Mutagenetix > Incidental Mutation

Incidental Mutation 'R1513:Zfy2'

168589

Institutional Source

Beutler Lab

Gene Symbol

Zfy2

Ensembl Gene

ENSMUSG00000000103

Gene Name

zinc finger protein 2, Y-linked

Synonyms

Zfy-2

MMRRC Submission

039560-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R1513 (G1)

Quality Score

222

Status

Not validated

Chromosome

Chromosomal Location

2106015-2170409 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 2116185 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 285 (V285A)

Ref Sequence

ENSEMBL: ENSMUSP00000139591 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115891] [ENSMUST00000187148]

AlphaFold

P20662

Predicted Effect

probably benign
Transcript: ENSMUST00000115891
AA Change: V285A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000111557
Gene: ENSMUSG00000000103
AA Change: V285A

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
Pfam:Zfx_Zfy_act	68	388	1.1e-115	PFAM
ZnF_C2H2	403	425	3.69e-4	SMART
ZnF_C2H2	434	456	1.26e-2	SMART
ZnF_C2H2	491	514	1.41e0	SMART
ZnF_C2H2	520	542	3.69e-4	SMART
ZnF_C2H2	548	571	3.63e-3	SMART
ZnF_C2H2	577	599	1.02e1	SMART
ZnF_C2H2	605	628	3.58e-2	SMART
ZnF_C2H2	634	656	2.95e-3	SMART
ZnF_C2H2	662	685	1.23e0	SMART
ZnF_C2H2	691	713	1.45e-2	SMART
ZnF_C2H2	719	742	1.2e-3	SMART
ZnF_C2H2	748	770	3.34e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187148
AA Change: V285A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000139591
Gene: ENSMUSG00000000103
AA Change: V285A

Domain	Start	End	E-Value	Type
low complexity region	3	13	N/A	INTRINSIC
Pfam:Zfx_Zfy_act	67	388	2.6e-149	PFAM
ZnF_C2H2	403	425	3.69e-4	SMART
ZnF_C2H2	434	456	1.26e-2	SMART
ZnF_C2H2	491	514	1.41e0	SMART
ZnF_C2H2	520	542	3.69e-4	SMART
ZnF_C2H2	548	571	3.63e-3	SMART
ZnF_C2H2	577	599	1.02e1	SMART
ZnF_C2H2	605	628	3.58e-2	SMART
ZnF_C2H2	634	656	2.95e-3	SMART
ZnF_C2H2	662	685	1.23e0	SMART
ZnF_C2H2	691	713	1.45e-2	SMART
ZnF_C2H2	719	742	1.2e-3	SMART
ZnF_C2H2	748	770	3.34e-2	SMART

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 94.7%
20x: 87.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 107 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1500011B03Rik	A	T	5: 114,809,273 (GRCm38)	C64*	probably null	Het
1700003H04Rik	A	C	3: 124,575,336 (GRCm38)	Y109D	possibly damaging	Het
Abca15	A	T	7: 120,340,099 (GRCm38)	I239F	probably damaging	Het
Adgrv1	A	T	13: 81,556,957 (GRCm38)	I1578K	probably damaging	Het
Adgrv1	A	G	13: 81,593,048 (GRCm38)	V99A	probably damaging	Het
Ap4e1	G	T	2: 127,061,555 (GRCm38)	K792N	probably null	Het
Ap5b1	G	A	19: 5,569,864 (GRCm38)	W437*	probably null	Het
Arhgef17	A	G	7: 100,930,862 (GRCm38)	L293P	probably benign	Het
Arhgef33	A	C	17: 80,371,389 (GRCm38)	M505L	probably benign	Het
Arih1	T	A	9: 59,403,380 (GRCm38)	R320S	probably damaging	Het
Atp1b3	A	T	9: 96,364,153 (GRCm38)	M1K	probably null	Het
AU022751	GTCATCATCATCATC	GTCATCATCATCATCATC	X: 6,082,591 (GRCm38)		probably benign	Het
Bbs2	T	C	8: 94,089,844 (GRCm38)	D130G	possibly damaging	Het
Bscl2	G	A	19: 8,841,145 (GRCm38)	R38H	probably damaging	Het
Cad	A	G	5: 31,068,762 (GRCm38)	Y1102C	probably damaging	Het
Cc2d1b	G	A	4: 108,633,226 (GRCm38)	R825Q	probably damaging	Het
Ccdc39	A	G	3: 33,839,145 (GRCm38)	V97A	possibly damaging	Het
Ccr1	T	C	9: 123,964,473 (GRCm38)	T7A	probably benign	Het
Cd33	A	G	7: 43,532,194 (GRCm38)	S181P	probably damaging	Het
Cdc20	A	C	4: 118,433,107 (GRCm38)	S452R	probably damaging	Het
Cdk8	A	T	5: 146,296,378 (GRCm38)	I229F	possibly damaging	Het
Ces3a	A	T	8: 105,050,277 (GRCm38)	N131Y	probably damaging	Het
Cgnl1	A	G	9: 71,724,590 (GRCm38)	I493T	probably benign	Het
Chia1	G	A	3: 106,131,904 (GRCm38)	V437M	probably benign	Het
Chrna2	G	A	14: 66,143,429 (GRCm38)	R49H	probably benign	Het
Clec12b	A	G	6: 129,376,302 (GRCm38)	C241R	probably damaging	Het
Col11a1	A	G	3: 114,097,154 (GRCm38)	D380G	unknown	Het
Crebbp	A	G	16: 4,115,885 (GRCm38)	S948P	probably damaging	Het
Dchs1	G	A	7: 105,772,071 (GRCm38)	R381*	probably null	Het
Defb19	A	T	2: 152,576,165 (GRCm38)	*84R	probably null	Het
Dnah8	T	C	17: 30,673,888 (GRCm38)	F816L	probably benign	Het
Dync2h1	T	A	9: 7,103,663 (GRCm38)	I371F	possibly damaging	Het
Fggy	T	C	4: 95,902,058 (GRCm38)		probably benign	Het
Galnt12	G	A	4: 47,117,956 (GRCm38)	C125Y	probably damaging	Het
Gm4952	A	T	19: 12,624,675 (GRCm38)	D149V	probably damaging	Het
Gm6309	A	T	5: 146,170,583 (GRCm38)	H37Q	possibly damaging	Het
Gmnn	A	G	13: 24,756,632 (GRCm38)	L78P	possibly damaging	Het
Golga4	C	A	9: 118,555,732 (GRCm38)	Q613K	probably benign	Het
Iqgap2	A	T	13: 95,630,010 (GRCm38)	I1495K	probably damaging	Het
Junb	T	C	8: 84,978,129 (GRCm38)	T101A	probably damaging	Het
Kif21b	T	C	1: 136,156,111 (GRCm38)	Y699H	probably damaging	Het
Klf17	T	C	4: 117,760,935 (GRCm38)	E75G	probably damaging	Het
Klra17	T	C	6: 129,872,314 (GRCm38)	E99G	possibly damaging	Het
Knop1	CTCTTCTTCTTCTTCTTCTTCTTC	CTCTTCTTCTTCTTCTTCTTC	7: 118,852,449 (GRCm38)		probably benign	Het
Krt83	C	T	15: 101,489,657 (GRCm38)	V167M	probably benign	Het
Lce1m	A	G	3: 93,018,625 (GRCm38)		probably benign	Het
Lpin3	A	T	2: 160,904,548 (GRCm38)	Y709F	probably damaging	Het
Ltbp2	T	A	12: 84,791,944 (GRCm38)	D1080V	probably damaging	Het
Mycbp2	G	A	14: 103,204,389 (GRCm38)	T1980I	probably damaging	Het
Myo1g	T	A	11: 6,515,140 (GRCm38)	K435M	probably damaging	Het
Mypn	T	A	10: 63,169,368 (GRCm38)	N320I	probably damaging	Het
Naip5	A	T	13: 100,222,206 (GRCm38)	W841R	probably benign	Het
Ncapd2	A	T	6: 125,170,992 (GRCm38)	M1124K	probably damaging	Het
Ncf4	A	G	15: 78,262,360 (GRCm38)	D330G	probably benign	Het
Ndst3	C	T	3: 123,601,455 (GRCm38)	V509M	possibly damaging	Het
Neb	A	T	2: 52,227,244 (GRCm38)	D4105E	probably damaging	Het
Nfix	G	A	8: 84,726,526 (GRCm38)	R300C	probably damaging	Het
Nsrp1	A	T	11: 77,046,619 (GRCm38)	F250L	probably benign	Het
Olfr1024	A	T	2: 85,904,671 (GRCm38)	Y128N	probably damaging	Het
Olfr1087	C	T	2: 86,690,797 (GRCm38)	M59I	possibly damaging	Het
Olfr552	G	T	7: 102,605,302 (GRCm38)	G316V	probably benign	Het
Olfr646	C	T	7: 104,106,464 (GRCm38)	L62F	probably benign	Het
Olfr724	T	C	14: 49,961,101 (GRCm38)		probably null	Het
Olfr740	A	G	14: 50,453,681 (GRCm38)	I210V	probably benign	Het
Oxr1	A	G	15: 41,797,474 (GRCm38)	D67G	probably damaging	Het
P2ry12	A	T	3: 59,218,077 (GRCm38)	I59N	probably damaging	Het
Pcdhb12	G	T	18: 37,437,058 (GRCm38)	G419V	probably damaging	Het
Pdzd2	G	T	15: 12,373,829 (GRCm38)	S2073R	possibly damaging	Het
Pex5l	C	A	3: 33,015,013 (GRCm38)	E112*	probably null	Het
Plaur	A	G	7: 24,472,591 (GRCm38)	D163G	probably benign	Het
Plk2	A	G	13: 110,400,088 (GRCm38)	Y638C	probably benign	Het
Ppp1r15b	A	G	1: 133,133,350 (GRCm38)	N535S	probably benign	Het
Ppp2r1b	T	C	9: 50,870,145 (GRCm38)	L21P	probably damaging	Het
Prkar2a	G	A	9: 108,728,270 (GRCm38)	V176I	possibly damaging	Het
Ptpro	T	A	6: 137,443,594 (GRCm38)	V1007D	probably damaging	Het
Rag1	A	G	2: 101,642,991 (GRCm38)	M602T	possibly damaging	Het
Rb1	A	G	14: 73,322,084 (GRCm38)	V60A	probably benign	Het
Rgs20	T	A	1: 4,912,337 (GRCm38)	I303F	probably damaging	Het
Rnf43	T	A	11: 87,729,431 (GRCm38)	I240N	probably damaging	Het
Romo1	G	A	2: 156,144,513 (GRCm38)	V19M	probably benign	Het
Ryr1	A	G	7: 29,070,621 (GRCm38)	S2676P	probably damaging	Het
Ryr3	G	A	2: 112,709,197 (GRCm38)	Q3233*	probably null	Het
Skiv2l	G	T	17: 34,847,444 (GRCm38)	P188T	probably damaging	Het
Slc26a6	A	G	9: 108,855,836 (GRCm38)	R5G	probably benign	Het
Slc33a1	A	G	3: 63,963,955 (GRCm38)	L79P	probably damaging	Het
Snx31	G	A	15: 36,545,600 (GRCm38)	R91C	probably damaging	Het
Tecpr2	T	C	12: 110,954,800 (GRCm38)	I1269T	possibly damaging	Het
Tjap1	G	T	17: 46,261,442 (GRCm38)	D89E	probably benign	Het
Tmem53	A	T	4: 117,265,893 (GRCm38)	Q39L	probably damaging	Het
Tmod1	G	T	4: 46,083,549 (GRCm38)	V95F	possibly damaging	Het
Trim30c	A	C	7: 104,382,689 (GRCm38)	H306Q	probably benign	Het
Trpm3	A	T	19: 22,986,872 (GRCm38)	M1244L	possibly damaging	Het
Tspan32	A	G	7: 143,005,149 (GRCm38)	I14V	probably null	Het
Ube4b	A	G	4: 149,351,578 (GRCm38)	V695A	probably benign	Het
Ubxn11	G	A	4: 134,124,141 (GRCm38)		probably null	Het
Ugt3a2	A	G	15: 9,361,524 (GRCm38)	I129V	probably benign	Het
Vmn1r45	A	G	6: 89,933,076 (GRCm38)	V304A	probably damaging	Het
Vmn2r124	A	T	17: 18,063,273 (GRCm38)	S410C	probably damaging	Het
Vmn2r15	T	A	5: 109,293,329 (GRCm38)	D221V	probably damaging	Het
Vmn2r79	G	A	7: 87,037,444 (GRCm38)	V678I	probably benign	Het
Vps13b	A	T	15: 35,438,730 (GRCm38)	R319*	probably null	Het
Wdr95	G	A	5: 149,599,294 (GRCm38)	R639Q	probably benign	Het
Xirp2	A	G	2: 67,511,530 (GRCm38)	I1372V	probably benign	Het
Xpo5	T	A	17: 46,226,980 (GRCm38)	M611K	probably benign	Het
Zfat	A	G	15: 68,212,680 (GRCm38)	C121R	probably damaging	Het
Zfp382	A	T	7: 30,133,296 (GRCm38)	Y124F	probably benign	Het
Zfp512b	A	G	2: 181,589,189 (GRCm38)	F371S	probably benign	Het

Other mutations in Zfy2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02850:Zfy2	APN	Y	2,117,188 (GRCm38)	missense	probably benign	0.00
IGL02850:Zfy2	APN	Y	2,106,894 (GRCm38)	missense	probably benign	0.01
IGL02851:Zfy2	APN	Y	2,117,188 (GRCm38)	missense	probably benign	0.00
IGL02851:Zfy2	APN	Y	2,106,894 (GRCm38)	missense	probably benign	0.01
IGL02852:Zfy2	APN	Y	2,117,188 (GRCm38)	missense	probably benign	0.00
IGL02852:Zfy2	APN	Y	2,106,894 (GRCm38)	missense	probably benign	0.01
PIT4515001:Zfy2	UTSW	Y	2,117,096 (GRCm38)	missense	probably benign	0.09
R0426:Zfy2	UTSW	Y	2,107,348 (GRCm38)	missense	possibly damaging	0.61
R0490:Zfy2	UTSW	Y	2,106,620 (GRCm38)	missense	possibly damaging	0.89
R1080:Zfy2	UTSW	Y	2,121,645 (GRCm38)	missense	probably benign	0.00
R1935:Zfy2	UTSW	Y	2,121,496 (GRCm38)	missense	probably benign	0.02
R1936:Zfy2	UTSW	Y	2,121,496 (GRCm38)	missense	probably benign	0.02
R2358:Zfy2	UTSW	Y	2,107,272 (GRCm38)	missense	possibly damaging	0.61
R4484:Zfy2	UTSW	Y	2,107,351 (GRCm38)	missense	possibly damaging	0.86
R4754:Zfy2	UTSW	Y	2,121,477 (GRCm38)	missense	probably benign	0.02
R4777:Zfy2	UTSW	Y	2,116,194 (GRCm38)	missense	probably benign	0.00
R4812:Zfy2	UTSW	Y	2,106,334 (GRCm38)	missense	probably benign	0.08
R5045:Zfy2	UTSW	Y	2,107,159 (GRCm38)	missense	possibly damaging	0.77
R5363:Zfy2	UTSW	Y	2,106,555 (GRCm38)	missense	possibly damaging	0.95
R6256:Zfy2	UTSW	Y	2,116,267 (GRCm38)	missense	probably benign	0.02
R6618:Zfy2	UTSW	Y	2,121,477 (GRCm38)	missense	probably benign	0.10
R6941:Zfy2	UTSW	Y	2,121,491 (GRCm38)	missense	probably benign	0.02
R7011:Zfy2	UTSW	Y	2,107,127 (GRCm38)	missense	possibly damaging	0.59
R7712:Zfy2	UTSW	Y	2,121,420 (GRCm38)	missense	probably benign	0.05
R7759:Zfy2	UTSW	Y	2,117,083 (GRCm38)	missense	probably benign	0.02
R7985:Zfy2	UTSW	Y	2,116,263 (GRCm38)	missense	probably benign	0.00
R8051:Zfy2	UTSW	Y	2,117,380 (GRCm38)	intron	probably benign
R8218:Zfy2	UTSW	Y	2,133,421 (GRCm38)	missense	unknown
R8345:Zfy2	UTSW	Y	2,107,096 (GRCm38)	missense	possibly damaging	0.95
R8371:Zfy2	UTSW	Y	2,117,168 (GRCm38)	missense	probably benign	0.00
R8830:Zfy2	UTSW	Y	2,106,600 (GRCm38)	missense	possibly damaging	0.60
R9448:Zfy2	UTSW	Y	2,109,904 (GRCm38)	missense	probably damaging	0.98
R9537:Zfy2	UTSW	Y	2,108,596 (GRCm38)	missense

Predicted Primers

Posted On

2014-04-13