Mutagenetix > Incidental Mutation

Incidental Mutation 'R1513:Vmn2r79'

168523

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r79

Ensembl Gene

ENSMUSG00000090362

Gene Name

vomeronasal 2, receptor 79

Synonyms

EG621430

MMRRC Submission

039560-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R1513 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

86645673-86687176 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 86686652 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 678 (V678I)

Ref Sequence

ENSEMBL: ENSMUSP00000132478 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164462]

AlphaFold

E9Q067

Predicted Effect

probably benign
Transcript: ENSMUST00000164462
AA Change: V678I

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: V678I

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	1.9e-31	PFAM
Pfam:NCD3G	506	559	3.1e-21	PFAM
Pfam:7tm_3	592	827	2.8e-53	PFAM

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 94.7%
20x: 87.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 107 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1500011B03Rik	A	T	5: 114,947,334 (GRCm39)	C64*	probably null	Het
1700003H04Rik	A	C	3: 124,368,985 (GRCm39)	Y109D	possibly damaging	Het
Abca15	A	T	7: 119,939,322 (GRCm39)	I239F	probably damaging	Het
Adgrv1	A	G	13: 81,741,167 (GRCm39)	V99A	probably damaging	Het
Adgrv1	A	T	13: 81,705,076 (GRCm39)	I1578K	probably damaging	Het
Ap4e1	G	T	2: 126,903,475 (GRCm39)	K792N	probably null	Het
Ap5b1	G	A	19: 5,619,892 (GRCm39)	W437*	probably null	Het
Arhgef17	A	G	7: 100,580,069 (GRCm39)	L293P	probably benign	Het
Arhgef33	A	C	17: 80,678,818 (GRCm39)	M505L	probably benign	Het
Arih1	T	A	9: 59,310,663 (GRCm39)	R320S	probably damaging	Het
Atp1b3	A	T	9: 96,246,206 (GRCm39)	M1K	probably null	Het
Bbs2	T	C	8: 94,816,472 (GRCm39)	D130G	possibly damaging	Het
Bscl2	G	A	19: 8,818,509 (GRCm39)	R38H	probably damaging	Het
Cad	A	G	5: 31,226,106 (GRCm39)	Y1102C	probably damaging	Het
Cc2d1b	G	A	4: 108,490,423 (GRCm39)	R825Q	probably damaging	Het
Ccdc39	A	G	3: 33,893,294 (GRCm39)	V97A	possibly damaging	Het
Ccr1	T	C	9: 123,764,510 (GRCm39)	T7A	probably benign	Het
Cd33	A	G	7: 43,181,618 (GRCm39)	S181P	probably damaging	Het
Cdc20	A	C	4: 118,290,304 (GRCm39)	S452R	probably damaging	Het
Cdk8	A	T	5: 146,233,188 (GRCm39)	I229F	possibly damaging	Het
Ces3a	A	T	8: 105,776,909 (GRCm39)	N131Y	probably damaging	Het
Cgnl1	A	G	9: 71,631,872 (GRCm39)	I493T	probably benign	Het
Chia1	G	A	3: 106,039,220 (GRCm39)	V437M	probably benign	Het
Chrna2	G	A	14: 66,380,878 (GRCm39)	R49H	probably benign	Het
Clec12b	A	G	6: 129,353,265 (GRCm39)	C241R	probably damaging	Het
Col11a1	A	G	3: 113,890,803 (GRCm39)	D380G	unknown	Het
Crebbp	A	G	16: 3,933,749 (GRCm39)	S948P	probably damaging	Het
Dchs1	G	A	7: 105,421,278 (GRCm39)	R381*	probably null	Het
Defb19	A	T	2: 152,418,085 (GRCm39)	*84R	probably null	Het
Dnah8	T	C	17: 30,892,862 (GRCm39)	F816L	probably benign	Het
Dync2h1	T	A	9: 7,103,663 (GRCm39)	I371F	possibly damaging	Het
Ezhip	GTCATCATCATCATC	GTCATCATCATCATCATC	X: 5,994,645 (GRCm39)		probably benign	Het
Fggy	T	C	4: 95,790,295 (GRCm39)		probably benign	Het
Galnt12	G	A	4: 47,117,956 (GRCm39)	C125Y	probably damaging	Het
Gm4952	A	T	19: 12,602,039 (GRCm39)	D149V	probably damaging	Het
Gm6309	A	T	5: 146,107,393 (GRCm39)	H37Q	possibly damaging	Het
Gmnn	A	G	13: 24,940,615 (GRCm39)	L78P	possibly damaging	Het
Golga4	C	A	9: 118,384,800 (GRCm39)	Q613K	probably benign	Het
Iqgap2	A	T	13: 95,766,518 (GRCm39)	I1495K	probably damaging	Het
Junb	T	C	8: 85,704,758 (GRCm39)	T101A	probably damaging	Het
Kif21b	T	C	1: 136,083,849 (GRCm39)	Y699H	probably damaging	Het
Klf17	T	C	4: 117,618,132 (GRCm39)	E75G	probably damaging	Het
Klra17	T	C	6: 129,849,277 (GRCm39)	E99G	possibly damaging	Het
Knop1	CTCTTCTTCTTCTTCTTCTTCTTC	CTCTTCTTCTTCTTCTTCTTC	7: 118,451,672 (GRCm39)		probably benign	Het
Krt87	C	T	15: 101,387,538 (GRCm39)	V167M	probably benign	Het
Lce1m	A	G	3: 92,925,932 (GRCm39)		probably benign	Het
Lpin3	A	T	2: 160,746,468 (GRCm39)	Y709F	probably damaging	Het
Ltbp2	T	A	12: 84,838,718 (GRCm39)	D1080V	probably damaging	Het
Mycbp2	G	A	14: 103,441,825 (GRCm39)	T1980I	probably damaging	Het
Myo1g	T	A	11: 6,465,140 (GRCm39)	K435M	probably damaging	Het
Mypn	T	A	10: 63,005,147 (GRCm39)	N320I	probably damaging	Het
Naip5	A	T	13: 100,358,714 (GRCm39)	W841R	probably benign	Het
Ncapd2	A	T	6: 125,147,955 (GRCm39)	M1124K	probably damaging	Het
Ncf4	A	G	15: 78,146,560 (GRCm39)	D330G	probably benign	Het
Ndst3	C	T	3: 123,395,104 (GRCm39)	V509M	possibly damaging	Het
Neb	A	T	2: 52,117,256 (GRCm39)	D4105E	probably damaging	Het
Nfix	G	A	8: 85,453,155 (GRCm39)	R300C	probably damaging	Het
Nsrp1	A	T	11: 76,937,445 (GRCm39)	F250L	probably benign	Het
Or11g7	A	G	14: 50,691,138 (GRCm39)	I210V	probably benign	Het
Or4l15	T	C	14: 50,198,558 (GRCm39)		probably null	Het
Or52d1	C	T	7: 103,755,671 (GRCm39)	L62F	probably benign	Het
Or52k2	G	T	7: 102,254,509 (GRCm39)	G316V	probably benign	Het
Or5m12	A	T	2: 85,735,015 (GRCm39)	Y128N	probably damaging	Het
Or8k3b	C	T	2: 86,521,141 (GRCm39)	M59I	possibly damaging	Het
Oxr1	A	G	15: 41,660,870 (GRCm39)	D67G	probably damaging	Het
P2ry12	A	T	3: 59,125,498 (GRCm39)	I59N	probably damaging	Het
Pcdhb12	G	T	18: 37,570,111 (GRCm39)	G419V	probably damaging	Het
Pdzd2	G	T	15: 12,373,915 (GRCm39)	S2073R	possibly damaging	Het
Pex5l	C	A	3: 33,069,162 (GRCm39)	E112*	probably null	Het
Plaur	A	G	7: 24,172,016 (GRCm39)	D163G	probably benign	Het
Plk2	A	G	13: 110,536,622 (GRCm39)	Y638C	probably benign	Het
Ppp1r15b	A	G	1: 133,061,088 (GRCm39)	N535S	probably benign	Het
Ppp2r1b	T	C	9: 50,781,445 (GRCm39)	L21P	probably damaging	Het
Prkar2a	G	A	9: 108,605,469 (GRCm39)	V176I	possibly damaging	Het
Ptpro	T	A	6: 137,420,592 (GRCm39)	V1007D	probably damaging	Het
Rag1	A	G	2: 101,473,336 (GRCm39)	M602T	possibly damaging	Het
Rb1	A	G	14: 73,559,524 (GRCm39)	V60A	probably benign	Het
Rgs20	T	A	1: 4,982,560 (GRCm39)	I303F	probably damaging	Het
Rnf43	T	A	11: 87,620,257 (GRCm39)	I240N	probably damaging	Het
Romo1	G	A	2: 155,986,433 (GRCm39)	V19M	probably benign	Het
Ryr1	A	G	7: 28,770,046 (GRCm39)	S2676P	probably damaging	Het
Ryr3	G	A	2: 112,539,542 (GRCm39)	Q3233*	probably null	Het
Skic2	G	T	17: 35,066,420 (GRCm39)	P188T	probably damaging	Het
Slc26a6	A	G	9: 108,733,035 (GRCm39)	R5G	probably benign	Het
Slc33a1	A	G	3: 63,871,376 (GRCm39)	L79P	probably damaging	Het
Snx31	G	A	15: 36,545,745 (GRCm39)	R91C	probably damaging	Het
Tecpr2	T	C	12: 110,921,234 (GRCm39)	I1269T	possibly damaging	Het
Tjap1	G	T	17: 46,572,368 (GRCm39)	D89E	probably benign	Het
Tmem53	A	T	4: 117,123,090 (GRCm39)	Q39L	probably damaging	Het
Tmod1	G	T	4: 46,083,549 (GRCm39)	V95F	possibly damaging	Het
Trim30c	A	C	7: 104,031,896 (GRCm39)	H306Q	probably benign	Het
Trpm3	A	T	19: 22,964,236 (GRCm39)	M1244L	possibly damaging	Het
Tspan32	A	G	7: 142,558,886 (GRCm39)	I14V	probably null	Het
Ube4b	A	G	4: 149,436,035 (GRCm39)	V695A	probably benign	Het
Ubxn11	G	A	4: 133,851,452 (GRCm39)		probably null	Het
Ugt3a1	A	G	15: 9,361,610 (GRCm39)	I129V	probably benign	Het
Vmn1r45	A	G	6: 89,910,058 (GRCm39)	V304A	probably damaging	Het
Vmn2r124	A	T	17: 18,283,535 (GRCm39)	S410C	probably damaging	Het
Vmn2r15	T	A	5: 109,441,195 (GRCm39)	D221V	probably damaging	Het
Vps13b	A	T	15: 35,438,876 (GRCm39)	R319*	probably null	Het
Wdr95	G	A	5: 149,522,759 (GRCm39)	R639Q	probably benign	Het
Xirp2	A	G	2: 67,341,874 (GRCm39)	I1372V	probably benign	Het
Xpo5	T	A	17: 46,537,906 (GRCm39)	M611K	probably benign	Het
Zfat	A	G	15: 68,084,529 (GRCm39)	C121R	probably damaging	Het
Zfp382	A	T	7: 29,832,721 (GRCm39)	Y124F	probably benign	Het
Zfp512b	A	G	2: 181,230,982 (GRCm39)	F371S	probably benign	Het
Zfy2	A	G	Y: 2,116,185 (GRCm39)	V285A	probably benign	Het

