|Institutional Source||Beutler Lab|
|Gene Name||potassium channel, subfamily K, member 16|
|Synonyms||4731413G05Rik, TALK1, TALK-1|
|Is this an essential gene?||Probably non essential (E-score: 0.081)|
|Stock #||R1515 (G1)|
|Chromosomal Location||20261376-20269199 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 20265277 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 73 (I73F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000024155 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000024155] [ENSMUST00000225596]|
|Predicted Effect||probably damaging
AA Change: I73F
PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
AA Change: I73F
|Predicted Effect||noncoding transcript
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered beta cell electrical excitability, second-phase insulin secretion and glucose homeostasis. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Kcnk16||
(F):5'- TGTGACCCAGAGAAGTGAGTCCAG -3'
(R):5'- GCCACTTAGTGTCTTAGCCAGAACC -3'
(F):5'- TCTGTCACCTCCGGGATAAAG -3'
(R):5'- CTCGGATCCTTCATGTCCAT -3'