Incidental Mutation 'R1497:Magi1'
| ID |
168954 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi1
|
| Ensembl Gene |
ENSMUSG00000045095 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
| MMRRC Submission |
039548-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.561)
|
| Stock # |
R1497 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 93724310 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 235
(F235S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000144769
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204532]
|
| AlphaFold |
Q6RHR9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055224
AA Change: F450S
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000062085
Gene: ENSMUSG00000045095
AA Change: F450S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
348 |
380 |
2.88e-9 |
SMART |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
|
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
|
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
|
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
|
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
|
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000089317
AA Change: F462S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000086730
Gene: ENSMUSG00000045095
AA Change: F462S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
|
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
|
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000093769
AA Change: F235S
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000091283
Gene: ENSMUSG00000045095
AA Change: F235S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
|
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
|
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
|
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000203519
AA Change: F462S
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000145244
Gene: ENSMUSG00000045095
AA Change: F462S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
360 |
392 |
2.88e-9 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
|
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
|
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
|
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
|
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
|
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203688
AA Change: F235S
PolyPhen 2
Score 0.370 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000145515
Gene: ENSMUSG00000045095
AA Change: F235S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
|
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
|
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
|
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204347
AA Change: F462S
PolyPhen 2
Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000144881
Gene: ENSMUSG00000045095
AA Change: F462S
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
|
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
|
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204532
AA Change: F235S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000144769
Gene: ENSMUSG00000045095
AA Change: F235S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
|
WW
|
74 |
106 |
5.8e-13 |
SMART |
|
WW
|
133 |
165 |
1.7e-11 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
|
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
| Meta Mutation Damage Score |
0.3712 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.4%
|
