm38)	V22D	possibly damaging	Het
Hspg2	C	T	4: 137,511,241 (GRCm38)		probably benign	Het
Ide	A	G	19: 37,285,204 (GRCm38)		probably null	Het
Ifnar1	C	A	16: 91,503,496 (GRCm38)	P462Q	probably damaging	Het
Itgb2l	T	A	16: 96,426,849 (GRCm38)	I485F	probably benign	Het
Jakmip3	C	T	7: 139,027,776 (GRCm38)	R549W	possibly damaging	Het
Lrrc36	A	G	8: 105,461,129 (GRCm38)	Q680R	probably damaging	Het
Lysmd3	T	G	13: 81,669,271 (GRCm38)	H122Q	probably benign	Het
Macf1	C	A	4: 123,684,009 (GRCm38)	V61L	possibly damaging	Het
Map1b	T	C	13: 99,431,528 (GRCm38)	T1562A	unknown	Het
Map3k20	A	T	2: 72,364,624 (GRCm38)		probably benign	Het
Mroh8	A	G	2: 157,233,205 (GRCm38)	V457A	probably benign	Het
Mrpl40	T	A	16: 18,875,409 (GRCm38)		probably null	Het
Ms4a10	C	T	19: 10,964,108 (GRCm38)	V166I	probably benign	Het
Mycl	A	G	4: 123,000,307 (GRCm38)	D300G	probably damaging	Het
Naca	T	A	10: 128,043,397 (GRCm38)		probably benign	Het
Ncoa4	T	C	14: 32,173,434 (GRCm38)	S172P	probably damaging	Het
Nfatc3	T	C	8: 106,083,854 (GRCm38)	F421L	possibly damaging	Het
Nucb1	C	A	7: 45,495,225 (GRCm38)	K301N	probably benign	Het
Olfr1451	T	A	19: 12,999,451 (GRCm38)	I155N	possibly damaging	Het
Olfr366	A	G	2: 37,219,954 (GRCm38)	H155R	probably damaging	Het
Olfr629	A	T	7: 103,741,036 (GRCm38)	M68K	probably benign	Het
Panx1	A	T	9: 15,010,045 (GRCm38)	V178E	possibly damaging	Het
Pkd1l3	G	A	8: 109,640,770 (GRCm38)	V1210I	probably damaging	Het
Polr2a	A	T	11: 69,747,213 (GRCm38)	H143Q	possibly damaging	Het
Prdm12	G	A	2: 31,654,174 (GRCm38)	R263H	probably damaging	Het
Prkdc	A	C	16: 15,731,566 (GRCm38)	K1998T	probably damaging	Het
Rab11fip1	A	T	8: 27,153,023 (GRCm38)	S583T	probably damaging	Het
Rnf157	T	A	11: 116,347,095 (GRCm38)	T567S	probably benign	Het
Rps10	A	C	17: 27,631,208 (GRCm38)	F150V	probably benign	Het
Rrp12	A	T	19: 41,882,200 (GRCm38)	F499I	probably damaging	Het
Sez6l2	G	A	7: 126,963,363 (GRCm38)	R604H	probably damaging	Het
Slc25a21	G	T	12: 56,858,079 (GRCm38)	Q57K	probably benign	Het
Slc27a2	A	G	2: 126,553,314 (GRCm38)	T54A	possibly damaging	Het
Slc9a9	T	A	9: 95,228,958 (GRCm38)	S610T	probably benign	Het
Smc1b	A	T	15: 85,086,134 (GRCm38)	S973T	probably benign	Het
Smc6	G	A	12: 11,279,733 (GRCm38)	S164N	possibly damaging	Het
Sp1	A	G	15: 102,407,879 (GRCm38)	T32A	possibly damaging	Het
Spen	T	C	4: 141,475,700 (GRCm38)	K1872R	possibly damaging	Het
Spen	T	C	4: 141,475,635 (GRCm38)	I1894V	probably benign	Het
Stab1	C	A	14: 31,151,584 (GRCm38)		probably benign	Het
Taar7d	T	G	10: 24,028,204 (GRCm38)	F328C	probably damaging	Het
Ticam1	A	T	17: 56,271,113 (GRCm38)	S327R	probably benign	Het
Tmem248	C	T	5: 130,229,454 (GRCm38)		probably benign	Het
Tom1	T	C	8: 75,054,631 (GRCm38)	S83P	probably damaging	Het