Other mutations in Vmn2r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01401:Vmn2r79	APN	7	86,686,481 (GRCm39)	missense	probably benign	0.01
IGL01675:Vmn2r79	APN	7	86,645,856 (GRCm39)	missense	probably benign	0.01
IGL01760:Vmn2r79	APN	7	86,651,366 (GRCm39)	missense	probably benign
IGL01834:Vmn2r79	APN	7	86,686,354 (GRCm39)	missense	probably benign	0.01
IGL01843:Vmn2r79	APN	7	86,686,485 (GRCm39)	missense	probably damaging	1.00
IGL01914:Vmn2r79	APN	7	86,686,571 (GRCm39)	missense	probably benign	0.14
IGL01980:Vmn2r79	APN	7	86,686,290 (GRCm39)	missense	possibly damaging	0.49
IGL02438:Vmn2r79	APN	7	86,651,744 (GRCm39)	missense	probably damaging	0.98
IGL02740:Vmn2r79	APN	7	86,653,366 (GRCm39)	missense	probably benign	0.00
IGL03052:Vmn2r79	UTSW	7	86,652,799 (GRCm39)	missense	probably benign	0.00
PIT4445001:Vmn2r79	UTSW	7	86,651,408 (GRCm39)	missense	possibly damaging	0.46
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0096:Vmn2r79	UTSW	7	86,686,527 (GRCm39)	missense	probably damaging	1.00
R0270:Vmn2r79	UTSW	7	86,652,594 (GRCm39)	missense	probably benign	0.00
R0336:Vmn2r79	UTSW	7	86,651,287 (GRCm39)	missense	probably benign	0.15
R0418:Vmn2r79	UTSW	7	86,651,611 (GRCm39)	missense	probably benign	0.18
R1070:Vmn2r79	UTSW	7	86,652,681 (GRCm39)	missense	probably damaging	1.00
R1234:Vmn2r79	UTSW	7	86,653,307 (GRCm39)	missense	possibly damaging	0.71
R1459:Vmn2r79	UTSW	7	86,687,002 (GRCm39)	missense	probably benign	0.01
R1624:Vmn2r79	UTSW	7	86,653,247 (GRCm39)	critical splice acceptor site	probably null
R1633:Vmn2r79	UTSW	7	86,687,042 (GRCm39)	missense	possibly damaging	0.52
R1676:Vmn2r79	UTSW	7	86,651,839 (GRCm39)	missense	probably benign
R1781:Vmn2r79	UTSW	7	86,651,555 (GRCm39)	missense	probably benign	0.00
R1794:Vmn2r79	UTSW	7	86,650,621 (GRCm39)	missense	probably benign	0.37
R1823:Vmn2r79	UTSW	7	86,687,080 (GRCm39)	missense	probably damaging	1.00
R2013:Vmn2r79	UTSW	7	86,653,289 (GRCm39)	missense	possibly damaging	0.50
R2018:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2019:Vmn2r79	UTSW	7	86,651,634 (GRCm39)	missense	probably benign	0.07
R2177:Vmn2r79	UTSW	7	86,645,839 (GRCm39)	missense	possibly damaging	0.94
R2984:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R3719:Vmn2r79	UTSW	7	86,651,245 (GRCm39)	missense	probably benign	0.05
R3798:Vmn2r79	UTSW	7	86,651,402 (GRCm39)	missense	possibly damaging	0.88
R3969:Vmn2r79	UTSW	7	86,652,801 (GRCm39)	missense	probably damaging	1.00
R4182:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4183:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4245:Vmn2r79	UTSW	7	86,651,624 (GRCm39)	missense	possibly damaging	0.73
R4301:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4391:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4393:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4394:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4396:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4397:Vmn2r79	UTSW	7	86,651,099 (GRCm39)	missense	possibly damaging	0.85
