Incidental Mutation 'R1511:Parp14'
| ID |
168364 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp14
|
| Ensembl Gene |
ENSMUSG00000034422 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 14 |
| Synonyms |
CoaSt6, collaborator of Stat6, 1600029O10Rik |
| MMRRC Submission |
039558-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.493)
|
| Stock # |
R1511 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
35653244-35691914 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 35677594 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Aspartic acid
at position 791
(E791D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000037657
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042665]
|
| AlphaFold |
Q2EMV9 |
| PDB Structure |
Solution structure of WWE domain in Parp14 protein [SOLUTION NMR]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000042665
AA Change: E791D
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000037657
Gene: ENSMUSG00000034422
AA Change: E791D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
38 |
49 |
N/A |
INTRINSIC |
|
low complexity region
|
93 |
115 |
N/A |
INTRINSIC |
|
RRM
|
228 |
297 |
4.71e-2 |
SMART |
|
coiled coil region
|
443 |
468 |
N/A |
INTRINSIC |
|
Blast:A1pp
|
693 |
746 |
6e-6 |
BLAST |
|
low complexity region
|
771 |
795 |
N/A |
INTRINSIC |
|
A1pp
|
814 |
948 |
7.62e-41 |
SMART |
|
A1pp
|
1026 |
1160 |
5.88e-24 |
SMART |
|
A1pp
|
1239 |
1358 |
6.82e-20 |
SMART |
|
PDB:1X4R|A
|
1532 |
1619 |
9e-53 |
PDB |
|
Pfam:PARP
|
1632 |
1817 |
2.5e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142946
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 95.4%
- 20x: 89.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit altered B cell subsets and inability to respond to the apoptosis protective affects of IL4. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aacs |
C |
A |
5: 125,592,041 (GRCm39) |
N576K |
probably benign |
Het |
| Abca5 |
G |
T |
11: 110,190,804 (GRCm39) |
L769M |
probably damaging |
Het |
| Abca5 |
T |
A |
11: 110,190,812 (GRCm39) |
H766L |
possibly damaging |
Het |
| Acvr1c |
A |
G |
2: 58,177,896 (GRCm39) |
I191T |
probably damaging |
Het |
| Agps |
A |
T |
2: 75,697,123 (GRCm39) |
E314D |
probably damaging |
Het |
| Agxt |
G |
A |
1: 93,063,490 (GRCm39) |
G131R |
probably damaging |
Het |
| Ak8 |
A |
G |
2: 28,632,758 (GRCm39) |
T326A |
probably benign |
Het |
| Aldoart2 |
T |
A |
12: 55,613,062 (GRCm39) |
I329N |
probably benign |
Het |
| Apaf1 |
T |
C |
10: 90,896,047 (GRCm39) |
I342V |
possibly damaging |
Het |
| Arhgap40 |
T |
C |
2: 158,369,081 (GRCm39) |
S68P |
probably benign |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| AU022252 |
C |
T |
4: 119,085,294 (GRCm39) |
R71Q |
possibly damaging |
Het |
| Baz1b |
T |
C |
5: 135,246,636 (GRCm39) |
L695P |
probably damaging |
Het |
| Baz2b |
A |
T |
2: 59,792,368 (GRCm39) |
S587T |
probably benign |
Het |
| Cep76 |
T |
C |
18: 67,758,028 (GRCm39) |
M421V |
probably benign |
Het |
| Clk2 |
A |
G |
3: 89,076,010 (GRCm39) |
D60G |
probably damaging |
Het |
| Clstn3 |
G |
T |
6: 124,439,128 (GRCm39) |
T6K |
probably damaging |
Het |
| Cluap1 |
T |
A |
16: 3,737,422 (GRCm39) |
D180E |
probably benign |
Het |
| Col12a1 |
T |
C |
9: 79,606,834 (GRCm39) |
I530V |
probably benign |
Het |
| Cpt1a |
T |
C |
19: 3,415,788 (GRCm39) |
|
probably benign |
Het |
| Cr2 |
T |
G |
1: 194,837,580 (GRCm39) |
K797Q |
possibly damaging |
Het |
| Crybg3 |
C |
A |
16: 59,374,475 (GRCm39) |
V2260L |
probably benign |
Het |
| Csnk1a1 |
T |
A |
18: 61,718,321 (GRCm39) |
|
probably benign |
Het |
| Cxcr1 |
T |
C |
1: 74,231,929 (GRCm39) |
D31G |
probably benign |
Het |
| Cyp2a5 |
G |
T |
7: 26,535,361 (GRCm39) |
D108Y |
probably damaging |
Het |
| Dnajc1 |
A |
G |
2: 18,227,538 (GRCm39) |
V376A |
possibly damaging |
Het |
| Eif4enif1 |
T |
C |
11: 3,186,278 (GRCm39) |
V462A |
probably benign |
Het |
| Elmo1 |
A |
G |
13: 20,474,647 (GRCm39) |
K357R |
possibly damaging |
Het |
| Eml6 |
T |
A |
11: 29,768,374 (GRCm39) |
H771L |
probably damaging |
Het |
| Epb41l4a |
A |
G |
18: 33,965,717 (GRCm39) |
I370T |
probably benign |
Het |
| Esp36 |
A |
T |
17: 38,728,172 (GRCm39) |
N79K |
possibly damaging |
Het |
| Fam229b |
A |
G |
10: 38,994,915 (GRCm39) |
*81Q |
probably null |
Het |
| Fat4 |
T |
C |
3: 39,037,225 (GRCm39) |
Y3626H |
probably damaging |
Het |
| Fbn1 |
A |
T |
2: 125,148,205 (GRCm39) |
F2681Y |
probably benign |
Het |
| Gad1-ps |
A |
G |
10: 99,281,331 (GRCm39) |
|
noncoding transcript |
Het |
| Galm |
C |
A |
17: 80,490,696 (GRCm39) |
N284K |
probably damaging |
Het |
| Gtf3c2 |
A |
T |
5: 31,316,446 (GRCm39) |
S735T |
probably benign |
Het |
| Hsph1 |
A |
T |
5: 149,553,848 (GRCm39) |
S207T |
probably benign |
Het |
| Il33 |
C |
T |
19: 29,932,615 (GRCm39) |
R159C |
probably damaging |
Het |
| Invs |
A |
G |
4: 48,382,148 (GRCm39) |
N106S |
possibly damaging |
Het |
| Kif21b |
G |
T |
1: 136,097,062 (GRCm39) |
|
probably null |
Het |
| Kirrel2 |
A |
G |
7: 30,155,923 (GRCm39) |
C42R |
probably damaging |
Het |
| Letm1 |
A |
C |
5: 33,909,899 (GRCm39) |
C378W |
probably damaging |
Het |
| Lrrc71 |
T |
A |
3: 87,652,791 (GRCm39) |
K160N |
probably benign |
Het |
| Lrrtm3 |
A |
G |
10: 63,924,804 (GRCm39) |
I121T |
probably damaging |
Het |
| Lztr1 |
T |
A |
16: 17,327,534 (GRCm39) |
V79E |
probably damaging |
Het |
| Mmp8 |
T |
G |
9: 7,566,279 (GRCm39) |
D378E |
probably damaging |
Het |
| Mpzl3 |
A |
G |
9: 44,977,827 (GRCm39) |
E145G |
probably damaging |
Het |
| Mrps2 |
C |
T |
2: 28,359,676 (GRCm39) |
L178F |
probably damaging |
Het |
| Mzb1 |
A |
G |
18: 35,780,875 (GRCm39) |
|
probably null |
Het |
| Nckap1 |
T |
C |
2: 80,383,759 (GRCm39) |
D135G |
probably damaging |
Het |
| Ndst1 |
A |
G |
18: 60,830,242 (GRCm39) |
F623L |
possibly damaging |
Het |
| Nlrp5 |
A |
T |
7: 23,112,772 (GRCm39) |
D143V |
probably damaging |
Het |
| Or14a260 |
T |
C |
7: 85,985,553 (GRCm39) |
D17G |
possibly damaging |
Het |
| Or4a69 |
T |
C |
2: 89,312,592 (GRCm39) |
M296V |
probably null |
Het |
| Or4b1d |
A |
G |
2: 89,968,748 (GRCm39) |
V245A |
probably benign |
Het |
| Or4c120 |
A |
G |
2: 89,001,281 (GRCm39) |
S92P |
probably damaging |
Het |
| Or4f58 |
A |
G |
2: 111,851,749 (GRCm39) |
V150A |
probably benign |
Het |
| Or52b4i |
T |
C |
7: 102,191,332 (GRCm39) |
L63P |
probably damaging |
Het |
| Or8b44 |
A |
G |
9: 38,410,114 (GRCm39) |
I50V |
probably benign |
Het |
| Or8g17 |
T |
C |
9: 38,930,321 (GRCm39) |
D172G |
probably benign |
Het |
| Pcdh8 |
C |
T |
14: 80,006,829 (GRCm39) |
R578H |
possibly damaging |
Het |
| Phrf1 |
T |
A |
7: 140,839,714 (GRCm39) |
|
probably benign |
Het |
| Polr3b |
C |
A |
10: 84,516,249 (GRCm39) |
H626N |
probably benign |
Het |
| Ppp1r12a |
A |
G |
10: 108,087,720 (GRCm39) |
T58A |
probably benign |
Het |
| Ppp4r3b |
T |
A |
11: 29,132,460 (GRCm39) |
V33D |
probably damaging |
Het |
| Ppp5c |
A |
G |
7: 16,743,907 (GRCm39) |
Y176H |
probably damaging |
Het |
| R3hdm1 |
A |
G |
1: 128,124,742 (GRCm39) |
Y343C |
probably damaging |
Het |
| Rabac1 |
C |
T |
7: 24,671,555 (GRCm39) |
V122M |
probably damaging |
Het |
| Rasef |
G |
T |
4: 73,653,985 (GRCm39) |
Q561K |
probably damaging |
Het |
| Rbl1 |
A |
G |
2: 157,037,554 (GRCm39) |
S198P |
probably damaging |
Het |
| Rbm12 |
A |
T |
2: 155,939,456 (GRCm39) |
M272K |
probably damaging |
Het |
| Rexo1 |
T |
G |
10: 80,385,884 (GRCm39) |
K391N |
possibly damaging |
Het |
| Rnf43 |
T |
C |
11: 87,622,173 (GRCm39) |
S384P |
probably benign |
Het |
| Rpsa |
A |
T |
9: 119,960,066 (GRCm39) |
I210F |
possibly damaging |
Het |
| Rslcan18 |
A |
G |
13: 67,247,016 (GRCm39) |
Y75H |
possibly damaging |
Het |
| Scn9a |
T |
A |
2: 66,357,157 (GRCm39) |
D1048V |
probably benign |
Het |
| Sec11a |
T |
C |
7: 80,577,482 (GRCm39) |
|
probably null |
Het |
| Sidt2 |
A |
G |
9: 45,861,387 (GRCm39) |
V19A |
probably damaging |
Het |
| Snx14 |
G |
A |
9: 88,280,417 (GRCm39) |
Q522* |
probably null |
Het |
| Stx1b |
A |
G |
7: 127,414,144 (GRCm39) |
L74S |
probably damaging |
Het |
| Tm7sf3 |
A |
T |
6: 146,511,376 (GRCm39) |
M371K |
probably benign |
Het |
| Tmem115 |
T |
C |
9: 107,412,174 (GRCm39) |
V166A |
probably benign |
Het |
| Traf5 |
T |
A |
1: 191,731,912 (GRCm39) |
T310S |
probably benign |
Het |
| Trdn |
A |
G |
10: 33,342,448 (GRCm39) |
K619E |
probably benign |
Het |
| Trmt10a |
T |
A |
3: 137,857,945 (GRCm39) |
|
probably null |
Het |
| Txk |
A |
C |
5: 72,865,014 (GRCm39) |
I287R |
probably damaging |
Het |
| Txndc16 |
T |
C |
14: 45,389,344 (GRCm39) |
D452G |
probably damaging |
Het |
| Ube2f |
G |
A |
1: 91,190,023 (GRCm39) |
|
probably null |
Het |
| Ubtfl1 |
T |
G |
9: 18,321,489 (GRCm39) |
I339R |
probably benign |
Het |
| Upf1 |
A |
G |
8: 70,791,155 (GRCm39) |
I529T |
probably damaging |
Het |
| Vmn1r197 |
A |
G |
13: 22,512,823 (GRCm39) |
D248G |
possibly damaging |
Het |
| Vmn1r5 |
A |
T |
6: 56,962,771 (GRCm39) |
T149S |
probably benign |
Het |
| Vmn1r83 |
C |
T |
7: 12,055,197 (GRCm39) |
V287I |
possibly damaging |
Het |
| Vmn2r118 |
G |
A |
17: 55,915,496 (GRCm39) |
R485* |
probably null |
Het |
| Vmn2r130 |
A |
G |
17: 23,282,775 (GRCm39) |
T152A |
probably benign |
Het |
| Vps13b |
T |
C |
15: 35,840,121 (GRCm39) |
F2448L |
probably damaging |
Het |
| Vps13b |
A |
G |
15: 35,841,719 (GRCm39) |
N2583S |
probably benign |
Het |
| Wscd1 |
C |
T |
11: 71,679,501 (GRCm39) |
P458L |
probably damaging |
Het |
| Xylt2 |
T |
A |
11: 94,561,259 (GRCm39) |
D168V |
probably damaging |
Het |
| Zdhhc2 |
A |
G |
8: 40,921,013 (GRCm39) |
T306A |
probably benign |
Het |
| Zfp804b |
A |
T |
5: 6,819,771 (GRCm39) |
D1097E |
possibly damaging |
Het |
| Zfp93 |
T |
A |
7: 23,975,156 (GRCm39) |
C380* |
probably null |
Het |
| Zfp960 |
T |
A |
17: 17,308,518 (GRCm39) |
C411S |
probably damaging |
Het |
| Zmynd15 |
T |
A |
11: 70,355,619 (GRCm39) |
V430E |
probably damaging |
Het |
|
| Other mutations in Parp14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00337:Parp14
|
APN |
16 |
35,661,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00497:Parp14
|
APN |
16 |
35,655,206 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00754:Parp14
|
APN |
16 |
35,659,741 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL00960:Parp14
|
APN |
16 |
35,661,589 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01321:Parp14
|
APN |
16 |
35,676,929 (GRCm39) |
missense |
probably benign |
|
|
IGL01397:Parp14
|
APN |
16 |
35,679,098 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01591:Parp14
|
APN |
16 |
35,678,877 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01728:Parp14
|
APN |
16 |
35,677,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01734:Parp14
|
APN |
16 |
35,678,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02156:Parp14
|
APN |
16 |
35,678,967 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02951:Parp14
|
APN |
16 |
35,678,903 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03067:Parp14
|
APN |
16 |
35,676,878 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03135:Parp14
|
APN |
16 |
35,678,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03141:Parp14
|
APN |
16 |
35,659,663 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03146:Parp14
|
APN |
16 |
35,678,823 (GRCm39) |
nonsense |
probably null |
|
|
IGL03333:Parp14
|
APN |
16 |
35,661,800 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03391:Parp14
|
APN |
16 |
35,678,640 (GRCm39) |
missense |
probably benign |
|
|
thurston
|
UTSW |
16 |
35,664,785 (GRCm39) |
splice site |
probably benign |
|
|
PIT4585001:Parp14
|
UTSW |
16 |
35,678,975 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0306:Parp14
|
UTSW |
16 |
35,676,944 (GRCm39) |
missense |
probably benign |
|
|
R0506:Parp14
|
UTSW |
16 |
35,661,779 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0586:Parp14
|
UTSW |
16 |
35,661,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0612:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0699:Parp14
|
UTSW |
16 |
35,680,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0786:Parp14
|
UTSW |
16 |
35,661,172 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0883:Parp14
|
UTSW |
16 |
35,678,888 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0900:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1087:Parp14
|
UTSW |
16 |
35,678,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1104:Parp14
|
UTSW |
16 |
35,664,785 (GRCm39) |
splice site |
probably benign |
|
|
R1120:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1134:Parp14
|
UTSW |
16 |
35,655,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1153:Parp14
|
UTSW |
16 |
35,678,041 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1159:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1160:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1237:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1238:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1239:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1423:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1518:Parp14
|
UTSW |
16 |
35,677,008 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1619:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1707:Parp14
|
UTSW |
16 |
35,678,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1831:Parp14
|
UTSW |
16 |
35,678,958 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1840:Parp14
|
UTSW |
16 |
35,683,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1889:Parp14
|
UTSW |
16 |
35,677,130 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Parp14
|
UTSW |
16 |
35,673,888 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1943:Parp14
|
UTSW |
16 |
35,656,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1954:Parp14
|
UTSW |
16 |
35,678,671 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2115:Parp14
|
UTSW |
16 |
35,678,904 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2216:Parp14
|
UTSW |
16 |
35,677,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2519:Parp14
|
UTSW |
16 |
35,678,573 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3851:Parp14
|
UTSW |
16 |
35,674,118 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4052:Parp14
|
UTSW |
16 |
35,678,771 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4671:Parp14
|
UTSW |
16 |
35,678,691 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4867:Parp14
|
UTSW |
16 |
35,677,697 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4941:Parp14
|
UTSW |
16 |
35,666,403 (GRCm39) |
missense |
probably benign |
|
|
R4992:Parp14
|
UTSW |
16 |
35,661,512 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5055:Parp14
|
UTSW |
16 |
35,664,733 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5073:Parp14
|
UTSW |
16 |
35,655,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5170:Parp14
|
UTSW |
16 |
35,677,649 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5422:Parp14
|
UTSW |
16 |
35,686,545 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5543:Parp14
|
UTSW |
16 |
35,655,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5549:Parp14
|
UTSW |
16 |
35,661,505 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5553:Parp14
|
UTSW |
16 |
35,677,306 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5691:Parp14
|
UTSW |
16 |
35,683,909 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5774:Parp14
|
UTSW |
16 |
35,678,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Parp14
|
UTSW |
16 |
35,661,297 (GRCm39) |
nonsense |
probably null |
|
|
R5942:Parp14
|
UTSW |
16 |
35,659,737 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5990:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5991:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6018:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6022:Parp14
|
UTSW |
16 |
35,661,827 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6075:Parp14
|
UTSW |
16 |
35,677,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6395:Parp14
|
UTSW |
16 |
35,676,918 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6525:Parp14
|
UTSW |
16 |
35,680,811 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6683:Parp14
|
UTSW |
16 |
35,655,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Parp14
|
UTSW |
16 |
35,677,861 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8011:Parp14
|
UTSW |
16 |
35,677,004 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8192:Parp14
|
UTSW |
16 |
35,691,584 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8367:Parp14
|
UTSW |
16 |
35,678,124 (GRCm39) |
missense |
probably benign |
0.36 |
|
R8526:Parp14
|
UTSW |
16 |
35,661,307 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8751:Parp14
|
UTSW |
16 |
35,677,181 (GRCm39) |
missense |
probably benign |
0.32 |
|
R8962:Parp14
|
UTSW |
16 |
35,677,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9231:Parp14
|
UTSW |
16 |
35,661,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9363:Parp14
|
UTSW |
16 |
35,678,586 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9366:Parp14
|
UTSW |
16 |
35,659,630 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9379:Parp14
|
UTSW |
16 |
35,680,853 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9562:Parp14
|
UTSW |
16 |
35,677,775 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9565:Parp14
|
UTSW |
16 |
35,677,775 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9696:Parp14
|
UTSW |
16 |
35,661,252 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9696:Parp14
|
UTSW |
16 |
35,661,251 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
X0026:Parp14
|
UTSW |
16 |
35,677,527 (GRCm39) |
nonsense |
probably null |
|
|
X0060:Parp14
|
UTSW |
16 |
35,655,077 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Parp14
|
UTSW |
16 |
35,661,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Parp14
|
UTSW |
16 |
35,665,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Parp14
|
UTSW |
16 |
35,691,573 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- GATAACAGCATTGCCGGGTAGGAC -3'
(R):5'- TGCTAACTGGCTGCAAGAGCAAAG -3'
Sequencing Primer
(F):5'- TTGGAGTTCAGGGCCAGC -3'
(R):5'- GAAATCCAGGATTCAGTCTGTGTC -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation