Incidental Mutation 'R1498:Vmn2r6'
ID |
169014 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r6
|
Ensembl Gene |
ENSMUSG00000090581 |
Gene Name |
vomeronasal 2, receptor 6 |
Synonyms |
EG667069, EG620718 |
MMRRC Submission |
039549-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.198)
|
Stock # |
R1498 (G1)
|
Quality Score |
203 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
64444916-64472855 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 64463890 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 315
(T315S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135148
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165012]
[ENSMUST00000176481]
|
AlphaFold |
H3BK29 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000165012
AA Change: T226S
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000131831 Gene: ENSMUSG00000090581 AA Change: T226S
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
1 |
416 |
1.4e-72 |
PFAM |
Pfam:Peripla_BP_6
|
58 |
244 |
1.2e-10 |
PFAM |
Pfam:NCD3G
|
458 |
511 |
1.8e-17 |
PFAM |
Pfam:7tm_3
|
542 |
779 |
3.9e-76 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000176481
AA Change: T315S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000135148 Gene: ENSMUSG00000090581 AA Change: T315S
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
88 |
505 |
9.8e-77 |
PFAM |
Pfam:Peripla_BP_6
|
142 |
331 |
3.4e-10 |
PFAM |
Pfam:NCD3G
|
547 |
600 |
5.4e-17 |
PFAM |
Pfam:7tm_3
|
633 |
867 |
3.9e-47 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.6%
|
Validation Efficiency |
97% (83/86) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 84 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acly |
A |
G |
11: 100,374,627 (GRCm39) |
S799P |
probably benign |
Het |
Acvr1b |
T |
C |
15: 101,091,891 (GRCm39) |
F57S |
probably benign |
Het |
Adamts5 |
T |
A |
16: 85,696,990 (GRCm39) |
T56S |
possibly damaging |
Het |
Adrb2 |
T |
C |
18: 62,312,004 (GRCm39) |
T274A |
probably damaging |
Het |
Agr3 |
A |
T |
12: 35,984,379 (GRCm39) |
|
probably null |
Het |
Ankrd6 |
A |
G |
4: 32,810,289 (GRCm39) |
M405T |
probably benign |
Het |
Aoc1l2 |
A |
G |
6: 48,908,305 (GRCm39) |
H435R |
probably benign |
Het |
Aqp5 |
T |
C |
15: 99,491,128 (GRCm39) |
I60T |
probably damaging |
Het |
Arf5 |
G |
T |
6: 28,426,153 (GRCm39) |
R180L |
probably benign |
Het |
Asap3 |
A |
G |
4: 135,966,505 (GRCm39) |
N528D |
probably benign |
Het |
Atmin |
G |
A |
8: 117,681,540 (GRCm39) |
E180K |
probably benign |
Het |
Bcl11a |
A |
T |
11: 24,114,005 (GRCm39) |
E449D |
probably damaging |
Het |
Cep128 |
A |
T |
12: 91,333,191 (GRCm39) |
F25I |
probably benign |
Het |
Cfp |
GCAC |
GC |
X: 20,795,905 (GRCm39) |
|
probably null |
Het |
Chpt1 |
T |
A |
10: 88,312,966 (GRCm39) |
Y282F |
possibly damaging |
Het |
Cul7 |
A |
G |
17: 46,966,636 (GRCm39) |
D355G |
probably benign |
Het |
Daxx |
T |
C |
17: 34,131,227 (GRCm39) |
Y385H |
probably damaging |
Het |
Dnah2 |
A |
C |
11: 69,411,493 (GRCm39) |
