Incidental Mutation 'R0058:Dazap1'
ID16860
Institutional Source Beutler Lab
Gene Symbol Dazap1
Ensembl Gene ENSMUSG00000069565
Gene NameDAZ associated protein 1
Synonyms2410042M16Rik, mPrrp
MMRRC Submission 038352-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.443) question?
Stock #R0058 (G1)
Quality Score
Status Validated
Chromosome10
Chromosomal Location80261486-80288408 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 80261581 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000117497 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020359] [ENSMUST00000020361] [ENSMUST00000092305] [ENSMUST00000105361] [ENSMUST00000105362] [ENSMUST00000105363] [ENSMUST00000105364] [ENSMUST00000156935]
Predicted Effect probably benign
Transcript: ENSMUST00000020359
SMART Domains Protein: ENSMUSP00000020359
Gene: ENSMUSG00000020150

DomainStartEndE-ValueType
PDB:1XCL|A 2 252 1e-151 PDB
SCOP:d1khha_ 44 252 3e-32 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000020361
SMART Domains Protein: ENSMUSP00000020361
Gene: ENSMUSG00000020153

DomainStartEndE-ValueType
low complexity region 36 46 N/A INTRINSIC
low complexity region 49 60 N/A INTRINSIC
Pfam:Oxidored_q6 98 208 1.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000092305
SMART Domains Protein: ENSMUSP00000089958
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 11 83 1.89e-24 SMART
RRM 114 186 6.25e-25 SMART
low complexity region 238 261 N/A INTRINSIC
low complexity region 270 332 N/A INTRINSIC
low complexity region 363 394 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105361
SMART Domains Protein: ENSMUSP00000101000
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 11 83 1.89e-24 SMART
RRM 113 185 6.25e-25 SMART
low complexity region 237 260 N/A INTRINSIC
low complexity region 269 331 N/A INTRINSIC
low complexity region 363 394 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105362
SMART Domains Protein: ENSMUSP00000101001
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 11 83 1.89e-24 SMART
RRM 113 185 6.25e-25 SMART
low complexity region 237 260 N/A INTRINSIC
low complexity region 269 331 N/A INTRINSIC
low complexity region 362 393 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105363
SMART Domains Protein: ENSMUSP00000101002
Gene: ENSMUSG00000020150

DomainStartEndE-ValueType
PDB:1XCL|A 2 236 1e-155 PDB
SCOP:d1khha_ 44 236 2e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105364
SMART Domains Protein: ENSMUSP00000101003
Gene: ENSMUSG00000020153

DomainStartEndE-ValueType
low complexity region 36 46 N/A INTRINSIC
low complexity region 49 60 N/A INTRINSIC
Pfam:Oxidored_q6 98 208 1.9e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148615
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150328
Predicted Effect probably benign
Transcript: ENSMUST00000156935
SMART Domains Protein: ENSMUSP00000117497
Gene: ENSMUSG00000069565

DomainStartEndE-ValueType
RRM 3 75 1.89e-24 SMART
RRM 105 171 6.71e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157063
Coding Region Coverage
  • 1x: 87.4%
  • 3x: 82.9%
  • 10x: 66.9%
  • 20x: 41.4%
Validation Efficiency 85% (62/73)
MGI Phenotype PHENOTYPE: Homozygotes for a null allele show partial lethality during fetal growth through weaning, growth retardation, spermatogenic arrest, and premature death. Homozygotes for a hypomorphic allele live longer but are small and sterile and display small gonads, spermatogenic arrest, and abnormal pregnancy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,182,672 V6088A possibly damaging Het
Ankrd36 A G 11: 5,630,691 probably benign Het
Anxa1 A T 19: 20,383,777 Y84N probably damaging Het
Arnt2 G A 7: 84,347,530 R63C probably damaging Het
Avpr1b A G 1: 131,599,786 T16A probably benign Het
Cables1 A G 18: 11,923,413 E316G possibly damaging Het
Cadm1 A T 9: 47,850,331 I427L probably damaging Het
Dip2b A G 15: 100,215,240 E1512G probably benign Het
Dock1 G A 7: 135,108,761 V1171M possibly damaging Het
Dock5 A T 14: 67,781,036 F1230Y probably benign Het
Dst T C 1: 34,006,224 S13P possibly damaging Het
Dym G A 18: 75,043,172 E15K possibly damaging Het
Faf1 A G 4: 109,736,624 Q133R probably benign Het
Fcer2a T C 8: 3,688,111 probably benign Het
Fmo2 A T 1: 162,886,324 S204R probably benign Het
Ghitm A G 14: 37,131,592 L97P probably damaging Het
Gins4 A G 8: 23,229,510 probably benign Het
Gm10573 G A 4: 121,920,736 Het
Golga3 T A 5: 110,202,777 F766Y possibly damaging Het
Hapln1 T C 13: 89,607,878 I267T probably benign Het
Helz A T 11: 107,672,558 probably benign Het
Igll1 A T 16: 16,863,876 V5E probably benign Het
Kif16b A G 2: 142,857,305 probably null Het
Limk1 A T 5: 134,659,871 W507R probably damaging Het
Marf1 C T 16: 14,142,534 A549T probably damaging Het
Mtif3 C A 5: 146,956,921 V159F probably benign Het
Ncoa7 T A 10: 30,647,541 D887V probably damaging Het
Pkd1 G C 17: 24,564,703 A162P probably benign Het
Plce1 A G 19: 38,525,184 D309G possibly damaging Het
Plk4 T C 3: 40,805,872 V401A probably benign Het
Prrc2c C T 1: 162,698,884 V253I unknown Het
Ranbp2 T A 10: 58,480,531 S2358T probably damaging Het
Setd2 T A 9: 110,594,426 V2183E probably damaging Het
Sgsm1 T A 5: 113,285,087 S232C probably damaging Het
Skint6 A T 4: 113,046,815 probably benign Het
Slc15a2 A G 16: 36,754,547 I531T probably benign Het
Slc36a1 C T 11: 55,221,994 probably benign Het
Sptan1 T C 2: 29,993,696 probably null Het
Tex15 C T 8: 33,581,502 probably benign Het
Tlr9 T G 9: 106,224,965 L485R possibly damaging Het
Tmem207 A G 16: 26,524,829 probably benign Het
Triml2 T C 8: 43,185,269 probably benign Het
Tspear T C 10: 77,869,631 F288L probably benign Het
Zfp644 A T 5: 106,637,003 S559R possibly damaging Het
Other mutations in Dazap1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03151:Dazap1 APN 10 80280920 splice site probably benign
R0058:Dazap1 UTSW 10 80261581 splice site probably benign
R0131:Dazap1 UTSW 10 80278226 splice site probably null
R0132:Dazap1 UTSW 10 80278226 splice site probably null
R0938:Dazap1 UTSW 10 80280961 missense possibly damaging 0.82
R1976:Dazap1 UTSW 10 80274620 splice site probably null
R2233:Dazap1 UTSW 10 80277599 missense possibly damaging 0.69
R2234:Dazap1 UTSW 10 80277599 missense possibly damaging 0.69
R2326:Dazap1 UTSW 10 80284233 missense possibly damaging 0.90
R3619:Dazap1 UTSW 10 80285360 unclassified probably benign
R3747:Dazap1 UTSW 10 80287664 missense possibly damaging 0.94
R6009:Dazap1 UTSW 10 80285304 unclassified probably benign
R6324:Dazap1 UTSW 10 80277660 missense probably benign 0.17
R6484:Dazap1 UTSW 10 80277647 missense probably benign 0.11
Posted On2013-01-20