Txk	T	A	5: 72,699,110 (GRCm38)	Y446F	probably damaging	Het
Ubap1l	T	A	9: 65,371,955 (GRCm38)	C179S	probably benign	Het
Utrn	T	C	10: 12,455,441 (GRCm38)	E474G	possibly damaging	Het
Vmn2r14	T	C	5: 109,215,996 (GRCm38)	M685V	probably benign	Het
Vmn2r7	A	T	3: 64,716,460 (GRCm38)	Y146*	probably null	Het
Wdr1	G	A	5: 38,540,562 (GRCm38)	T220M	probably damaging	Het
Xpo7	T	C	14: 70,678,142 (GRCm38)	D726G	probably damaging	Het
Zbtb14	C	G	17: 69,387,764 (GRCm38)	I152M	probably benign	Het
Zbtb3	A	G	19: 8,803,407 (GRCm38)	D128G	probably damaging	Het
Zfp462	T	A	4: 55,007,667 (GRCm38)	D35E	probably damaging	Het
Zfp467	A	G	6: 48,438,687 (GRCm38)	S344P	possibly damaging	Het
Zfpm1	A	T	8: 122,307,546 (GRCm38)	D73V	possibly damaging	Het

Other mutations in Rp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00323:Rp1	APN	1	4,346,746 (GRCm38)	missense	probably damaging	0.98
IGL00593:Rp1	APN	1	4,345,403 (GRCm38)	missense	possibly damaging	0.70
IGL00956:Rp1	APN	1	4,352,212 (GRCm38)	missense	probably damaging	1.00
IGL01070:Rp1	APN	1	4,345,238 (GRCm38)	missense	probably damaging	1.00
IGL01531:Rp1	APN	1	4,348,945 (GRCm38)	missense	probably benign	0.00
IGL01668:Rp1	APN	1	4,345,718 (GRCm38)	missense	probably damaging	1.00
IGL01907:Rp1	APN	1	4,348,507 (GRCm38)	missense	possibly damaging	0.56
IGL02055:Rp1	APN	1	4,352,522 (GRCm38)	missense	probably damaging	1.00
IGL02071:Rp1	APN	1	4,345,310 (GRCm38)	missense	possibly damaging	0.46
IGL02128:Rp1	APN	1	4,347,385 (GRCm38)	missense	probably damaging	0.99
IGL02244:Rp1	APN	1	4,348,780 (GRCm38)	missense	probably benign	0.00
IGL02381:Rp1	APN	1	4,352,390 (GRCm38)	missense	probably benign	0.01
IGL02499:Rp1	APN	1	4,349,048 (GRCm38)	missense	probably benign	0.17
IGL02619:Rp1	APN	1	4,348,450 (GRCm38)	missense	possibly damaging	0.73
IGL02832:Rp1	APN	1	4,349,713 (GRCm38)	missense	probably benign	0.03
IGL02861:Rp1	APN	1	4,346,152 (GRCm38)	nonsense	probably null
IGL03288:Rp1	APN	1	4,349,524 (GRCm38)	missense	possibly damaging	0.88
IGL03290:Rp1	APN	1	4,350,041 (GRCm38)	missense	probably damaging	1.00
IGL03303:Rp1	APN	1	4,344,817 (GRCm38)	missense	probably damaging	1.00
R0041:Rp1	UTSW	1	4,344,628 (GRCm38)	missense	probably benign	0.36
R0111:Rp1	UTSW	1	4,344,760 (GRCm38)	missense	probably damaging	1.00
R0363:Rp1	UTSW	1	4,347,718 (GRCm38)	missense	probably damaging	1.00
R0440:Rp1	UTSW	1	4,345,640 (GRCm38)	missense	probably damaging	1.00
R0442:Rp1	UTSW	1	4,346,747 (GRCm38)	missense	probably benign	0.09
R0528:Rp1	UTSW	1	4,344,865 (GRCm38)	missense	possibly damaging	0.82
R0586:Rp1	UTSW	1	4,347,837 (GRCm38)	missense	possibly damaging	0.76
R0639:Rp1	UTSW	1	4,346,498 (GRCm38)	missense	probably benign	0.00
