Incidental Mutation 'R1512:Zfp608'
ID 168459
Institutional Source Beutler Lab
Gene Symbol Zfp608
Ensembl Gene ENSMUSG00000052713
Gene Name zinc finger protein 608
Synonyms 4932417D18Rik
MMRRC Submission 039559-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.899) question?
Stock # R1512 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 55021120-55125627 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 55079738 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 349 (V349A)
Ref Sequence ENSEMBL: ENSMUSP00000068192 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064763]
AlphaFold Q56A10
Predicted Effect probably damaging
Transcript: ENSMUST00000064763
AA Change: V349A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000068192
Gene: ENSMUSG00000052713
AA Change: V349A

DomainStartEndE-ValueType
low complexity region 51 61 N/A INTRINSIC
low complexity region 150 184 N/A INTRINSIC
low complexity region 214 234 N/A INTRINSIC
low complexity region 252 266 N/A INTRINSIC
low complexity region 309 326 N/A INTRINSIC
low complexity region 428 445 N/A INTRINSIC
low complexity region 459 471 N/A INTRINSIC
ZnF_C2H2 552 577 1.86e0 SMART
low complexity region 624 636 N/A INTRINSIC
low complexity region 706 718 N/A INTRINSIC
low complexity region 734 773 N/A INTRINSIC
low complexity region 807 822 N/A INTRINSIC
low complexity region 833 846 N/A INTRINSIC
low complexity region 934 956 N/A INTRINSIC
coiled coil region 1028 1054 N/A INTRINSIC
low complexity region 1182 1193 N/A INTRINSIC
low complexity region 1255 1268 N/A INTRINSIC
low complexity region 1439 1450 N/A INTRINSIC
low complexity region 1458 1466 N/A INTRINSIC
low complexity region 1486 1502 N/A INTRINSIC
Meta Mutation Damage Score 0.1385 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 93.0%
Validation Efficiency 95% (79/83)
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,086,295 (GRCm39) D40E probably benign Het
Acsf2 C T 11: 94,452,224 (GRCm39) probably benign Het
Adamts19 C T 18: 59,181,917 (GRCm39) H1119Y possibly damaging Het
Akap6 A G 12: 52,983,937 (GRCm39) D827G probably damaging Het
Ankrd33b T C 15: 31,367,375 (GRCm39) D55G probably damaging Het
Ano5 T A 7: 51,229,316 (GRCm39) H569Q probably benign Het
Aox1 A G 1: 58,346,510 (GRCm39) D548G probably benign Het
Baz2a A G 10: 127,960,021 (GRCm39) D1433G possibly damaging Het
BC031181 T G 18: 75,141,767 (GRCm39) V8G probably damaging Het
Bicdl2 A T 17: 23,887,083 (GRCm39) M457L probably damaging Het
C130074G19Rik T C 1: 184,615,103 (GRCm39) D29G probably damaging Het
Cd200r1 A T 16: 44,586,390 (GRCm39) T7S probably benign Het
Cdc37 A G 9: 21,053,712 (GRCm39) probably benign Het
Cmtr2 T C 8: 110,949,267 (GRCm39) S526P probably damaging Het
Cntn2 G T 1: 132,451,430 (GRCm39) A433D probably damaging Het
Cntnap5a T C 1: 115,828,680 (GRCm39) S35P probably benign Het
Csf3r A G 4: 125,923,777 (GRCm39) T96A possibly damaging Het
Ctbs A G 3: 146,160,720 (GRCm39) N96D probably benign Het
Cyp26b1 C A 6: 84,553,979 (GRCm39) V213L probably benign Het
Dach1 A G 14: 98,138,835 (GRCm39) L536P probably damaging Het
Dcaf6 T C 1: 165,179,589 (GRCm39) Q517R probably benign Het
Dnah1 G T 14: 31,014,994 (GRCm39) Q1733K probably damaging Het
Dnah17 A T 11: 117,985,841 (GRCm39) I1416N probably benign Het
Dock11 G A X: 35,283,688 (GRCm39) R1102H probably damaging Het
Dpp8 T C 9: 64,971,096 (GRCm39) probably benign Het
Emc1 G A 4: 139,087,495 (GRCm39) probably null Het
Emc8 A G 8: 121,384,983 (GRCm39) L76P possibly damaging Het
Emx2 T C 19: 59,448,035 (GRCm39) Y130H possibly damaging Het
Fbf1 C T 11: 116,038,753 (GRCm39) R815Q probably damaging Het
Foxb2 G A 19: 16,849,878 (GRCm39) P376L probably damaging Het
Gabrb1 C A 5: 72,266,047 (GRCm39) L202I probably damaging Het
Gabrb1 T A 5: 72,266,048 (GRCm39) L202Q probably damaging Het
Grin2c T A 11: 115,144,676 (GRCm39) I617F probably damaging Het
Gtf2h3 T A 5: 124,728,933 (GRCm39) V164E probably damaging Het
Gusb T C 5: 130,029,731 (GRCm39) Q88R probably damaging Het
Hormad2 T A 11: 4,374,788 (GRCm39) K75N probably damaging Het
Il33 A G 19: 29,929,390 (GRCm39) T38A possibly damaging Het
Ivns1abp A T 1: 151,236,687 (GRCm39) Q416L possibly damaging Het
Ivns1abp G C 1: 151,236,688 (GRCm39) Q416H probably benign Het
Kcnh5 T A 12: 75,166,711 (GRCm39) H178L probably benign Het
Kif21b A G 1: 136,080,543 (GRCm39) N579S probably benign Het
Kif26a G C 12: 112,113,389 (GRCm39) R95P possibly damaging Het
Kl A G 5: 150,912,062 (GRCm39) I604V probably benign Het
Klhl24 A G 16: 19,941,686 (GRCm39) K545E probably damaging Het
Mcm3ap A G 10: 76,306,347 (GRCm39) I153M probably damaging Het
Meis1 T G 11: 18,831,682 (GRCm39) D452A probably damaging Het
Msantd4 C T 9: 4,384,138 (GRCm39) P153L probably benign Het
Myot A G 18: 44,475,422 (GRCm39) E181G probably damaging Het
Nf1 T C 11: 79,281,195 (GRCm39) F150S probably damaging Het
Nyap2 T A 1: 81,219,566 (GRCm39) S529R probably damaging Het
Or10d3 T C 9: 39,461,390 (GRCm39) Y259C probably damaging Het
Or12e10 A T 2: 87,640,988 (GRCm39) T275S probably benign Het
Or2y1c A G 11: 49,361,286 (GRCm39) I103V probably benign Het
Or8b56 T A 9: 38,739,660 (GRCm39) Y224* probably null Het
Pcnt C T 10: 76,240,496 (GRCm39) probably null Het
Pik3c3 T C 18: 30,455,289 (GRCm39) probably null Het
Pkdcc A T 17: 83,527,473 (GRCm39) Y217F possibly damaging Het
Pnpla6 C A 8: 3,585,459 (GRCm39) probably benign Het
Polr3gl T C 3: 96,488,190 (GRCm39) M26V probably benign Het
Ppp1r13b T C 12: 111,838,842 (GRCm39) N12S possibly damaging Het
Ppp1r26 G A 2: 28,341,528 (GRCm39) R386K probably benign Het
Prdm10 A G 9: 31,248,697 (GRCm39) E355G probably damaging Het
Prex2 T C 1: 11,131,554 (GRCm39) F41S possibly damaging Het
Prkar1b G T 5: 139,036,428 (GRCm39) Y231* probably null Het
Prkdc A T 16: 15,505,268 (GRCm39) I857L probably benign Het
Psg21 A T 7: 18,390,425 (GRCm39) N10K probably benign Het
Rapgef3 A T 15: 97,655,382 (GRCm39) V444E probably benign Het
Rnf17 A T 14: 56,705,243 (GRCm39) T716S probably benign Het
Rps6ka1 C T 4: 133,578,315 (GRCm39) R577H probably damaging Het
Scn1a A C 2: 66,161,629 (GRCm39) N306K possibly damaging Het
Skint6 A G 4: 113,095,329 (GRCm39) I110T probably damaging Het
Ssu2 A G 6: 112,364,959 (GRCm39) M1T probably null Het
Stag3 A T 5: 138,296,247 (GRCm39) T437S probably benign Het
Tal2 A G 4: 53,786,107 (GRCm39) Y96C probably benign Het
Thoc3 A T 13: 54,613,991 (GRCm39) probably null Het
Tle1 T C 4: 72,059,495 (GRCm39) D19G probably damaging Het
Trpm4 A G 7: 44,964,468 (GRCm39) I690T probably benign Het
Trpm6 A T 19: 18,853,295 (GRCm39) M1772L probably benign Het