|
probably null |
Het |
Dscc1 |
CTGAATGAAT |
CTGAAT |
15: 54,943,572 (GRCm39) |
|
probably benign |
Het |
Erc2 |
T |
A |
14: 28,024,855 (GRCm39) |
M578K |
probably benign |
Het |
Evc |
T |
A |
5: 37,481,044 (GRCm39) |
H267L |
possibly damaging |
Het |
Exosc10 |
A |
C |
4: 148,666,243 (GRCm39) |
Q837P |
possibly damaging |
Het |
Fasn |
G |
A |
11: 120,706,245 (GRCm39) |
T1033I |
probably damaging |
Het |
Fat1 |
C |
A |
8: 45,478,521 (GRCm39) |
Y2522* |
probably null |
Het |
Fbxw8 |
G |
A |
5: 118,203,850 (GRCm39) |
|
probably benign |
Het |
Fyn |
A |
G |
10: 39,408,120 (GRCm39) |
D321G |
possibly damaging |
Het |
Grm6 |
G |
A |
11: 50,748,083 (GRCm39) |
V398M |
probably damaging |
Het |
Gtpbp1 |
T |
A |
15: 79,603,222 (GRCm39) |
|
probably null |
Het |
Hnf1a |
A |
G |
5: 115,108,596 (GRCm39) |
V103A |
probably damaging |
Het |
Hsp90aa1 |
A |
T |
12: 110,662,122 (GRCm39) |
|
probably null |
Het |
Iqgap2 |
C |
T |
13: 95,783,313 (GRCm39) |
V1288I |
probably benign |
Het |
Irx5 |
A |
G |
8: 93,086,514 (GRCm39) |
D199G |
probably damaging |
Het |
Klrh1 |
A |
G |
6: 129,748,703 (GRCm39) |
S105P |
probably damaging |
Het |
Krt9 |
G |
T |
11: 100,079,195 (GRCm39) |
C732* |
probably null |
Het |
Lifr |
T |
C |
15: 7,220,099 (GRCm39) |
S910P |
probably damaging |
Het |
Lrig1 |
G |
A |
6: 94,604,968 (GRCm39) |
A209V |
possibly damaging |
Het |
Lrrk1 |
T |
A |
7: 65,952,419 (GRCm39) |
R506* |
probably null |
Het |
Lyst |
T |
A |
13: 13,824,960 (GRCm39) |
I1525K |
possibly damaging |
Het |
Mad2l1 |
C |
T |
6: 66,516,826 (GRCm39) |
Q173* |
probably null |
Het |
Mcoln1 |
T |
A |
8: 3,562,861 (GRCm39) |
I524N |
probably damaging |
Het |
Mmp3 |
A |
T |
9: 7,446,967 (GRCm39) |
D49V |
possibly damaging |
Het |
Morc3 |
A |
T |
16: 93,650,743 (GRCm39) |
N321I |
probably damaging |
Het |
Mrpl48 |
T |
C |
7: 100,195,695 (GRCm39) |
|
probably benign |
Het |
Myo6 |
T |
A |
9: 80,214,961 (GRCm39) |
D1231E |
probably damaging |
Het |
Nlrc4 |
A |
G |
17: 74,753,408 (GRCm39) |
I325T |
probably benign |
Het |
Or1j19 |
A |
T |
2: 36,677,358 (GRCm39) |
I274F |
probably damaging |
Het |
Or2ag17 |
T |
C |
7: 106,389,623 (GRCm39) |
Y195C |
possibly damaging |
Het |
Or4f61 |
A |
T |
2: 111,922,938 (GRCm39) |
M36K |
probably benign |
Het |
Or8c16 |
C |
G |
9: 38,130,676 (GRCm39) |
P183A |
probably damaging |
Het |
Or8k32 |
A |
G |
2: 86,368,902 (GRCm39) |
V117A |
probably benign |
Het |
Parvg |
T |
A |
15: 84,218,832 (GRCm39) |
S230T |
possibly damaging |
Het |
Pcca |
T |
C |
14: 122,854,230 (GRCm39) |
I118T |
probably damaging |
Het |
Pde6a |
A |
G |
18: 61,365,932 (GRCm39) |
N219S |
possibly damaging |
Het |
Phldb1 |
G |
T |
9: 44,612,915 (GRCm39) |
P935Q |
possibly damaging |
Het |
Plppr5 |
T |
C |
3: 117,456,261 (GRCm39) |
S261P |
probably damaging |
Het |
Ppl |
T |
C |
16: 4,922,629 (GRCm39) |
N260S |
probably benign |
Het |
Ppp1r3e |
A |
T |
14: 55,113,882 (GRCm39) |
H263Q |
probably benign |
Het |
Ppp3cb |
T |
C |
14: 20,559,567 (GRCm39) |
|
probably null |
Het |
Ppt2 |
A |
T |
17: 34,842,075 (GRCm39) |
D185E |
probably benign |
Het |
Prr27 |
A |
T |
5: 87,998,600 (GRCm39) |
|
probably benign |
Het |
Ptcd3 |
A |
T |
6: 71,870,479 (GRCm39) |
V327E |
probably damaging |
Het |
Pwwp4a |
G |
T |
X: 72,171,261 (GRCm39) |
G218C |
probably damaging |
Het |
Rsf1 |
GCG |
GCGACG |
7: 97,229,114 (GRCm39) |
|
probably benign |
Het |
Rtp1 |
A |
T |
16: 23,249,970 (GRCm39) |
M112L |
probably benign |
Het |
Slc22a5 |
A |
T |
11: 53,760,140 (GRCm39) |
L392Q |
probably damaging |
Het |
Slc6a7 |
A |
G |
18: 61,129,764 (GRCm39) |
I614T |
probably benign |
Het |
Slu7 |
C |
A |
11: 43,329,044 (GRCm39) |
P89T |
possibly damaging |
Het |
Smarcc2 |
T |
C |
10: 128,318,061 (GRCm39) |
V618A |
probably benign |
Het |
Sorl1 |
C |
T |
9: 41,952,369 (GRCm39) |
R729Q |
probably damaging |
Het |
Sptbn2 |
T |
C |
19: 4,794,274 (GRCm39) |
F1493L |
possibly damaging |
Het |
Sulf1 |
C |
T |
1: 12,918,574 (GRCm39) |
T66I |
probably damaging |
Het |
Tgtp2 |
A |
G |
11: 48,950,165 (GRCm39) |
Y136H |
probably damaging |
Het |
Tmem117 |
T |
C |
15: 94,536,242 (GRCm39) |
F92S |
probably damaging |
Het |
Tmprss9 |
T |
A |
10: 80,730,934 (GRCm39) |
V820E |
probably benign |
Het |
Tpcn2 |
A |
G |
7: 144,822,648 (GRCm39) |
Y266H |
probably damaging |
Het |
Trat1 |
A |
G |
16: 48,555,304 (GRCm39) |
S143P |
probably benign |
Het |
Vmn1r49 |
T |
A |
6: 90,049,298 (GRCm39) |
R235W |
probably damaging |
Het |
Vmn1r71 |
A |
T |
7: 10,482,575 (GRCm39) |
C38S |
probably benign |
Het |
Wdr36 |
A |
G |
18: 32,986,021 (GRCm39) |
D575G |
possibly damaging |
Het |
Zfp292 |
G |
T |
4: 34,805,397 (GRCm39) |
A2549E |
possibly damaging |
Het |
Zfp354a |
A |
T |
11: 50,961,073 (GRCm39) |
H426L |
probably damaging |
Het |
Zfp407 |
C |
T |
18: 84,577,898 (GRCm39) |
A1072T |
probably benign |
Het |
Zfp648 |
T |
A |
1: 154,081,119 (GRCm39) |
I426N |
probably damaging |
Het |
Zfp87 |
T |
C |
13: 74,520,736 (GRCm39) |
N114S |
probably benign |
Het |
|
Other mutations in Vmn2r6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01547:Vmn2r6
|
APN |
3 |
64,445,525 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01968:Vmn2r6
|
APN |
3 |
64,463,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02009:Vmn2r6
|
APN |
3 |
64,445,323 (GRCm39) |
missense |
possibly damaging |
0.61 |
IGL02039:Vmn2r6
|
APN |
3 |
64,463,610 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02652:Vmn2r6
|
APN |
3 |
64,463,749 (GRCm39) |
missense |
probably benign |
0.24 |
IGL02737:Vmn2r6
|
APN |
3 |
64,463,911 (GRCm39) |
missense |
possibly damaging |
0.55 |
IGL02808:Vmn2r6
|
APN |
3 |
64,463,917 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03066:Vmn2r6
|
APN |
3 |
64,472,574 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03331:Vmn2r6
|
APN |
3 |
64,445,428 (GRCm39) |
missense |
probably damaging |
1.00 |
BB010:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
BB020:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
R0010:Vmn2r6
|
UTSW |