R4592:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R4697:Vmn2r79	UTSW	7	86,687,168 (GRCm39)	missense	probably damaging	0.98
R4897:Vmn2r79	UTSW	7	86,650,675 (GRCm39)	missense	probably benign
R5016:Vmn2r79	UTSW	7	86,686,548 (GRCm39)	missense	probably benign	0.00
R5058:Vmn2r79	UTSW	7	86,651,423 (GRCm39)	missense	probably damaging	0.98
R5177:Vmn2r79	UTSW	7	86,651,177 (GRCm39)	missense	probably damaging	0.97
R6078:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6079:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6138:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
R6257:Vmn2r79	UTSW	7	86,651,778 (GRCm39)	missense	probably benign	0.27
R6260:Vmn2r79	UTSW	7	86,686,365 (GRCm39)	missense	probably benign	0.00
R6307:Vmn2r79	UTSW	7	86,686,976 (GRCm39)	missense	probably damaging	1.00
R6323:Vmn2r79	UTSW	7	86,650,522 (GRCm39)	missense	probably benign	0.05
R6374:Vmn2r79	UTSW	7	86,651,498 (GRCm39)	missense	probably benign	0.02
R6530:Vmn2r79	UTSW	7	86,651,252 (GRCm39)	missense	possibly damaging	0.91
R6546:Vmn2r79	UTSW	7	86,652,741 (GRCm39)	missense	probably benign	0.01
R6682:Vmn2r79	UTSW	7	86,653,370 (GRCm39)	missense	possibly damaging	0.69
R6858:Vmn2r79	UTSW	7	86,686,580 (GRCm39)	missense	probably benign
R6965:Vmn2r79	UTSW	7	86,651,100 (GRCm39)	missense	probably benign	0.10
R7130:Vmn2r79	UTSW	7	86,651,474 (GRCm39)	missense	probably damaging	0.99
R7156:Vmn2r79	UTSW	7	86,686,851 (GRCm39)	missense	probably damaging	0.98
R7604:Vmn2r79	UTSW	7	86,652,592 (GRCm39)	critical splice acceptor site	probably null
R7691:Vmn2r79	UTSW	7	86,687,111 (GRCm39)	missense	probably damaging	0.96
R8055:Vmn2r79	UTSW	7	86,686,541 (GRCm39)	missense	possibly damaging	0.94
R8070:Vmn2r79	UTSW	7	86,651,336 (GRCm39)	missense	probably benign
R8073:Vmn2r79	UTSW	7	86,651,462 (GRCm39)	missense	probably benign	0.00
R8145:Vmn2r79	UTSW	7	86,686,862 (GRCm39)	missense	probably benign	0.02
R8263:Vmn2r79	UTSW	7	86,686,726 (GRCm39)	missense	possibly damaging	0.89
R8350:Vmn2r79	UTSW	7	86,686,741 (GRCm39)	nonsense	probably null
R8400:Vmn2r79	UTSW	7	86,651,308 (GRCm39)	missense	probably benign	0.00
R8814:Vmn2r79	UTSW	7	86,651,714 (GRCm39)	missense	probably benign	0.00
R8862:Vmn2r79	UTSW	7	86,645,712 (GRCm39)	missense	probably benign	0.23
R9146:Vmn2r79	UTSW	7	86,650,681 (GRCm39)	nonsense	probably null
R9276:Vmn2r79	UTSW	7	86,687,045 (GRCm39)	missense	probably damaging	1.00
R9361:Vmn2r79	UTSW	7	86,652,822 (GRCm39)	critical splice donor site	probably null
R9676:Vmn2r79	UTSW	7	86,686,452 (GRCm39)	missense	probably damaging	1.00
U15987:Vmn2r79	UTSW	7	86,653,319 (GRCm39)	missense	possibly damaging	0.86
X0054:Vmn2r79	UTSW	7	86,653,270 (GRCm39)	missense	probably benign	0.01
Z1088:Vmn2r79	UTSW	7	86,651,549 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r79	UTSW	7	86,686,377 (GRCm39)	missense	probably benign
Z1176:Vmn2r79	UTSW	7	86,651,526 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GTCCAGAGGATGAGTATGCCAACAC -3'
(R):5'- GAGCCCATGTATCCAAGGACACAG -3'

Sequencing Primer
(F):5'- TGCCTCAAGAAAGTTGTGACC -3'
(R):5'- GAAGGCAATCACTGAACCTTTG -3'

Posted On

2014-04-13