Incidental Mutation 'R1509:Vmn2r14'
| ID |
168131 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r14
|
| Ensembl Gene |
ENSMUSG00000091059 |
| Gene Name |
vomeronasal 2, receptor 14 |
| Synonyms |
EG231591 |
| MMRRC Submission |
039556-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.469)
|
| Stock # |
R1509 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109362822-109372488 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109363862 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 685
(M685V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128015
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170341]
|
| AlphaFold |
E9Q759 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170341
AA Change: M685V
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: M685V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.3e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
594 |
829 |
1.2e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 93.1%
|
| Validation Efficiency |
99% (89/90) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
C |
13: 77,340,766 (GRCm39) |
S132P |
probably benign |
Het |
| AC153895.1 |
T |
C |
6: 50,020,451 (GRCm39) |
R54G |
unknown |
Het |
| Acot12 |
G |
A |
13: 91,919,994 (GRCm39) |
|
probably null |
Het |
| Adhfe1 |
T |
A |
1: 9,623,671 (GRCm39) |
D98E |
probably benign |
Het |
| Ago2 |
A |
G |
15: 72,988,213 (GRCm39) |
F594S |
probably damaging |
Het |
| Aldh18a1 |
A |
G |
19: 40,545,927 (GRCm39) |
I620T |
probably damaging |
Het |
| Aspscr1 |
C |
A |
11: 120,592,342 (GRCm39) |
A294D |
probably damaging |
Het |
| Bod1l |
C |
G |
5: 41,976,883 (GRCm39) |
R1477T |
probably damaging |
Het |
| Ccdc18 |
C |
A |
5: 108,336,844 (GRCm39) |
A741D |
possibly damaging |
Het |
| Ces4a |
G |
A |
8: 105,864,729 (GRCm39) |
G69S |
probably damaging |
Het |
| Cfap52 |
C |
T |
11: 67,829,819 (GRCm39) |
V317I |
probably benign |
Het |
| Cgn |
A |
T |
3: 94,681,568 (GRCm39) |
L509Q |
probably benign |
Het |
| Crb2 |
A |
G |
2: 37,676,631 (GRCm39) |
H204R |
probably benign |
Het |
| Cspg4b |
A |
G |
13: 113,504,790 (GRCm39) |
N431S |
probably damaging |
Het |
| Ddx39a |
G |
A |
8: 84,446,527 (GRCm39) |
V99M |
probably damaging |
Het |
| Dis3l2 |
T |
A |
1: 86,948,808 (GRCm39) |
C582S |
possibly damaging |
Het |
| Dmbt1 |
G |
A |
7: 130,676,061 (GRCm39) |
|
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,004,425 (GRCm39) |
E3846G |
probably damaging |
Het |
| Dstyk |
A |
G |
1: 132,384,084 (GRCm39) |
E655G |
probably damaging |
Het |
| Epha4 |
T |
C |
1: 77,357,523 (GRCm39) |
Y825C |
probably damaging |
Het |
| Esp36 |
T |
A |
17: 38,728,173 (GRCm39) |
N36I |
probably damaging |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Fem1c |
A |
G |
18: 46,657,280 (GRCm39) |
S145P |
probably benign |
Het |
| Galnt13 |
T |
C |
2: 54,623,094 (GRCm39) |
I80T |
probably damaging |
Het |
| Gm5698 |
T |
C |
1: 31,016,728 (GRCm39) |
T108A |
probably benign |
Het |
| Hipk3 |
A |
G |
2: 104,271,607 (GRCm39) |
S442P |
probably benign |
Het |
| Hmcn2 |
T |
A |
2: 31,204,491 (GRCm39) |
V22D |
possibly damaging |
Het |
| Hspg2 |
C |
T |
4: 137,238,552 (GRCm39) |
|
probably benign |
Het |
| Ide |
A |
G |
19: 37,262,603 (GRCm39) |
|
probably null |
Het |
| Ifnar1 |
C |
A |
16: 91,300,384 (GRCm39) |
P462Q |
probably damaging |
Het |
| Itgb2l |
T |
A |
16: 96,228,049 (GRCm39) |
I485F |
probably benign |
Het |
| Jakmip3 |
C |
T |
7: 138,629,505 (GRCm39) |
R549W |
possibly damaging |
Het |
| Lrrc36 |
A |
G |
8: 106,187,761 (GRCm39) |
Q680R |
probably damaging |
Het |