3 |
64,466,966 (GRCm39) |
nonsense |
probably null |
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0208:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0427:Vmn2r6
|
UTSW |
3 |
64,467,008 (GRCm39) |
missense |
probably damaging |
1.00 |
R0466:Vmn2r6
|
UTSW |
3 |
64,463,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R1018:Vmn2r6
|
UTSW |
3 |
64,464,261 (GRCm39) |
missense |
probably benign |
0.00 |
R1104:Vmn2r6
|
UTSW |
3 |
64,445,487 (GRCm39) |
missense |
possibly damaging |
0.93 |
R1186:Vmn2r6
|
UTSW |
3 |
64,472,488 (GRCm39) |
missense |
probably benign |
0.01 |
R1245:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1295:Vmn2r6
|
UTSW |
3 |
64,445,694 (GRCm39) |
missense |
probably damaging |
1.00 |
R1473:Vmn2r6
|
UTSW |
3 |
64,445,579 (GRCm39) |
nonsense |
probably null |
|
R1925:Vmn2r6
|
UTSW |
3 |
64,463,698 (GRCm39) |
missense |
possibly damaging |
0.87 |
R2044:Vmn2r6
|
UTSW |
3 |
64,445,262 (GRCm39) |
missense |
probably damaging |
0.96 |
R2069:Vmn2r6
|
UTSW |
3 |
64,463,519 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2253:Vmn2r6
|
UTSW |
3 |
64,467,139 (GRCm39) |
missense |
probably damaging |
1.00 |
R2261:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
R2262:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
R2350:Vmn2r6
|
UTSW |
3 |
64,463,773 (GRCm39) |
missense |
probably benign |
0.01 |
R2680:Vmn2r6
|
UTSW |
3 |
64,445,707 (GRCm39) |
missense |
possibly damaging |
0.91 |
R2846:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
R2860:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
R2861:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
R3766:Vmn2r6
|
UTSW |
3 |
64,463,929 (GRCm39) |
missense |
probably benign |
0.19 |
R3870:Vmn2r6
|
UTSW |
3 |
64,464,042 (GRCm39) |
missense |
probably damaging |
0.96 |
R4018:Vmn2r6
|
UTSW |
3 |
64,463,893 (GRCm39) |
missense |
probably benign |
0.05 |
R4024:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
R4026:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
R4227:Vmn2r6
|
UTSW |
3 |
64,445,369 (GRCm39) |
missense |
probably damaging |
0.99 |
R4526:Vmn2r6
|
UTSW |
3 |
64,445,145 (GRCm39) |
missense |
probably benign |
0.32 |
R4570:Vmn2r6
|
UTSW |
3 |
64,467,068 (GRCm39) |
missense |
probably benign |
0.31 |
R4894:Vmn2r6
|
UTSW |
3 |
64,454,829 (GRCm39) |
missense |
probably benign |
|
R4934:Vmn2r6
|
UTSW |
3 |
64,463,766 (GRCm39) |
missense |
probably damaging |
0.99 |
R5057:Vmn2r6
|
UTSW |
3 |
64,445,207 (GRCm39) |
missense |
probably damaging |
1.00 |
R5059:Vmn2r6
|
UTSW |
3 |
64,445,044 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5148:Vmn2r6
|
UTSW |
3 |
64,464,015 (GRCm39) |
missense |
probably damaging |
0.99 |
R5155:Vmn2r6
|
UTSW |
3 |
64,445,935 (GRCm39) |
missense |
probably benign |
0.44 |
R5179:Vmn2r6
|
UTSW |
3 |
64,445,411 (GRCm39) |
missense |
probably benign |
0.00 |
R5256:Vmn2r6
|
UTSW |
3 |
64,464,263 (GRCm39) |
missense |
probably benign |
0.33 |
R5861:Vmn2r6
|
UTSW |
3 |
64,463,454 (GRCm39) |