Unc5b G A 10: 60,667,254 (GRCm39) probably benign Het
Usf3 G T 16: 44,041,561 (GRCm39) V2014F probably damaging Het
Utp18 C T 11: 93,776,390 (GRCm39) A32T probably benign Het
Wdfy4 A G 14: 32,682,765 (GRCm39) V2981A probably damaging Het
Znfx1 A C 2: 166,898,237 (GRCm39) I229S probably benign Het
Other mutations in Zfp608
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00500:Zfp608 APN 18 55,121,405 (GRCm39) missense probably benign
IGL00920:Zfp608 APN 18 55,022,903 (GRCm39) missense probably benign 0.00
IGL01088:Zfp608 APN 18 55,031,159 (GRCm39) missense probably benign 0.03
IGL01447:Zfp608 APN 18 55,032,083 (GRCm39) missense possibly damaging 0.75
IGL01534:Zfp608 APN 18 55,032,004 (GRCm39) missense probably damaging 0.99
IGL01547:Zfp608 APN 18 55,027,521 (GRCm39) critical splice donor site probably null
IGL01933:Zfp608 APN 18 55,120,871 (GRCm39) missense probably benign
IGL01998:Zfp608 APN 18 55,024,890 (GRCm39) missense probably damaging 0.99
IGL02167:Zfp608 APN 18 55,121,296 (GRCm39) missense probably damaging 1.00
IGL02266:Zfp608 APN 18 55,030,653 (GRCm39) missense probably benign 0.08
IGL02335:Zfp608 APN 18 55,030,509 (GRCm39) nonsense probably null
IGL02455:Zfp608 APN 18 55,032,405 (GRCm39) missense probably damaging 1.00
IGL02612:Zfp608 APN 18 55,031,273 (GRCm39) missense probably damaging 1.00
IGL02900:Zfp608 APN 18 55,079,865 (GRCm39) missense probably damaging 1.00
PIT4243001:Zfp608 UTSW 18 55,031,096 (GRCm39) missense probably damaging 1.00
PIT4519001:Zfp608 UTSW 18 55,079,783 (GRCm39) missense possibly damaging 0.71
R0005:Zfp608 UTSW 18 55,028,592 (GRCm39) missense possibly damaging 0.88
R0010:Zfp608 UTSW 18 55,028,286 (GRCm39) splice site probably benign
R0010:Zfp608 UTSW 18 55,028,286 (GRCm39) splice site probably benign
R0064:Zfp608 UTSW 18 55,031,888 (GRCm39) missense probably benign
R0401:Zfp608 UTSW 18 55,032,066 (GRCm39) missense probably benign
R0722:Zfp608 UTSW 18 55,033,306 (GRCm39) missense probably damaging 1.00
R1351:Zfp608 UTSW 18 55,031,463 (GRCm39) missense probably benign 0.00
R1554:Zfp608 UTSW 18 55,031,126 (GRCm39) missense probably damaging 1.00
R1622:Zfp608 UTSW 18 55,121,366 (GRCm39) missense probably benign 0.07
R1669:Zfp608 UTSW 18 55,120,811 (GRCm39) missense probably benign 0.09
R1690:Zfp608 UTSW 18 55,120,706 (GRCm39) missense possibly damaging 0.62
R1721:Zfp608 UTSW 18 55,032,321 (GRCm39) missense probably benign
R1826:Zfp608 UTSW 18 55,031,648 (GRCm39) missense probably benign 0.03
R1864:Zfp608 UTSW 18 55,030,983 (GRCm39) missense probably benign 0.00
R1952:Zfp608 UTSW 18 55,030,851 (GRCm39) nonsense probably null
R2049:Zfp608 UTSW 18 55,028,637 (GRCm39) missense probably damaging 1.00
R2051:Zfp608 UTSW 18 55,121,386 (GRCm39) missense probably benign
R2168:Zfp608 UTSW 18 55,031,125 (GRCm39) nonsense probably null
R2218:Zfp608 UTSW 18 55,120,756 (GRCm39) missense probably benign 0.14
R2283:Zfp608 UTSW 18 55,121,446 (GRCm39) missense probably damaging 1.00
R2399:Zfp608 UTSW 18 55,030,974 (GRCm39) missense probably damaging 1.00
R2520:Zfp608 UTSW 18 55,121,578 (GRCm39) missense possibly damaging 0.92
R2961:Zfp608 UTSW 18 55,031,544 (GRCm39) missense possibly damaging 0.60
R4074:Zfp608 UTSW 18 55,031,180 (GRCm39) missense probably damaging 1.00