| Lysmd3 |
T |
G |
13: 81,817,390 (GRCm39) |
H122Q |
probably benign |
Het |
| Macf1 |
C |
A |
4: 123,577,802 (GRCm39) |
V61L |
possibly damaging |
Het |
| Map1b |
T |
C |
13: 99,568,036 (GRCm39) |
T1562A |
unknown |
Het |
| Map3k20 |
A |
T |
2: 72,194,968 (GRCm39) |
|
probably benign |
Het |
| Mroh8 |
A |
G |
2: 157,075,125 (GRCm39) |
V457A |
probably benign |
Het |
| Mrpl40 |
T |
A |
16: 18,694,159 (GRCm39) |
|
probably null |
Het |
| Ms4a10 |
C |
T |
19: 10,941,472 (GRCm39) |
V166I |
probably benign |
Het |
| Mycl |
A |
G |
4: 122,894,100 (GRCm39) |
D300G |
probably damaging |
Het |
| Naca |
T |
A |
10: 127,879,266 (GRCm39) |
|
probably benign |
Het |
| Ncoa4 |
T |
C |
14: 31,895,391 (GRCm39) |
S172P |
probably damaging |
Het |
| Nfatc3 |
T |
C |
8: 106,810,486 (GRCm39) |
F421L |
possibly damaging |
Het |
| Nucb1 |
C |
A |
7: 45,144,649 (GRCm39) |
K301N |
probably benign |
Het |
| Or1af1 |
A |
G |
2: 37,109,966 (GRCm39) |
H155R |
probably damaging |
Het |
| Or52ae9 |
A |
T |
7: 103,390,243 (GRCm39) |
M68K |
probably benign |
Het |
| Or5b99 |
T |
A |
19: 12,976,815 (GRCm39) |
I155N |
possibly damaging |
Het |
| Panx1 |
A |
T |
9: 14,921,341 (GRCm39) |
V178E |
possibly damaging |
Het |
| Pkd1l3 |
G |
A |
8: 110,367,402 (GRCm39) |
V1210I |
probably damaging |
Het |
| Polr2a |
A |
T |
11: 69,638,039 (GRCm39) |
H143Q |
possibly damaging |
Het |
| Potefam1 |
A |
T |
2: 111,048,972 (GRCm39) |
M269K |
probably benign |
Het |
| Prdm12 |
G |
A |
2: 31,544,186 (GRCm39) |
R263H |
probably damaging |
Het |
| Prkdc |
A |
C |
16: 15,549,430 (GRCm39) |
K1998T |
probably damaging |
Het |
| Rab11fip1 |
A |
T |
8: 27,643,051 (GRCm39) |
S583T |
probably damaging |
Het |
| Rnf157 |
T |
A |
11: 116,237,921 (GRCm39) |
T567S |
probably benign |
Het |
| Rp1 |
T |
C |
1: 4,417,917 (GRCm39) |
K1065R |
probably damaging |
Het |
| Rp1 |
A |
G |
1: 4,418,760 (GRCm39) |
I784T |
probably benign |
Het |
| Rps10 |
A |
C |
17: 27,850,182 (GRCm39) |
F150V |
probably benign |
Het |
| Rrp12 |
A |
T |
19: 41,870,639 (GRCm39) |
F499I |
probably damaging |
Het |
| Sez6l2 |
G |
A |
7: 126,562,535 (GRCm39) |
R604H |
probably damaging |
Het |
| Slc25a21 |
G |
T |
12: 56,904,864 (GRCm39) |
Q57K |
probably benign |
Het |
| Slc27a2 |
A |
G |
2: 126,395,234 (GRCm39) |
T54A |
possibly damaging |
Het |
| Slc9a9 |
T |
A |
9: 95,111,011 (GRCm39) |
S610T |
probably benign |
Het |
| Smc1b |
A |
T |
15: 84,970,335 (GRCm39) |
S973T |
probably benign |
Het |
| Smc6 |
G |
A |
12: 11,329,734 (GRCm39) |
S164N |
possibly damaging |
Het |
| Sp1 |
A |
G |
15: 102,316,314 (GRCm39) |
T32A |
possibly damaging |
Het |
| Spen |
T |
C |
4: 141,202,946 (GRCm39) |
I1894V |
probably benign |
Het |
| Spen |
T |
C |
4: 141,203,011 (GRCm39) |
K1872R |
possibly damaging |
Het |
| Stab1 |
C |
A |
14: 30,873,541 (GRCm39) |
|
probably benign |
Het |
| Taar7d |
T |
G |
10: 23,904,102 (GRCm39) |
F328C |
probably damaging |
Het |
| Ticam1 |
A |
T |
17: 56,578,113 (GRCm39) |
S327R |
probably benign |
Het |
| Tmem248 |
C |
T |
5: 130,258,295 (GRCm39) |
|
probably benign |
Het |
| Tom1 |
T |
C |
8: 75,781,259 (GRCm39) |
S83P |
probably damaging |
Het |
| Txk |
T |
A |
5: 72,856,453 (GRCm39) |
Y446F |
probably damaging |
Het |
| Ubap1l |
T |
A |
9: 65,279,237 (GRCm39) |
C179S |
probably benign |
Het |
| Utrn |
T |
C |
10: 12,331,185 (GRCm39) |
E474G |
possibly damaging |
Het |
| Vmn2r7 |
A |
T |
3: 64,623,881 (GRCm39) |
Y146* |
probably null |
Het |
| Wdr1 |
G |
A |
5: 38,697,905 (GRCm39) |
T220M |
probably damaging |
Het |
| Xpo7 |
T |
C |
14: 70,915,582 (GRCm39) |
D726G |