R0856:Rp1	UTSW	1	4,344,655 (GRCm38)	missense	probably benign	0.05
R0908:Rp1	UTSW	1	4,344,655 (GRCm38)	missense	probably benign	0.05
R0968:Rp1	UTSW	1	4,345,352 (GRCm38)	missense	probably benign	0.00
R1099:Rp1	UTSW	1	4,352,290 (GRCm38)	missense	possibly damaging	0.45
R1242:Rp1	UTSW	1	4,344,962 (GRCm38)	missense	probably benign	0.03
R1301:Rp1	UTSW	1	4,345,936 (GRCm38)	missense	possibly damaging	0.56
R1327:Rp1	UTSW	1	4,347,970 (GRCm38)	missense	probably benign	0.01
R1403:Rp1	UTSW	1	4,346,297 (GRCm38)	missense	possibly damaging	0.73
R1403:Rp1	UTSW	1	4,346,297 (GRCm38)	missense	possibly damaging	0.73
R1406:Rp1	UTSW	1	4,351,921 (GRCm38)	missense	possibly damaging	0.88
R1406:Rp1	UTSW	1	4,351,921 (GRCm38)	missense	possibly damaging	0.88
R1440:Rp1	UTSW	1	4,347,396 (GRCm38)	missense	probably damaging	1.00
R1509:Rp1	UTSW	1	4,348,537 (GRCm38)	missense	probably benign	0.20
R1538:Rp1	UTSW	1	4,345,676 (GRCm38)	missense	probably damaging	1.00
R1609:Rp1	UTSW	1	4,349,201 (GRCm38)	missense	probably damaging	1.00
R1666:Rp1	UTSW	1	4,349,863 (GRCm38)	missense	probably damaging	1.00
R1703:Rp1	UTSW	1	4,345,169 (GRCm38)	missense	probably damaging	1.00
R1782:Rp1	UTSW	1	4,349,089 (GRCm38)	missense	probably benign	0.00
R1799:Rp1	UTSW	1	4,348,832 (GRCm38)	missense	possibly damaging	0.94
R1848:Rp1	UTSW	1	4,347,232 (GRCm38)	missense	possibly damaging	0.76
R1908:Rp1	UTSW	1	4,348,720 (GRCm38)	missense	probably damaging	0.99
R1919:Rp1	UTSW	1	4,352,671 (GRCm38)	missense	probably damaging	0.99
R2087:Rp1	UTSW	1	4,348,352 (GRCm38)	missense	probably damaging	1.00
R2211:Rp1	UTSW	1	4,348,139 (GRCm38)	missense	probably damaging	0.96
R2278:Rp1	UTSW	1	4,348,027 (GRCm38)	missense	possibly damaging	0.51
R2287:Rp1	UTSW	1	4,345,959 (GRCm38)	nonsense	probably null
R2316:Rp1	UTSW	1	4,345,640 (GRCm38)	missense	probably damaging	1.00
R2346:Rp1	UTSW	1	4,348,013 (GRCm38)	missense	probably damaging	1.00
R2878:Rp1	UTSW	1	4,348,139 (GRCm38)	missense	probably damaging	1.00
R3023:Rp1	UTSW	1	4,352,675 (GRCm38)	missense	probably damaging	1.00
R3025:Rp1	UTSW	1	4,352,675 (GRCm38)	missense	probably damaging	1.00
R3716:Rp1	UTSW	1	4,349,765 (GRCm38)	missense	probably benign	0.38
R3814:Rp1	UTSW	1	4,349,708 (GRCm38)	missense	probably benign
R3929:Rp1	UTSW	1	4,352,645 (GRCm38)	missense	probably damaging	1.00
R4064:Rp1	UTSW	1	4,345,400 (GRCm38)	missense	probably benign	0.08
R4426:Rp1	UTSW	1	4,347,924 (GRCm38)	missense	probably benign	0.13
R4557:Rp1	UTSW	1	4,344,663 (GRCm38)	missense	possibly damaging	0.61
R4764:Rp1	UTSW	1	4,345,878 (GRCm38)	missense	probably damaging	0.96
R4845:Rp1	UTSW	1	4,349,228 (GRCm38)	missense	probably benign	0.02
R4850:Rp1	UTSW	1	4,348,675 (GRCm38)	missense	probably damaging	1.00
R4857:Rp1	UTSW	1	4,352,317 (GRCm38)	missense	probably damaging	1.00
R4857:Rp1	UTSW	1	4,352,316 (GRCm38)	missense	probably damaging	0.99
R5159:Rp1	UTSW	1	4,346,203 (GRCm38)	missense	possibly damaging	0.73
R5226:Rp1	UTSW	1	4,348,033 (GRCm38)	missense	probably benign	0.01
R5327:Rp1	UTSW	1	4,349,360 (GRCm38)	splice site	probably null
R5352:Rp1	UTSW	1	4,347,098 (GRCm38)	missense	probably benign	0.00
R5504:Rp1	UTSW	1	4,349,890 (GRCm38)	missense	probably damaging	1.00
R5527:Rp1	UTSW	1	4,346,393 (GRCm38)	missense	possibly damaging	0.75
R5529:Rp1	UTSW	1	4,345,832 (GRCm38)	missense	probably benign	0.42
R5569:Rp1	UTSW	1	4,345,237 (GRCm38)	missense	probably damaging	1.00
R5622:Rp1	UTSW	1	4,347,837 (GRCm38)	missense	possibly damaging	0.76
R5970:Rp1	UTSW	1	4,348,462 (GRCm38)	missense	probably benign	0.05
R5992:Rp1	UTSW	1	4,148,703 (GRCm38)	missense	unknown
R6004:Rp1	UTSW	1	4,197,585 (GRCm38)	missense	unknown
R6018:Rp1	UTSW	1	4,352,836 (GRCm38)	missense	possibly damaging	0.83
R6074:Rp1	UTSW	1	4,345,379 (GRCm38)	missense	probably benign	0.02
R6127:Rp1	UTSW	1	4,349,311 (GRCm38)	missense	possibly damaging	0.80
R6187:Rp1	UTSW	1	4,349,869 (GRCm38)	missense	probably damaging	1.00
R6301:Rp1	UTSW	1	4,347,254 (GRCm38)	missense	probably benign	0.04
R6317:Rp1	UTSW	1	4,041,989 (GRCm38)	missense	unknown
R6405:Rp1	UTSW	1	4,345,771 (GRCm38)	missense	probably damaging	1.00
R6445:Rp1	UTSW	1	4,226,617 (GRCm38)	missense	unknown
R6466:Rp1	UTSW	1	4,347,886 (GRCm38)	missense	probably benign	0.01
R6501:Rp1	UTSW	1	4,311,280 (GRCm38)	intron	probably benign
R6547:Rp1	UTSW	1	4,170,305 (GRCm38)	missense	unknown
R6604:Rp1	UTSW	1	4,019,128 (GRCm38)	missense	unknown
R6700:Rp1	UTSW	1	4,349,896 (GRCm38)	missense	probably damaging	1.00
R6706:Rp1	UTSW	1	4,142,664 (GRCm38)	missense	unknown
R6831:Rp1	UTSW	1	4,349,864 (GRCm38)	splice site	probably null
R6918:Rp1	UTSW	1	3,999,608 (GRCm38)	missense	unknown
R6973:Rp1	UTSW	1	4,351,994 (GRCm38)	nonsense	probably null
R6981:Rp1	UTSW	1	4,345,655 (GRCm38)	missense	probably benign	0.06
R7009:Rp1	UTSW	1	4,042,068 (GRCm38)	missense	unknown
R7078:Rp1	UTSW	1	4,206,791 (GRCm38)	missense	unknown
R7112:Rp1	UTSW	1	4,349,018 (GRCm38)	missense	probably benign	0.43
R7135:Rp1	UTSW	1	4,348,168 (GRCm38)	missense	possibly damaging	0.83
R7165:Rp1	UTSW	1	4,349,917 (GRCm38)	missense	probably damaging	0.99
R7199:Rp1	UTSW	1	4,347,290 (GRCm38)	missense	possibly damaging	0.73
R7232:Rp1	UTSW	1	4,228,601 (GRCm38)	missense	unknown
R7367:Rp1	UTSW	1	4,347,998 (GRCm38)	missense	probably benign	0.42
R7484:Rp1	UTSW	1	4,345,481 (GRCm38)	missense	probably benign	0.10
R7500:Rp1	UTSW	1	4,311,278 (GRCm38)	missense	unknown
R7569:Rp1	UTSW	1	4,284,840 (GRCm38)	missense	unknown
R7642:Rp1	UTSW	1	4,147,831 (GRCm38)	missense	unknown
R7693:Rp1	UTSW	1	4,347,403 (GRCm38)	missense	probably damaging	1.00
R7742:Rp1	UTSW	1	4,170,234 (GRCm38)	missense	unknown
R7759:Rp1	UTSW	1	4,344,884 (GRCm38)	missense	probably benign
R7784:Rp1	UTSW	1	4,142,658 (GRCm38)	missense	unknown
R7816:Rp1	UTSW	1	4,347,703 (GRCm38)	missense	probably damaging	0.98
R7866:Rp1	UTSW	1	4,347,701 (GRCm38)	missense	probably benign	0.02
R8215:Rp1	UTSW	1	4,245,095 (GRCm38)	missense	unknown
R8281:Rp1	UTSW	1	4,347,916 (GRCm38)	missense	probably damaging	1.00
R8294:Rp1	UTSW	1	4,345,997 (GRCm38)	missense	probably benign	0.09
R8309:Rp1	UTSW	1	4,347,089 (GRCm38)	missense	probably benign	0.00
R8311:Rp1	UTSW	1	4,348,349 (GRCm38)	missense	probably benign	0.11
R8500:Rp1	UTSW	1	4,346,590 (GRCm38)	missense	possibly damaging	0.91
R8559:Rp1	UTSW	1	4,349,561 (GRCm38)	missense	probably damaging	1.00
R8672:Rp1	UTSW	1	4,348,784 (GRCm38)	missense	possibly damaging	0.55
R8688:Rp1	UTSW	1	4,346,405 (GRCm38)	missense	probably benign	0.01
R8792:Rp1	UTSW	1	4,024,868 (GRCm38)	missense	unknown
R8859:Rp1	UTSW	1	4,349,960 (GRCm38)	missense	probably benign	0.07
R8945:Rp1	UTSW	1	4,349,594 (GRCm38)	missense	probably benign	0.42
R8959:Rp1	UTSW	1	4,349,427 (GRCm38)	intron	probably benign
R8979:Rp1	UTSW	1	4,148,714 (GRCm38)	missense	unknown
R9126:Rp1	UTSW	1	4,346,913 (GRCm38)	missense	probably damaging	0.99
R9156:Rp1	UTSW	1	4,163,938 (GRCm38)	missense	unknown
R9160:Rp1	UTSW	1	4,346,497 (GRCm38)	missense	probably benign	0.00
R9221:Rp1	UTSW	1	4,245,043 (GRCm38)	missense	unknown
R9263:Rp1	UTSW	1	4,348,937 (GRCm38)	missense	probably benign	0.02
R9263:Rp1	UTSW	1	4,348,452 (GRCm38)	missense	probably benign	0.25
R9302:Rp1	UTSW	1	4,346,566 (GRCm38)	missense	probably damaging	1.00
R9318:Rp1	UTSW	1	4,348,265 (GRCm38)	missense	probably benign	0.09
R9414:Rp1	UTSW	1	4,243,618 (GRCm38)	missense	unknown
R9474:Rp1	UTSW	1	4,092,615 (GRCm38)	critical splice donor site	probably null
R9478:Rp1	UTSW	1	4,347,322 (GRCm38)	missense	probably benign	0.06
R9529:Rp1	UTSW	1	4,346,224 (GRCm38)	missense	probably benign
R9572:Rp1	UTSW	1	4,348,439 (GRCm38)	missense	probably benign
R9673:Rp1	UTSW	1	4,267,569 (GRCm38)	missense	unknown
R9709:Rp1	UTSW	1	4,042,032 (GRCm38)	missense	unknown
R9716:Rp1	UTSW	1	4,142,610 (GRCm38)	critical splice donor site	probably null
RF003:Rp1	UTSW	1	4,344,694 (GRCm38)	missense	probably damaging	0.99
V1662:Rp1	UTSW	1	4,349,560 (GRCm38)	missense	probably damaging	1.00
X0012:Rp1	UTSW	1	4,347,695 (GRCm38)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- GCAGCCTTCAAGTCATCAGCTTCC -3'
(R):5'- CATCACTGTGAGAGCCAGAATGGG -3'

Sequencing Primer
(F):5'- CTCTGTGATGGCAACATGC -3'
(R):5'- AGCCAGAATGGGTCTCTGTATG -3'

Posted On

2014-04-13