missense |
probably benign |
0.00 |
R5950:Vmn2r6
|
UTSW |
3 |
64,472,652 (GRCm39) |
missense |
probably benign |
0.05 |
R6081:Vmn2r6
|
UTSW |
3 |
64,463,953 (GRCm39) |
missense |
probably benign |
0.25 |
R6173:Vmn2r6
|
UTSW |
3 |
64,467,176 (GRCm39) |
missense |
probably damaging |
1.00 |
R6190:Vmn2r6
|
UTSW |
3 |
64,445,424 (GRCm39) |
missense |
probably benign |
0.04 |
R6240:Vmn2r6
|
UTSW |
3 |
64,464,226 (GRCm39) |
missense |
probably damaging |
1.00 |
R6433:Vmn2r6
|
UTSW |
3 |
64,454,801 (GRCm39) |
nonsense |
probably null |
|
R6645:Vmn2r6
|
UTSW |
3 |
64,464,297 (GRCm39) |
missense |
probably damaging |
1.00 |
R6791:Vmn2r6
|
UTSW |
3 |
64,445,580 (GRCm39) |
missense |
probably damaging |
1.00 |
R7265:Vmn2r6
|
UTSW |
3 |
64,464,195 (GRCm39) |
missense |
probably benign |
0.00 |
R7503:Vmn2r6
|
UTSW |
3 |
64,447,372 (GRCm39) |
nonsense |
probably null |
|
R7562:Vmn2r6
|
UTSW |
3 |
64,463,941 (GRCm39) |
missense |
probably benign |
0.00 |
R7584:Vmn2r6
|
UTSW |
3 |
64,472,683 (GRCm39) |
missense |
probably benign |
0.07 |
R7611:Vmn2r6
|
UTSW |
3 |
64,472,563 (GRCm39) |
missense |
probably damaging |
0.98 |
R7759:Vmn2r6
|
UTSW |
3 |
64,463,991 (GRCm39) |
missense |
probably damaging |
1.00 |
R7834:Vmn2r6
|
UTSW |
3 |
64,445,443 (GRCm39) |
missense |
probably damaging |
1.00 |
R7933:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
R7982:Vmn2r6
|
UTSW |
3 |
64,467,241 (GRCm39) |
missense |
probably damaging |
1.00 |
R8024:Vmn2r6
|
UTSW |
3 |
64,467,245 (GRCm39) |
missense |
probably benign |
0.40 |
R8074:Vmn2r6
|
UTSW |
3 |
64,455,064 (GRCm39) |
intron |
probably benign |
|
R8169:Vmn2r6
|
UTSW |
3 |
64,447,310 (GRCm39) |
missense |
probably benign |
0.01 |
R8337:Vmn2r6
|
UTSW |
3 |
64,463,526 (GRCm39) |
nonsense |
probably null |
|
R8736:Vmn2r6
|
UTSW |
3 |
64,467,221 (GRCm39) |
missense |
probably damaging |
1.00 |
R8962:Vmn2r6
|
UTSW |
3 |
64,463,576 (GRCm39) |
missense |
probably damaging |
1.00 |
R9139:Vmn2r6
|
UTSW |
3 |
64,464,277 (GRCm39) |
missense |
probably benign |
0.12 |
R9206:Vmn2r6
|
UTSW |
3 |
64,467,032 (GRCm39) |
missense |
probably damaging |
0.97 |
R9295:Vmn2r6
|
UTSW |
3 |
64,463,484 (GRCm39) |
missense |
probably benign |
0.00 |
R9332:Vmn2r6
|
UTSW |
3 |
64,454,671 (GRCm39) |
missense |
probably benign |
0.01 |
R9616:Vmn2r6
|
UTSW |
3 |
64,445,724 (GRCm39) |
missense |
probably damaging |
1.00 |
R9663:Vmn2r6
|
UTSW |
3 |
64,463,549 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9685:Vmn2r6
|
UTSW |
3 |
64,464,081 (GRCm39) |
missense |
probably benign |
0.19 |
X0020:Vmn2r6
|
UTSW |
3 |
64,445,871 (GRCm39) |
missense |
probably benign |
|
X0066:Vmn2r6
|
UTSW |
3 |
64,454,799 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn2r6
|
UTSW |
3 |
64,463,746 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- GGTGGTCCACATTGTATGGCACAG -3'
(R):5'- AGGTGGGATATGCTTCTTCCTCCTC -3'
Sequencing Primer
(F):5'- TTGGGCCAGGTACAGTTAAAAG -3'
(R):5'- CCCAGTGATAAATTCCAGTCTGAGG -3'
|
Posted On |
2014-04-13 |