| Validation Efficiency |
99% (79/80) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
G |
T |
11: 109,864,647 (GRCm39) |
|
probably benign |
Het |
| Abhd17a |
A |
G |
10: 80,420,164 (GRCm39) |
|
probably benign |
Het |
| Acacb |
G |
A |
5: 114,334,868 (GRCm39) |
E646K |
probably damaging |
Het |
| Afap1l2 |
T |
C |
19: 56,916,743 (GRCm39) |
M262V |
probably benign |
Het |
| Anapc7 |
T |
A |
5: 122,573,578 (GRCm39) |
|
probably benign |
Het |
| Car5b |
T |
A |
X: 162,771,400 (GRCm39) |
K188N |
probably benign |
Het |
| Caskin1 |
C |
T |
17: 24,723,515 (GRCm39) |
R768* |
probably null |
Het |
| Casp8ap2 |
T |
C |
4: 32,639,938 (GRCm39) |
S331P |
probably benign |
Het |
| Ccdc68 |
C |
T |
18: 70,093,585 (GRCm39) |
|
probably benign |
Het |
| Cd44 |
A |
T |
2: 102,673,300 (GRCm39) |
|
probably null |
Het |
| Celsr3 |
A |
G |
9: 108,726,064 (GRCm39) |
S3090G |
probably benign |
Het |
| Clasp1 |
A |
T |
1: 118,479,788 (GRCm39) |
M1023L |
probably benign |
Het |
| Clec16a |
T |
C |
16: 10,453,123 (GRCm39) |
F608S |
probably damaging |
Het |
| Col7a1 |
A |
C |
9: 108,807,893 (GRCm39) |
E2531A |
unknown |
Het |
| Ctc1 |
T |
A |
11: 68,913,387 (GRCm39) |
C128S |
probably benign |
Het |
| Cyp2d41-ps |
T |
C |
15: 82,666,223 (GRCm39) |
|
noncoding transcript |
Het |
| Cyp2j6 |
T |
A |
4: 96,419,898 (GRCm39) |
I278F |
probably damaging |
Het |
| Dhtkd1 |
A |
T |
2: 5,908,924 (GRCm39) |
S723R |
probably damaging |
Het |
| Dhx8 |
A |
G |
11: 101,626,213 (GRCm39) |
|
probably benign |
Het |
| Dnah17 |
A |
T |
11: 118,005,059 (GRCm39) |
L775Q |
probably damaging |
Het |
| Dnah8 |
C |
A |
17: 30,971,049 (GRCm39) |
T2701K |
probably damaging |
Het |
| Eml3 |
T |
A |
19: 8,913,733 (GRCm39) |
S424R |
probably damaging |
Het |
| Epm2aip1 |
A |
G |
9: 111,101,315 (GRCm39) |
E96G |
possibly damaging |
Het |
| Ezr |
T |
C |
17: 7,010,107 (GRCm39) |
H314R |
probably benign |
Het |
| Fam193b |
G |
T |
13: 55,702,247 (GRCm39) |
H43Q |
probably damaging |
Het |
| Fam217a |
T |
A |
13: 35,095,195 (GRCm39) |
N340I |
probably damaging |
Het |
| Fcrl1 |
A |
T |
3: 87,292,109 (GRCm39) |
Q89H |
probably damaging |
Het |
| Flg2 |
A |
T |
3: 93,127,076 (GRCm39) |
H1996L |
unknown |
Het |
| Gabpb1 |
C |
T |
2: 126,481,169 (GRCm39) |
V327M |
possibly damaging |
Het |
| Gtf3c3 |
A |
G |
1: 54,477,098 (GRCm39) |
V36A |
probably benign |
Het |
| Hspg2 |
A |
G |
4: 137,275,407 (GRCm39) |
N2739S |
probably damaging |
Het |
| Hyal1 |
A |
G |
9: 107,455,194 (GRCm39) |
|
probably null |
Het |
| Ipo13 |
T |
C |
4: 117,761,856 (GRCm39) |
D448G |
probably benign |
Het |
| Kcnq5 |
T |
C |
1: 21,472,610 (GRCm39) |
D860G |
possibly damaging |
Het |
| Kif13b |
A |
G |
14: 64,973,715 (GRCm39) |
N355S |
probably damaging |
Het |
| Kmt2c |
T |
A |
5: 25,519,513 (GRCm39) |
H2199L |
possibly damaging |
Het |
| Maml1 |
A |
C |
11: 50,156,534 (GRCm39) |
M547R |
possibly damaging |
Het |
| Mapk7 |
T |
C |
11: 61,384,689 (GRCm39) |
K6E |
possibly damaging |
Het |
| Mbd5 |
T |
A |
2: 49,147,393 (GRCm39) |
N534K |
possibly damaging |
Het |
| Mcat |
G |
A |
15: 83,433,453 (GRCm39) |
Q34* |
probably null |
Het |
| Mcu |
T |
A |
10: 59,284,670 (GRCm39) |
D180V |
probably damaging |
Het |
| Mettl21c |
G |
T |
1: 44,048,951 (GRCm39) |
P199T |
probably benign |
Het |
| Mndal |
A |
T |
1: 173,700,441 (GRCm39) |
S177T |
probably benign |
Het |
| Mpeg1 |
G |
T |
19: 12,438,611 (GRCm39) |
C23F |
probably benign |
Het |
| Mup15 |
T |
A |
4: 61,356,471 (GRCm39) |
Y98F |
probably benign |
Het |
| Myh8 |
T |
C |