R4076:Zfp608 UTSW 18 55,031,180 (GRCm39) missense probably damaging 1.00
R4206:Zfp608 UTSW 18 55,121,267 (GRCm39) missense probably damaging 1.00
R4756:Zfp608 UTSW 18 55,027,544 (GRCm39) missense probably damaging 1.00
R4771:Zfp608 UTSW 18 55,121,372 (GRCm39) missense probably benign
R4820:Zfp608 UTSW 18 55,120,756 (GRCm39) missense probably benign 0.14
R4825:Zfp608 UTSW 18 55,031,041 (GRCm39) missense probably benign 0.01
R4912:Zfp608 UTSW 18 55,079,663 (GRCm39) missense probably damaging 1.00
R4975:Zfp608 UTSW 18 55,022,962 (GRCm39) missense probably damaging 1.00
R5138:Zfp608 UTSW 18 55,024,871 (GRCm39) missense probably damaging 1.00
R5192:Zfp608 UTSW 18 55,031,569 (GRCm39) missense probably damaging 1.00
R5557:Zfp608 UTSW 18 55,120,942 (GRCm39) missense possibly damaging 0.81
R5624:Zfp608 UTSW 18 55,031,344 (GRCm39) missense probably damaging 1.00
R5818:Zfp608 UTSW 18 55,028,468 (GRCm39) missense probably benign 0.02
R5840:Zfp608 UTSW 18 55,031,978 (GRCm39) missense probably damaging 1.00
R5992:Zfp608 UTSW 18 55,032,320 (GRCm39) missense probably benign 0.15
R6106:Zfp608 UTSW 18 55,120,944 (GRCm39) missense possibly damaging 0.54
R6174:Zfp608 UTSW 18 55,121,616 (GRCm39) start gained probably benign
R6181:Zfp608 UTSW 18 55,028,700 (GRCm39) missense possibly damaging 0.56
R6517:Zfp608 UTSW 18 55,032,150 (GRCm39) missense possibly damaging 0.94
R6567:Zfp608 UTSW 18 55,030,628 (GRCm39) missense probably damaging 1.00
R6668:Zfp608 UTSW 18 55,031,091 (GRCm39) missense probably damaging 1.00
R6920:Zfp608 UTSW 18 55,121,337 (GRCm39) missense probably damaging 1.00
R7061:Zfp608 UTSW 18 55,121,069 (GRCm39) missense probably benign
R7074:Zfp608 UTSW 18 55,030,454 (GRCm39) missense possibly damaging 0.69
R7087:Zfp608 UTSW 18 55,032,469 (GRCm39) missense probably damaging 1.00
R7391:Zfp608 UTSW 18 55,030,619 (GRCm39) missense possibly damaging 0.49
R7600:Zfp608 UTSW 18 55,121,092 (GRCm39) missense probably damaging 1.00
R7723:Zfp608 UTSW 18 55,030,673 (GRCm39) missense probably damaging 1.00
R8054:Zfp608 UTSW 18 55,032,618 (GRCm39) missense probably benign 0.28
R8236:Zfp608 UTSW 18 55,032,281 (GRCm39) missense probably damaging 1.00
R8260:Zfp608 UTSW 18 55,030,821 (GRCm39) missense possibly damaging 0.60
R8732:Zfp608 UTSW 18 55,121,072 (GRCm39) missense probably benign 0.06
R8781:Zfp608 UTSW 18 55,031,801 (GRCm39) missense probably damaging 1.00
R8851:Zfp608 UTSW 18 55,032,194 (GRCm39) missense possibly damaging 0.94
R8940:Zfp608 UTSW 18 55,033,301 (GRCm39) missense possibly damaging 0.93
R9051:Zfp608 UTSW 18 55,032,266 (GRCm39) missense probably damaging 1.00
R9091:Zfp608 UTSW 18 55,032,190 (GRCm39) missense probably damaging 1.00
R9092:Zfp608 UTSW 18 55,031,648 (GRCm39) missense probably benign 0.03
R9236:Zfp608 UTSW 18 55,032,354 (GRCm39) missense probably benign 0.39
R9270:Zfp608 UTSW 18 55,032,190 (GRCm39) missense probably damaging 1.00
R9283:Zfp608 UTSW 18 55,030,913 (GRCm39) missense possibly damaging 0.50
R9288:Zfp608 UTSW 18 55,033,341 (GRCm39) missense probably benign 0.39
R9463:Zfp608 UTSW 18 55,030,274 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTAGCCCTCAGCATGAAGACGC -3'
(R):5'- CTTCACCTTCCTGGACACGAGAAC -3'

Sequencing Primer
(F):5'- TTCCCCTCACAGATGGACAG -3'
(R):5'- TTTTGGCACCATGAAAGCACTC -3'
Posted On 2014-04-13