Mutagenetix > Incidental Mutation

Incidental Mutation 'R0060:Cep162'

16902

Institutional Source

Beutler Lab

Gene Symbol

Cep162

Ensembl Gene

ENSMUSG00000056919

Gene Name

centrosomal protein 162

Synonyms

4922501C03Rik

MMRRC Submission

038353-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.123) question?

Stock #

R0060 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

87189577-87255536 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 87237825 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000091319 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093802]

AlphaFold

Q6ZQ06

Predicted Effect

probably benign
Transcript: ENSMUST00000093802

SMART Domains

Protein: ENSMUSP00000091319
Gene: ENSMUSG00000056919

Domain	Start	End	E-Value	Type
low complexity region	198	208	N/A	INTRINSIC
low complexity region	528	539	N/A	INTRINSIC
coiled coil region	630	674	N/A	INTRINSIC
coiled coil region	695	899	N/A	INTRINSIC
coiled coil region	953	1124	N/A	INTRINSIC
coiled coil region	1235	1386	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144137

Coding Region Coverage

1x: 90.4%
3x: 88.3%
10x: 83.8%
20x: 78.1%

Validation Efficiency

94% (74/79)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810011H11Rik	C	A	14: 32,806,769 (GRCm38)		probably benign	Het
1810065E05Rik	A	C	11: 58,422,182 (GRCm38)		probably benign	Het
4930432E11Rik	A	G	7: 29,574,170 (GRCm38)		noncoding transcript	Het
A630091E08Rik	A	G	7: 98,543,668 (GRCm38)		noncoding transcript	Het
Abca8a	T	C	11: 110,070,480 (GRCm38)	T539A	probably damaging	Het
Adam34	A	T	8: 43,675,883 (GRCm38)		probably benign	Het
Ankrd60	A	T	2: 173,572,613 (GRCm38)	M1K	probably null	Het
Cald1	T	C	6: 34,715,459 (GRCm38)		probably benign	Het
Capn7	T	C	14: 31,365,604 (GRCm38)		probably benign	Het
Cd109	G	A	9: 78,703,107 (GRCm38)	E1145K	probably damaging	Het
Celsr1	A	T	15: 85,922,198 (GRCm38)	V2353D	probably damaging	Het
Cep135	A	T	5: 76,621,350 (GRCm38)	I616F	probably benign	Het
Cep350	C	T	1: 155,928,626 (GRCm38)	D904N	probably damaging	Het
Cep85	T	C	4: 134,167,300 (GRCm38)	D65G	probably damaging	Het
Cfdp1	T	C	8: 111,840,354 (GRCm38)		probably benign	Het
Chl1	T	A	6: 103,711,058 (GRCm38)		probably benign	Het
Colec10	G	A	15: 54,439,146 (GRCm38)		probably benign	Het
Crxos	A	G	7: 15,898,523 (GRCm38)	T40A	possibly damaging	Het
Dnhd1	A	G	7: 105,668,514 (GRCm38)	D472G	probably damaging	Het
Dpp6	C	A	5: 27,598,819 (GRCm38)	N254K	probably damaging	Het
Eps8l3	T	C	3: 107,879,541 (GRCm38)	L11S	probably damaging	Het
Flad1	G	A	3: 89,402,245 (GRCm38)	R515*	probably null	Het
Fzd5	T	C	1: 64,735,676 (GRCm38)	T309A	probably benign	Het
Gm19685	T	C	17: 60,768,423 (GRCm38)			Het
Gsdme	A	G	6: 50,221,029 (GRCm38)	I317T	possibly damaging	Het
Hist1h2ba	A	T	13: 23,933,945 (GRCm38)	I71N	possibly damaging	Het
Incenp	A	G	19: 9,885,459 (GRCm38)		probably benign	Het
Itgad	T	C	7: 128,202,986 (GRCm38)	S979P	probably damaging	Het
Kat2b	T	C	17: 53,654,543 (GRCm38)	V557A	probably damaging	Het
Lamc1	A	T	1: 153,241,868 (GRCm38)		probably benign	Het
Lgi4	G	A	7: 31,063,571 (GRCm38)	G157D	probably damaging	Het
Mga	T	C	2: 119,960,961 (GRCm38)		probably null	Het
Nubpl	T	C	12: 52,310,687 (GRCm38)		probably benign	Het
Olfr1105	T	C	2: 87,033,774 (GRCm38)	Y149C	probably damaging	Het
Olfr124	T	C	17: 37,806,000 (GRCm38)	L285P	probably damaging	Het
Olfr898	C	T	9: 38,349,512 (GRCm38)	S143F	probably benign	Het
Peak1	A	T	9: 56,227,823 (GRCm38)	I78K	probably damaging	Het
Prune2	T	A	19: 17,003,733 (GRCm38)	F85I	probably damaging	Het
Rbm11	G	T	16: 75,598,779 (GRCm38)	D113Y	probably damaging	Het
Rif1	C	T	2: 52,111,117 (GRCm38)	R1528C	probably damaging	Het
Sema4d	A	G	13: 51,705,257 (GRCm38)		probably benign	Het
Slc30a4	T	A	2: 122,685,184 (GRCm38)	T381S	probably benign	Het
Slf2	G	T	19: 44,948,004 (GRCm38)	G696V	probably damaging	Het
Suv39h2	T	C	2: 3,464,916 (GRCm38)	Y134C	probably damaging	Het
Tmem89	T	A	9: 108,915,417 (GRCm38)	V126D	probably damaging	Het
Trf	T	C	9: 103,220,922 (GRCm38)	T46A	probably benign	Het
Trmt6	C	T	2: 132,806,769 (GRCm38)	R415Q	possibly damaging	Het
Trp53bp1	T	C	2: 121,204,525 (GRCm38)	K1625E	probably damaging	Het
Usp6nl	T	A	2: 6,440,890 (GRCm38)	D559E	probably benign	Het
Wdr75	A	G	1: 45,816,617 (GRCm38)	D476G	probably benign	Het
Wrap53	A	C	11: 69,563,430 (GRCm38)	L261V	possibly damaging	Het
Zcchc4	T	A	5: 52,807,078 (GRCm38)	I292N	possibly damaging	Het

Other mutations in Cep162

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00422:Cep162	APN	9	87,227,167 (GRCm38)	missense	probably benign	0.24
IGL00584:Cep162	APN	9	87,221,090 (GRCm38)	splice site	probably benign
IGL01387:Cep162	APN	9	87,211,811 (GRCm38)	missense	probably benign	0.08
IGL01862:Cep162	APN	9	87,253,933 (GRCm38)	missense	possibly damaging	0.90
IGL02304:Cep162	APN	9	87,227,147 (GRCm38)	splice site	probably benign
IGL02558:Cep162	APN	9	87,225,726 (GRCm38)	missense	probably benign
IGL02558:Cep162	APN	9	87,225,733 (GRCm38)	missense	probably benign	0.04
IGL02602:Cep162	APN	9	87,246,153 (GRCm38)	missense	probably benign	0.19
IGL02636:Cep162	APN	9	87,248,379 (GRCm38)	missense	possibly damaging	0.90
IGL02680:Cep162	APN	9	87,246,744 (GRCm38)	missense	possibly damaging	0.64
IGL03195:Cep162	APN	9	87,225,786 (GRCm38)	missense	probably benign	0.00
circus	UTSW	9	87,206,862 (GRCm38)	missense	probably damaging	1.00
moscow	UTSW	9	87,193,697 (GRCm38)	missense	probably damaging	1.00
smiley	UTSW	9	87,217,081 (GRCm38)	nonsense	probably null
PIT4378001:Cep162	UTSW	9	87,217,145 (GRCm38)	missense	probably benign	0.01
PIT4431001:Cep162	UTSW	9	87,244,345 (GRCm38)	missense	probably benign	0.00
PIT4434001:Cep162	UTSW	9	87,193,648 (GRCm38)	missense	probably damaging	1.00
R0218:Cep162	UTSW	9	87,211,809 (GRCm38)	missense	possibly damaging	0.73
R0366:Cep162	UTSW	9	87,220,484 (GRCm38)	missense	probably damaging	0.96
R0468:Cep162	UTSW	9	87,193,697 (GRCm38)	missense	probably damaging	1.00
R0764:Cep162	UTSW	9	87,201,745 (GRCm38)	missense	probably damaging	1.00
R1386:Cep162	UTSW	9	87,221,202 (GRCm38)	missense	probably benign
R1614:Cep162	UTSW	9	87,212,932 (GRCm38)	missense	probably damaging	1.00
R1633:Cep162	UTSW	9	87,203,683 (GRCm38)	missense	probably benign	0.23
R1831:Cep162	UTSW	9	87,206,932 (GRCm38)	missense	probably damaging	1.00
R1847:Cep162	UTSW	9	87,204,080 (GRCm38)	missense	probably benign	0.06
R1941:Cep162	UTSW	9	87,199,995 (GRCm38)	missense	probably benign	0.14
R2228:Cep162	UTSW	9	87,244,331 (GRCm38)	missense	probably benign	0.05
R2256:Cep162	UTSW	9	87,206,914 (GRCm38)	missense	probably damaging	1.00
R2257:Cep162	UTSW	9	87,206,914 (GRCm38)	missense	probably damaging	1.00
R2936:Cep162	UTSW	9	87,227,414 (GRCm38)	missense	probably benign
R3005:Cep162	UTSW	9	87,232,060 (GRCm38)	missense	probably benign	0.00
R3508:Cep162	UTSW	9	87,231,977 (GRCm38)	critical splice donor site	probably null
R3689:Cep162	UTSW	9	87,225,694 (GRCm38)	nonsense	probably null
R3743:Cep162	UTSW	9	87,217,177 (GRCm38)	splice site	probably benign
R4118:Cep162	UTSW	9	87,204,176 (GRCm38)	missense	probably benign	0.30
R4380:Cep162	UTSW	9	87,200,003 (GRCm38)	missense	probably damaging	0.99
R4450:Cep162	UTSW	9	87,225,808 (GRCm38)	missense	probably damaging	1.00
R4540:Cep162	UTSW	9	87,212,939 (GRCm38)	missense	probably damaging	1.00
R4598:Cep162	UTSW	9	87,203,795 (GRCm38)	missense	possibly damaging	0.95
R4700:Cep162	UTSW	9	87,206,862 (GRCm38)	missense	probably damaging	1.00
R4941:Cep162	UTSW	9	87,225,969 (GRCm38)	intron	probably benign
R5356:Cep162	UTSW	9	87,206,895 (GRCm38)	missense	probably damaging	1.00
R5468:Cep162	UTSW	9	87,227,237 (GRCm38)	missense	probably benign	0.00
R5579:Cep162	UTSW	9	87,203,671 (GRCm38)	missense	probably benign	0.26
R5859:Cep162	UTSW	9	87,204,092 (GRCm38)	missense	probably damaging	1.00
R6114:Cep162	UTSW	9	87,203,710 (GRCm38)	missense	probably benign
R6143:Cep162	UTSW	9	87,212,851 (GRCm38)	critical splice donor site	probably null
R6422:Cep162	UTSW	9	87,232,016 (GRCm38)	missense	possibly damaging	0.92
R6517:Cep162	UTSW	9	87,222,174 (GRCm38)	missense	probably damaging	0.99
R6576:Cep162	UTSW	9	87,217,145 (GRCm38)	missense	probably benign	0.01
R6782:Cep162	UTSW	9	87,211,684 (GRCm38)	missense	probably benign	0.07
R6867:Cep162	UTSW	9	87,217,081 (GRCm38)	nonsense	probably null
R7293:Cep162	UTSW	9	87,203,783 (GRCm38)	missense	probably benign	0.01
R7355:Cep162	UTSW	9	87,253,955 (GRCm38)	nonsense	probably null
R7391:Cep162	UTSW	9	87,248,494 (GRCm38)	nonsense	probably null
R7426:Cep162	UTSW	9	87,192,766 (GRCm38)	missense	probably damaging	1.00
R7593:Cep162	UTSW	9	87,204,197 (GRCm38)	missense	probably benign	0.40
R7710:Cep162	UTSW	9	87,232,119 (GRCm38)	missense	probably damaging	1.00
R7841:Cep162	UTSW	9	87,244,316 (GRCm38)	missense	probably benign	0.00
R7949:Cep162	UTSW	9	87,206,848 (GRCm38)	missense	probably benign	0.04
R8351:Cep162	UTSW	9	87,192,850 (GRCm38)	nonsense	probably null
R8451:Cep162	UTSW	9	87,192,850 (GRCm38)	nonsense	probably null
R8552:Cep162	UTSW	9	87,244,308 (GRCm38)	missense	probably benign	0.34
R8755:Cep162	UTSW	9	87,232,011 (GRCm38)	missense	probably benign	0.02
R8762:Cep162	UTSW	9	87,227,261 (GRCm38)	missense	probably benign	0.00
R9640:Cep162	UTSW	9	87,244,299 (GRCm38)	missense	probably benign	0.06
X0063:Cep162	UTSW	9	87,222,042 (GRCm38)	critical splice donor site	probably null
Z1177:Cep162	UTSW	9	87,199,980 (GRCm38)	critical splice donor site	probably null

Posted On

2013-01-20