11: 67,180,638 (GRCm39) |
S625P |
probably benign |
Het |
| Nipsnap2 |
T |
C |
5: 129,830,282 (GRCm39) |
|
probably benign |
Het |
| Nlrp4e |
T |
C |
7: 23,019,797 (GRCm39) |
S95P |
probably benign |
Het |
| Or1e19 |
T |
A |
11: 73,316,653 (GRCm39) |
D52V |
possibly damaging |
Het |
| Or4a66 |
T |
C |
2: 88,531,106 (GRCm39) |
D189G |
probably damaging |
Het |
| Otop2 |
A |
G |
11: 115,220,675 (GRCm39) |
|
probably null |
Het |
| Pcnx4 |
G |
C |
12: 72,621,174 (GRCm39) |
G998A |
probably benign |
Het |
| Pnkd |
C |
A |
1: 74,390,681 (GRCm39) |
|
probably null |
Het |
| Ppp4r4 |
T |
A |
12: 103,573,204 (GRCm39) |
V701E |
probably benign |
Het |
| Ryr2 |
A |
G |
13: 11,616,727 (GRCm39) |
I3897T |
probably damaging |
Het |
| Scn1a |
T |
C |
2: 66,162,631 (GRCm39) |
E205G |
probably damaging |
Het |
| Sdk2 |
G |
A |
11: 113,784,401 (GRCm39) |
|
probably benign |
Het |
| Serpinb5 |
A |
T |
1: 106,803,782 (GRCm39) |
Q156L |
probably benign |
Het |
| Setdb1 |
A |
T |
3: 95,234,778 (GRCm39) |
V975D |
probably benign |
Het |
| Shc1 |
A |
G |
3: 89,335,752 (GRCm39) |
*470W |
probably null |
Het |
| Sik3 |
T |
A |
9: 46,113,320 (GRCm39) |
V587E |
probably damaging |
Het |
| Sik3 |
C |
A |
9: 46,132,387 (GRCm39) |
H1276Q |
probably benign |
Het |
| Spata7 |
T |
C |
12: 98,635,120 (GRCm39) |
I384T |
probably damaging |
Het |
| Tanc2 |
T |
A |
11: 105,812,963 (GRCm39) |
V1469D |
probably benign |
Het |
| Tasor2 |
T |
C |
13: 3,620,409 (GRCm39) |
E2164G |
probably damaging |
Het |
| Tdrd5 |
A |
T |
1: 156,083,372 (GRCm39) |
N888K |
probably benign |
Het |
| Tex22 |
T |
C |
12: 113,039,000 (GRCm39) |
S34P |
probably benign |
Het |
| Tmed6 |
T |
C |
8: 107,790,754 (GRCm39) |
T98A |
probably benign |
Het |
| Trim66 |
G |
A |
7: 109,083,826 (GRCm39) |
P141L |
probably benign |
Het |
| Trpa1 |
T |
C |
1: 14,956,036 (GRCm39) |
I778V |
probably benign |
Het |
| Urb2 |
T |
A |
8: 124,754,816 (GRCm39) |
H174Q |
probably damaging |
Het |
| Usb1 |
T |
C |
8: 96,065,325 (GRCm39) |
V59A |
probably benign |
Het |
| Vmn1r11 |
T |
A |
6: 57,114,394 (GRCm39) |
N19K |
probably damaging |
Het |
| Vmn1r185 |
A |
T |
7: 26,311,219 (GRCm39) |
F95L |
probably benign |
Het |
| Vmn1r206 |
C |
T |
13: 22,805,160 (GRCm39) |
V16M |
probably benign |
Het |
| Vmn2r92 |
T |
C |
17: 18,387,625 (GRCm39) |
V210A |
probably benign |
Het |
| Wdr17 |
A |
T |
8: 55,125,536 (GRCm39) |
I448K |
possibly damaging |
Het |
| Zfp768 |
T |
A |
7: 126,942,733 (GRCm39) |
Q465L |
probably damaging |
Het |
| Zfp804b |
T |
A |
5: 6,821,105 (GRCm39) |
N617Y |
probably damaging |
Het |
|
| Other mutations in Magi1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4670:Magi1
|
UTSW |
6 |
93,663,624 (GRCm39) |
splice site |
probably null |
|
|
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4839:Magi1
|
UTSW |
6 |
93,671,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7224:Magi1
|
UTSW |
6 |
93,660,070 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
|
R7549:Magi1
|
UTSW |
6 |
93,685,095 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9300:Magi1
|
UTSW |
6 |
93,724,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9432:Magi1
|
UTSW |
6 |
93,660,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9567:Magi1
|
UTSW |
6 |
93,655,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACGCATTAGCACCTAACAGGTC -3'
(R):5'- AACAGGATTATGCAGAAGCACCCTC -3'
Sequencing Primer
(F):5'- GGTCCCTAAGGTCAAAGGACTTTC -3'
(R):5'- tcccccgcaagagcaac -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation