Mutagenetix > Incidental Mutation

Incidental Mutation 'R1505:Olfr860'

169119

Institutional Source

Beutler Lab

Gene Symbol

Olfr860

Ensembl Gene

ENSMUSG00000066905

Gene Name

olfactory receptor 860

Synonyms

MOR146-2, GA_x6K02T2PVTD-13586614-13585661

MMRRC Submission

040868-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R1505 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

19845156-19849747 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19845788 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 277 (M277K)

Ref Sequence

ENSEMBL: ENSMUSP00000148568 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086482] [ENSMUST00000211924] [ENSMUST00000212353]

AlphaFold

Q8VFF7

Predicted Effect

probably benign
Transcript: ENSMUST00000086482
AA Change: M277K

PolyPhen 2 Score 0.389 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000130735
Gene: ENSMUSG00000066905
AA Change: M277K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.5e-56	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.1e-8	PFAM
Pfam:7tm_1	41	290	9.3e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211924

Predicted Effect

probably benign
Transcript: ENSMUST00000212353
AA Change: M277K

PolyPhen 2 Score 0.389 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212525

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212838

Coding Region Coverage

1x: 98.9%
3x: 97.8%
10x: 94.5%
20x: 86.3%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	T	A	5: 104,951,565	R444W	probably damaging	Het
Adnp	A	G	2: 168,183,741	S545P	possibly damaging	Het
Ankrd17	T	C	5: 90,300,026	R219G	possibly damaging	Het
Ap2m1	C	G	16: 20,542,697	P372A	probably benign	Het
Calml3	T	A	13: 3,804,071	T45S	probably benign	Het
Casp8	A	G	1: 58,828,922	E174G	probably damaging	Het
Ces4a	G	A	8: 105,138,097	G69S	probably damaging	Het
Cfap221	A	C	1: 119,953,628	L368R	probably benign	Het
Chd9	A	G	8: 91,006,495		probably null	Het
Cnot1	A	T	8: 95,728,667	I2035N	probably damaging	Het
Cyp2c67	T	C	19: 39,648,964	R23G	probably benign	Het
Dnah10	A	C	5: 124,754,239	H777P	possibly damaging	Het
Fabp3	C	T	4: 130,312,387	T57I	probably benign	Het
Fam162b	G	A	10: 51,587,202	A123V	probably damaging	Het
Golgb1	T	A	16: 36,919,643	N2781K	possibly damaging	Het
Hs2st1	C	A	3: 144,434,561	R333L	probably benign	Het
Kmt2e	A	G	5: 23,500,535	H1319R	probably null	Het
Necab1	A	T	4: 14,960,047	M300K	probably benign	Het
Ntrk3	T	A	7: 78,460,524	I321F	probably damaging	Het
Olfr228	A	T	2: 86,483,213	H176Q	possibly damaging	Het
Olfr484	A	G	7: 108,124,993	V90A	probably benign	Het
Olfr965	A	G	9: 39,719,478	N84D	probably damaging	Het
Osbpl6	T	C	2: 76,579,242	S483P	probably damaging	Het
Pcdhb17	A	C	18: 37,486,822	N555T	probably damaging	Het
Pdgfc	G	A	3: 81,209,236	R299H	possibly damaging	Het
Ptpn7	A	T	1: 135,134,564	T83S	probably benign	Het
Rapgef5	T	C	12: 117,688,619	V79A	possibly damaging	Het
Rexo5	T	A	7: 119,799,603	C54*	probably null	Het
Riok3	A	G	18: 12,152,878	K418R	probably benign	Het
Robo4	G	A	9: 37,403,227	G170D	probably damaging	Het
Rpl8	A	G	15: 76,904,410	D33G	possibly damaging	Het
Rspo2	T	C	15: 43,075,843	T184A	probably damaging	Het
Ryr2	A	T	13: 11,554,592	M4942K	possibly damaging	Het
Sel1l	T	C	12: 91,813,962	Y585C	probably damaging	Het
Slc25a11	G	T	11: 70,646,824	D13E	probably benign	Het
Slc5a6	G	T	5: 31,037,111	H584N	probably benign	Het
Snrpf	A	G	10: 93,583,519	V69A	possibly damaging	Het
Sorbs3	T	A	14: 70,190,802	K475*	probably null	Het
Speg	G	A	1: 75,375,542	V35I	probably benign	Het
Tlk2	T	G	11: 105,260,295	V468G	probably damaging	Het
Trim6	T	A	7: 104,232,564	W341R	probably damaging	Het
Ttll5	T	A	12: 85,879,410	I326N	probably damaging	Het
Vipas39	T	C	12: 87,246,160	Y318C	probably damaging	Het
Vmn1r185	T	A	7: 26,611,478	I201F	probably damaging	Het
Vwce	A	G	19: 10,664,244	H778R	probably benign	Het
Zbtb14	C	G	17: 69,387,764	I152M	probably benign	Het

Other mutations in Olfr860

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00942:Olfr860	APN	9	19846259	missense	probably damaging	1.00
IGL02216:Olfr860	APN	9	19846565	missense	probably damaging	0.99
IGL02269:Olfr860	APN	9	19845728	missense	possibly damaging	0.85
IGL02964:Olfr860	APN	9	19846254	nonsense	probably null
R0042:Olfr860	UTSW	9	19845779	missense	probably benign
R1941:Olfr860	UTSW	9	19845950	missense	probably damaging	0.99
R2030:Olfr860	UTSW	9	19846413	missense	probably benign	0.30
R3150:Olfr860	UTSW	9	19846214	missense	possibly damaging	0.80
R4597:Olfr860	UTSW	9	19845691	missense	probably benign	0.01
R5004:Olfr860	UTSW	9	19846102	missense	probably benign	0.00
R5006:Olfr860	UTSW	9	19846271	missense	probably benign	0.33
R5350:Olfr860	UTSW	9	19846616	start codon destroyed	probably null	0.97
R6163:Olfr860	UTSW	9	19845728	missense	probably benign	0.45
R6368:Olfr860	UTSW	9	19846409	missense	probably damaging	1.00
R7206:Olfr860	UTSW	9	19846560	missense	probably damaging	0.99
R7315:Olfr860	UTSW	9	19845835	missense	probably damaging	0.99
R8195:Olfr860	UTSW	9	19846484	missense	probably damaging	0.99
R8537:Olfr860	UTSW	9	19846552	missense	probably damaging	0.96
R8546:Olfr860	UTSW	9	19846389	missense	probably damaging	0.99
R8803:Olfr860	UTSW	9	19846166	missense	possibly damaging	0.95
R9049:Olfr860	UTSW	9	19845749	missense	probably damaging	1.00
R9164:Olfr860	UTSW	9	19846208	missense	possibly damaging	0.73
R9254:Olfr860	UTSW	9	19845916	missense	possibly damaging	0.83
R9379:Olfr860	UTSW	9	19845916	missense	possibly damaging	0.83
R9513:Olfr860	UTSW	9	19846520	missense	possibly damaging	0.73
R9515:Olfr860	UTSW	9	19846520	missense	possibly damaging	0.73

Predicted Primers

Posted On

2014-04-13