probably damaging |
Het |
| Zbtb14 |
C |
G |
17: 69,694,759 (GRCm39) |
I152M |
probably benign |
Het |
| Zbtb3 |
A |
G |
19: 8,780,771 (GRCm39) |
D128G |
probably damaging |
Het |
| Zeb1os1 |
A |
G |
18: 5,583,794 (GRCm39) |
|
noncoding transcript |
Het |
| Zfp462 |
T |
A |
4: 55,007,667 (GRCm39) |
D35E |
probably damaging |
Het |
| Zfp467 |
A |
G |
6: 48,415,621 (GRCm39) |
S344P |
possibly damaging |
Het |
| Zfpm1 |
A |
T |
8: 123,034,285 (GRCm39) |
D73V |
possibly damaging |
Het |
|
| Other mutations in Vmn2r14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01472:Vmn2r14
|
APN |
5 |
109,364,180 (GRCm39) |
nonsense |
probably null |
|
|
IGL01504:Vmn2r14
|
APN |
5 |
109,369,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Vmn2r14
|
APN |
5 |
109,372,443 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02093:Vmn2r14
|
APN |
5 |
109,368,275 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02103:Vmn2r14
|
APN |
5 |
109,372,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Vmn2r14
|
APN |
5 |
109,367,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02145:Vmn2r14
|
APN |
5 |
109,368,454 (GRCm39) |
nonsense |
probably null |
|
|
IGL02676:Vmn2r14
|
APN |
5 |
109,367,882 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02720:Vmn2r14
|
APN |
5 |
109,369,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02877:Vmn2r14
|
APN |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02974:Vmn2r14
|
APN |
5 |
109,369,292 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03151:Vmn2r14
|
APN |
5 |
109,364,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Vmn2r14
|
APN |
5 |
109,363,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03386:Vmn2r14
|
APN |
5 |
109,368,350 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03394:Vmn2r14
|
APN |
5 |
109,367,702 (GRCm39) |
missense |
probably null |
0.83 |
|
ANU74:Vmn2r14
|
UTSW |
5 |
109,366,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0316:Vmn2r14
|
UTSW |
5 |
109,366,762 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0755:Vmn2r14
|
UTSW |
5 |
109,364,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1219:Vmn2r14
|
UTSW |
5 |
109,372,440 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1321:Vmn2r14
|
UTSW |
5 |
109,364,117 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1551:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Vmn2r14
|
UTSW |
5 |
109,367,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1668:Vmn2r14
|
UTSW |
5 |
109,366,913 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Vmn2r14
|
UTSW |
5 |
109,369,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r14
|
UTSW |
5 |
109,366,698 (GRCm39) |
splice site |
probably null |
|
|
R2417:Vmn2r14
|
UTSW |
5 |
109,372,329 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3029:Vmn2r14
|
UTSW |
5 |
109,363,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3120:Vmn2r14
|
UTSW |
5 |
109,372,431 (GRCm39) |
missense |
probably null |
0.00 |
|
R3729:Vmn2r14
|
UTSW |
5 |
109,364,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r14
|
UTSW |
5 |
109,368,033 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3943:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4224:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4239:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4240:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4782:Vmn2r14
|
UTSW |
5 |
109,369,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4832:Vmn2r14
|
UTSW |
5 |
109,363,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4884:Vmn2r14
|
UTSW |
5 |
109,369,384 (GRCm39) |
splice site |
probably null |
|
|
R4896:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5004:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5117:Vmn2r14
|
UTSW |
5 |
109,363,961 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5285:Vmn2r14
|
UTSW |
5 |
109,365,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5413:Vmn2r14
|
UTSW |
5 |
109,369,154 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5569:Vmn2r14
|
UTSW |
5 |
109,368,261 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5701:Vmn2r14
|
UTSW |
5 |
109,367,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Vmn2r14
|
UTSW |
5 |
109,365,486 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5763:Vmn2r14
|
UTSW |
5 |
109,363,724 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5872:Vmn2r14
|
UTSW |
5 |
109,369,222 (GRCm39) |
missense |
probably benign |
|
|
R5985:Vmn2r14
|
UTSW |
5 |
109,368,082 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6268:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6273:Vmn2r14
|
UTSW |
5 |
109,369,133 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6409:Vmn2r14
|
UTSW |
5 |
109,364,096 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,364,140 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,363,925 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7608:Vmn2r14
|
UTSW |
5 |
109,369,276 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7740:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7768:Vmn2r14
|
UTSW |
5 |
109,368,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7804:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7872:Vmn2r14
|
UTSW |
5 |
109,369,219 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7993:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8006:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8007:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8187:Vmn2r14
|
UTSW |
5 |
109,368,420 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8369:Vmn2r14
|
UTSW |
5 |
109,369,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8463:Vmn2r14
|
UTSW |
5 |
109,369,340 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8968:Vmn2r14
|
UTSW |
5 |
109,365,533 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9008:Vmn2r14
|
UTSW |
5 |
109,367,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9030:Vmn2r14
|
UTSW |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9039:Vmn2r14
|
UTSW |
5 |
109,367,902 (GRCm39) |
nonsense |
probably null |
|
|
R9150:Vmn2r14
|
UTSW |
5 |
109,367,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9164:Vmn2r14
|
UTSW |
5 |
109,364,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Vmn2r14
|
UTSW |
5 |
109,369,112 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9225:Vmn2r14
|
UTSW |
5 |
109,369,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r14
|
UTSW |
5 |
109,368,176 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9342:Vmn2r14
|
UTSW |
5 |
109,368,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Vmn2r14
|
UTSW |
5 |
109,367,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9678:Vmn2r14
|
UTSW |
5 |
109,364,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Vmn2r14
|
UTSW |
5 |
109,369,126 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1177:Vmn2r14
|
UTSW |
5 |
109,367,741 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTTCCTAGCCAAGAAAGCCACAG -3'
(R):5'- TGTGAAGGCCAATAACCGCATTCTC -3'
Sequencing Primer
(F):5'- ACAGTGAAGCTCCCCAGAG -3'
(R):5'- GCATTCTCAGCAACATCCTG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation